检索结果-南通市图书馆

Nonlinear Saturation Amplitude in Classical Planar Richtmyer–Meshkov Instability

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2016年第4期65卷 523-526页

作者：刘万海王翔蒋宏彬马文芳 research center of Computational Physics Mianyang Normal University School of Bailie Engineering and Technology Lanzhou City University

The classical planar Richtmyer–Meshkov instability(RMI) at a fluid interface supported by a constant pressure is investigated by a formal perturbation expansion up to the third order,and then according to definition of nonlinear saturation amplitude(NSA) in Rayleigh–Taylor instability(RTI),the NSA in planar RMI is obtained *** is found that the NSA in planar RMI is affected by the initial perturbation wavelength and the initial amplitude of the interface,while the effect of the initial amplitude of the interface on the NSA is less than that of the initial perturbation *** marginal influence of the initial amplitude,the NSA increases linearly with *** NSA normalized by the wavelength in planar RMI is about 0.11,larger than that corresponding to RTI.

关键词： Richtmyer–Meshkov instability nonlinear saturation amplitude perturbation expansion

Residential energy transition and chronic respiratory diseases

在线全文

学校读者我要写书评

暂无评论

The Innovation 2024年第3期5卷 33-43页

作者： Hongcheng Wei Qiurun Yu Danrong Chen Mingzhi Zhang Quanquan Guan Bo Hang Antoine M.Snijders Adrian Covaci Yankai Xia State Key Laboratory of Reproductive Medicine and Offspring Health Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China Key Laboratory of Modern Toxicology of Ministry of Education School of Public HealthNanjing Medical UniversityNanjing 211166China The Affiliated Wuxi People’s Hospital of Nanjing Medical University Wuxi People’s HospitalWuxi Medical CenterNanjing Medical UniversityWuxi 214023China Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA toxicological Centre University of Antwerp2610 WilrijkBelgium

Obtaining clean energy is of prime importance for planetary health and sustainable *** aimed to assess the association between residential energy transition and the risk of chronic respiratory *** data from the Global Health Observatory and Global Burden of Diseases,Injuries,and Risk Factors Study,we delineated the spatial distribution and temporal trends of the population using clean fuels for cooking at a global *** the China Health and Retirement Longitudinal Study,we performed rigorous and well-structured multistage analyses incorporating both cross-sectional and prospective data analyses to examine the associations between solid fuel use,residential energy transition,duration of solid fuel use,and the risk of chronic respiratory *** great progress,huge disparities in access to clean energy persist *** energy transition was associated with a lower risk of chronic respiratory *** the period of 2011–2013,compared with persistent solid fuel users,both participants who switched from solid to clean fuels(adjusted risk ratio[RR]0.78,95%confidence interval[CI]0.62–0.98)and persistent clean fuel users(adjusted RR 0.71,95%CI 0.57–0.89)had significantly lower risk of chronic respiratory diseases(p<0.001 for trend).Consistent associations were observed in the period of 2011–2015 and 2011–*** energy transition from solid to clean fuels could reduce the risk of chronic respiratory *** is a valuable lesson for policy-makers and the general public to accelerate energy switching to alleviate the burden of chronic respiratory diseases and achieve health benefits,particularly in low-and middle-income countries.

关键词： cooking income globally

research progress of disinfection and disinfection by-products in China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2019年第7期31卷 52-67页

作者： Xuefeng Sun Miao Chen Dongbin Wei Yuguo Du State Key Laboratory of Environmental Chemistry and Eco-Toxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences

Disinfection is an indispensable water treatment process for killing harmful pathogens and protecting human health. However, the disinfection has caused significant public concern due to the formation of toxic disinfection by-products(DBPs). Lots of studies on disinfection and DBPs have been performed in the world since 1974. Although related studies in China started in1980 s, a great progress has been achieved during the last three decades. Therefore, this review summarized the main achievements on disinfection and DPBs studies in China, which included:(1) the occurrence of DBPs in water of China,(2) the identification and detection methods of DBPs,(3) the formation mechanisms of DBPs during disinfection process,(4) the toxicological effects and epidemiological surveys of DBPs,(5) the control and management countermeasures of DBPs in water disinfection, and(6) the challenges and chances of DBPs studies in future. It is expected that this review would provide useful information and reference for optimizing disinfection process, reducing DBPs formation and protecting human health.

关键词： Disinfection Disinfection by-products Identification Formation mechanisms Toxicology Control

Development and characterization of monoclonal antibodies against human aryl hydrocarbon receptor

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2016年第1期28卷 165-174页

作者： Wenjing Tian Xinhui Pei Heidi Qunhui Xie Sherry Li Xu Jijing Tian Qin Hu Haiming Xu Yangsheng Chen Hualing Fu Zhengyu Cao Bin Zhao research center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing I00085 China China Pharmaceutical University Nanjing 211198 China

Aryl hydrocarbon receptor（Ah R）, a ligand-dependent nuclear receptor, is involved in a diverse spectrum of biological and toxicological effects. Due to the lack of three dimensional（3D）crystal or nuclear magnetic resonance structure, the mechanisms of these complex effects of AhR remain to be unclear. Also, commercial monoclonal antibodies（mA bs） against human AhR protein（h Ah R）, as alternative immunological tools, are very limited. Thus, in order to provide more tools for further studies on h Ah R, we prepared two m Abs（1D6 and 4A6） against h Ah R. The two newly generated m Abs specifically bound to amino acids 484–508（located in transcription activation domain） and amino acids 201–215（located in Per-ARNT-Sim domain）of h Ah R, respectively. These epitopes were new as compared with those of commercial m *** m Abs were also characterized by enzyme-linked immunosorbent assay, western blot,immunoprecipitation and indirect immunofluorescence assay in different cell lines. The results showed that the two m Abs could recognize the linearized AhR s in six different human cell lines and a rat hepatoma cell line, as well as the h Ah R with native conformations. We concluded that the newly generated m Abs could be employed in AhR-based bioassays for analysis of environmental contaminants, and held great potential for further revealing the spatial structure of AhR and its biological functions in future studies.

关键词： Aryl hydrocarbon receptor Monoclonal antibody Western blot Immunoprecipitation Indirect immunofluorescence assay

Observation and analysis of morphology abnormalities in development of Oryzias melastigma embryos

在线全文

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2021年第4期39卷 1485-1499页

作者： Jingjing SONG Haiyi WU Kaikai LIU Wendan CHI Shanshan GE Zhipeng ZHANG Mingqi WANG Yi YU Daode YU Healthy Mariculture Engineering research center of Shandong Province Marine Science Research Institute of Shandong ProvinceQingdao 266104China Tianjin research Institute for Water Transport Engineering Ministry of TransportTianjin 300456China Ocean University of China Qingdao 266100China

Fish embryos are widely used as models in toxicology,drug development,and human disease research because of their high sensitivity,observability,and operability,providing the basis for an in-depth understanding of the *** studies have indicated that birth defects are *** this study,we used Oryzias melastigma as a model to conduct a study of 185-day embryogenesis and observed self-induced non-pathological abnormal *** experienced pre-puberty stage,adolescence stage,and senescence stage,and individuals produced up to 102 eggs per ***,the fecundity was markedly reduced during the senescent *** the active egg and blastodisc stages,pseudo-fertilization and pseudo-blastocysts were *** cleavage at the 4-to 32-cell stages,we observed blastomeres separation or *** separated blastomeres formed double blastoderms,eventually resulting in conjoined *** the blastula stage,we observed abnormally increased cell volume,narrowed and elongated blastocysts,and abnormally coated *** the organogenesis stage,we observed abnormal numbers of Kupff er’s vesicles and conjoined *** in the location and number of oil droplets were observed in various development *** development was more commonly observed in fertilized eggs produced by broodstock in pre-puberty or senescence stages,which is probably related to the age of fish and the egg *** study can provide the materials for comparative analysis in toxicological and molecular studies of ***,and may provide evidence for other economic fish that produce sticky eggs.

关键词： marine fish model abnormal embryogenesis blastomeres separation Kupffer’s vesicle conjoined twins

Interesting Features of Ionization Potentials for Elements(Z≤119)along the Periodic Table

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2016年第4期33卷 19-23页

作者：顾春金锐曾德灵岳现房高翔李家明 Key Laboratory for Laser Plasmas (Ministry of Education) and Department of Physics and Astronomy Shanghai Jiao Tong University Beijing Computational Science research center Department of Physics and center for Atomic and Molecular Nanosciences Tsinghua University Department of Physics and Information Engineering Jining University Collaborative Innovation center of Quantum Matter

The ionization potential （IP） is a basic property of an atom, which has many applications such as in element analysis. With the Dirac-Slater methods （i.e., mean field theory）, IPs of all occupied orbitals for elements with atomic number （Z ≤ 119） are calculated conveniently and systematically. Compared with available experimental measurements, the theoretical accuracies of IPs for various occupied orbitals are ascertained. The map of the inner orbital IPs with Mood accuracies should be useful to select x-ray energies for element analysis. Based on systematic variations of the first IPs for the outermost orbitals in good agreement with experimental values as well as other IPs, mechanisms of electronic configurations of all atomic elements （Z ≤ 119） along the periodic table are elucidated. It is interesting to note that there exist some deficiencies of the intermediate orbital IPs, which are due to electron correlations and should be treated beyond the mean field theory.

关键词： of on IP for along the Periodic Table in

Removal characteristics of microplastics by Fe-based coagulants during drinking water treatment

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2019年第4期31卷 267-275页

作者： Baiwen Ma Wenjing Xue Yanyan Ding Chengzhi Hu Huijuan Liu Jiuhui Qu Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of Sciences College of Environment and Safety Engineering Qingdao University of Science and Technology University of Chinese Academy of Sciences School of Environment State Key Joint Laboratory of Environment Simulation and Pollution ControlTsinghua University research center for Water Quality and Ecology Tsinghua University

Microplastics have caused great concern worldwide recently due to their ubiquitous presence within the marine environment. Up to now, most attention has been paid to their sources,distributions, measurement methods, and especially their eco-toxicological effects. With microplastics being increasingly detected in freshwater, it is urgently necessary to evaluate their behaviors during coagulation and ultrafiltration(UF) processes. Herein, the removal behavior of polyethylene(PE), which is easily suspended in water and is the main component of microplastics, was investigated with commonly used Fe-based salts. Results showed that although higher removal efficiency was induced for smaller PE particles, low PE removal efficiency(below 15%) was observed using the traditional coagulation process, and was little influenced by water characteristics. In comparison to solution pH, PAM addition played a more important role in increasing the removal efficiency, especially anionic PAM at high dosage(with efficiency up to 90.9%). The main reason was ascribed to the dense floc formation and high adsorption ability because of the positively charged Fe-based flocs under neutral conditions. For ultrafiltration, although PE particles could be completely rejected,slight membrane fouling was caused owing to their large particle size. The membrane flux decreased after coagulation; however, the membrane fouling was less severe than that induced by flocs alone due to the heterogeneous nature of the cake layer caused by PE, even at high dosages of Fe-based salts. Based on the behavior exhibited during coagulation and ultrafiltration, we believe these findings will have potential application in drinking water treatment.

关键词： Microplastics Removal FeCl3·6H2O Coagulation Ultrafiltration

Bufalin-induced cardiotoxicity: new findings into mechanisms

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2020年第7期18卷 550-560页

作者： LI Min WANG Xi-Jie ZHAO Qi WANG Jia-Xian XING Hong-Yan ZHANG Yi-Zhe ZHANG Xue-Xia ZHI Yang-Yang LI Hua MA Jing China State Institutes of Pharmaceutical Industry national Shanghai center for New Drug Safety Evaluation and research Shanghai 201203China Shanghai InnoStar Bio-Tech Co. Ltd.Shanghai 201203China Department of Cardiology the First Affiliated Hospital of Nanjing Medical UniversityNanjing Medical UniversityNanjing 211100China Department of research and Development HELP Stem Cell TherapeuticsNanjing 211100China

Bufalin is one of the main pharmacological and toxicological components of Venenum Bufonis and many traditional Chinese medicine *** cardiotoxicity clearly limits its application to patients living in ***,an investigation of its toxicological mechanism is helpful for new drug development and treatment of the related clinical adverse *** investigate the cardiotoxicity of bufalin using human induced pluripotent stem cells-derived cardiomyocytes(hiPSC-CMs)(0.003–0.1μmol·L–1),human induced pluripotent stem cells-derived cardiomyocytes(hiPSC-CMs)(0.03–0.3μmol·L–1)and eight human cardiac ion channel currents(0.01–100μmol·L–1)combined with an impedance-based bioanalytical and patch clamp *** effect of bufalin on the contractility in hiPSC-CMs,which has been shown to strengthen myocardial contractility,accelerate conduction,and increase beating rate at the earlier stage of administration,whereas weakened myocardial contractility,abolished conduction,and ceased beating rate at the later stage of *** decreased the action potential duration(Action potential duration at 30%,50%and 90%repolarization),cardiac action potential amplitude,and maximal depolarization rate and depolarized the resting membrane potential of *** beating rates of hiPSC-CMs were markedly increased at 0.03μmol·L–1,while were weakened at 0.3μmol·L–1 after *** blocks INav1.5 in a concentration-dependent manner with half maximal inhibitory concentration of 74.5μmol·L–*** respectively increased the late sodium current and Na+-Ca2+exchange current with a concentration for 50%of maximal effect of 2.48 and 66.06μmol·L–1 in ***,bufalin showed no significant effects on other cardiac ion channel *** enhancement of the late sodium current is one of the main mechanism for cardiotoxicity of bufalin.

关键词： Bufalin Cardiomyocytes Cardiotoxicity Ion channels Stem cell

磺酸基转移酶1A1基因启动子区SNPs位点单体型及其功能分析

在线全文

学校读者我要写书评

暂无评论

磺酸基转移酶1A1基因启动子区SNPs位点单体型及其功能分析