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Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

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Hepatobiliary & Pancreatic diseases International 2024年第2期23卷 160-170页

作者： Zi-Bing Qian Jun-Feng Li Wan-Yuan Xiong Xiao-Rong Mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of infectious diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic *** forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver *** general,more than one form of cell death pathways is responsible for the disease ***,it is particularly important to study the regulation and interaction of various cell death forms in liver *** sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver *** also used terms such as signal path,inducer,and inhibitor to supplement the query ***:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver ***:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis Liver disease

Clinical Trials of Respiratory Virus Infections: How to Address Challenges and Prepare for the Future

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infectious diseases & Immunity 2024年第3期4卷 101-102页

作者： Jingwen Ai Wenhong Zhang Department of infectious diseases Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency ResponseNational Medical Center for Infectious DiseasesHuashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Shanghai Sci-Tech InnoCenter for Infection and Immunity Shanghai 20052China Institute of Infection and Health Fudan UniversityShanghai 200040China.

*** Prior to the coronavirus disease 2019(COVID-19)outbreak,the only antiviral treatment widely used in clinical settings was for ***,following the global pandemic,there has been renewed research interest in medications for respiratory viral *** trials of antiviral medications often need to consider multiple dimensions because of the significant differences in disease severity among *** example,during respiratory viral epidemic seasons,the clinical spectrum of diseases is usually complex,including asymptomatic infections,symptomatic infections(mild to moderate without hospitalization),severe cases(requiring hospitalization),and fatalities.

关键词： Clinical respiratory clinical

Comment on:Clinical Characteristics,Diagnosis,and Treatments for COVID-19

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Current Medical Science 2024年第3期44卷 667-668页

作者： Ying WEN Xin-dan HU Department of infectious diseases The First Affiliated Hospital of China Medical UniversityShenyang 110001China

The clinical characteristics of COVID-19 patients have been well summarized by Xie et ***,we should pay attention to another special manifestation of COVID-19,COVID-19-related immune reconstitution inflammatory syndrome(IRIS).SARS-CoV-2,an infectious agent,can alscoause IRIS,similar to Mycobacterium *** the era of the COVID-19 pandemic,increasing cases of COVID-19-related IRIS have been ***,the definition and detailed criteria of COVID-19-related IRIS have not been thoroughly *** should pay attention to 3 essential components in a classical model of IRIS,including a primary disease that causes immunosuppression,a trigger that induces immune reconstitution.

关键词： al. clinical Clinical

Long noncoding nuclear enriched abundant transcript 1_2 is a promising biomarker for childhood-onset systemic lupus erythematosus

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Pediatric Investigation 2024年第2期8卷 101-107页

作者： Shipeng Li Xia Wang Xiaozhen Zhao Jianghong Deng Weiying Kuang Junmei Zhang Xiaohua Tan Chao Li Caifeng Li Department of Rheumatology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Center for infectious diseases Beijing Youan HospitalCapital Medical UniversityBeijing Key Laboratory for HIV/AIDS ResearchBeijingChina

Importance:Systemic lupus erythematosus(SLE)is a diffuse connective tissue disease with complex clinical manifestations and prolonged *** early diagnosis and condition monitoring of SLE are crucial to disease ***:To assess the diagnostic value of long noncoding RNA(lncRNA)nuclear enriched abundant transcript 1(NEAT1)in childhood-onset SLE(cSLE).Methods:Fifty-seven children diagnosed with SLE,40 children diagnosed with juvenile idiopathic arthritis(JIA),and 40 healthy children were *** blood samples from each patient were collected.A quantitative polymerase chain reaction was used to confirm the expression of lncNEAT1_1 and lncNEAT1_2 in peripheral *** among parameters were analyzed using the Mann-Whitney U test or independent sample ***:The expression of both lncNEAT1_1 and lncNEAT1_2 in patients with cSLE were significantly higher than that of healthy control and patients with *** operating characteristic curves revealed an area under the curve(AUC)of 0.633(95%confidence interval[CI],0.524-0.742;P=0.024)for lncNEAT1_*** AUC of lncNEAT1_2 was 0.812(95%CI,0.727-0.897;P<0.0001)to discriminate individuals with cSLE from health control and children with JIA with a sensitivity of 0.622 and a specificity of ***,lncNEAT1_2 expression was higher in patients with cSLE presenting with fever,lupus nephritis,elevated erythrocyte sedimentation rate,active disease activity,and decreased C3 level,compared with those without these ***,no similar correlation was observed for lncNEAT1_***:The expression of lncNEAT1_2 was significantly elevated in children with SLE,especially those with fever,renal involvement,and low C3 *** findings suggest that lncNEAT1_2 may represent a potential biomarker for cSLE.

关键词： Biomarker Children LncRNA SLE NEAT1

Rocahepevirus ratti: An underrecognised cause of acute hepatitis

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World Journal of Hepatology 2024年第8期16卷 1084-1090页

作者： George S Gherlan Department of infectious diseases “Carol Davila”University of Medicine and PharmacyBucharest 050474Romania

Zoonoses are responsible for many of all emerging infectious diseases as well as for those already *** ratti is a rat-originated virus related to the hepatitis E virus(Paslahepevirus balayani)but highly divergent genetically from this,with a high cross-species infection potential and zoonotic *** can infect humans,leading to acute hepatitis,and is primarily transmitted through the consumption of contaminated *** ratti was first discovered in Germany in *** first human case was described in 2017 in Hong Kong in an immune-compromised *** first case of chronic infection with Rocahep-evirus ratti was described in 2023.A meta-analysis based on 38 studies published between 2000 and 2023 identified 21 cases in humans described up to this date and 489 infections in different *** awareness regarding this virus is essential,as there are probably many cases that remain undiagnosed,and the virus even has the ability to produce chronic infections in selected patients.

关键词： Hepatitis Rocahepevirus ratti Rats Zoonoses Hepeviridae Liver

Global status and trends in hepatitis B virus DNA mutation research from 2003 to 2022:A comprehensive bibliometric view

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Portal Hypertension & Cirrhosis 2024年第1期3卷 14-21页

作者： Ming Li Xiaoming Xu Yong Liu Minxin Mao Yu Geng Shengxia Yin Xin Tong Chao Wu Jie Li Department of infectious diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjingJiangsuChina Department of infectious diseases Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChina Department of laboratory Medicine Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChina Institute of Viruses and infectious diseases Nanjing UniversityNanjingJiangsuChina

Aims:Hepatitis B virus(HBV)is an enveloped DNA virus belonging to the Hepadnaviridae *** is a significant contributor to the prevalence of chronic liver disease on a global *** in HBV DNA can affect the diagnosis,treatment,and prognosis of patients with chronic hepatitis *** numerous studies on HBV DNA mutations have been conducted,few bibliometric studies have been performed to *** study aimed to analyze changes in scientific output to gain a better understanding of the current research status and identify potential new research directions in the field of HBV DNA ***:Relevant studies published between 2003 and 2022 were retrieved from the Web of Science Core Collection *** version 6.1.R6 was used to construct network maps to evaluate collaborations among countries,institutions,authors,journals,and ***:In total,1508 publications over the past 20 years were obtained,mainly from China,the United States,and *** major research institutions in China included the University of Hong Kong,Fudan University,and Peking *** Ching Lung was the most productive author,whereas Anna Suk-Fong Lok was the most frequently co-cited *** keyword“HBsAg”was the strongest burst keyword in recent years,indicating possible future study ***:This bibliometric analysis intuitively revealed the overall research status of HBV DNA mutations,providing valuable information for researchers,funding agencies,and policymakers to explore the current research status,research hotspots,and new directions for future research.

关键词： bibliometrics DNA hepatitis B virus mutation

Treatment strategy for erythropoietic protoporphyria accompanied by severe abdominal pain and liver injury

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Portal Hypertension & Cirrhosis 2024年第1期3卷 36-38页

作者： Xiaoxin Wu Xiumei Zhou Shuai Zhao Keting He Wenxin Zhoudi Shangci Chen Xiaowei Xu State Key laboratory for Diagnosis and Treatment of infectious diseases National Clinical Research Centre for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of infectious diseases People's Hospital of Pujiang CountyJinhuaZhejiangChina

To the Editor,Erythropoietic protoporphyria(EPP)is a genetic disease caused by a lack of the enzyme ferrochelatase(FECH)in the heme biosynthesis pathway due to genetic *** deficiency is caused by a deleterious FECH variant in transposition to the frequently occurring hypomorphic allele or by the presence of biallelic pathogenic variants.1 EPP could lead to abnormal production and excretion of protoporphyrin IX,2 causing clinical manifestations such as skin damage and liver injury.3–5.

关键词： liver damage clinical

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng Li Jiangtao Sheng Department of Microbiology and immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

infectious causes of fever of unknown origin in developing countries: An international ID-IRI study

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Journal of Intensive Medicine 2024年第1期4卷 94-100页

作者： Hakan Erdem Jaffar AAl-Tawfiq Maha Abid Wissal Ben Yahia George Akafity Manar Ezzelarab Ramadan Fatma Amer Amani El-Kholy Atousa Hakamifard Bilal Ahmad Rahimi Farouq Dayyab Hulya Caskurlu Reham Khedr Muhammad Tahir Lysien Zambrano Mumtaz Ali Khan Aun Raza Nagwa Mostafa El-Sayed Magdalena Baymakova Aysun Yalci Yasemin Cag Umran Elbahr Aamer Ikram Department of infectious diseases&Clinical Microbiology Gulhane School of MedicineTurkish Health Sciences UniversityAnkaraTurkey Specialty Internal Medicine and Quality and Patient Safety Department Johns Hopkins Aramco HealthcareDhahranSaudi Arabia Division of infectious diseases Indiana University School of MedicineIndianapolisINUSA Department of infectious diseases Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Internal Medicine Department Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Cape Coast Teaching Hospital Cape CoastGhana Medical Parasitology Faculty of MedicineSuez UniversitySuezEgypt Department of Medical Microbiology and immunology Faculty of MedicineZagazig UniversityZagazigEgypt Department of Clinical Pathology Faculty of MedicineCairo UniversityGizaEgypt Department of infectious diseases School of MedicineIsfahan University of Medical SciencesIsfahanIran Department of infectious diseases Kandahar University Medical FacultyTeaching HospitalKandaharAfghanistan Department of infectious diseases Mohammed Bn Khalifa Bn Salman Alkhalifa Specialist Cardiac CenterAwaliBahrain Department of infectious diseases and Clinical Microbiology Faculty of MedicineIstanbul Medeniyet UniversityIstanbulTurkey Department of Pediatric Oncology National Cancer Institute–Cairo UniversityChildren Cancer Hospital EgyptCairoEgypt Department of Medicine Federal General HospitalIslamabadPakistan Institute for research in Medical Sciences and Right to Health(ICIMEDES) Scientific Research Unit(UIC)Faculty of Medical Sciences(FCM)National Autonomous University of Honduras(UNAH)TegucigalpaHonduras National Institute of Health IslamabadPakistan Shaukat Khanum Memorial Cancer Hospital and research Center LahorePakistan Medical Parasitology Department Research Institute of OphthalmologyGizaEgypt Department of infectious diseases Military Medical AcademySofiaBulgaria Department of Infecti

Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of ***:A multi-center study for infectious causes of FUO in lower middle-income countries(LMIC)and lowincome countries(LIC)was conducted between January 1,2018 and January 1,*** total,15 participating centers from seven different countries provided the data,which were collected through the infectious diseasesInternational research Initiative *** adult patients with confirmed infection as the cause of FUO were included in the *** severity parameters were quick Sequential Organ Failure Assessment(qSOFA)≥2,intensive care unit(ICU)admission,vasopressor use,and invasive mechanical ventilation(IMV).Results:A total of 160 patients with infectious FUO were included in the ***,148(92.5%)patients had community-acquired infections and 12(7.5%)had hospital-acquired *** most common infectious syndromes were tuberculosis(TB)(n=27,16.9%),infective endocarditis(n=25,15.6%),malaria(n=21,13.1%),brucellosis(n=15,9.4%),and typhoid fever(n=9,5.6%).Plasmodium falciparum,Mycobacterium tuberculosis,Brucellae,Staphylococcus aureus,Salmonella typhi,and Rickettsiae were the leading infectious agents in this study.A total of 56(35.0%)cases had invasive procedures for *** mean qSOFA score was 0.76±0.94{median(interquartile range[IQR]):0(0–1)}.ICU admission(n=26,16.2%),vasopressor use(n=14,8.8%),and IMV(n=10,6.3%)were not ***,38(23.8%)patients had at least one of the severity *** mortality rate was 15(9.4%),and the mortality was attributable to the infection causing FUO in 12(7.5%)***:In LMIC and LIC,tuberculosis and cardiac infections were the most severe and the leading infections causing FUO.

关键词： Developing countries Fever of unknown origin Infection