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Enhancing Security for Legacy Factory Machines: A Continuous Key Renewal Algorithm for Securing Group of Machines

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Journal of Software Engineering and Applications 2023年第12期16卷 714-743页

作者： Nicolas Ferry Paul-Eric Dossou Gabriel Ihowa Gaspard Laouenan icam Nantes Carquefou France icam grand paris sud Carré Sénart Lieusaint France IFSTTAR/AME/SPLOTT Université Gustave Eiffel Marne-la-Vallée France

Companies are generally focused on how to improve their global performance. Concepts, methods and tools are regularly used to transform them. Key performance indicators are used to measure how performance is increased. Industry 4.0 concepts and sustainability expectations actually contribute to this performance improvement. Indeed, cybersecurity as one of these concepts is required to increase the company performance. Even if it is well-known and applied in companies through the protection of their information systems, progress is expected in research on how to ensure the security of data and factory processes in the manufacturing, as the number of cyberattacks towards industries is growing these last few years. This paper aims to increase the company performance and sustainability to enforce factory machines protection by creating private security network groups. But currently, most of the Programmable Logic Controller PLC protocols have not been securely designed. Thus, the creation of secure groups of machines by combining strong authentication, strong or lightweight ciphering, and data stream integrity is proposed. The security is enforced by a continuous key’s renewal algorithm. An experiment on an industry’s architecture has been led to validate the concepts of the proposition. The study is compared to existing OPC-UA and MACsec standards in terms of drawbacks and advantages. This work could be implemented in hardware for further performance improvement.

关键词： Sustainable Industries Cybersecurity Networks Protocols Side-Channel Analysis

Nanoparticles with high payloads of pipemidic acid, a poorly soluble crystalline drug: drug-initiated polymerization and self-assembly approach

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Acta Pharmaceutica Sinica B 2018年第3期8卷 420-431页

作者： Elisabetta Pancani Mario Menendez-Miranda Alexandra Pastor Francois Brisset Marie-Francoise Bernet-Camard Didier Desmaele Ruxandra Gref Institut de Sciences Moléculaires d'Orsay(ISMO) Univ.of Paris-SudUniversitéParis-Saclay Institut Galien UMR8612 Univ.of Paris-SudUniversitéParis-Saclay Institut de Chimie Moléculaire et des Matériaux d'Orsay(ICMMO) Univ.of Paris-SudUniversitéParis-Saclay EA4043" UnitéBactéries Pathogènes et Santé"(UBaPS) Univ.of Paris-SudUniversitéParis-Saclay

Nowadays, biodegradable polymers such as poly(lactic acid)(PLA), poly(D,L-lactic-coglycolic acid)(PLGA) and poly(ε-caprolactone)(PCL) remain the most common biomaterials to produce drug-loaded nanoparticles(NPs). Pipemidic acid(PIP) is a poorly soluble antibiotic with a strong tendency to crystallize. PIP incorporation in PLA/PLGA NPs was challenging because of PIP crystals formation and burst release. As PIP had a poor affinity for the NPs, an alternative approach to encapsulation was used, consisting in coupling PIP to PCL. Thus, a PCL–PIP conjugate was successfully synthesized by an original drug-initiated polymerization in a single step without the need of ***–PIP was characterized by NMR, IR, SEC and mass spectrometry. PCL–PIP was used to prepare selfassembled NPs with PIP contents as high as 27%(w/w). The NPs were characterized by microscopy,DLS, NTA and TRPS. This study paves the way towards the production of NPs with high antibiotic payloads by drug-initiated polymerization. Further studies will deal with the synthesis of novel polymer–PIP conjugates with ester bonds between the drug and PCL. PIP can be considered as a model drug and the strategy developed here could be extended to other challenging antibiotics or anticancer drugs and employed to efficiently incorporate them in NPs.

关键词： Pipemidic acid Nanoparticle Antibiotic Nanoprecipitation Crystalline drug Drug-initiated polymerization

Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair

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Neural Regeneration Research 2017年第6期12卷 886-889页

作者： Angelina Angelova Borislav Angelov Institut Galien paris-sud CNRS UMR 8612 University of Paris-Sud Université Paris-Saclay Lab Ex LERMIT Institute of Physics ELI Beamlines Academy of Sciences of the Czech Republic

Among the macromolecular drug targets in neurodegenerative disorders, the neurotrophin brain-derived neurotrophic factor（BDNF） and its high-affinity tropomyosin-related kinase receptor（Trk B） present strong interest for nanomedicine development aiming at neuronal and synaptic repair. Currently, BDNF is regarded as the neurotrophic factor of highest therapeutic significance. However, BDNF has delivery problems as a protein drug. The enhanced activation of the transcription factor CREB（c AMP response element-binding protein） has been evidenced to increase the BDNF gene expression and hence the production of endogenous BDNF. We assume that BDNF delivery by nanocarriers and mitochondrial protection may provide high potential for therapeutic amelioration of the neuroregenerative strategies. Beneficial therapeutic outcomes may be expected for synergistic dual or multi-drug action aiming at（i） neurotrophic protein regulation in the central and peripheral nervous systems, and（ii） diminishment of the production of reactive oxygen species（ROS） and the oxidative damage in mitochondria. Our research strategy is based on a nanoarchitectonics approach for the design of nanomedicine assemblies by hierarchical self-assembly. We explore nanoarchitectonics concepts in soft-matter nanotechnology towards preparation of biodegradable self-assembled lipid nanostructures for safe neuro-therapeutic applications of multi-target nanomedicines.

关键词： neuronal synaptic repair neurotrophic neurotrophin mitochondria CREB biodegradable endogenous aiming

Role of the ejaculatory bulb in biosynthesis of the male pheromone cis-vaccenyl acetate in Drosophila melanogaster

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Integrative Zoology 2007年第2期2卷 89-99页

作者： Gaëlle GUIRAUDIE-CAPRAZ Dang Ba PHO Jean-Marc JALLON UnitéMixte de Recherche Universitéde paris-sud et Centre National de la Recherche Scientifique n°8620 University of Paris SudOrsayFrance

In Drosophila melanogaster,the male ejaculatory bulb is the site of synthesis of a male-specific pheromone,cis-vaccenyl acetate,which functions as both an attractant and an *** long monounsaturated acetate is structurally similar to a number of shorter gland-synthesized moth *** cell monolayer that forms the Drosophila male ejaculatory bulb wall is responsible for the production and secretion of cis-vaccenyl acetate into the seminal *** dissected bulbs were incubated with sodium[14-C]-acetate(or deuterated acetate),a labeled acetate ester was *** labeled acetate ester co-migrated with cis-vaccenyl acetate in thin layer *** of the abdomens of males from which the ejaculatory bulbs had been removed,or the abdomens of females,with radiolabeled acetate did not yield any acetate ester,but did yield other lipid products,including *** the isolated labeled acetate ester was hydrolyzed,no radioactive vaccenol was *** strongly suggests that the acetyl group is incorporated via a transacetylation reaction,but that the vaccenyl moiety is not synthetized in the *** transacetylation enzyme activity was localized in the microsomal subfraction of the bulb homogenate,and its affinity for vaccenol was not very different from that reported for monounsaturated alcohol substrates in moths.

关键词： cis-vaccenyl acetate Drosophila melanogaster ejaculatory bulb male pheromone microsomes transacetylation

Recapture probability, flight morphology, and microorganisms

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Current Zoology 2018年第3期64卷 277-283页

作者： Zaid AL RUBAIEE Haider AL-MURAYATI Anders Pape MФLLER Ecologie Systematique Evolution Universite Paris-Sud CNRS AgroParisTech Universite Paris-Saclay F-91405 Orsay Cedex France

Microorganisms on and within organisms are ubiquitous and interactions with their hosts range from mutualistic over commensal, to pathogenic. We hypothesized that microorganisms might affect the ability of barn swallows Hirundo rustica to escape from potential predators, with positive associations between the abundance of microorganisms and escape ability implying mutualistic effects, while negative associations would imply antagonistic effects. We quantified escape behavior as the ability to avoid capture in a mist net and hence as a small number of recaptures. Because recapture probability may also depend on timing of reproduction and reproductive success, we also tested whether the association between recapture and microorganisms was mediated by an association between recapture and life history. We found intermediate to strong positive relationships between recapture probability and abundance of Bacillus megaterium, but not abundance of other bacteria or fungi. The abundance of B. megaterium was associated with an advance in laying date and an increase in reproductive success. However, these effects were independent of the number of recaptures. This interpretation is supported by the fact that there was no direct correlation between laying date and reproductive success on one hand and the number of recaptures on the other. These findings have implications not only for predator-prey interactions, but also for capture-mark-recapture analyses of vital rates such as survival and dispersal.

关键词： bacteria barn swallow capture-mark-recapture analyses fungi Hirundo rustica microbiome.

THERMODYNAMIQUE　DES　ENSEMBLES　DE　CANTOR　AUTOSIMILAIRES　（THERMODYNAMICS　OF　SELF－SIMILAR　CANTOR　SETS）

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Chinese Annals of Mathematics,Series B 1994年第3期15卷 253-272页

作者： G. MICHON J. PEYRIERE(University de Bourgogne, URA 755, BP 138, 21004 Dijon, dance.)(University de paris-sud, Centre d’Orsayl URA 757, 91405 Orsayt dance.) Universite de Bourgogne 法国 Universite de paris-sud 法国

A class of metric, compact, and totally disconllected spaces, called self-similar Cantor setsis illtroduced. A self-similar structure is defined to be a graph with weighted edges. Theintroduction of ultrametrics and quasi-isometries gives versatility to this construction. Thermodynamical functions as free energy and elltropy are associated with self-similar *** analysis, based on a 'Large Deviations' inequality and Gibbs measures, leads toa fairly general Hausdoffi dimension theorem.

关键词： Cantor set Graph Dimension Thermodynamics Gibbs meajsure,Multifractals.

Fashion and out of fashion:appearance and disappearance of a novel nest building innovation

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Avian Research 2017年第2期8卷 71-75页

作者： Anders P.Møller Ecologie Systematique Evolution Universite Paris‑SudCNRSAgroParisTechUniversite Paris‑Saclay91405 Orsay CedexFrance

Background:Nests are composed of and built with different materials that are handled in specific ways. These mate?rials must initially have been used de novo before commonly being incorporated into nests. Plastic and plastic bags were invented in the 1950s, and they are widely distributed in the environment. Birds started picking up plastic from plastic used to cover farm produce such as silage, potatoes, beets and other crops for use in their nests in the ***:I recorded the frequency of such plastic use by the Blackbird(Turdus merula) in nests in Denmark, starting in 1966, followed by a peak in use in the 1970s and a subsequent ***:Nests with plastic were initially built earlier in the season than those without plastic, indicating an associa?tion between innovation and early reproduction. Plastic use was subsequently selected against because nests with plastic suffered from higher rates of predation than nests without plastic, probably because nests with plastic were easier to locate. However, the elevated risk of nest predation only applied to outdoor nests, but not to nests inside buildings, probably because visually searching nest predators such as corvids do not enter ***:These findings show that the dynamics of nest material use depend on the benefits of innovation and the fitness costs of nest predation.

关键词： Fashion Indoor breeding Innovation Nest predation Turdus merula

Cancer drug resistance: rationale for drug delivery systems and targeted inhibition of HSP90 family proteins

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Cancer Drug Resistance 2019年第3期2卷 381-398页

作者： Clélia Mathieu Samir Messaoudi Elias Fattal Juliette Vergnaud-Gauduchon Institut Galien paris-sud CNRSUMR 8612UniversitéParis-Sud/Paris-SaclayChâtenay-Malabry 92296France BioCIS CNRSUMR 8076UniversitéParis-Sud/Paris-SaclayChâtenay-Malabry 92296France.

Nanocarriers have been developed in order to protect drugs or to improve drugs efficiency by reaching the damaged tissue and avoiding systemic and local *** using HSP90 inhibitors,some cancer drug resistances have been overcome and the loading into nanocarriers of such drugs has shown an increase of their *** review will present some advantages of HSP90 inhibitors to treat resistant tumors;especially those targeting the mitochondrial protein *** will also focus on the targeting of the primary tumors,cancer stem cells and metastatic cells.

关键词： Heat-shock proteins cancer resistance nanoparticles

Equidistribution for meromorphic transforms and the dd^c-method

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Science China Mathematics 2005年第Z1期48卷 180-194页

作者： Tien-Cuong Dinh Nessim Sibony Mathématique-Bt.425 UMR 8628 Université Paris-Sud91405 OrsayFranceMathématique-Bt.425 UMR 8628Université Paris-Sud91405 OrsayFrance

In this paper we give an introduction to the notion of meromorphic *** describe some equidistribution problems and their solution, using the ddc-method. In particular, we give some statistical properties of the equilibrium measure for meromorphic maps on compact Kahler manifolds: K-mixing, exponential decay of correlations and central limit theorem.

关键词： meromorphic map, correspondence, compact Kahler manifold.