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Comparative Study on the Immunogenicity and Efficacy of Different Post-exposure Intramuscular Rabies Vaccination Regimens in China

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Biomedical and Environmental Sciences 2024年第2期37卷 178-186页

作者： SONG Yun HE Ying LU Xue Xin ZHANG Xiao Mei JIANG XIAO Lin SONG Qing HUANG Xue Yong MA Hong Xia YU Peng Cheng ZHU Wu Yang Henan provincial Center for Disease control and Prevention Infectious Disease Prevention and Control InstituteHenan Provincial Key Laboratory of Infectious Disease PathogensZhengzhou 450000HenanChina National institute for Viral Disease control and Prevention China CDCKey Laboratory of BiosafetyNational Health CommissionBeijing 102206China Shandong provincial Center for Disease control and Prevention Jinan 250014ShandongChina Qingdao Chengyang District Center for Disease control and Prevention Qingdao 266108ShandongChina

Objective This study aimed to compare the current Essen rabies post-exposure immunization schedule(0-3-7-14-28)in China and the simple 4-dose schedule(0-3-7-14)newly recommended by the World Health Organization in terms of their safety,efficacy,and protection.Methods Mice were vaccinated according to different immunization schedules,and blood was collected for detection of rabies virus neutralizing antibodies(RVNAs)on days 14,21,28,35,and 120after the first immunization.Additionally,different groups of mice were injected with lethal doses of the CVS-11 virus on day 0,subjected to different rabies immunization schedules,and assessed for morbidity and death status.In a clinical trial,185 rabies-exposed individuals were selected for post-exposure vaccination according to the Essen schedule,and blood was collected for RVNAs detection on days 28and 42 after the first immunization.Results A statistically significant difference in RVNAs between mice in the Essen and 0-3-7-14 schedule groups was observed on the 35th day(P0.05)in RVNAs levels at any time point.The post-exposure immune protective test showed that the survival rate of mice in the control group was 20%,whereas that in the immunization groups was 40%.In the clinical trial,the RVNAs positive conversion rates on days 28(14 days after 4 doses)and 42(14 days after 5 doses)were both 100%,and no significant difference in RVNAs levels was observed(P>0.05).Conclusion The simple 4-dose schedule can produce sufficient RVNAs levels,with no significant effect of a delayed fourth vaccine dose(14–28 d)on the immunization potential.

关键词： Rabies Post-exposure immunization Essen regimen RVNAs

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Iodine Nutrition, Thyroid-stimulating Hormone, and Related Factors of Postpartum Women from three Different Areas in China: A Cross-sectional Survey

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Biomedical and Environmental Sciences 2024年第3期37卷 254-265页

作者： SHAN Xiao Yun ZOU Yan HUANG Li Chun JIANG Shan ZHOU Wei Wen QIN Qiu Lan LIU Chang Qing LUO Xiao Yan LU Jia Xi MAO De Qian LI Min YANG Zhen Yu YANG Li Chen Key Laboratory of Trace Element Nutrition of National Health Committee National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China hunan Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 241001HunanChina Zhejiang provincial Center for Disease Prevention and control Hangzhou 310051ZhejiangChina Guangxi Zhuang Autonomous Region Center for Disease control and Prevention Nanning 530028GuangxiChina Hebei provincial Center for Disease control and Prevention Shijiazhuang 050021HebeiChina

Objective Studies on the relationship between iodine,vitamin A(VA),and vitamin D(VD)and thyroid function are limited.This study aimed to analyze iodine and thyroid-stimulating hormone(TSH)status and their possible relationships with VA,VD,and other factors in postpartum women.Methods A total of 1,311 mothers(896 lactating and 415 non-lactating)from Hebei,Zhejiang,and Guangxi provinces were included in this study.The urinary iodine concentration(UIC),TSH,VA,and VD were measured.Results The median UIC of total and lactating participants were 142.00µg/L and 139.95µg/L,respectively.The median TSH,VA,and VD levels in all the participants were 1.89 mIU/L,0.44μg/mL,and 24.04 ng/mL,respectively.No differences in the UIC were found between lactating and non-lactating mothers.UIC and TSH levels were significantly different among the three provinces.The rural UIC was higher than the urban UIC.Obese mothers had a higher UIC and a higher prevalence of excessive TSH.Higher UICs and TSHs levels were observed in both the VD deficiency and insufficiency groups than in the VD-sufficient group.After adjustment,no linear correlation was observed between UIC and VA/VD.No interaction was found between vitamins A/D and UIC on TSH levels.Conclusion The mothers in the present study had no iodine deficiency.Region,area type,BMI,and VD may be related to the iodine status or TSH levels.

关键词： Median urinary iodine concentration Thyroid-stimulating hormone Vitamin A Vitamin D Postpartum women

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Single-cell transcriptomic analysis reveals transcript enrichment in oxidative phosphorylation,fluid sheer stress,and inflammatory pathways in obesity-related glomerulopathy

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Genes & Diseases 2024年第4期11卷 314-326页

作者： Yinyin Chen Yushun Gong Jia Zou Guoli Li Fan Zhang Yiya Yang Yumei Liang Wenni Dai Liyu He Hengcheng Lu Department of Nephrology Hunan Provincial People's HospitalThe First Affliated Hospital of Hunan Normal UniversityHunan Clinical Research Center for Chronic Kidney DiseaseChangshaHunan 410000China Department of Nephrology The Second Xiangya Hospital of Central South UniversityHunan Key Laboratory of Kidney Disease and Blood PurificationChangshaHunan 410011China Cardiovascular Research institute of Jiangxi Province Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchangJiangxi 330006China

Obesity-related glomerulopathy(ORG)is an independent risk factor for chronic kid-ney disease and even progression to end-stage renal disease.Efforts have been undertaken to elucidate the mechanisms underlying the development of ORG and substantial advances have been made in the treatment of ORG,but relatively little is known about cell-specific changes in gene expression.To define the transcriptomic landscape at single-cell resolution,we analyzed kidney samples from four patients with ORG and three obese control subjects without kidney disease using single-cell RNA sequencing.We report for the first time that immune cells,including T cells and B cells,are decreased in ORG patients.Further analysis indicated that SPP1 was significantly up-regulated in T cells and B cells.This gene is related to inflammation and cell proliferation.Analysis of differential gene expression in glomerular cells(endothelial cells,mesangial cells,and podocytes)showed that these cell types were mainly enriched in genes related to oxidative phosphorylation,cell adhesion,thermogenesis,and inflammatory pathways(PI3K-Akt signaling,MAPK signaling).Furthermore,we found that the podocytes of ORG patients were enriched in genes related to the fluid shear stress pathway.Moreover,an evaluation of cell-cell communications revealed that there were interactions between glomerular parietal epithelial cells and other cells in ORG patients,with major interactions between parietal epithelial cells and podocytes.Altogether,our identification of molecular events,cell types,and differentially expressed genes may facilitate the development of new preventive or therapeutic approaches for ORG.

关键词： Fluid shear stress Inflammation Obesity-related glomerulopathy Oxidative phosphorylation Single-cell RNA seq

Erosion-induced recovery CO_(2) sink offset the horizontal soil organic carbon removal at the basin scale

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Science China Earth Sciences 2024年第6期67卷 2019-2033页

作者： Lingxia WANG Xiaodong NIE Jiaqi LI Yaojun LIU Hui WANG Yazhe LI Zhongwu LI School of Geographic Science Hunan Normal UniversityChangsha 410081China institute of Interdisciplinary Studies Hunan Normal University and Hunan Provincial Key Laboratory for Eco-environmental Changes and Carbon Sequestration of the Dongting Lake BasinChangsha 410081China College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangsha 410082China

To improve soil carbon sequestration capacity,the full soil carbon cycle process needs to be understood and quantified.It is essential to evaluate whether water erosion acts as a net source or sink of atmospheric CO_(2)at the basin scale,which encompasses the entire hydrological process.This study introduced an approach that combined a spatially distributed sediment delivery model and biogeochemical model to estimate the lateral and vertical carbon fluxes by water erosion at the basin scale.Applying this coupling model to the Dongting Lake Basin,the results showed that the annual average amount of soil erosion during 1980-2020 was 1.33×10^(8)t,displaying a decreasing trend followed by a slight increase.Only 12% of the soil organic carbon displacement was ultimately lost in the riverine systems,and the rest was deposited downhill within the basin.The average lateral soil organic carbon loss induced by erosion was 8.86×10^(11)g C in 1980 and 1.50×10^(11)g C in 2020,with a decline rate of 83%.A net land sink for atmospheric CO_(2)of 5.54×1011g C a^(-1)occurred during erosion,primarily through sediment burial and dynamic replacement.However,ecological restoration projects and tillage practice policies are still significant in reducing erosion,which could improve the capacity of the carbon sink for recovery beyond the rate of horizontal carbon removal.Moreover,our model enables the spatial explicit simulation of erosion-induced carbon fluxes using costeffective and easily accessible input data across large spatial scales and long timeframes.Consequently,it offers a valuable tool for predicting the interactions between carbon dynamics,land use changes,and future climate.

关键词： Water erosion Sediment transfer Lateral soil carbon loss Land-atmosphere CO_(2) flux Dongting Lake Basin

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Leucine regulates lipid metabolism in adipose tissue through adipokine-mTOR-SIRT1 signaling pathway and bile acid—microbe axis in a finishing pig model

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Animal Nutrition 2024年第1期16卷 158-173页

作者： Yunju Yin Saiming Gong Mengmeng Han Jingzun Wang Hanjing Shi Xianji Jiang Liu Guo Yehui Duan Qiuping Guo Qinghua Chen Fengna Li Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessHunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production College of Animal Science and Technology Hunan Agricultural University College of Modern Agricultural Sciences University of Chinese Academy of Sciences College of Life Science and Engineering Northwest Minzu University

This study was conducted to explore the regulatory mechanism of leucine (Leu) on lipid metabolism of finishing pigs.Twenty-four Duroc×Landrace×Large cross pigs with an average body weight of68.33±0.97 kg were randomly allocated into 3 treatment groups with 8 replicates per group (1 pig per replicate).The dietary treatments were as follows:control group (CON),0.25%Leu group and 0.50%Leu group.The experimental period was 42 d.The results showed as follows.(1) Compared with the CON,0.25%and 0.50%Leu increased (P<0.01) the average daily gain (ADG),while the average backfat thickness (ABT) and the ratio of feed intake to body weight gain (F:G ratio) were decreased (P<0.05).(2)In the 0.25%Leu group,the relative mRNA expression levels of sterol regulatory element binding protein-1c (SREBP1c),recombinant fatty acid transport protein 1 (FATP1),chemerin and peroxisome proliferatoractivated receptor γ (PPARγ) were decreased but the level of fatty acid binding protein 4 (FABP4) and fatty acid translocase (FAT/CD36) were increased in backfat tissue.In the 0.25%Leu group,the protein levels of p-Rictor,p-Raptor,p-eIF4E-binding protein 1 (p-4EBP1),p-silent mating type information regulator 2homolog 1 (p-SIRT1) and acetylation ribosome s6 protein kinase 1 (Ac—S6K1) were increased (P<0.05).(3) Compared to the CON,the diversity of gut microbiota in the 0.25%Leu group was increased.Principal component analysis showed that the relative abundance of Bacteroidetes,Lactobacillus and Desulfovibrio was higher in the 0.25%Leu group than the CON,but the relative abundance of Firmicutes,Treponema and Shigella was lower than in the CON (P<0.05).(4) Four different metabolites were screened out from the serum of finishing pigs including allolithocholic acid (alloLCA),isolithocholic acid (isoLCA),ursodeoxycholic acid (UDCA) and hyodeoxycholic acid (HDCA),which correlate to various degrees with the above microorganisms.In conclusion,Leu could promote adipose tissue lipolysis of finishing pigs through the mTOR-SIRT1 signaling pathway,and S6K1 is a

关键词： Leu Lipid metabolism Gut microbiota Bile acid

Shi-pi-xiao-ji formula suppresses hepatocellular carcinoma by reducing cellular stiffness through upregulation of acetyl-coA acetyltransferase 1

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2727-2741页

作者： Hui-Ying Jian Zi-Cheng Liang Huan Wen Zhen Zhang Pu-Hua Zeng Graduate School Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina hunan provincial Hospital of Integrated Traditional Chinese and Western Cancer Research Institute of Hunan Academy of Traditional Chinese MedicineHunan Academy of Chinese MedicineChangsha 410006Hunan ProvinceChina

BACKGROUND Previous studies have shown that the Shi-pi-xiao-ji(SPXJ)herbal decoction formula is effective in suppressing hepatocellular carcinoma(HCC),but the underlying mechanisms are not known.Therefore,this study investigated whether the antitumor effects of the SPXJ formula in treating HCC were mediated by acetyl-coA acetyltransferase 1(ACAT1)-regulated cellular stiffness.Through a series of experiments,we concluded that SPXJ inhibits the progression of HCC by upregulating the expression level of ACAT1,lowering the level of cholesterol in the cell membrane,and altering the cellular stiffness,which provides a new idea for the research of traditional Chinese medicine against HCC.AIM To investigate the anti-tumor effects of the SPXJ formula on the malignant progression of HCC.METHODS HCC cells were cultured in vitro with SPXJ-containing serum prepared by injecting SPXJ formula into wild-type mice.The apoptotic rate and proliferative,invasive,and migratory abilities of control and SPXJ-treated HCC cells were compared.Atomic force microscopy was used to determine the cell surface morphology and the Young’s modulus values of the control and SPXJ-treated HCC cells.Plasma membrane cholesterol levels in HCC cells were detected using the Amplex Red cholesterol detection kit.ACAT1 protein levels were estimated using western blotting.RESULTS Compared with the vehicle group,SPXJ serum considerably reduced proliferation of HCC cells,increased stiffness and apoptosis of HCC cells,inhibited migration and invasion of HCC cells,decreased plasma membrane cholesterol levels,and upregulated ACAT1 protein levels.However,treatment of HCC cells with the water-soluble cholesterol promoted proliferation,migration,and invasion of HCC cells as well as decreased cell stiffness and plasma membrane cholesterol levels,but did not alter the apoptotic rate and ACAT1 protein expression levels compared with the vehicle control.CONCLUSION SPXJ formula inhibited proliferation,invasion,and migration of HCC cells by decreasing plasma membrane chole

关键词： Shi-pi-xiao-ji formula Hepatocellular carcinoma Cellular stiffness Plasma membrane cholesterol level AcetylcoA acetyltransferase 1

Food-Borne Poisoning Accident from Amanitin Toxin in Wild Mushrooms—Xingtai City,Hebei Province,China,2023

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China CDC weekly 2024年第3期6卷 56-59页

作者： Baopu Lv Liang Liu Hao Xiao Qingbing Meng Rui Zhang Yaqing An Yingli Jin Yu Ma Hengbo Gao Yongkai Li Qian He Yutao Zhang Changqing Liu Xiaoyan Luo Xiaomin Xu Fenshuang Zheng Yingping Tian Hongshun Zhang Dongqi Yao Emergency Department The Second Hospital of Hebei Medical UniversityShijiazhuang CityHebei ProvinceChina National institute of Occupational Health and Poison control Chinese Centre for Disease Control and PreventionBeijingChina Hebei provincial Center for Disease control and Prevention Shijiazhuang CityHebei ProvinceChina Zhejiang provincial Center for Disease control and Prevention Hangzhou CityZhejiang ProvinceChina Emergency Department The Affiliated Hospital of Yunnan UniversityKunming CityYunnan ProvinceChina

What is already known about this topic?Fatal poisonings caused by wild mushrooms containing amanita toxins pose a significant threat in the southern regions of China.These toxins primarily induce gastrointestinal symptoms initially,which are then followed by potentially life-threatening acute liver damage.What is added by this report?This report contributes to the existing knowledge on these cases of poisoning by documenting the second occurrences in Hebei Province and the first occurrences in Xingtai City.Five individuals reported consuming wild mushrooms from the same origin,and laboratory tests confirmed the presence ofα-amanitin in their blood samples.What are the implications for public health practice?This underscores the risk associated with the collection and consumption of amanita toxin-containing mushrooms in Hebei.It is important to note that the identification of toxic and non-toxic mushrooms should not solely rely on personal experience or appearance.

关键词： Hebei consuming initially

Analysis of Epidemiological and Issues Encountered in Case Reports on Echinococcosis—China,2022

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China CDC weekly 2024年第6期6卷 100-104页

作者： Yan Kui Shuai Han Xiaojuan Zhang Guangzhong Shi Yale Yu Ruirui Li Peizheng Zhan Hongju Duan Wenbo Luo Benfu Li Shaoqi Ning Yalan Zhang Aiya Zhu Jingbo Xue National institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)National Health Commission Key Laboratory of Parasite and Vector BiologyWorld Health Organization Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Gansu provincial Center for Disease control and Prevention Lanzhou CityGansu ProvinceChina The Center for Disease control and Prevention of Xinjiang Uygur Autonomous Region Urumuqi CityXinjiang Uygur Autonomous RegionChina Xinjiang Production and Construction Corps Center for Disease control and Prevention Urumuqi CityXinjiang Uygur Autonomous RegionChina Sichuan provincial Center for Disease control and Prevention Chengdu CitySichuan ProvinceChina Qinhai institute for Endemic Disease control and Prevention Xining CityQinghai ProvinceChina Ningxia Center for Disease control and Prevention Yinchuan CityNingxia Hui Autonomous RegionChina Inner Mongolia Autonomous Region Center for Comprehensive Disease control and Prevention Hohhot CityInner Mongolia AutonomousChina Yunnan institute of Parasitic Diseases Puer CityYunnan ProvinceChina Shaanxi provincial Center for Disease control and Prevention Xi'an CityShaanxi ProvinceChina Henan provincial Center for Disease control and Prevention Zhengzhou CityHenan ProvinceChina Guizhou provincial Center for Disease control and Prevention Guiyang CityGuizhou ProvinceChina

Summary What is already known about this topic?Echinococcosis is classified as a Class C infectious disease in China.It is endemic in 370 counties located in the agricultural and pastoral regions of western China.What is added by this report?This report provides a comprehensive overview of the cases of echinococcosis reported in China in 2022.Following a thorough evaluation conducted by provincial CDCs.

关键词： China Ech counties

Zinc lactate alleviates oxidative stress by modulating crosstalk between constitutive androstane receptor signaling pathway and gut microbiota profile in weaned piglets

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Animal Nutrition 2024年第1期16卷 23-33页

作者： Wenjie Tang Xuan Xiang Houfu Wang Wentao Zhou Liuqin He Yulong Yin Tiejun Li College of Animal Science and Technology Hunan Agricultural University Sichuan Academy of Animal Sciences Animal Breeding and Genetics Key Laboratory of Sichuan Province Livestock and Poultry Biological Products Key Laboratory of Sichuan Province Sichuan Animtech Feed Co. Ltd hunan provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production Institute of Subtropical Agriculture Chinese Academy of Sciences College of Advanced Agricultural Science University of Chinese Academy of Sciences hunan provincial Key Laboratory of Animal Intestinal Function and Regulation Laboratory of Animal Nutrition and Human Health College of Life Sciences Hunan Normal University

This study aimed to determine the regulatory mechanism of dietary zinc lactate (ZL) supplementation on intestinal oxidative stress damage in a paraquat (PQ)-induced piglet model. Twenty-eight piglets (mean body weight 9.51±0.23 kg) weaned at 28 d of age were randomly divided into control, ZL, PQ, and ZL+PQ groups (n=7 in each group). The ZL-supplemented diet had little effect on growth performance under normal physiological conditions. However, under PQ challenge, ZL supplementation significantly improved average daily gain (P<0.05) and reduced the frequency of diarrhea. ZL improved intestinal morphology and ultrastructure by significantly increasing the expression level of the jejunal tight junction protein, zonula occludens-1(ZO-1) (P<0.05), and intestinal zinc transport and absorption in PQ-induced piglets, which reduced intestinal permeability. ZL supplementation also enhanced the expression of antioxidant and antiinflammatory factor-related genes and decreased inflammatory cytokine expression and secretion in PQinduced piglets. Furthermore, ZL treatment significantly inhibited the activation of constitutive androstane receptor (CAR) signaling (P<0.01) in PQ-induced piglets and altered the structure of the gut microbiota, especially by significantly increasing the abundance of beneficial gut microbes, including UCG＿002, Ruminococcus, Rikenellaceae＿RC9＿gut＿group, Christensenellaceae＿R＿7＿group, Treponema, unclassified＿Christensenellaceae, and unclassified＿Erysipelotrichaceae (P <0.05). These data reveal that pre-administration of ZL to piglets can suppress intestinal oxidative stress by improving antioxidant and anti-inflammatory capacity and regulating the crosstalk between CAR signaling and gut microbiota.

关键词： Zinc lactate Intestinal barrier Oxidative stress Inflammation Constitutive androstane receptor Gut microbiota