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Relation of COVID-19 with liver diseases and their impact on healthcare systems:The Portuguese case

World Journal of Gastroenterology 2023年第6期29卷 1109-1122页

作者： Sara Fernandes Milaydis Sosa-Napolskij Graça Lobo Isabel Silva instituto de ciências biomédicas abel salazar da Universidade do Porto(icbas-UP) Porto 4050-313Portugal ciNTESIS@RISE Center for Health Technology and Services Research at The Associate Laboratory RISE–Health Research NetworkFaculty of Medicine of The University of PortoPorto 4200-219Portugal Laboratory of Pharmacology and Neurobiology–department of Immuno-physiology and Pharmacology Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto(ICBAS-UP)Porto 4050-313Portugal Center for Drug Discovery and Innovative Medicines(MedInUP) Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto(ICBAS-UP)Porto 4050-313Portugal

BACKGROUND The impact caused by the coronavirus disease 2019(COVID-19)on the Portuguese population has been addressed in areas such as clinical manifestations,frequent comorbidities,and alterations in consumption ***,comorbidities like liver conditions and changes concerning the Portuguese population's access to healthcare-related services have received less *** To(1)Review the impact of COVID-19 on the healthcare system;(2)examine the relationship between liver diseases and COVID-19 in infected individuals;and(3)investigate the situation in the Portuguese population concerning these *** For our purposes,we conducted a literature review using specific *** COVID-19 is frequently associated with liver ***,liver injury in COVID-19 individuals is a multifactor-mediated ***,it remains unclear whether changes in liver laboratory tests are associated with a worse prognosis in Portuguese individuals with *** COVID-19 has impacted healthcare systems in Portugal and other countries;the combination of COVID-19 with liver injury is *** liver damage may represent a risk factor that worsens the prognosis in individuals with COVID-19.

关键词： COVID-19 Healthcare systems Liver Portuguese individuals Comorbidities Clinical outcomes

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Immunomodulatory biomaterial-based wound dressings advance the healing of chronic wounds via regulating macrophage behavior

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Regenerative biomaterials 2022年第1期9卷 1131-1142页

作者： Ana Beatriz Sousa Artur P.Águas Mário A.Barbosa Judite N.Barbosa i3S—instituto de Inovaçäo e Investigaçäo em Saúde Universidade do PortoRua Alfredo Allen2084200-125 PortoPortugal INEB—instituto de Engenharia biomédica Rua Alfredo Allen2084200-125 PortoPortugal icbas—instituto de ciências biomédicas abel salazar Universidade do PortoRua de Jorge Viterbo Ferreira2284050-313 PortoPortugal UMIB—Unit for Multidisciplinary biomedical Research of icbas—instituto de ciências biomédicas de abel salazar Universidade do PortoRua de Jorge Viterbo Ferreira2284050-313 PortoPortugal

Successful wound healing is a process that has three overlying phases:inflammatory,proliferative and *** wounds are characterized by a perpetuated inflammation that inhibits the proliferative and remodeling phases and impairs the wound *** are key modulators of the wound healing ***,they are responsible for the wound cleaning and for the phagocytosis of pathogens and afterwards they lead to the resolution of the inflammatory response and they express growth factors important for angiogenesis and cytokines and growth factors needed for cell proliferation and deposition of extracellular *** phenotype of the macrophage changes gradually throughout the healing process from the initial M1 pro-inflammatory phenotype characteristic of the acute response to the M2 pro-regenerative phenotype that allows an accurate tissue *** chronic wounds,M1 pro-inflammatory macrophages persist and impair tissue *** such,immunomodulatory biomaterials arise as promising solutions to accelerate the wound healing *** this review,we discuss the importance of macrophages and their polarization throughout the different phases of wound healing;macrophage dysfunction in chronic wounds and the use of immunomodulatory biomaterials to overcome the critical problem of chronic wounds-the continued inflammatory phase that impairs healing.

关键词： wound healing chronic wounds macrophage immunomodulatory biomaterials

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Oxidative stress in N88S seipinopathy:novel insights into the mechanisms of neurodegeneration and therapeutic avenues

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Neural Regeneration Research 2023年第8期18卷 1719-1720页

作者： Vítor Costa Vitor Teixeira i3S-instituto de Investigação e Inovação em Saúde Universidade do PortoPortoPortugal Yeast Signalling Networks IBMC-Instituto de Biologia Molecular e CelularUniversidade do PortoPortoPortugal icbas Instituto de Ciências Biomédicas Abel SalazarUniversidade do PortoPortoPortugal

Lipid droplets (LDs) are ubiquitous cellular orga nelles that perform functions mostly dedicated to energy homeostasis and lipid *** neutral lipid depots (triacylglycerol,sterol esters),they can be rapidly mobilized through lipase-mediated hydrolysis (lipolysis) or via lipophagy,a specific form of autophagy devoted to consumption of LDs inside the lysosome.

关键词： hydrolysis insight devoted

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Sympathetic activity in breast cancer and metastasis:partners in crime

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Bone Research 2021年第1期9卷 26-36页

作者： Francisco Conceição Daniela M.Sousa Joana Paredes Meriem Lamghari I 3S-instituto de Investigação e Inovação em Saúde Universidade do Porto4200-135 PortoPortugal INEB-instituto Nacional de Engenharia biomédica Universidade do Porto4200-135 PortoPortugal icbas-instituto de ciências biomédicas abel salazar Universidade do Porto4050-313 PortoPortugal IPATIMUP-instituto de Patologia e Imunologia Molecular da Universidade do Porto 4200-135 PortoPortugal FMUP-Faculdade de Medicina da Universidade do Porto 4200-319 PortoPortugal

The vast majority of patients with advanced breast cancer present skeletal complications that severely compromise their quality of *** cancer cells are characterized by a strong tropism to the bone *** engraftment and colonization of bone,breast cancer cells interact with native bone cells to hinder the normal bone remodeling process and establish an osteolytic“metastatic vicious cycle”.The sympathetic nervous system has emerged in recent years as an important modulator of breast cancer progression and metastasis,potentiating and accelerating the onset of the vicious cycle and leading to extensive bone ***,sympathetic neurotransmitters and their cognate receptors have been shown to promote several hallmarks of breast cancer,such as proliferation,angiogenesis,immune escape,and invasion of the extracellular *** this review,we assembled the current knowledge concerning the complex interactions that take place in the tumor microenvironment,with a special emphasis on sympathetic modulation of breast cancer cells and stromal ***,the differential action of epinephrine and norepinephrine,through eitherα-orβ-adrenergic receptors,on breast cancer progression prompts careful consideration when designing new therapeutic *** addition,the contribution of sympathetic innervation to the formation of bone metastatic foci is *** particular,we address the remarkable ability of adrenergic signaling to condition the native bone remodeling process and modulate the bone vasculature,driving breast cancer cell engraftment in the bone ***,clinical perspectives and developments on the use ofβ-adrenergic receptor inhibitors for breast cancer management and treatment are discussed.

关键词： breast metastasis invasion

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Association between EGF +61A/G polymorphism and gastric cancer in Caucasians

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World Journal of Gastroenterology 2011年第4期17卷 488-492页

作者： Ana Paula Araújo Bruno M Costa Ana L Pinto-Correia Maria Fragoso Paula Ferreira Mário Dinis-Ribeiro Sandra Costa Rui M Reis Rui Medeiros Molecular Oncology Group Portuguese Institute of Oncology of Porto Life and Health Sciences Research Institute (ICVS) School of Health Sciences Oncology department Portuguese Institute of Oncology of Porto Gastroenterology department Portuguese Institute of Oncology of Porto Portugal cintesis/Faculty of Medicine University of Porto Centro de Estudos em biomedicina Health Sciences Faculty-Fernando Pessoa University instituto de ciencias biomédicas de abel salazar Abel Salazar Institute for the Biomedical Sciences

AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (ci): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% ci: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men.

关键词： Epidermal growth factor polymorphism Epidermal growth factor receptor Gastric cancer

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3D Photo-Fabrication for Tissue Engineering and Drug delivery

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Engineering 2015年第1期1卷 90-112页

作者： Rúben F.Pereira Paulo J.Bártolo Centre for Rapid and Sustainable Product development (CDRsp) Polytechnic Institute of Leiria instituto de Investiga??o e Inova??o em Saúde (I3S) Universidade do Porto instituto Nacional de Engenharia biomédica (INEB) Universidade do Porto instituto de ciências biomédicas abel salazar (icbas) Universidade do Porto School of Mechanical Aerospace and Civil EngineeringUniversity of Manchester Manchester Institute of Biotechnology University of Manchester

The most promising strategies in tissue engineering involve the integration of a triad of biomaterials, living cells, and biologically active molecules to engineer synthetic environments that closely mimic the healing milieu present in human tissues, and that stimulate tissue repair and regeneration. To be clinically effective, these environments must replicate, as closely as possible, the main characteristics of the native extracellular matrix(ECM) on a cellular and subcellular scale. Photo-fabrication techniques have already been used to generate 3D environments with precise architectures and heterogeneous composition, through a multi-layer procedure involving the selective photocrosslinking reaction of a light-sensitive prepolymer. Cells and therapeutic molecules can be included in the initial hydrogel precursor solution, and processed into 3D constructs. Recently, photofabrication has also been explored to dynamically modulate hydrogel features in real time, providing enhanced control of cell fate and delivery of bioactive compounds. This paper focuses on the use of 3D photo-fabrication techniques to produce advanced constructs for tissue regeneration and drug delivery applications. State-of-the-art photo-fabrication techniques are described, with emphasis on the operating principles and biofabrication strategies to create spatially controlled patterns of cells and bioactive factors. Considering its fast processing, spatiotemporal control, high resolution, and accuracy, photo-fabrication is assuming a critical role in the design of sophisticated 3D constructs. This technology is capable of providing appropriate environments for tissue regeneration, and regulating the spatiotemporal delivery of therapeutics.

关键词： 3D photo-fabrication biomaterials tissueengineering drug delivery

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Expression and activity of heterologous hydroxyisocaproate dehydrogenases in Synechocystis *** 6803ΔhoxYH

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Engineering Microbiology 2022年第1期2卷 1-7页

作者： Valentina Jurka Christoph K.Winkler Silvan Poschenrieder Paulo Oliveira Catarina C.Pacheco Eunice A.Ferreira Florian Weissensteiner Piera de Santis Selin Kara Robert Kourist Paula Tamagnini Wolfgang Kroutil a Institute of Chemistry University of GrazNAWI GrazHeinrichstrasse 288010 GrazAustria i3S–instituto de Investigação e Inovação em Saúde Universidade do Porto4200-135 PortoPortugal IBMC–instituto de Biologia Molecular e Celular Universidade do Porto4200-135 PortoPortugal departamento de Biologia Faculdade de CiênciasUniversidade do Porto4169-007 PortoPortugal icbas–instituto de ciências biomédicas abel salazar Universidade do Porto4050-313 PortoPortugal Aarhus University Department of EngineeringBiological and Chemical Engineering SectionBiocatalysis and Bioprocessing GroupGustav Wieds Vej 10DK 8000 AarhusDenmark Institute of Molecular Biotechnology Graz University of Technology8010 GrazAustria Field of Excellence BioHealth University of Graz8010 GrazAustria BioTechMed Graz 8010 GrazAustria.

Exploiting light to drive redox reactions is currently a hot topic since light is considered as an environmentally friendly source of ***,cyanobacteria,which can use light e.g.,for generating NADPH,are in the focus of ***,it has been shown that various heterologous redox enzymes could be expressed in these *** we demonstrated the successful inducer-free expression of𝛼-keto-acid dehydroge-nases(L-HicDH and D-HicDH)from Lactobacillus confusus DSM 20196 and Lactobacillus paracasei DSM 20008 in Synechocystis *** 6803ΔhoxYH mutant using replicative *** the L-HicDH showed poor activity limited by the amount of expressed enzyme,the D-HicDH was applied both in vivo and in vitro,transforming the selected𝛼-keto acids to the corresponding optically pure(R)-𝛼-hydroxy acids(ee>99%)in up to 53%and 90%conversion,respectively.

关键词： Cyanobacteria Biocatalysis Photobiotransformation Synechocystis sp.PCC 6803 Hydroxyisocaproate dehydrogenase Ketoacid dehydrogenase

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Digenean parasites of the marine gastropods Littorina littorea and Gibbula umbilicalis in the Northern Portuguese Atlantic coast,with a review of digeneans infecting the two gastropod genera

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Journal of Coastal Life Medicine 2016年第5期4卷 345-352页

作者： Graça Costa Sónia Soares Fernando Carvalho João Bela Estação de Biologia Marinha do Funchal Universidade da MadeiraPromenade Orla Marítima do FunchalMadeiraPortugal instituto de ciências biomédicas abel salazar Universidade do PortoRua Jorge ViterboPortoPortugal CON-AQUA Rua Mário SacramentoAveiroPortugal

Objective:To study the digenean parasites of the prosobranch gastropods,Littorina littorea(***)and Gibbula umbilicalis(***)from rocky shores of the Northern Atlantic coast of ***:A total of 413 *** and 2603 *** were collected from rocky shores,at Aveiro estuary,Aguda Beach,and Foz Beach at Porto(Northern Atlantic coast of Portugal)from January to July 2014 and February 2014 to January 2015,*** and digestive glands of the gastropods were examined under light microscopy for the presence of *** gonads of *** were prepared for histological observation,whereas digeneans found in *** were studied and identified with the aid of light and scanning electron ***:Two species of digeneans were found infecting the digestive gland and gonads of ***,namely,Cainocreadium labracis and Lecithochirium furcolabiatum with a combined prevalence of 3%.Histological observations of gonads of *** revealed the infection with digeneans,with considerable replacement of gonadal *** digeneans were not identified to species *** prevalence of digeneans in this snail host was 0.7%.Conclusions:The present study adds *** as another first intermediate host for Cainocreadium labracis and extends its geographical range to the Portuguese Atlantic *** of Lecithochirium furcolabiatum were previously reported from ***.A literature review of digeneans occurring in the gastropod genera Gibbula and Littorina is given.

关键词： Littorina littorea Gibbula umbilicalis Digeneans Sea snails Atlantic Ocean Portugal

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Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound abnormalities

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World Journal of Gastroenterology 2022年第31期28卷 4310-4327页

作者： Pedro Moutinho-Ribeiro Ines A Batista Sofia T Quintas Bárbara Adem Marco Silva Rui Morais Armando Peixoto Rosa Coelho Pedro Costa-Moreira Renato Medas Susana Lopes Filipe Vilas-Boas Manuela Baptista Diogo Dias-Silva Ana L Esteves Filipa Martins Joanne Lopes Helena Barroca Fátima Carneiro Guilherme Macedo Sonia A Melo Serviço de Gastrenterologia Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Faculty of Medicine University of PortoPorto 4200Portugal instituto de Investigacao e Inovacao em Saúde(i3S) Universidade do PortoPorto 4200Portugal IPATIMUP-Institute of Molecular Pathology and Immunology University of PortoPorto 4200Portugal instituto de ciencias biomédicas abel salazar(icbas) University of PortoPorto 4050Portugal Servico de cirurgia Geral Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Unidade de Saúde Familiar Serpa Pinto ACeS Porto OcidentalPorto 4250Portugal Serviço de Anatomia Patológica Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal

BACKGROUND Individuals within specific risk groups for pancreatic ductal adenocarcinoma(PDAC)[mucinous cystic lesions(MCLs),hereditary risk(HR),and new-late onset diabetes mellitus(NLOD)]represent an opportunity for early cancer *** ultrasound(EUS)is a premium image modality for PDAC screening and precursor lesion *** no specific biomarker is currently clinically available for this purpose,glypican-1(GPC1)is overexpressed in the circulating exosomes(crExos)of patients with PDAC compared with healthy subjects or those harboring benign pancreatic *** To evaluate the capacity of GPC1+crExos to identify individuals at higher risk within these specific groups,all characterized by *** This cross-sectional study with a prospective unicentric cohort included 88 subjects:40 patients with MCL,20 individuals with HR,and 20 patients with NLOD.A control group(CG)was submitted to EUS for other reasons than pancreatic pathology,with normal pancreas and absence of hereditary risk factors(n=8).The inclusion period was between October 2016 and January 2019,and the study was approved by the Ethics Committee of Centro Hospitalar Universitário de São João,Porto,*** patients provided written informed *** and blood tests for quantification of GPC1+crExos by flow cytometry and carbohydrate antigen 19-9(CA 19-9)levels by ELISA were performed in all ***-guided tissue acquisition was done whenever *** statistical analysis,SPSS®27.0(IBM Corp.,Armonk,NY,United States)version was *** graphs were created using GraphPad Prism 7.00(GraphPad Software,San Diego,CA,United States).RESULTS Half of MCLs harbored worrisome features(WF)or high-risk stigmata(HRS).Pancreatic abnormalities were detected by EUS in 10.0%and 35.0%in HR and NLOD individuals,respectively,all considered non-malignant and“harmless.”Median levels of GPC1+crExos were statistically different:MCL[99.4%,interquartile range(IQR):94.9%-99.8%],HR(8

关键词： Glypican-1 circulating exosomes Endoscopic ultrasound Pancreatic cancer risk groups Pancreatic cancer precursor lesions Genetic predisposition

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Robotic in situ bioprinting for cartilage tissue engineering

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International Journal of Extreme Manufacturing 2023年第3期5卷 118-142页

作者： Yaxin Wang Rúben F Pereira Chris Peach Boyang Huang cian Vyas Paulo Bartolo department of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchester M139PLUnited Kingdom instituto de ciências biomédicas abel salazar Universidade do Porto4050-313PortoPortugal instituto de Investigacao e Inovaao em Saúde Universidade do Porto4200-135PortoPortugal instituto de Engenharia biomédica Universidade do Porto4200-135PortoPortugal Manchester University NHS Foundation Trust ManchesterUnited Kingdom Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore639798Singapore

Articular cartilage damage caused by trauma or degenerative pathologies such as osteoarthritis can result in significant pain,mobility issues,and *** surgical treatments have a limited capacity for efficacious cartilage repair,and long-term patient outcomes are not ***-dimensional bioprinting has been used to fabricate biochemical and biophysical environments that aim to recapitulate the native microenvironment and promote tissue ***,conventional in vitro bioprinting has limitations due to the challenges associated with the fabrication and implantation of bioprinted constructs and their integration with the native cartilage *** situ bioprinting is a novel strategy to directly deliver bioinks to the desired anatomical site and has the potential to overcome major shortcomings associated with conventional *** this review,we focus on the new frontier of robotic-assisted in situ bioprinting surgical systems for cartilage *** outline existing clinical approaches and the utilization of robotic-assisted surgical *** and robotic-assisted in situ bioprinting techniques including minimally invasive and non-invasive approaches are defined and ***,we discuss the challenges and potential future perspectives of in situ bioprinting for cartilage applications.

关键词： in situ bioprinting cartilage tissue engineering robotic in situ bioprinting minimally invasive surgery bioinks

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