Contribution of High Sensible C-Reactive Protein (hsCRP) in the Assessment of the Risk of Onset of Type 2 Diabetes and Its Cardiovascular Complications

作     者：Maïmouna Touré Léopold Ngor Sène Jean Pierre Diagne Demba Diédhiou Souleymane Thiam Abdou Khadir Sow Mor Diaw Aïssatou Seck Salimata Diagne Houndjo Abdoulaye Ba Abdoulaye Samb Fatou Diallo-Agne Modou Oumy Kane Maïmouna Touré;Léopold Ngor Sène;Jean Pierre Diagne;Demba Diédhiou;Souleymane Thiam;Abdou Khadir Sow;Mor Diaw;Aïssatou Seck;Salimata Diagne Houndjo;Abdoulaye Ba;Abdoulaye Samb;Fatou Diallo-Agne;Modou Oumy Kane

作者机构：Laboratoire de Physiologie et d’Explorations Fonctionnelles Physiologiques Faculté de Médecine de Pharmacie et d’OdontoStomatologie (FMPOS) Université Cheikh Anta Diop (UCAD) Dakar Sénégal IRL3189 “Environnement Santé Société” CNRS CNRST Bamako-UCAD Faculté de Médecine de Pharmacie et d’OdontoStomatologie (FMPOS) Université Cheikh Anta Diop (UCAD) Dakar Sénégal Laboratoire Privé de Biologie General Kaolack Sénégal Centre Hospitalier Universitaire (CHU) Abasse Ndao Université Cheikh Anta Diop (UCAD) Dakar Sénégal Laboratoire de Biochimie et de Biologie moléculaire Faculté de Médecine de Pharmacie et d’OdontoStomatologie (FMPOS) Université Cheikh Anta Diop (UCAD) Dakar Sénégal Laboratoire de Physiologie Pharmaceutique Faculté de Médecine de Pharmacie et d'OdontoStomatologie (FMPOS) Université Cheikh Anta Diop (UCAD) Dakar Sénégal 

出 版 物：《Journal of Diabetes Mellitus》 (糖尿病（英文）)

年 卷 期：2024年第14卷第2期

页      面：95-107页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：hsCRP Biomarker Inflammation Type 2 Diabetes 

摘      要：Background: Type 2 diabetes is a metabolic disease characterized by chronic hyperglycemia. The latter plays an essential role in inflammation by stimulating the production of pro-inflammatory cytokines or by increasing their secretion by an oxidative mechanism. These cytokines control the hepatic synthesis of an inflammatory protein called C-Reactive Protein (CRP). High or average values of CRP would have a predictive value of cardiovascular diseases and type 2 diabetes. The relationship between low CRP values and the risk of developing type 2 diabetes and its cardiovascular complications is not sufficiently studied. The hsCRP could serve as a predictive biomarker of risk of onset, follow-up and prognosis for type 2 diabetes and its cardiovascular complications. To answer this problem, we conducted this study, the aim of which was to study the predictive role of hsCRP in the risk of occurrence of type 2 diabetes and its cardiovascular complications. Materials and Methods: This is a prospective and cross-sectional case-control study involving 200 participants including 100 control women and 100 women with type 2 diabetes (mean age was respectively 49.89 years ± 8.26 & 51.92 years ± 7.18;p = 0.066). The interviews were conducted on the basis of a questionnaire. Physical examination collected biometric data and cardiovascular constants. The biochemical parameters such as hsCRP were analyzed by an automated Abbott device. Results: We noted that hsCRP was significantly higher in type 2 diabetic subjects compared to control subjects (p (rho = 0.40, p systolic blood pressure (rho = 0.30, p = 0.003), diastolic blood pressure (rho = 0.28, p = 0.006), total body fat (rho = 0.48, p Conclusion: hsCRP has a prognostic value in the evaluation of cardiovascular risk. It seems to play an important role in the pathogenesis of type 2 diabetes mellitus and its cardiovascular complications. It could thus be considered as a biomarker for the screening, monitoring and prognosis of type 2