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Developments in the study of Chinese herbal medicine's assessment index and action mechanism for diabetes mellitus

Animal Models and Experimental Medicine 2024年第4期7卷 433-443页

作者： Xin-Yue Liu Han-Wen Zheng Feng-Zhong Wang Tul-Wahab Atia Bei Fan Qiong Wang institute of food Science and Technology Chinese Academy of Agricultural SciencesBeijingChina Sino-Portugal TCM International Cooperation Center the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhouChina Dr.Panjwani Center for Molecular Medicine and drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachiPakistan

In traditional Chinese medicine(TCM),based on various pathogenic symptoms and the‘golden chamber’medical text,Huangdi Neijing,diabetes mellitus falls under the category‘collateral disease’.TCM,with its wealth of experience,has been treating diabetes for over two *** antidiabetic Chinese herbal medicines re-duce blood sugar,with their effective ingredients exerting unique *** well as a glucose lowering effect,TCM also regulates bodily functions to prevent diabetes associated complications,with reduced side effects compared to western synthetic *** herbal medicine is usually composed of polysaccharides,saponins,al-kaloids,flavonoids,and *** active ingredients reduce blood sugar via various mechanism of actions that include boosting endogenous insulin secretion,enhancing insulin sensitivity and adjusting key enzyme activity and scavenging free *** actions regulate glycolipid metabolism in the body,eventually achiev-ing the goal of normalizing blood *** different animal models,a number of molecular markers are available for the detection of diabetes induction and the molecular pathology of the disease is becoming ***,there is a dearth of scientific data about the pharmacology,dose-effect relationship,and structure-activity relationship of TCM and its *** research into the efficacy,toxicity and mode of action of TCM,using different metabolic and molecular markers,is key to developing novel TCM antidiabetic formulations.

关键词： animal model Chinese herbal medicine diabetes mellitus evaluation index mechanism of action

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Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

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food Science and Human Wellness 2024年第3期13卷 1711-1728页

作者： Crystal Ngofi Zumbi Chun-Hsu Pan Hui-Yu Huang Chieh-Hsi Wu Program in Clinical drug Development from Herbal Medicine College of PharmacyTaipei Medical UniversityTaipei 11031China Program in drug Discovery and Development Industry College of PharmacyTaipei Medical UniversityTaipei 11031China School of Pharmacy Taipei Medical UniversityTaipei 11031China Graduate institute of Metabolism and Obesity Sciences Taipei Medical UniversityTaipei 11031China

Restenosis is a common complication following coronary *** traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the development of restenosis and gut *** aim of this study was to investigate the potential of seaweed extracts(SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells(vSMCs).16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured *** indicated by the results,SE significantly inhibited the progression of intimal hyperplasia in vivo,attenuated inflammation in macrophages and could inhibit the proliferation,dedifferentiation and migration of *** was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in ***,according to the 16S rRNA gene sequencing analysis,supplementation with SE modulated gut microbiota composition in injured *** conclusion,SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.

关键词： Ascophyllum nodosum Fucus vesiculosus PTEN/PI3K/AKT Restenosis Macrophage Vascular smooth muscle cells Gut microbiota

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Effects of Different Seed Stem Sizes on the Changes of Available Elements in Rhizosphere Soil of Fritillaria thunbergii Miq.

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Agricultural Biotechnology 2024年第3期13卷 18-23页

作者： Yong PENG Rui PAN Zhengyan LIU Xiaohong WU Nong ZHOU Wenwu YANG Qijing District State Forest Farm Chongqing 401420China Chongqing Academy of Chinese Materia Medica Chongqing 400065China College of Biological and food Engineering/Chongqing Engineering Laboratory for Green Cultivation and Deep Processing of the Three Gorges Reservoir Area's Medicinal Herbs Chongqing Three Gorges UniversityChongqing 404120China Chongqing Wangzhou food and drug inspection institute/Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area Chongqing 404000China

[Objectives]This study was conducted to screen suitable seed stems of Fritillaria thunbergii *** different provenances and to provide a theoretical basis for the high-yielding and high-efficiency cultivation of *** *** to different places.[Methods]*** *** four different provenances including Zhejiang,Nantong and Chongqing were introduced and cultivated in Wanzhou of *** contents of available Zn,Fe,Mn,Cu,Mo,N,P,K,Ca and Mg in rhizosphere soil of *** *** five growing stages were determined after selecting different stem sizes for field cultivation.[Results]Small stems of Pan an and Ningbo provenances(SSG3,121-160/kg)and middle stems of Nantong and Fengjie provenances(SSG2,81-120/kg)showed higher soil availability.[Conclusions]In the process of introduction and cultivation of *** Miq.,high yield and high efficiency can be achieved by selecting smaller seed stems of *** Miq.

关键词： Fritillaria thunbergii Miq. Different provenances Stem size Introduction Cultivation Soil nutrient element Availability

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Circadian disturbance induces erectile dysfunction by impairing endothelial function

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Asian Journal of Andrology 2024年第2期26卷 205-211页

作者： Tao Li Yi-Ting Jiang Xin-Zhu Qi Peng Chen Jun-Hao Zhang Fu Luo Jun Qiao Jiang Gu Guang-Shi Du Qiang Wang Department of Urology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Urology Guizhou Provincial People's HospitalGuiyang 550002China Department of Otorhinolaryngology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Guizhou institute for food and drug Control Guiyang 550004China Department of Reproductive Center Guizhou Provincial People's HospitalGuiyang 550002China Translational Medicine Research Center of Guizhou Medical University Guiyang 550025China

In order to explore the impact of circadian disturbance on erectile function,we randomly divided 24 adult male rats into groups of control(light on at 8:00 *** off at 8:00 p.m.),dark/dark(DD;constant dark),light/light(LL;constant light),and shift dark/light(DL;light off at 8:00 *** on at 8:0o p.m.).Four weeks later,erectile function was measured and corpora cavernosa were harvested for *** maximum intracavernous pressure(mlcP)and mCP/mean arterial pressure(MAP)ratio in the DD,LL,and DL groups were significantly lower than that in the control *** LL and DL groups showed significantly attenuated endothelial nitric oxide synthase(eNOS),while DD,LL,and DL showed reduced neuronal nitric oxide synthase(nNOS)at both mRNA and protein *** production of nitric oxide(NO)and cyclic guanosinemonophosphate(cGMP)was inhibited by altered light/dark cycles to varying *** disturbance impaired endothelial function and contributed to erectile *** the core circadian elements,mRNA expression of circadian locomotor output cycles kaput(Clock)and brain/muscle aryl-hydrocarbon receptor nuclear translocator-like protein 1(Bmal1)was elevated in the DL group,but their protein expression was not significantly ***,LL,and DL increased period 1(Per1)and Per3 levels,while LL and DL increased PER1 *** significant difference was found for Per2levels,and PER2 and PER3 concentrations were not significantly ***,LL and DL significantly increased cryptochrome-1(CRY1)and CRY2 at both mRNA and protein *** altered light/dark rat model showed that circadian disturbance contributed to erectile dysfunction probably by impairing endothelial ***,the core circadian elements were detected in the corpora cavernosa,but these were ***,which circadian element regulates erectile function and how it works need further analysis.

关键词： circadian disturbance endothelial function erectile function light/dark cycle NO/cGMP

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Diversity synthesis of tetrahydroprotoberberines glycosides by combined chemical and microbial catalysis

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Chinese Journal of Natural Medicines 2016年第10期14卷 783-788页

作者： GE Hai-Xia ZHANG Jian QIAN Kun YU Bo-Yang CHEN Xiao-Ping Department of Pharmacy Huzhou UniversityHuzhou 313000China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Department of Complex Prescription of Traditional Chinese Medieine China Pharmaceutical UniversityNanjing 211198 China huzhou food and drug inspection institute Huzhou 313000China

The present study was designed to construct the structurally diverse library of tetrahydroprotoberberines(THPBs) by combining the methods of chemical nonselective demethylation and microbial glycosylation. HPLC-MS/MS analyses tentativelyidentified 12 de-methylated and 9 glycosylated derivates of THPBs and 5 rarely oxidized glycosides of THPBs in the library. Through this effort, we achieved not only a variety of the THPBs and their glycosides but also tested the catalytic characteristics and capabilities of G. deliquescens NRRL 1086.

关键词： THPBs library Diversity synthesis Microbial glycosylation Chemical demethylation

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Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms:A narrative review

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Animal Nutrition 2024年第1期16卷 251-266页

作者： Pengju Wang Lv-hui Sun Xu Wang Qinghua Wu Aimei Liu Hubei Key Laboratory of Diabetes and Angiopathy Medicine Research InstituteXianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Hubei Hongshan Laboratory College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan430070China National Reference Laboratory of Veterinary drug Residues(HZAU)and MAO Key Laboratory for Detection of Veterinary drug Residues Huazhong Agricultural UniversityWuhan430070China College of Life Science Yangtze UniversityJingzhou 434025China

T-2 toxin is one of the most widespread and toxic fungal toxins in food and *** can cause gastrointestinal toxicity,hepatotoxicity,immunotoxicity,reproductive toxicity,neurotoxicity,and nephrotoxicity in humans and animals.T-2 toxin is physicochemically stable and does not readily degrade during food and feed ***,suppressing T-2 toxin-induced organ toxicity through antidotes is an urgent *** agents against the organ toxicity of T-2 toxin have been recorded widely in the literature,but these protective agents and their molecular mechanisms of detoxification have not been comprehensively *** this review,we provide an overview of the various protective agents to T-2 toxin and the molecular mechanisms underlying the detoxification *** appropriate targets to antagonize T-2 toxin toxicity is also an important *** review will provide essential guidance and strategies for the better application and development of T-2 toxin antidotes specific for organ toxicity in the future.

关键词： T-2 toxin Organ toxicity Protective agent Detoxification mechanism

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Fluorescence analysis of antibiotics and antibiotic-resistance genes in the environment: A mini review

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Chinese Chemical Letters 2024年第10期35卷 82-91页

作者： Yuxin Li Chengbin Liu Qiuju Li Shun Mao College of Environmental Science and Engineering State Key Laboratory of Pollution Control and Resource ReuseTongji UniversityShanghai 200092China institute for Agri-food Standards and Testing Technology Shanghai Academy of Agricultural SciencesShanghai 201403China

Antibiotics,as widely used antibacterial drug,exist in various environmental *** residues can affect biological metabolism and lead to bacterial resistance and the formation of antibiotic-resistance genes,posing a threat to human health and ecological *** efficient detection methods for antibiotics and antibiotic-resistance genes has great environmental *** detection methods,due to their fast response,high sensitivity and specificity,and low-cost,are widely used in chemical and biological *** review first summarizes the pre-treatment methods for different types of environmental samples,and then focuses on the recent advances of fluorescence methods for the detection of antibiotics and antibiotic-resistance ***,main challenges and future research directions of fluorescence methods for antibiotic and antibiotic-resistance genes detection are *** review highlights the promising prospect of fluorescence methods in-situ detection and monitoring of antibiotics and antibiotic-resistance genes,and provides guidance for the construction of overall risk assessment system of environmental media.

关键词： Antibiotics Antibiotic-resistancegenes Fluorescence detection Environmental samples In-situdetection

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Function and Application Progress of Probiotics in food

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Agricultural Biotechnology 2024年第4期13卷 63-64,69页

作者： Junpeng ZHAO Richard Avoi Azman Bin Atil@Azmi Jiao CHEN Ling YUN Tangshan food and drug Comprehensive inspection and Testing Center Tangshan 063000China Hebei Agricultural Products Quality and Safety Testing Technology Innovation Center Tangshan 063000China Tangshan institute of Industrial Technology for Functional Agricultural Products Tangshan 063000China Universiti Malaysia Sabah Faculty of Medicine and Health SciencesMalaysia Guizhou Forerunner College Guiyang 550000China Tangshan Center for Disease Prevention and Control Tangshan 063000China

Probiotics have a long history of use in human production and *** the gradual deepening of the research on the functions of probiotics,their various nutritional and health benefits for the human body have also become increasingly *** research shows that probiotics can regulate intestinal flora,and improve immunity and even the symptoms of some ***,in the food industry,the application of probiotics from traditional fermented foods to functional foods has become more and more *** this paper,the research progress of nutritional function and application of probiotics in food at home and abroad was reviewed,in order to provide some reference for the safe application of probiotics in food.

关键词： Probiotics Physiological function food Development and application

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Determination of 14 Organophosphorus Pesticide Residues in Mutton by Gel Permeation Chromatography-Gas Chromatography-Mass Spectrometry(GPC-GC-MS)

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Agricultural Biotechnology 2024年第3期13卷 28-30,33页

[Objectives]This study was conducted to purify mutton samples by gel permeation chromatography(GPC).[Methods]Fourteen organophosphorus pesticide residues in samples were qualitatively and quantitatively analyzed by gas chromatography-mass spectrometry(GC-MS)in selective ion scanning mode(SIM).[Results]The organophosphorus pesticide standard solutions showed good linearity in the mass concentration range of 0.1-10.0μg/ml with correlation coefficients(r)not lower than 0.999,and the detection limits(S=3 N)ranged from 0.01 to 0.05 mg/*** average recovery values were in the range of 80.2%-99.7%,with relative standard deviations(RSDs,n=3)in the range of 1.8%-6.3%,at the addition levels of 0.5,1.0 and 2.0 mg/kg.[Conclusions]The method is simple,sensitive and accurate,and can be used for the determination of organophosphorus pesticide residues in mutton.

关键词： Mutton Gas chromatography-mass spectrometry Gel permeation chromatography Organophosphorus Pesticide residue

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Cancer treatment with biosimilar drugs:A review

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Cancer Innovation 2024年第2期3卷 45-62页

作者： Shilpa Malakar Emmanuel Nuah Gontor Moses YDugbaye Kamal Shah Sakshi Sinha Priya Sutaoney Nagendra Singh Chauhan Department of Microbiology Kalinga UniversityRaipurChhattisgarhIndia institute of Pharmaceutical Research GLA UniversityMathuraUttar PradeshIndia drug Testing Laboratory Avam Anusandhan KendraRaipurChhattisgarhIndia

Biosimilars are biological drugs created from living organisms or that contain living *** share an identical amino-acid sequence and *** drugs are considered to be cost-effective and are utilized in the treatment of cancer and other endocrine *** primary aim of biosimilars is to predict biosimilarity,efficacy,and treatment costs;they are approved by the food and drug Administration(FDA)and have no clinical *** involve analytical studies to understand the similarities and dissimilarities.A biosimilar manufacturer sets up FDA-approved reference products to evaluate *** contribution of next-generation sequencing is evolving to study the organ tumor and its progression with its impactful therapeutic approach on cancer patients to showcase and target rare *** study shall help to understand the future perspectives of biosimilars for use in gastro-entero-logic diseases,colorectal cancer,and thyroid *** also help target specific organs with essential mutational categories and drug prototypes in clinical practices with blood and liquid biopsy,cell treatment,gene therapy,recombinant therapeutic proteins,and personalized *** derivatives such as monoclonal antibodies like trastuzumab and rituximab are common drugs used in cancer *** coli produces more than six antibodies or antibody-derived proteins to treat cancer such as filgrastim,epoetin alfa,and so on.

关键词： biologics biosimilars cancer Escherichia coli monoclonal antibody next-generation sequencing pharmacovigilance

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