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Interest of Cardiac Rehabilitation in Patients with Heart Disease in a Cardiology Department in senegal

World Journal of Cardiovascular Diseases 2024年第4期14卷 217-227页

作者： Awa Ba-Diop Abdou Khadir sow Rim Mohamed Khaled Mor Diaw Mame saloum Coly Fulgence Abdou Faye Amadou Ndiadé Bamba Gaye Abdoulaye Ba Abdoulaye samb Laboratory of Physiology and Functional Explorations Department of Medicine Alioune Diop University of Bambey Bambey Senegal irl3189 Environment Health Societies CNRS-UCAD Dakar Senegal the African Research Network Noncommunicable Diseases Dakar Senegal Laboratory of Physiology and Functional Explorations FMPOS UCAD Dakar Senegal Laboratory of Physiology and Functional Explorations UFR Sant&#233 UAS of Thi&#232s Thi&#232s Senegal INsERM U970 team 4 Paris France

Cardiac rehabilitation helps improve the prognosis and quality of life for patients with heart disease. to show its interest in the African context, in the management of heart disease, a prospective study was carried out. Its objective was to evaluate the effects of physical rehabilitation on cardiac function. Methods: Patients were evaluated at the beginning and at the end of cardiovascular rehabilitation by cardiovascular, biological, and echocardiographic parameters including the size of the heart chambers, the kinetics of the walls, and the systolic function of the ventricles. Results: the study involved 12 patients, 67% of whom were men. After cardiac rehabilitation, the mean hemodynamic constants had not been significantly modified. However, a significant decrease in total-Cholesterol, LDL-Cholesterol and triglyceride levels was noted. Mean fasting blood sugar decreased from 1.25 ± 0.48 g/L to 0.92 ± 0.18 g/L and glycated hemoglobin from 7.72% ± 0.01% to 6.45% ± 0.008%. the echocardiographic parameters studied showed an improvement in the dilation of the heart chambers in 8.33% of the patients, the normalization of the ejection fraction of the left ventricle in 16% patients, the improvement of the kinetic disorders in 16% of patients and recovery of right ventricular systolic function in all patients. Conclusion: Cardiac rehabilitation as a secondary preventive measure for cardiovascular disease has contributed significantly to improving the clinico-biological parameters of the disease.

关键词： Cardiac Rehabilitation Heart Disease Cardiovascular Disease

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Acute toxicity and Anthelmintic Effects of Gomphrena serrata L. (Amaranthaceae) Extracts on Adult Worms and Eggs of Haemonchus contortus

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Pharmacology & Pharmacy 2024年第5期15卷 207-221页

作者： Hippolyte Ouedraogo Mohamed Bonewendé Belemlilga Aristide traore Gilchrist Abdoul Laurent Boly Félicité Moyenga Gueswindé Geoffroy Ouedraogo sylvain Ilboudo Lazare Belemnaba sylvin Ouedraogo Laboratoire de Recherche-Dé veloppement de Phytom&#233dicaments et M&#233dicaments (LR-D/PM) Institut de Recherche en Sciences de la Sant&#233 (IRSS) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso Laboratoire de Dé veloppement du M&#233dicament (LADME) Centre de Formation deRecherche et d&#8217Expertises en Sciences du M&#233dicament (CEA-CFOREM) &#201cole Doctorale Sciences de la Sant&#233 (ED2S) Universit&#233 Joseph KI-ZERBO Ouagadougou Burkina Faso International Research Laboratory-environnement Sant&#233 Soci&#233t&#233s (IRL 3189 ESS) CNRS/CNRST/UCAD/UGB/USTTB Ouagadougou Burkina Faso

Gomphrena serrata L. (Amaranthaceae) is a medicinal plant widely used traditionally in rural areas to treat many diseases, including gastrointestinal helminthiasis of small ruminants. this work aims to estimate the plant extracts phytochemical potential and study the activities of the aqueous decoction (Gs_AD), aqueous macerate (Gs_AM), and hydroalcoholic macerate (Gs_HEM) of Gomphrena serrata extracts on two developmental stages (eggs and adult worms) of Haemonchus contortus. Phytochemical screening was carried out. the acute toxicity test was performed according to the Organisation for Economic Co-operation and Development (OECD) test guideline 423. the Haemonchus contortus eggs hatching inhibition test was performed left to incubate for 48 hours in the presence of the different plant extracts at increasing concentrations of 0.125;0.25;0.5;0.625;1;2;3 mg/mL. For the motility inhibition test on adult worms, the worms were contacted with the extracts at concentrations of 0.75;1;1.25;1.5;2;3;4 mg/mL and left to incubate for 24 hours. Albendazole and levamisole were used as standard. Phytochemical screening revealed the presence of tannins, saponins, reducing compounds, coumarins and derivatives, anthocyanins, steroids, triterpenes, and flavonoids. An acute toxicity study showed that the oral LDsub>50sub> value of G. serrata was estimated to be 5000 mg/kg. All extracts showed an effect on both stages of parasite development. the hatching inhibition rate was 100% from 3 mg/mL for all three extracts. the rate of inhibition of motility was 100% from 4 mg/mL for each extract. HEM is more efficient on eggs and Haemonchus contortus adult worms than other extracts with ICsub>50sub> of 0.457 mg/mL and LCsub>50sub>sub> sub>of 1.329 mg/mL, respectively. these results suggest that Gomphrena serrata, a plant used by farmers, has anthelmintic properties.

关键词： Gomphrena serrata Haemonchus contortus Anthelmintic In Vitro

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Humoral Response and tolerance of Vaccination against sARs-CoV-2 in Adults senegalese Patients Undergoing Hemodialysis: A Multicenter Prospective study

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Open Journal of Nephrology 2024年第1期14卷 70-80页

作者： Lot Nehemie Motoula Latou Moustapha Mbow Modou Ndongo Gnagna Faye Gora Lo sidy Mohamed seck Department of Nephrology and Dialysis Military Hospital of Ouakam Dakar Senegal Immunology Laboratory Military Hospital of Ouakam Dakar Senegal Department of Nephrology and Dialysis Regional Hospital of Kedougou Kedougou Senegal Department of Nephrology Idrissa Pouye General Hospital Dakar Senegal Bacterioloy and Virology Laboratory CMIA Dakar Senegal irl-3189 ess/UGB/CNRs/UCAD/CNRst/UstB Faculty of Health Sciences University Gaston Berger Saint-Louis Senegal

Introduction: Following the COVID-19 pandemic, vaccination has been proposed in several countries as the main preventive measure despite very limited data, particularly in dialysis patients. We conducted this study to assess the immunological response to vaccination in senegalese hemodialysis patients. Patients and Methods: We conducted a prospective study, in two dialysis centers in Dakar from March 30sup>thsup> to August 30sup>thsup>, 2021 including patients on hemodialysis for >6 months, vaccinated against sARs-CoV-2 according to the vaccination schedule recommended by WHO. A vaccine response was considered positive when seroconversion was observed after one dose of vaccine. the clinical efficacy of immunization was defined as the absence of new COVID-19 infection in patients who received a complete vaccination. Results: Among the 81 patients included in the study, 7.4% had anti-spike IgM antibodies before their first vaccination. seroprevalence of IgM antibodies was 38.3% one month after the first vaccine dose (at M1) and 8.6% one month after the second dose (at M4). Anti-spike IgG antibodies were present in 40.3% of patients before vaccination, in 90.1% at M1, and in 59.7% at M4. Among patients previously infected with sARs-CoV-2, 10.2% had IgM antibodies at M0, 31.6% at M1, and 10.5% at M4 post-vaccination. similarly, seroprevalences of IgG antibodies in this subgroup were 31.5%, 61.3%, and 50.0% respectively at M0, M1, and M4 post-vaccination. A comparison of seroconversion rates between M0 and M4 showed significant differences only for IgG in COVID-19 naive patients. Mean duration in dialysis and the existence of previous COVID-19 infection were associated with patients’ vaccinal response after the two doses. Age, gender and the use of immunosuppressive treatment did not influence post-vaccinal antibody production. Conclusion: Vaccination against COVID-19 in senegalese hemodialysis patients induced a low seroconversion rate but it was well tolerated. M

关键词： sARs-Cov2 Vaccination Humoral Response tolerance Hemodialysis senegal

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Influence of anthropic and eco-hydrological factors on the floristic diversity of the herbaceous vegetation around the temporary ponds in Ferlo,northern senegal

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Journal of Plant Ecology 2022年第1期15卷 26-38页

作者： Ndiabou Faye Aly Diallo Moustapha Bassimbésagna Jean Luc Peiry Papa saliou sarr Aliou Guisse Département de Biologie Végétale UniversitéCheikh Anta DiopDakarSenegal irl3189 Environment SantéSociétésCentre National de la Recherche Scientifiques(CNRS)ParisFrance irl3189 environnement SantéSociétésUniversitéCheikh Anta DiopDakarSenegal Observatoire international Hommes Milieux-OHMi tessekere UniversitéCheikh Anta DiopDakarSenegal Observatoire international Hommes Milieux-OHMi tessekere Centre National de la Recherche Scientifique(CNRS)ParisFrance Departement d’Agroforesterie UniversitéAssane Seck de ZiguinchorZinguinchorSenegal Département de Géographie Universitéde Clermont FerrandClermont-FerrandFrance Japan International Research Center for Agricultural sciences(JIRCAs) TsukubaIbarakiJapan

temporary ponds play substantial roles in preserving biodiversity in the *** study investigated the influence of anthropic and eco-hydrological factors on the plant diversity around two grazed ponds and one ungrazed pond in Ferlo,northern *** phytoecological transects were established per *** each transect,homogenous herbaceous vegetation units were identified and characterized(herbaceous cover,exposure,soil texture,soil moisture and pH,average height and slope).the herbaceous flora comprised 55 species,41 genera and 22 families across the three *** of the Poaceae,particularly Eragrostis tremula and Enteropogon prieurii,mostly colonized the grazed ponds,while the ungrazed pond favored other families’species such as Achyranthes sp.,Commelina forsskaolii,Corchorus *** shannon’s diversity index(H′)of Wendu Marodi(ungrazed pond)was slightly higher(4.9 bits)than that of Belel Lougal and Belel sow(grazed ponds)with 4.8 and 4.5 bits,*** equitability indices were relatively high in the three ponds(0.85,0.83 and 0.78).Eco-ecological factors distinguished four species’groupings:a tribulus terrestris grouping colonizing the constraining and over-grazed zones,a Digitaria horizontalis grouping,and Chloris barbata grouping found in the transition zones,and an Achyranthes aspera grouping in the wetlands,where woody plants were strongly present and the anthropic action *** study highlighted the importance of maintaining a landscape mosaic of ungrazed or semi-protected ponds and grazed ponds to preserve the herbaceous floristic diversity in the center of Ferlo(senegal)and the sahel in general.

关键词： ponds Ferlo grazing herbaceous vegetation transect

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Contribution of High sensible C-Reactive Protein (hsCRP) in the Assessment of the Risk of Onset of type 2 Diabetes and Its Cardiovascular Complications

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Journal of Diabetes Mellitus 2024年第2期14卷 95-107页

作者： Maïmouna touré Léopold Ngor sène Jean Pierre Diagne Demba Diédhiou souleymane thiam Abdou Khadir sow Mor Diaw Aïssatou seck salimata Diagne Houndjo Abdoulaye Ba Abdoulaye samb Fatou Diallo-Agne Modou Oumy Kane Laboratoire de Physiologie et d’ Explorations Fonctionnelles Physiologiques Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal irl3189 &#8220Environnement Sant&#233 Soci&#233t&#233&#8221 CNRS CNRST Bamako-UCAD Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire Privé de Biologie General Kaolack S&#233n&#233gal Centre Hospitalier Universitaire (CHU) Abasse Ndao Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire de Biochimie et de Biologie molé culaire Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire de Physiologie Pharmaceutique Facult&#233 de M&#233decine de Pharmacie et d'OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal

Background: type 2 diabetes is a metabolic disease characterized by chronic hyperglycemia. the latter plays an essential role in inflammation by stimulating the production of pro-inflammatory cytokines or by increasing their secretion by an oxidative mechanism. these cytokines control the hepatic synthesis of an inflammatory protein called C-Reactive Protein (CRP). High or average values of CRP would have a predictive value of cardiovascular diseases and type 2 diabetes. the relationship between low CRP values and the risk of developing type 2 diabetes and its cardiovascular complications is not sufficiently studied. the hsCRP could serve as a predictive biomarker of risk of onset, follow-up and prognosis for type 2 diabetes and its cardiovascular complications. to answer this problem, we conducted this study, the aim of which was to study the predictive role of hsCRP in the risk of occurrence of type 2 diabetes and its cardiovascular complications. Materials and Methods: this is a prospective and cross-sectional case-control study involving 200 participants including 100 control women and 100 women with type 2 diabetes (mean age was respectively 49.89 years ± 8.26 & 51.92 years ± 7.18;p = 0.066). the interviews were conducted on the basis of a questionnaire. Physical examination collected biometric data and cardiovascular constants. the biochemical parameters such as hsCRP were analyzed by an automated Abbott device. Results: We noted that hsCRP was significantly higher in type 2 diabetic subjects compared to control subjects (p (rho = 0.40, p systolic blood pressure (rho = 0.30, p = 0.003), diastolic blood pressure (rho = 0.28, p = 0.006), total body fat (rho = 0.48, p Conclusion: hsCRP has a prognostic value in the evaluation of cardiovascular risk. It seems to play an important role in the pathogenesis of type 2 diabetes mellitus and its cardiovascular complications. It could thus be considered as a biomarker for the screening, monitoring and prognosis of type 2

关键词： hsCRP Biomarker Inflammation type 2 Diabetes

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Anti-Biofilm, Anti-Quorum sensing, and Anti-Proliferative Activities of Methanolic and Aqueous Roots Extracts of Carica papaya L. and Cocos nucifera L.

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Advances in Microbiology 2023年第4期13卷 165-180页

作者： Wendkouni Leila Marie Esther Belem-Kabré Vincent Ouédraogo Bagora Bayala Alimata Bancé Estelle Ouédraogo Boubacar Yaro Lazare Belemnaba Moussa Compaoré Martin Kiendrébeogo Noufou Ouédraogo Department of traditional Medicine and Pharmacopoeia-Pharmacy Health Sciences Research Institute Ouagadougou Burkina Faso Laboratory of Biochemistry and Applied Chemistry (LABIOCA) Doctoral School of Science and Technology Joseph KI-ZERBO University Ouagadougou Burkina Faso Laboratory of Molecular Biology and Genetics (LABIOGENE) Doctoral School of Science and Technology Joseph KI-ZERBO University Ouagadougou Burkina Faso International Research Laboratory: environnement Santé Sociétés (IRL 3189 ESS) CNRST/CNRS/UCAD/UGB/USTTB Ouagadougou Burkina Faso

Objective: this study focused on the antibacterial and anti-proliferative activity of extracts from Carica papaya and Cocos nucifera roots. Methodology: the minimum inhibitory concentration and the minimum bactericidal concentration of the extracts on Escherichia coli, Pseudomonas aeruginosa, streptococcus mutans, and staphylococcus aureus were deduced by the microdilution method. the anti-biofilm activity was determined on all four strains and anti-quorum sensing activity by inhibition of violacein production in Chromobacterium violaceum. Anti-proliferative activity on prostate cultured cancer cells was evaluated by Mtt assay. sterols and triterpenes were also assayed in this study. Results: the methanolic extract of Carica papaya showed the best anti-biofilm effect with a percentage inhibition of 66.10 ± 1.79. the methanolic extract of Cocos nucifera had the strongest inhibition on the production of quorum sensing (61.42 ± 0.28). In addition, the methanolic extract of Cocos nucifera roots showed the best cytotoxic effect on prostate cancer LNCaP cell lines (ICsub>50sub> = 26.98 ± 2.6 μg/mL) and Carica papaya on the PC-3 lines (ICsub>50sub> = 127.20 ± 5.99 μg/mL). the extracts were also rich in triterpenes and sterols. Conclusion: this study provides support for the ethnomedical use of Carica papaya and Cocos nucifera roots as an antimicrobial and anticancer.

关键词： triterpenes and sterols Content Antibacterial Biofilm Quorum sensing Anti-Proliferative Medicinal Plants

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Phytochemical screening by High-Performance thin-Layer Chromatography, Antioxidant Activities and Acute toxicity of trunk Barks Extracts of Lannea velutina A. Rich

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American Journal of Analytical Chemistry 2022年第10期13卷 365-381页

作者： Boukaré Kaboré Moumouni Koala Mathieu Nitiema Windingoudi Rimwagna Christian Ouedraogo souleymane Compaoré Lazare Belemnaba salfo Ouedraogo sylvain Ilboudo Noufou Ouedraogo Constantin M. Dabiré Félix B. Kini sylvin Ouedraogo Eloi Palé Laboratoire de Chimie Organique et de Physique Appliquée (LCOPA) école Doctorale Sciences et Technologie UniversitéJoseph KI-ZERBO Ouagadougou Burkina Faso Département Médecine-Pharmacopée traditionnelles/Pharmacie (MEPHAtRA/Ph) Institut de Recherche en Sciences de la Santé (IRSS/CNRST) Ouagadougou Burkina Faso International ResearchLoboratory-environnement Santé Sociétés (IRL 3189 ESS) CNRST/CNRS/UCAD/UGB/USTTB Burkina Faso Laboratoire de Chimie et énergies Renouvelables Université Nazi BONI Bobo Burkina Faso

Lannea velutina is a traditional herbal remedy used to treat various diseases, including hypertension (HBP). Herbal medicines are affordable, and some have minimal side effects;they are rich in bioactive components that encourage prevention and treatment. this work uses appropriate experimental paradigms to investigate the phytochemical composition, antioxidant activity, and acute oral toxicity of L. velutina trunk bark extracted in water, methanol, ethyl acetate, dichloromethane, and hexane. According to a high-performance thin-layer chromatography profile, this shrub’s bark contains sterols, saponosides, flavonoids, and tannins. Compared to ethyl acetate and aqueous extracts, the methanol extract had the highest total phenolic (607.06 ± 0.6 mg GAE/g DW), flavonoid (20.97 ± 0.23 mg QE/g DW), and condensed tannins (194.50 ± 0.75 CE/g DW) content. the methanol extract displayed the highest antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capability assay (ICsub>50sub> = 8.59 g/mL;AAI = 4.66) compared to the other extracts. It exhibited antiradical action comparable to that of trolox (ICsub>50sub> = 15.16 g/mL), ascorbic acid (ICsub>50sub> = 11.94 g/mL), and catechin (ICsub>50sub> = 11.64 g/mL). the connection between flavonoid concentration and hydrophilic antioxidant activity was robust (r = 0.997). Mice were used to evaluate the acute oral toxicity of ethyl acetate, methanol, and aqueous extracts using guidelines 425 of the Organization for Economic Cooperation and Development. All tested extracts have an estimated LDsub>50sub> greater than 2000 mg/kg body weight. the truncal bark of L. velutina could be an alternative source for HtA management.

关键词： Lannea velutina Phytochemicals Proanthocyanidins Antioxidants LD50

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HPtLC Phytochemical screening and Hydrophilic Antioxidant Activities of Apium graveolensL., Cleome gynandraL., and Hibiscus sabdariffaL. Used for Diabetes Management

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American Journal of Analytical Chemistry 2021年第1期12卷 15-28页

作者： Moumouni Koala Alphonsine Ramde-tiendrebeogo Noufou Ouedraogo sylvain Ilboudo Boukaré Kaboré Félix B. Kini sylvin Ouedraogo Institut de Recherche en sciences de la santé Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouagadougou Burkina Faso Laboratoire de Chimie Organique et Physique Appliquées (L.C.O.P.A.) Université Joseph KI-ZERBO UFR/SEA Département de Chimie Ouagadougou Burkina Faso Unité Mixte Internationale Environnement-Santé-Société (UMI 3189 ESS) CNRST/CNRS/UCAD/UGB/USTTB-P&ocirc le Burkina Ouagadougou Burkina Faso

Diabetes mellitus is a socially significant disease characterized by chronic hyperglycemia and metabolic disorders of proteins, carbohydrates, and lipids due to reduced function of insulin. Medicinal plants, rich in bioactive components that promote prevention and treatment, are inexpensive and no side effects. Apium graveolens, Cleome gynandra, and Hibiscus sabdariffa from Burkina Faso were investigated for their phytochemical profile and antioxidant activities. the high-performance thin-layer chromatography profile revealed flavonoids, tannins, and sterols in these herbaceous. the Hibiscus sabdariffa methanolic extract exhibited the highest total phenolic (138.4 ± 0.5 mg GAE/g DW) and flavonoid (52.8 ± 0.6 mg RuE/g DW) contents comparatively to Cleome gynandra and Apium graveolens. Hibiscus sabdariffa methanolic extract also presented the highest antioxidant activity (ICsub>50sub> = 0.31 ± 0.002 mg/mL) using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity assay. A high correlation between flavonoid contents and hydrophilic antioxidant activities (r = 0.99) was observed, indicating that flavonoids contribute significatively to these herbaceous antioxidant properties. Apium graveolens, Cleome gynandra, and Hibiscus sabdariffa constitute a natural source of phenolic compounds that could be exploited in diabetes mellitus management.

关键词： Diabetes Mellitus Medicinal Plants Flavonoids Contents Hydrophilic Antioxidant Activity HPtLC screening

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Phytochemical Profile, Antioxidant, and Anti-Inflammatory Activities, safety of Use and spasmolytic Effects of Aqueous Decoction Extract of Diospyros mespiliformis Leaves Hochst. ex A. DC. (Ebenaceae) on the Isolated Duodenum of Rat

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Pharmacology & Pharmacy 2023年第12期14卷 513-529页

作者： Mathieu Nitiéma Pegdwendé Esther Ouédraogo tata Kadiatou traoré Oumarou Maman Noura Boukaré Kaboré Wendkouni Leila Marie Esther Bélem-Kabré Windingoudi Rimwagna Christian Ouédraogo Moumouni Koala Bruno Nébié Abdel Magid Arsène Ouoba Makumbu Joseph Makaya sylvain Ilboudo Lazare Belemnaba Noufou Ouédraogo sylvin Ouédraogo Laboratoire de Recherche-Développement des Phytomédicaments et Médicaments (LR-D/PM) Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouagadougou Burkina Faso Initiative Pour la Résilience et la Gouvernance (IRG) Ouagadougou Burkina Faso International Research Laboratory 3189 Environnement Santé Sociétés (IRL 3189 ESS) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso UFR/science et technologie Université Aube Nouvelle Ouagadougou Burkina Faso Laboratoire du Développement du Médicament (LADME) école Doctorale Sciences et Santé Université Joseph KI-ZERBO Ouagadougou Burkina Faso Ecole Doctorale sciences et techniques Laboratoire de Biochimie et Chimie Appliquées (LABIOCA) Université Joseph KI-ZERBO Ouagadougou Burkina Faso

Diospyros mespiliformis Hochst. ex A. DC. (Ebenaceae) is a multi-use plant, including for therapeutic purposes. It is used in alternative medicine in Burkina Faso to treat conjunctivitis, menorrhagia, dysentery, and diarrhea. the aim of our study was to evaluate the chemical profile, antioxidant and anti-inflammatory activities, safety of use and spasmolytic effects of the aqueous decoction of Diospyros mespiliformis leaves. Phytochemical screening by HPtLC and assay of compounds of interest were carried out. Four methods were used to assess antioxidant activity. Inhibitory activity against 15-lipoxygenase and phospholipase A2 was assessed. Acute oral toxicity of the extract was tested on female mice (NMRI). Following these tests, the extract contained bioactive compounds of interest such as flavonoids, tannins, sterols, triterpenes, and saponosides. the total phenolic and flavonoid contents of the aqueous decoctate were 70.59 ± 3.20 mg EAt/g and 31.57 ± 0.78 mg EQ/g respectively. the extract was less active than trolox with inhibitory concentrations of 50% (ICsub>50sub>) for the ABts, DPPH, FRAP, and LPO tests of 7.53 ± 0.08 μg/mL, 29.47 ± 0.06 μg/mL, 1128.83 ± 4.82 mol EAA/g, and 32.30 ± 1.60 μg/mL respectively. the extract has an anti-inflammatory effect with inhibition of phospholipase A2 compared to betamethasone. In addition, the aqueous extract produced an antispasmodic effect with Emax of 70% and 80% respectively during contractions induced by BaClsub>2sub> and ACh. Finally, this study provided basic scientific data and could justify the use of D. mespiliformis leaves in the treatment of diarrhea.

关键词： Diospyros mespiliformis Phytoconstituents Antioxidants Acute Oral toxicity spasmolytic Leaves

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Evaluation of Orthodontic treatment Needs among Widou schoolchildren in Ferlo (sENEGAL): A transversal study

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Open Journal of Epidemiology 2022年第3期12卷 343-354页

作者： Amadou Dieng Alpha Badiane Abdoulaye Amath Diop serigne Ndame Dieng Engueran Macia Massamba Diouf Public Health service Odontostomatology Institute Cheikh-Anta-Diop University Dakar Senegal irl 3189 ess UCAD Dakar Senegal Dento-Facial Orthopedics Department Odontostomatology Institute Cheikh-Anta-Diop University Dakar Senegal Dental surgeon Specialist in Public Health Paris France

the aim of this study was to evaluate orthodontic treatment needs among Ferlo scholars. the design of the study was descriptive and transversal. For Inclusion criteria, children must live in Widou or live around Widou’s school at least 6 km, be students at primary school of Widou thiengoly, have a general health state which permits a clinical oral examination and teacher’s and/or parent’s agreement. the investigation was exhaustive and concerned the only school of the locality. More of 4/5 schoolchildren was 10.25 years ± 2.15 old. the majority (83.74%) of children presented an overjet between 0 and 3.5 mm, 1.63% presented a crossbite and 15.45% had OIM and RC different over to 2 mm. More of 30% of schoolchildren presented an overbite between 1 and 2 mm. More of 1/10 of them had an aesthetic teeth perception classified levels 8.9 and 10 corresponding to an orthodontic treatment needed according to IOtN while 20.33% had a score of 4 and 3.25% recorded score of 5 corresponding to a high treatment needed according to IOtN. the results of this study reveal that people need to be informed better about the therapeutic possibilities that orthodontics offer.

关键词： Evaluation Orthodontic treatment Needs schoolchildren Ferlo

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