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Microstructure and properties of novel Al-Ce-Sc,Al-Ce-Y,Al-Ce-Zr and Al-Ce-Sc-Y alloy co.ductors processed by die casting,hot extrusion and co.d drawing

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Journal of Materials Science & Technology 2020年第23期58卷 155-170页

作者： Weiyi Wang Qinglin Pan Geng Lin Xiaoping Wang Yuqiao Sun Xiangdong Wang Ji Ye Yuanwei Sun Yi Yu Fuqing Jiang Jun Li Yaru Liu School of Materials Science and Engineering Central South UniversityChangsha 410083China Light Alloy Research Institute Central South UniversityChangsha 410083China hunan oriental scandium industry co. Ltd.Changsha 410100China Manufacturing Center CRRC Times Electric Co.Ltd.Zhuzhou 412001China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China The Seco.d Xiangya Hospital Central South UniversityChangsha 410011China

In order to overco.e the trade-off between the strength and electrical co.ductivity of aluminum alloy co.ductors,the new Al-Ce-Sc,Al-Ce-Y,Al-Ce-Zr and Al-Ce-Sc-Y alloys were prepared by die casting,high temperature homogenization treatment,hot extrusion and co.d *** Sc and Y eliminated the dendrite segregation of the as-cast Al-0.2 Ce alloy and promoted the formation of equiaxed grains with the average grain size of 142.5μ*** Al-0.2 Ce-0.2 Sc-0.1 Y alloy inherited the great tensile properties of Al-0.2 Ce-0.2 Sc alloy and the high electrical co.ductivity of Al-0.2 Ce-0.1 Y alloy *** co.d drawing and annealing at 200℃for 5 h,the ultimate tensile strength of Al-0.2 Ce-0.2 Sc-0.1 Y alloy reached 200 MPa and 198 MPa,the elongation reached 6.8%and 8.5%,and the electrical co.ductivity reached 61.01%and 61.77%,*** main seco.d phase of Al-0.2 Ce-0.2 Sc-0.1 Y alloy after hot extrusion were Al_(13)Fe_3 Ce co.taining a few Y and Si *** larger size and proportion of the seco.d phase greatly reduced the co.centration of solute Fe and Si atoms and the addition of Y significantly decreased the density of defects after co.d drawing co.pared to Al-0.2 Ce-0.2 Sc alloy,which improved electrical co.ductivity of the ***,the dispersed and co.erent nano-size Al_3 Sc precipitions of Al-0.2 Ce-0.2 Sc-0.1 Y alloy greatly improved strength,elongation and heat *** with Al-0.2 Ce-0.2 Sc alloy,the lower density of dislocation,stacking fault and subgrain boundary and the larger size of Al_3 Sc precipitions with enrichment of Y atoms enable the Al-0.2 Ce-0.2 Sc-0.1 Y alloy to maintain high strength,elongation and electrical co.ductivity after annealing.

关键词： Al-Ce-Sc-Y alloy Electrical co.ductivity Mechanical properties Seco.d phase Nano-size precipitates

Relation between Doping and Texture and Property of Tantalum Bar and Wire

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Journal of Wuhan University of Technology(Materials Science) 2009年第2期24卷 278-282页

作者：万庆峰 School of Materials Science and Engineering Central South University The Key Laboratory of Nonferrous Metal Materials Science and Engineering of Ministry of Education Central South University Ningxia oriental Tantalum industry co. Ltd

Relation between doping and texture and property of tantalum bar and wire was carefully investigated by optical microsco.e, SEM fractograph, electron microprobe analysis, density test. observation of TEM and mechanical property test at room temperature. It is illustrated that the grain of tantalum bar after sintering reduces with the increasing of dopant quantity, and the effect of dopant Ce on reduction of the grain is more obvious than that of dopant Ge, even that sintering is be- co.ing insufficient and the density of tantalum bar tends to be lower with the increaseing of dopant Ce The recrystallization temperature of tantalum wire increases and the grain of texture reduces with the increaseing of dopants quantity. The tensile strength of tantalum wire at room temperature increases with the increasing of dopants quantity, while its elongation decreases with the increase of dopant Ge quantity and rises with theincrease of dopant Ce quantity. And the strengthening effect of dopant Ce is clearer than that of dopant Ge.

关键词： tantalum wire tantalum bar doping texture property

RANKL,a necessary chance for clinical application to osteoporosis and cancer-related bone diseases

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World Journal of Orthopedics 2013年第4期4卷 207-217页

作者： Hisataka Yasuda Bioindustry Division Oriental Yeast Co. Ltd.

Osteoporosis is a co.mon bone disease characterized by reduced bone and increased risk of fracture. In postmenopausal women, osteoporosis results from bone loss attributable to estrogen deficiency. Osteoclast differentiation and activation is mediated by receptor activator of nuclear factor-κB ligand(RANKL), its receptor receptor activator of nuclear factor-κB(RANK), and a deco. receptor for RANKL, osteoprotegerin(OPG). The OPG/RANKL/RANK system plays a pivotal role in osteoclast biology. Currently, a fully human antiRANKL monoclonal antibody named denosumab is being clinically used for the treatment of osteoporosis and cancer-related bone disorders. This review describes recent advances in RANKL-related research, a story from bench to bedside. First, the disco.ery of the key factors, OPG/RANKL/RANK, revealed the molecular mechanism of osteoclastogenesis. Seco.d, we established three animal models:(1) a novel and rapid bone loss model by administration of glutathione-S transferase-RANKL fusion protein to mice;(2) a novel mouse model of hypercalcemia with anorexia by overexpression of soluble RANKL using an adenovirus vector; and(3) a novel mouse model of osteopetrosis by administration of a denosumab-like anti-mouse RANKL neutralizing monoclonal antibody. Lastly, anti-human RANKL monoclonal antibody has been successfully applied to the treatment of osteoporosis and cancer-related bone disorders in many co.ntries. This is a real example of applying basic science to clinical practice.

关键词： Osteoclast Osteoblast Receptor activator of nuclear factor-κB ligand Denosumab Receptor activator of nuclear factor-κB Osteoprotegerin

Hypolipidemic effect of SIPI-7623,a derivative of an extract from oriental wormwood,through farnesoid X receptor antagonism

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Chinese Journal of Natural Medicines 2018年第8期16卷 572-579页

作者： DENG Yi-Fang HUANG Xiao-Ling SU Mei YU Peng-Xia ZHANG Zhen LIU Quan-Hai WANG Guo-Ping LIU Min-Yu Department of Pharmaco.ogy Shanghai Institute of Pharmaceutical Industry Jiangsu Carephar Pharmaceutical co. Ltd.

Farnesoid X receptor(FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription *** a metabolic regulator,FXR plays key roles in bile acid and cholesterol metabolism and lipid and gluco.e ***,FXR is a potential drug target for several metabolic syndromes,especially those related to lipidemia *** the present study,we identified small molecule SIPI-7623,a derivative of an extract from oriental wormwood(Artemisia capillaris),and found that it specifically upregulated the expression of cholesterol-7-alpha-hydroxylase(CYP7 A1),downregulated the expression of sterol-regulatory element-binding protein 1 c(SREBP-1 c) in the liver,and inhibited the expression of ileal bile acid binding-protein(IBABP) in the ileum of *** found that inhibition of FXR by SIPI-7623 decreased the level of cholesterol and ***-7623 reduced the levels of cholesterol and triglyceride in in vitro Hep G2 cell models,ameliorated diet-induced atherosclerosis,and decreased the serum lipid co.tent on rats and rabbits model of atherosclerosis in ***,SIPI-7623 decreased the extent of atherosclerotic *** resutls demonstrated that antagonism of the FXR pathway can be employed as a therapeutic strategy to treat metabolic diseases such as hyperlipidemia and *** co.clusion,SIPI-7623 co.ld be a promising lead co.pound for development of drugs to treat hyperlipidemia and atherosclerosis.

关键词： Farnesoid X receptor antagonist Hypolipidemic Bile acid enterohepatic circulation Cholesterol-7-alpha-hydroxylase Sterol-regulatory element-binding protein 1c

Magnetic property improvement of niobium doped with rare earth elements

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Chinese Physics B 2014年第5期23卷 542-546页

作者：江涛贺斐思焦飞何法鲁向阳赵夔赵红运游雨松陈林 State Key Laboratory of Nuclear Physics and Technology Peking University Ningxia Orient Tantalum industry co. Ltd.

A new idea is proposed by the PKU group to improve the magnetic properties of the Type-Ⅱ superco.ductor niobium. Rare earth elements like scandium and yttrium are doped into ingot niobium during the smelting processes. A series of experiments have been done since 2010. The preliminary testing results show that the magnetic properties of niobium materials have changed with different doping elements and proportions while the superco.ductive transition temperature does not change very much. This method may increase the superheating magnetic field of niobium so as to improve the performance of the niobium cavity, which is a key co.ponent of SRF accelerators. A Tesla-type single-cell cavity made of scandium-doped niobium is being fabricated.

关键词： niobium rare earth element impurity magnetization curve

Evaluation of Feed and Feeding Regime on Growth Performance, Flesh Quality and Fecal Visco.ity of Atlantic Salmon(Salmo salar L.) in Recirculating Aquaculture Systems

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Journal of Ocean University of China 2015年第5期14卷 849-857页

作者： SUN Guoxiang LIU Ying LI Yong LI Xian WANG Shunkui Institute of Oceanology Chinese Academy of Sciences University of Chinese Academy of Sciences Shandong oriental Ocean Sci-Tech co. Ltd

The effects of different feeds and feeding regimes on growth performance, flesh quality and fecal visco.ity of Atlantic salmon （Salmo salar L.） in recirculating aquaculture systems （***） were investigated. Fish （initial body weight of 1677 g＋ 157 g） were fed with four co.mercial feeds （Nosan salmon-NS, Aller gold-AG, Skretting salmon-SS and Hart ye-HY） in two feeding regimes （80% and 100% satiation） for 78 d. The results showed that salmon specific growth ratio （SGR） and weight gain ratio （WGR） were significantly affected by feed type and feeding regime （P〈0.05）. Feed co.version ratio （FCR） varied between 0.93 and 3.40, which was significantly affected by feed type （P〈0.05）, and slightly improved with increased satiation degree. The activities of digestive enzymes including protease, lipase and amylase were also significantly affected by feed type and feeding regime （P〈0.05）, increasing with satiation degree. Flesh qualities for vitamin E, hydroxyproline （HYP）, liquid loss and muscle pH among all groups showed significant differences （P〈0.05）, ranging from 26.67 to 29.67, while no obvious difference was found in flesh co.or. Fecal visco.ity for different treatments showed no significant difference, though improvement was found in 100% satiation group. From present experiment, it was co.cluded that both feed type and feeding regime can affect the important quality attributes of Atlantic salmon.

关键词： Atlantic salmon Salmo salar L. recireulating aquaculture systems R.AS feed feeding growth flesh quality fecal visco.ity

Abrasion test of flexible protective materials on hydraulic structures

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Water Science and Engineering 2014年第1期7卷 106-116页

作者： Xin WANG Shao-ze LUO Guang-sheng LIU Lu-chen ZHANG Yong WANG State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing Hydraulic Research Institute Beijing oriental Yuhong Waterproof Technology co. Ltd.

In this study, several kinds of flexible protective materials sprayed with polyurea elastomers （hereinafter referred to as polyurea elastomer protective material） were adopted to meet the abrasion resistance requirement of hydraulic structures, and their abrasion resistances against the water flow with suspended load or bed load were studied systematically through tests. Natural basalt stones were adopted as the abrasive for simulation of the abrasion effect of the water flow with bed load, and test results indicate that the basalt stone is suitable for use in the abrasion resistance test of the flexible protective material. The wear process of the polyurea elastomer protective material is stable, and the wear loss is linear with the time of abrasion. If the wear thickness is regarded as the abrasion resistance evaluation factor, the abrasion resistance of the 351 pure polyurea is about twice those of pure polyurea with a high level of hardness and aliphatic polyurea, and over five times that of high-performance abrasion-resistant co.crete under the abrasion of the water flow with suspended load. It is also about 50 times that of high-performance abrasion-resistant co.crete under the abrasion of the water flow with bed load. Overall, the abrasion resistance of pure polyurea presented a decreasing trend with increasing hardness. Pure polyurea with a Shore hardness of D30 has the best abrasion resistance, which is 60 to 70 times that of high-performance abrasion-resistant co.crete under the abrasion of the water flow with bed load, and has been reco.mended, among the five kinds of pure polyurea materials with different hardness, in anti-abrasion protection of hydraulic structures.

关键词： flexible protective material polyurea elastomer material abrasion resistance hardness influence hydraulic structure

Experimental and numerical investigations on fatigue behavior of aluminum alloy 7050-T7451 single lap four-bolted joints

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Journal of Materials Science & Technology 2018年第7期34卷 1205-1213页

作者： Xiaomei Liu Hao Cui Shangzhou Zhang Haipo Liu Gaofeng Liu Shujun Li School of Fmvironmental and Materials Engineering Yantai University Yantai 264005 China oriental Bluesky Titanium Technology co. LTD. Yantai 264005 China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

The fatigue behavior of aluminum alloy 7050-T7451 single lap four-bolted joints was studied by high- frequency fatigue test and finite element （FE） methods. The fatigue test results showed that a better enhancement of fatigue life was achieved for the joints with highlocked bolts by employing the co.binations of co.d expansion, interference fit, and clamping force. The fractography revealed that fatigue cracks propagated tortuously; more fatigue micro-cliffs, tearing ridges, lamellar structure were observed, and fatigue striation spacing was simultaneously reduced. The evaluation of residual stress co.ducted by FE methods co.firmed the experimental results and locations of fatigue crack initiation. The extension of fatigue lives can be attributed to the evolution of fatigue damage and effect of beneficial co.pressive residual stresses around the hole, resulting in the delay of crack initiation, crack deflection, and plasticityinduced crack closure.2017 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science ＆ Technology.

关键词： 7050 aluminum alloy Bolted joint Fatigue behavior Finite element analysis Residual stress

Enhanced structural and magnetic properties of microwave sintered Li–Ni–co.ferrites prepared by sol–gel method

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Chinese Physics B 2019年第2期28卷 358-362页

作者： NANDeibam Nilima M Maisnam Sumitra Phanjoubam Department of Physics Oriental College Department of Physics Oriental CollegeTakyel Department of Physics Manipur University

The properties of lithium ferrites are very sensitive to chemical co.position, synthesis method, and sintering techniques. Li–Ni–co.ferrites with co.positional formula Li_(0.45-0.5x)Ni_(0.1)co.xFe_(2.45-0.5x)O_4, where 0.00 ≤ x ≤ 0.1 in steps of 0.02 were prepared by chemical sol–gel method and sintered by microwave sintering technique. The x-ray diffraction patterns co.firmed the formation of single phase with spinel structure in all the samples. The structural parameter *** co.stant, crystallite size, and x-ray density for these samples were studied and co.pared with those measured from samples of similar co.position prepared by the sol–gel method and sintered by co.ventional sintering technique. Enhancement in the magnetic properties like Curie temperature, hysteresis parameters was observed by employing sol–gel synthesis co.bined with microwave sintering. The results obtained and mechanisms involved are discussed in the paper.

关键词： lithium ferrites sol–gel chemistry magnetic properties x-ray diffraction