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Measurement of Glutathionylated Haemoglobin by MAL-DI-ToF Mass Spectrometry as a Biomarker of Oxidative Stress in Heavy Smokers and in Occupational Obese Subjects

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International Journal of Analytical Mass Spectrometry and Chromatography 2013年第1期1卷 22-30页

作者： Federico Maria Rubino Cinzia Della Noce Luisella Vigna Rachele De Giuseppe Cristina Novembrino Federica de Liso Rita Maiavacca Lorenzo Patrini Luciano Riboldi Fabrizia Bamonti Consiglio Nazionale delle Ricerche Istituto di Fisiologia Clinica Dipartimento CardioToracico e VascolareOspedale Niguarda Ca’ Granda Milano Italy Dipartimento di Medicina Preventiva U.O. Medicina del Lavoro “Clinica del Lavoro L Devoto” Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico Milano Italy Dipartimento di Scienze Biomediche Chirurgiche e Odontoiatriche Università degli Studi di Milano Unità Operativa di Ematologia e CTMO Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico via F. Sforza 35 Milano Italy Laboratorio Centrale di Analisi Chimico Cliniche e Microbiologia Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico via F. Sforza 35 Milano Italy Laboratorio di Tossicologia e Metabonomica Analitica (LaTMA) Dipartimento di Scienze della Salute Università degli Studi di Milano Milano Italy

Glutathionyl-haemoglobin (Hb-SSG) is a minor form of haemoglobin characterized by the presence of a disulfide bond between the β-93 cysteine residue and the thiol group of glutathione. Hb-SSG is naturally present in the erythrocytes at levels comparable to those of glycated haemoglobin and can be measured by MALDI mass spectrometry on very small samples of erythrocytes from peripheral blood. Since Hb-SSG has been recognized as a sensitive biomarker of oxidative stress in several degenerative diseases (diabetes, hyperlipidemia, kidney disease) and in healthy workers exposed to glutathione-depleting toxic agents such as butadiene, we have measured for the first time the levels of Hb-SSG in two groups: healthy heavy cigarette smokers and overweight-obese. For both classes of subjects, the measured levels (6.4%±1.7%, n=30 for smokers;3.0%±0.8%, n=20 for overweight-obese) are in the upper 97thpercentile of those measured in the Italian general population. Levels in smokers show a small, yet statistically significant dependence on the level of smoking addiction (>20 cig./day vs. ￡20 cig./day: 7.0% ± 1.4% vs. 5.7% ± 1.1%;p < 0.05). This biomarker thus adds to those presently available to rationally assess the extent of biological damage caused by tobacco smoking.

关键词： Biomarker Glutathionyl-Haemoglobin Oxidative Stress Erythrocyte Mass Spectrometry

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欧洲肿瘤内科协会对新发和复发性卵巢上皮癌的诊断、治疗和随访制定的临床实践指南

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国际妇产科学杂志 2011年第3期38卷 256-260页

作者： Colombo N Peiretti M Parma G Lapresa M Mancari R Carinelli S Sessa C Castiglione M 杨华郎景和 the ESMO Guidelines Working Group Division of Gynecologic Oncology Division of Pathology European Institute of Oncology Oncology Institute of Southern Switzerland Montabone Unit for New Drug Development Fondazione IRCCSIstituto dei Tumori di Milano RGT University of Geneva

发病率卵巢癌在女性常见癌症中（皮肤癌除外）位列第九,在癌症所致的女性死亡原因中居第五位。女性在一生中患卵巢浸润癌的风险是1/71,而死于卵巢浸润癌的风险是1/95。在美国,据估计每年有21 550例的新发病例,且有14 600人死于卵巢癌。... 详细信息

发病率卵巢癌在女性常见癌症中（皮肤癌除外）位列第九,在癌症所致的女性死亡原因中居第五位。女性在一生中患卵巢浸润癌的风险是1/71,而死于卵巢浸润癌的风险是1/95。在美国,据估计每年有21 550例的新发病例,且有14 600人死于卵巢癌。然而,在世界不同地区卵巢癌的发病率大不相同,2004年欧盟国家估计每年新发病例42 700例,而病死率为12/10万。

关键词：复发性卵巢上皮癌临床实践指南肿瘤内科卵巢浸润癌诊断协会欧洲随访

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Current controversies and future perspectives on treatment of intensive care unit delirium in adults

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World Journal of Critical Care Medicine 2019年第3期8卷 18-27页

作者： Marco Cascella Marco Fiore Sebastiano Leone Domenico Carbone Raffaela Di Napoli Division of Anesthesia and Pain Medicine Istituto Nazionale TumoriIRCCS Fondazione G.PascaleNaples 80049Italy Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Division of Infectious Diseases “San Giuseppe Moscati”HospitalAvellino 83100Italy Department of Emergency Medicine Umberto I HospitalNocera InferioreSalerno 84014Italy Department of Anesthesiology Institut Jules BordetUniversitéLibre de BruxellesBruxelles 1000Belgium

Delirium is the most frequent manifestation of acute brain dysfunction in intensive care unit(ICU).Although antipsychotics are widely used to treat this serious complication,recent evidence has emphasized that these agents did not reduce ICU delirium(ICU-D)prevalence and did not improve survival,length of ICU or hospital stay after its *** note,no pharmacological strategy to prevent or treat delirium has been identified,so *** this scenario,new scientific evidences are urgently *** on specific ICU-D subgroups,or focused on different clinical settings,and studies on medications other than antipsychotics,such as dexmedetomidine or melatonin,may represent interesting fields of *** the meantime,because there is some evidence that ICU-D can be effectively prevented,the literature suggests strengthening all the strategies aimed at prevention through no-pharmacological approaches mostly focused on the correction of risk *** more appropriate strategy useful to treat established delirium remains the use of antipsychotics managed by choosing the right doses after a careful case-by-case *** the evidence regarding the use of dexmedetomidine is still conflicting and sparse,this drug offers interesting perspectives for both ICU-D prevention and *** paper aims to provide an overview of current pharmacological approaches of evidence-based medicine *** state of the art of the on-going clinical research on the topic and perspectives for future research are also addressed.

关键词： Delirium Intensive care Haloperidol Antipsychotic agents Major tranquilizers Cognitive decline Dexmedetomidine

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Microscopic tumor foci in axillary lymph nodes may reveal the recurrence dynamics of breast cancer

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Cancer Communications 2019年第1期39卷 334-337页

作者： Romano Demicheli Marco Fornili Patrizia Querzoli Massimo Pedriali Saverio Alberti Christine Desmedt Elia Biganzoli Unit of Medical Statistics Biometry and BioinformaticsCampus Cascina RosaFondazione IRCCS Istituto Nazionale TumoriLaboratory of Medical Statistics and Epidemiology“Giulio A.Maccacaro”Department of Clinical Sciences and Community HealthUniversity of MilanVia Vanzetti 520133 MilanItaly Laboratory of Medical Statistics and Epidemiology “Giulio A.Maccacaro”Department of Clinical Sciences and Community HealthUniversity of MilanVia Vanzetti 520133 MilanItaly Section of Surgical Pathology Department of MorphologySurgical and Experimental MedicineUniversity of Ferrara44121 FerraraItaly Operative Unit of Surgical Pathology Azienda Ospedaliera-UniversitariaUniversity of Ferrara44121 FerraraItaly Section of Medical Genetics Department of Biomedical and Odontoiatric SciencesMorphological and Functional ImagingUniversity of Messina98125 MessinaItaly Laboratory for Translational Breast Cancer Research Department of OncologyKatholieke Universiteit LeuvenHerestraat 493000 LouvainBelgium

Dear Editor,In early breast cancer,the prognostic value of the num-ber of macroscopically metastasized axillary nodes has been recognized in earlier reports[1].However,the impact of microscopic tumour cell deposits on the sur-vival outcome of early breast cancer patients is still debated[2].This issue has gained increasing attention since the implementation of sentinel node biopsy in axil-lary node staging for tailoring breast cancer treatments,and the status of the single resected node would deter-mine the clinical decision of whether or not to perform the axillary lymph node dissection[3].Moreover,this issue raises more questions on whether to administer primary or adjuvant systemic treatment for patients with lymph nodes bearing isolated tumour cells(pN0[i+])or micrometastases(pN1mi).Despite the wide debate on the clinical treatment dilemma encountered by early breast cancer patients with microscopic tumour cell deposits,the biology underlying different pathologi-cal presentations at microscopic level(pN0,pN0[i+],pN1mi)and the disease outcomes remain poorly *** an attempt to shed some light on this topic,we have analyzed,in the context of dormancy-based metastasis development model[4],early breast cancer patients con-ventionally classified as pN0(tumour foci with largest diameter≤2 mm)[5]by systematically reassessing their tumor recurrence dynamics following primary tumour resection at a single institution.

关键词： lymph dynamics gained

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从NNRTI +FTC/TDF方案转换到Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF(STRIBILD,STB)仍然维持HIV抑制和耐受性良好:STRATEGY-NNRTI(研究121)96周结果

从NNRTI +FTC/TDF方案转换到Elvitegravir/Cobicistat/Emtricitab...

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中华医学会第七次全国艾滋病、丙型肝炎学术会议

作者： Anton Pozniak Jason Flamm Andrea Antinori Mark Bloch Douglas Ward Juan Berenguer Pierre Cote Chelsea and Westminster Hospital Kaiser Permanente istituto Nazionale Malattie Infettive Lazzaro Spallanzani irccs Holdsworth House Medical Practice Dupont Circle Physicians Group Hospital General Universitario Gregorio Maranon Clinique Medicale Du Quartier Latin

目的:单一片剂STB用于无病毒学失败史抑制良好的HIV-1感染者,简化、方便且耐受性较好。121研究是一项前瞻、随机、开放的三期临床试验,观察病毒抑制的HIV-1患者从接受"FTC/TDF+NNRTI"方案转换为STB的疗效和安全性。方法:接受"FTC/TDF+NN... 详细信息

目的:单一片剂STB用于无病毒学失败史抑制良好的HIV-1感染者,简化、方便且耐受性较好。121研究是一项前瞻、随机、开放的三期临床试验,观察病毒抑制的HIV-1患者从接受"FTC/TDF+NNRTI"方案转换为STB的疗效和安全性。方法:接受"FTC/TDF+NNRTI"且病毒载量<50拷贝/ml大于6个月的患者按2:1随机分组,转换到STB或维持NNRTI。入选标准Cr≥70 mL/min,

关键词： HIV STRIBILD,STB FTC/TDF Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF NNRTI STRATEGY-NNRTI 耐受性 TDF

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增强MRI与增强US成像:术中融合成像在胶质母细胞瘤手术中的对比研究

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国际医学放射学杂志 2017年第6期 727-727页

作者： F.Prada V.Vitale M.Del Bene C.Boffano L.M.Sconfenza V.Pinzi 刘鸽 Department of Neurosurgery Fondazione IRCCS Istituto Neurologico “C.Besta”

摘要目的利用实时融合成像技术对胶质母细胞瘤在术中超声成像与术前增强T1WI对比剂增强研究的比较。材料与方法对常规收集10例GBM病人的匿名数据进行回顾

关键词：胶质母细胞瘤对比剂增强超声成像融合成像 MRI US

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肺小结节:多层CT在肺癌筛查中容积测量的可重复性

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国际医学放射学杂志 2009年第4期32卷 398-398页

作者： A.Marchianò E.Calabrò E.Civelli G.D.Tolla L.F.Frigerio C.Morosi 赵蕾 Department of Diagnostic Imaging and Radiotherapy Fondazione IRCCS Istituto Nazionale dei Tumori

目的评价肺癌筛查研究中使用自动化计算软件对在体肺内小结节容积测量的可重复性。方法本研究经机构伦理委员会批准，并获得所有参与者的书面知情同意书。数据由意大利多中心肺（癌）发现计划收集，此项目为一随机对照肺癌筛查研究。研... 详细信息

目的评价肺癌筛查研究中使用自动化计算软件对在体肺内小结节容积测量的可重复性。方法本研究经机构伦理委员会批准，并获得所有参与者的书面知情同意书。数据由意大利多中心肺（癌）发现计划收集，此项目为一随机对照肺癌筛查研究。研究分析了在米兰国家肿瘤研究所完成的首批连续1236例的初次CT检查。在登记的全部参与者中．只考虑那些在之后的3个月进行低剂量CT复查并且至少有一个体积超过60mm，（直径≥4．8mm）的不确定结节的病人。

关键词：肺癌筛查可重复性容积测量肺小结节多层CT 机构伦理委员会肺内小结节知情同意书

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Impact of pre-existing cardiometabolic diseases on metastatic cancer stage at diagnosis:a prospective multinational cohort study

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Cancer Communications 2024年第5期44卷 593-597页

作者： Anna Jansana Aviane Auguste Marina Kvaskoff Agnès Fournier Emma Fontvieille Laia Peruchet-Noray Carine Biessy Reynalda Cordova Kristina Elin Nielsen Petersen Anne Tjoneland Verena Katzke Rudolf Kaaks Fulvio Ricceri Salvatore Panico Paolo Contiero Maria-Jose Sánchez Jesus Castilla Marta Crous-Bou Alicia Heath Elom Kouassivi Aglago Elisabete Weiderpass Marc James Gunter Pietro Ferrari Elio Riboli Vivian Viallon Heinz Freisling International Agency for Research on Cancer(IARC-WHO) LyonFrance Paris-Saclay University University of Versailles-Saint-Quentin-en-YvelineUniversity Paris-SudFrench National Institute for Health and Medical Research(Inserm)Gustave Roussy“Exposome and Heredity”TeamCESPVillejuifFrance Department of Nutritional Sciences University of ViennaViennaAustria Danish Cancer Society Research Center CopenhagenDenmark Department of Public Health University of CopenhagenCopenhagenDenmark Division of Cancer Epidemiology German Cancer Research CentreHeidelbergGermany Department of Clinical and Biological Sciences University of TurinTurinItaly Unit of Epidemiology Regional Health Service ASL TO3GrugliascoTurinItaly Department of Clinical Medicine and Surgery Federico II UniversityNaplesItaly Environmental Epidemiology Unit Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)-Istituto Nazionale dei TumoriMilanItaly Cancer Registry of Granada Institute for Biosanitary Research of Granada(ibs.GRANADA)GranadaSpain Epidemiology and Control of Chronic Diseases Group Epidemiology and Public Health Networking Biomedical Research CentreMadridSpain Navarra Public Health Institute PamplonaSpain Unit of Nutrition and Cancer Cancer Epidemiology Research ProgramCatalan Institute of Oncology(ICO)-Bellvitge Biomedical Research Institute(IDIBELL)L’Hospitalet de LlobregatBarcelonaSpain Department of Epidemiology Harvard Tseng-Hsi Chan School of Public HealthBostonMassachusettsUSA Department of Epidemiology and Biostatistics School of Public HealthImperial College LondonSt Mary’s CampusNorfolk PlaceLondonUK

Owing to shared risk factors between cardiometabolic diseases(CMDs)and cancer,coupled with population aging,the lifetime risk of an individual developing cancer after a CMD is ***,biological mechanisms such as insulin resistance or inflammation may not only predispose individuals withCMDto an elevated risk of certain types of cancer but also to a diagnosis of cancer at an advanced stage[1,2].

关键词： diagnosis diseases cancer

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Non-invasive ventilation for acute hypoxemic respiratory failure,including COVID-19

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Journal of Intensive Medicine 2023年第1期3卷 11-19页

作者： Tommaso Rosà Luca Salvatore Menga Ambika Tejpal Melania Cesarano Teresa Michi Michael C.Sklar Domenico Luca Grieco Department of Emergency Intensive Care Medicine and AnesthesiaFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy istituto di Anestesiologiae Rianimazione UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Cardiology Department of MedicineUniversity of TorontoToronto ON M5S 1A1Canada Interdepartmental Division of Critical Care Medicine University of TorontoToronto ON M5S 1A1Canada Department of Anesthesia and Pain Medicine St.Michael's Hospital–Unity Health TorontoUniversity of TorontoToronto ON M5S 1A1Canada

Optimal initial non-invasive management of acute hypoxemic respiratory failure(AHRF),of both coronavirus disease 2019(COVID-19)and non-COVID-19 etiologies,has been the subject of significant *** of endotracheal intubation reduces related complications,but maintenance of spontaneous breathing with intense respiratory effort may increase risks of patients’self-inflicted lung injury,leading to delayed intubation and worse clinical ***-flow nasal oxygen is currently recommended as the optimal strategy for AHRF management for its simplicity and beneficial physiological ***-invasive ventilation(NIV),delivered as either pressure support or continuous positive airway pressure via interfaces like face masks and helmets,can improve oxygenation and may be associated with reduced endotracheal intubation ***,treatment failure is common and associated with poor *** and knowledge of the specific features of each interface are necessary to fully exploit their potential benefits and minimize *** clinical and physiological monitoring is necessary during any treatment to avoid delays in endotracheal intubation and protective *** this narrative review,we analyze the physiological benefits and risks of spontaneous breathing in AHRF,and the characteristics of tools for delivering *** goal herein is to provide a contemporary,evidence-based overview of this highly relevant topic.

关键词： Non-invasive ventilation Hypoxemic respiratory failure Self-inflicted lung injury

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Potential benefit of lymph node dissection during radical nephrectomy for kidney cancer:A review and critical analysis of current literature

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Asian Journal of Urology 2022年第3期9卷 215-226页

作者： Michele Marchioni Daniele Amparore Igino Andrea Magli Riccardo Bertolo Umberto Carbonara Selcuk Erdem Alexandre Ingels Constantijn H.J.Muselaers Onder Kara Marco Mascitti Tobias Klatte Maximilian Kriegmair Nicola Pavan Eduard Roussel Angela Pecoraro Laura Marandino Riccardo Campi Luigi Schips Department of Urology SS Annunziata Hospital“G.D’Annunzio”University of ChietiChietiItaly Division of Urology Department of OncologySchool of MedicineSan Luigi HospitalUniversity of TurinOrbassanoTurinItaly Department of Urology San Carlo Di Nancy HospitalRomeItaly Department of Emergency and Organ Transplantation-Urology Andrology and Kidney Transplantation UnitUniversity of BariBariItaly Division of Urologic Oncology Department of UrologyIstanbul University Istanbul Faculty of MedicineIstanbulTurkey Department of Urology University Hospital Henri MondorAPHPCreteilFrance Department of Urology Radboud University Medical CenterNijmegenthe Netherlands Department of Urology Kocaeli University School of MedicineKocaeliTurkey Department of Urology Royal Bournemouth HospitalBournemouthUK Department of Urology University Medical Centre MannheimMannheimGermany Urology Clinic Department of MedicalSurgical and Health ScienceUniversity of TriesteTriesteItaly Department of Urology University Hospitals LeuvenLeuvenBelgium Department of Medical Oncology Fondazione IRCCS Istituto Nazionale dei TumoriMilanItaly Unit of Urological Robotic Surgery and Renal Transplantation University of FlorenceCareggi HospitalFlorenceItaly

Objective:The role of lymph node dissection(LND)is still controversial in patients with renal cell carcinoma undergoing *** aimed to provide a comprehensive review of the literature about the effect of LND on survival,prognosis,surgical outcomes,as well as patient selection and available LND ***:Recent literature(from January 2011 to December 2021)was assessed through PubMed and MEDLINE databases.A narrative review of most relevant articles was ***:The frequencies in which LNDs are being carried out are decreasing due to an increase in minimally invasive and nephron sparing ***,randomized clinical trials and meta-analyses failed to show any survival advantage of LND versus no ***,retrospective studies suggest a survival benefit of LND in high-risk patients(bulky tumors,T3-4 stage,and cN1 patients).Moreover,extended LND might provide important staging information,which could be of interest for adjuvant treatment ***:No level 1 evidence of any survival advantage deriving from LND is currently available in ***,the role of LND is limited to staging ***,low grade evidence suggests a possible role of LND in high-risk *** clinical trials are warranted to corroborate these findings.

关键词： Renal cell carcinoma Lymph node dissection Radical nephrectomy Salvage lymph node dissection

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