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Decentralized Control for Residential Energy Management of a Smart Users' Microgrid with Renewable Energy Exchange

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IEEE/CAA Journal of Automatica Sinica 2019年第3期6卷 641-656页

作者： Raffaele Carli Mariagrazia Dotoli IEEE the Department of Electrical and Information Engineering of the Polytechnic of bari

This paper presents a decentralized control strategy for the scheduling of electrical energy activities of a microgrid composed of smart homes connected to a distributor and exchanging renewable energy produced by individually owned distributed energy resources. The scheduling problem is stated and solved with the aim of reducing the overall energy supply from the grid, by allowing users to exchange the surplus renewable energy and by optimally planning users' controllable loads. We assume that each smart home can both buy/sell energy from/to the grid taking into account time-varying non-linear pricing signals. Simultaneously, smart homes cooperate and may buy/sell locally harvested renewable energy from/to other smart homes. The resulting optimization problem is formulated as a non-convex non-linear programming problem with a coupling of decision variables in the constraints. The proposed solution is based on a novel heuristic iterative decentralized scheme algorithm that suitably extends the Alternating Direction Method of Multipliers to a non-convex and decentralized setting. We discuss the conditions that guarantee the convergence of the presented algorithm. Finally, the application of the proposed technique to a case study under several scenarios shows its effectiveness.

关键词： Alternating direction method of multipliers decentralized control energy management microgrid non-convex optimization renewable energy residential energy management smart homes

SARS-CoV-2 induced myocarditis:Current knowledge about its molecular and pathophysiological mechanisms

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BIOCELL 2022年第8期46卷 1779-1788页

作者： DOMENICO MARIA CARRETTA MARINA DI DOMENICO ROBERTO LOVERO ROBERTO ARRIGONI ANGELIKA ELZBIETA WEGIERSKA MARIAROSARIA BOCCELLINO ANDREA BALLINI IOANNIS ALEXANDROS CHARITOS LUIGI SANTACROCE AOU Policlinico Consorziale di bari-Ospedale Giovanni XXIII Cardiology UnitPoliclinico University Hospital of BariBari70124Italy Department of Precision Medicine University of Campania Luigi VanvitelliNaples80138Italy AOU Policlinico Consorziale di bari-Ospedale Giovanni XXIII Clinical Pathology UnitPoliclinico University Hospital of BariBari70124Italy CNR Institute of Biomembranes Bioenergetics and Molecular Biotechnologies(IBIOM)Bari70125Italy Department Interdisciplinary of Medicine University of Bari Aldo MoroBari70124Italy School of Medicine University of Bari Aldo MoroBari70124Italy Department of Emergency and Urgency National Poisoning CentreRiuniti University Hospital of FoggiaFoggia71122Italy

The existence of an inflammatory process in the heart muscle,related to a progressive worsening of myocardial function,different etiopathogenetic mechanisms concur and often overlap,thus making the diagnosis and the therapeutic approach *** the COVID-19 pandemic progresses,the effects of the disease on the organ systems and in particular on the cardiovascular system are becoming more and more *** involvement is a well-known event with a high percentage of findings in the heart’s magnetic field,even in asymptomatic *** are numerous uncertainties regarding their evolution,in the long and short term,due not only to a difficult to determine the varied clinical expression and the rarely performed intramyocardial biopsy which additionally presents diagnostic problems but also in part to different clinical ***,the new SARS-CoV-2 virus that uses the angiotensin converting enzyme 2(ACE2)which is present at high levels in myocardial cells as its entrance it can create even severe heart *** pathophysiology in all of these cases can involve multiple immune and non-immune mechanisms within organs and vessels and can be occur in the clinical *** mechanisms of direct and indirect myocardial infarction in patients with COVID-19 include additional lesion and oxygen-rich and generalized inflammation response with myocardial immune hyperactivity(myocarditis).Therefore,these can occur through the excessive release of cytokines,the presence of thrombocytopenia,endocrine damage,heart failure,arrhythmias and *** can show average signs of myocardial damage,and some develop spontaneous cardiac complications,such as heart failure,arrhythmias and,rarely,rare cardiogenic *** in all of these may involve multiple mechanisms within the cytokine cephalic membrane,endocrine damage and *** diagnosis of this myocardial injuri is mainly based on the myocardial enzyme *** viewpoint paper

关键词： Viruses Infections SARS-CoV-2 Pandemics Myocarditis Molecular diagnosis

Importance of clinical suspicion and multidisciplinary management for early diagnosis of a cardiac laminopathy patient:A case report

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World Journal of Clinical Cases 2021年第25期9卷 7472-7477页

作者： Vincenzo Ezio Santobuono Andrea Igoren Guaricci Eugenio Carulli Nicola Bozza Martino Pepe Alfredo Ranauro Carlotta Ranieri Maria Cristina Carella Francesco Loizzi Nicoletta Resta Stefano Favale Cinzia Forleo Department of Emergency and Organ Transplantation Cardiology Unit of Policlinic University of BariBari 70124BAItaly Division of Medical Genetics Department of Biomedical Sciences and Human OncologyPoliclinic University of BariBari 70124BAItaly

BACKGROUND Laminopathies are rare diseases,whose cardiac manifestations are heterogeneous and,especially in their initial stage,similar to those of more common conditions,such as ischemic heart *** diagnosis is essential,as these conditions can first manifest themselves with sudden cardiac *** complications usually appear before structural complications;therefore,it is important to take into consideration these rare genetic disorders for the differential diagnosis of brady and tachyarrhythmias,even when left ventricle systolic function is still *** SUMMARY A 60-year-old man,without history of previous disorders,presented in September 2019 to the emergency department because of the onset of syncope associated with *** patient was diagnosed with a high-grade atrioventricular block.A dual chamber pacemaker was implanted,but after the onset of a sustained ventricular tachycardia during physical exertion,a drug eluting stent was implanted on an intermediate stenosis on the left anterior descending artery,which had previously been considered non-haemodynamically *** the follow-up,the treating cardiologist,suspicious of the overall clinical picture,recommended a genetic test for the diagnosis of cardiomyopathies,which tested positive for a pathogenetic mutation of the lamin A/C *** awaiting the result of the genetic test and,later,the pacemaker to be upgraded to a biventricular defibrillator,a remote monitoring device was given to the patient in 2019-related *** case aims to raise awareness of the cardiological manifestations of laminopathies,which can be dangerously misdiagnosed as other, more common conditions.

关键词： Lamin A/C-mutation Cardiolaminopathy Ventricular tachyarrhythmias Remote-monitoring COVID-19 Case report

Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures

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Nano Research 2016年第3期9卷 644-662页

作者： Gianpiero Valente Nicoletta Depalo Ivan de Paola Rosa Maria lacobazzi Nunzio Denora Valentino Laquintana Roberto Comparelli Emiliano Altamura Tiziana Latronico Michele Altomare Elisabetta Fanizza Marinella Striccoli Angela Agostiano Michele Saviano Annarita Del Gatto Laura Zaccaro Maria Lucia Curri Universita degli Studi di bari Aldo Moro Dipartimento di Chimica Via Orabona 4 70125 - Bari Italy Istituto per i Processi Chimico-Fisici-CNR UOS bari Via Orabona 4 70125 - Bari Italy Istituto di Biostrutture e Bioimmagini-CNR Via Mezzocannone 16 80134 - Napoli Italy Universita degli Studi di bari Aldo Moro Dipartimento di Farmacia - Scienze del Farmaco Via Orabona 4 70125 - Bari Italy Universita degli Studi di bariAIdo Moro Dipartimento di Bioscienze Biotecnologie e Biofarmaceutica Via Orabona 4 70125 - Bari Italy lstituto di Cristallografia-CNR Via Amendola 122/0 70126 Bari Italy

Binary asymmetric nanocrystals （BNCs）, composed of a photoactive TiO2 nanorod joined with a superparamagnetic γ-Fe203 spherical domain, were embedded in polyethylene glycol modified phospholipid micelle and successfully bioconjugated to a suitably designed peptide containing an RGD motif. BNCs represent a relevant multifunctional nanomaterial, owing to the coexistence of two distinct domains in one particle, characterized by high photoactivity and magnetic properties, that is particularly suited for use as a phototherapy and hyperthermia agent as well as a magnetic probe in biological imaging. We selected the RGD motif in order to target integrin expressed on activated endothelial cells and several types of cancer cells. The prepared RGD-peptide/BNC conjugates, comprehensively monitored by using complementary optical and structural techniques, demon- strated a high stability and uniform dispersibility in biological media. The cytotoxicity of the RGD-peptide/BNC conjugates was studied in vitro. The cellular uptake of RGD-peptide conjugates in the cells, assessed by means of two distinct approaches, namely confocal microscopy analysis and emission spectroscopy determination in cell lysates, displayed selectivity of the RGD-peptide-BNC conjugate for the cw]33 integrin. These RGD-peptide-BNC conjugates have a high potential for theranostic treatment of cancer.

关键词： nanocrystallineheterostructures photoactive semiconductor magnetic nanostructure cyclic RGD peptide αvβ3 integrin active targeting

Total hip arthroplasty following the failure of intertrochanteric nailing:First implant or salvage surgery?

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World Journal of Orthopedics 2023年第10期14卷 763-770页

作者： Giuseppe Solarino Davide Bizzoca Pasquale Dramisino Giovanni Vicenti Lorenzo Moretti Biagio Moretti Andrea Piazzolla University of bari Aldo Moro Bari 70154Italy Orthopaedic and Trauma Unit Policlinico di bari Bari 70124Italy UOSD Vertebral Surgery Policlinico di BariBari 70124Italy

BACKGROUND Proximal femur fractures,including both intracapsular(femoral neck fractures)and extracapsular fractures(intertrochanteric femoral fractures,IFFs),affect around 1.5 million people per year *** failures of intertrochanteric nailing in IFFs could be managed with revision total hip arthroplasty(THA).AIM To describe the surgical complexity and the procedure-related complication rates in patients with trochanteric nailing failure and treated with *** Patients referred to our level I trauma center between April 2012 and July 2018 with failed cephalomedullary nailing following trochanteric fractures were retrospectively *** patients underwent a salvage surgical procedure,i.e.,cephalomedullary nail removal and conversion to *** same surgical and anesthesiology team performed the surgical procedures under spinal *** patients underwent clinical and radiographic follow-ups for at least 24 *** and re-operations were *** Seventy-four patients met the inclusion criteria(male:29;female:45;mean age:73.8-years-old;range:65-89)and were included in the current *** average operative time was 117 min(76-192 min).The average blood loss was 585 mL(430-1720 mL).Among the 74 patients,43(58.1%)required transfusion of three or more blood *** patients died within the 4th d after surgery because of pulmonary embolism,and 1 patient died 9 mo after surgery due to ischemic myocardial *** complication rate in the 71 patients who completed the minimum 24-mo follow-up was 22.5%.In 3 cases out of 71(4.2%)periprosthetic acetabular fracture was observed during the *** of these periacetabular fractures occurred *** intraoperative periprosthetic femur fracture was observed in 5 patients out of 71(7.0%).Four of these patients needed a re-operation to fix the fracture with plates and cerclages;in one of these patients,femoral stem revision was also *** 4 patients ou

关键词： Femoral nailing Total hip arthroplasty Proximal femur fractures Osteoporosis Fragility fractures Geriatric patients Hip traumatology Hip replacement

An update on the role of RANKL-RANK/osteoprotegerin and WNT-β-catenin signaling pathways in pediatric diseases

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World Journal of Pediatrics 2019年第1期15卷 4-11页

作者： Giacomina Brunetti Gabriele D'Amato Mariancgela Chiarito Apollonia Tullo Graziana Colaianni Silvia Colucci Maria Grano Maria Felicia Faienza Section of Human Anatomy and Histology Department of Basic Medical SciencesNeuroscience and Sense Organs.University"A.Moro”of Bari.Piazza G.Cesare 11 70124 BariItaly Neonatal Intensive Care Unit Di Venere HospitalBariItaly Pediatric Section Department of Biomedical Sciences and Human Oncology.University"A.Moro”of BariPiazza G.Cesare 1 170124 BariItaly Institute of Biomembranes Bioenergetics and Molecular Biotechnologies—IBIOMCNR70126 BariItaly Department of Emergency and Organ Transplantation University“A.Moro”of bari.bari.Italy

Background Bone remodeling is a lifelong process due to the balanced activity of osteoclasts (OCs),the bone-reabsorbing cells,and osteoblasts (OBs),and the bone-forming *** equilibrium is regulated by numerous cytokines,but it has been largely demonstrated that the RANK/RANKL/osteoprotegerin and Wnt/β-catenin pathways play a key role in the control of osteoclastogenesis and osteoblastogenesis,*** pro-osteoblastogenic activity of the Wnt/β-catenin can be inhibited by sclerostin and Dickkopf-1 (DKK-1).RANKL,sclerostin and DKKs-1 are often up-regulated in bone diseases,and they are the target of new monoclonal *** sources The authors performed a systematic literature search in PubMed and EMBASE to June 2018,reviewed and selected articles,based on pre-determined selection *** We re-evaluated the role of RANKL,osteoprotegerin,sclerostin and DKK-1 in altered bone remodeling associated with some inherited and acquired pediatric diseases,such as type 1 diabetes mellitus (T1DM),alkaptonuria (AKU),hemophilia A,osteogenesis imperfecta (OI),21-hydroxylase deficiency (21 OH-D) and Prader-Willi syndrome (PWS).To do so,we considered recent clinical studies done on pediatric patients in which the roles of RANKL-RANK/osteoprotegerin and WNT-β-catenin signaling pathways have been investigated,and for which innovative therapies for the treatment of osteopenia/osteoporosis are being *** The case studies taken into account for this review demonstrated that quite frequently both bone reabsorbing and bone deposition are impaired in pediatric ***,for some of them,bone damage began in childhood but only manifested with *** use of denosumab could represent a valid alternative therapeutic approach to improve bone health in children,although further studies need to be carried out.

关键词： RANKL-RANK/Osteoprotegerin WNT-β-catenin signaling Pediatric diseases

Heart failure in elderly: progress in clinical evaluation and therapeutic approach

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Journal of Geriatric Cardiology 2013年第2期10卷 165-177页

作者： Massimo Iacoviello Valeria Antoncecchi Cardiology Unit Department of Emergency and Organ Transplantation University of Bari Piazza Giulio Cesare 1170124 Bari Italy

Chronic heart failure (CHF) represents a major and growing health problem, due to its high incidence and prevalence, its poor prognosis and its impact on health-care costs. Although CHF patients are mainly elderly, few studies were aimed at testing the efficacy of diagnostic and therapeutic approaches in this population. The difficulty in CHF diagnosis among the elderly is related to different factors, such as: the frequent presence of co-morbidity conditions mimicking or masking heart failure signs and symptoms; the different diagnostic cut-offs of natriuretic peptides; and the need to correctly evaluate diastolic function in order to assess CHF with preserved ejection fraction. Furthermore,the therapy of elderly CHF patients has not beenwell defined, considering the few studies involving very aged patients and the absence of a therapeutic strategy demonstrated to improve prognosis of CHF patients with preserved ejection fraction. The aim of this review is to focus on the most recent issues concerning the diagnosis and therapy of elderly patients affected byCHF.

关键词： Diagnosis Elderly patient Heart failure Prognosis Therapy

Unified Analysis for Calculating the Incoherent Spontaneous Emission of Cooperative Radiations

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Chinese Physics Letters 2017年第11期34卷 20-23页

作者： Hesham Fares Enrica Chiadroni infn-LNF Department of Physics Faculty of Science Assiut University

A unified analysis is presented to calculate the incoherent spontaneous power of cooperative radiations based on self-amplified spontaneous emission. Using quantum mechanical tools, we derive analytical expressions for the incoherent spontaneous power of undulator and Cherenkov free-electron lasers （FELs）. The undulator and Cherenkov FELs are considered as two different examples for the radiation that accumulate cooperatively. In the case of the undulator FEL, we show an excellent agreement between an expression for the incoherent radiation power derived in the present work and that obtained using a completely different approach [Phys. Ftev. E 65 （2002） 026501]. For the Cherenkov radiation, we demonstrate a satisfactory agreement between the incoherent power predicted in our analysis and previous experimental results.

关键词： In Unified Analysis for Calculating the Incoherent Spontaneous Emission of Cooperative Radiations

Mechanisms of altered bone remodeling in children with type 1 diabetes

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World Journal of Diabetes 2021年第7期12卷 997-1009页

作者： Giacomina Brunetti Gabriele D'Amato Stefania De Santis Maria Grano Maria Felicia Faienza Department of Biosciences Biotechnologies and BiopharmaceuticsUniversity"A.Moro"of BariBari 70125Italy Department of Women’s and Children’s Health ASL BariNeonatal Intensive Care UnitDi Venere HospitalBari 70124Italy Department of Pharmacy-Drug Science University of Bari Aldo MoroBari 70126Italy Department of Emergency and Organ Transplantation Univ BariBari 70124Italy Department of Biomedical Sciences and Human Oncology Pediatric UnitUniversity"A.Moro"Bari 70124Italy

Bone loss associated with type 1 diabetes mellitus(T1DM)begins at the onset of the disease,already in childhood,determining a lower bone mass peak and hence a greater risk of osteoporosis and fractures later in *** mechanisms underlying diabetic bone fragility are not yet completely *** and insulin deficiency can affect the bone cells functions,as well as the bone marrow fat,thus impairing the bone strength,geometry,and *** factors,like insulin and growth hormone/insulin-like growth factor 1,can control bone marrow mesenchymal stem cell commitment,and the receptor activator of nuclear factor-κB ligand/osteoprotegerin and Wnt-b catenin pathways can impair bone *** myokines may have a key role in regulating metabolic control and improving bone mass in T1DM *** aim of this review is to provide an overview of the current knowledge of the mechanisms underlying altered bone remodeling in children affected by T1DM.

关键词： Type 1 diabetes Children Bone remodeling Osteoclasts Osteoblasts