Potential benefit of lymph node dissection during radical nephrectomy for kidney cancer:A review and critical analysis of current literature

作     者：Michele Marchioni Daniele Amparore Igino Andrea Magli Riccardo Bertolo Umberto Carbonara Selcuk Erdem Alexandre Ingels Constantijn H.J.Muselaers Onder Kara Marco Mascitti Tobias Klatte Maximilian Kriegmair Nicola Pavan Eduard Roussel Angela Pecoraro Laura Marandino Riccardo Campi Luigi Schips European Association of Urology(EAU)Young Academic Urologists(YAU)Renal Cancer group

作者机构：Department of UrologySS Annunziata Hospital“G.D’Annunzio”University of ChietiChietiItaly Division of UrologyDepartment of OncologySchool of MedicineSan Luigi HospitalUniversity of TurinOrbassanoTurinItaly Department of UrologySan Carlo Di Nancy HospitalRomeItaly Department of Emergency and Organ Transplantation-UrologyAndrology and Kidney Transplantation UnitUniversity of BariBariItaly Division of Urologic OncologyDepartment of UrologyIstanbul University Istanbul Faculty of MedicineIstanbulTurkey Department of UrologyUniversity Hospital Henri MondorAPHPCreteilFrance Department of UrologyRadboud University Medical CenterNijmegenthe Netherlands Department of UrologyKocaeli University School of MedicineKocaeliTurkey Department of UrologyRoyal Bournemouth HospitalBournemouthUK Department of UrologyUniversity Medical Centre MannheimMannheimGermany Urology ClinicDepartment of MedicalSurgical and Health ScienceUniversity of TriesteTriesteItaly Department of UrologyUniversity Hospitals LeuvenLeuvenBelgium Department of Medical OncologyFondazione IRCCS Istituto Nazionale dei TumoriMilanItaly Unit of Urological Robotic Surgery and Renal TransplantationUniversity of FlorenceCareggi HospitalFlorenceItaly 

出 版 物：《Asian Journal of Urology》 (亚洲泌尿外科杂志（英文）)

年 卷 期：2022年第9卷第3期

页      面：215-226页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Renal cell carcinoma Lymph node dissection Radical nephrectomy Salvage lymph node dissection 

摘      要：Objective:The role of lymph node dissection(LND)is still controversial in patients with renal cell carcinoma undergoing *** aimed to provide a comprehensive review of the literature about the effect of LND on survival,prognosis,surgical outcomes,as well as patient selection and available LND ***:Recent literature(from January 2011 to December 2021)was assessed through PubMed and MEDLINE databases.A narrative review of most relevant articles was ***:The frequencies in which LNDs are being carried out are decreasing due to an increase in minimally invasive and nephron sparing ***,randomized clinical trials and meta-analyses failed to show any survival advantage of LND versus no ***,retrospective studies suggest a survival benefit of LND in high-risk patients(bulky tumors,T3-4 stage,and cN1 patients).Moreover,extended LND might provide important staging information,which could be of interest for adjuvant treatment ***:No level 1 evidence of any survival advantage deriving from LND is currently available in ***,the role of LND is limited to staging ***,low grade evidence suggests a possible role of LND in high-risk *** clinical trials are warranted to corroborate these findings.