Diversity synthesis of tetrahydroprotoberberines glycosides by combined chemical and microbial catalysis

作     者：GE Hai-Xia ZHANG Jian QIAN Kun YU Bo-Yang CHEN Xiao-Ping 

作者机构：Department of PharmacyHuzhou UniversityHuzhou 313000China State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Department of Complex Prescription of Traditional Chinese MedieineChina Pharmaceutical UniversityNanjing 211198 China Huzhou Food and Drug Inspection InstituteHuzhou 313000China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2016年第14卷第10期

页      面：783-788页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100701[医学-药物化学] 10[医学] 

基　　金：funded by the National Nature Science Foundation of China(No.21302052) the Program for New Century Excellent Talents in University the‘111 Project’from the Ministry of Education of China the Fundamental Research Funds for the Central Universities(No.JKZ2011017) 

主　　题：THPBs library Diversity synthesis Microbial glycosylation Chemical demethylation 

摘      要：The present study was designed to construct the structurally diverse library of tetrahydroprotoberberines(THPBs) by combining the methods of chemical nonselective demethylation and microbial glycosylation. HPLC-MS/MS analyses tentativelyidentified 12 de-methylated and 9 glycosylated derivates of THPBs and 5 rarely oxidized glycosides of THPBs in the library. Through this effort, we achieved not only a variety of the THPBs and their glycosides but also tested the catalytic characteristics and capabilities of G. deliquescens NRRL 1086.