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Proteomics identifies EGF-like domain multiple 7 as a potential therapeutic target for epidermal growth factor receptor-positive glioma

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Cancer Communications 2020年第10期40卷 518-530页

作者： Fei-yi-fan Wang Si-yi Wang-gou Hang Cao Nian Jiang Qi Yang Qi Huang Chun-hai Huang Xue-jun Li Department of Neurosurgery Xiangya HospitalCentral South UniversityChangshaHunan 410008P.R.China Department of Neurosurgery the First Affiliated Hospital of Jishou UniversityJishouHunan 416000P.R.China hunan international scientific and technological cooperation base of brain tumor research Xiangya HospitalCentral South UniversityChangshaHunan 410008P.R.China

Background:Glioma,the most frequent primary tumor of the central nervous system,has poor *** epidermal growth factor receptor(EGFR)pathway and angiogenesis play important roles in glioma growth,invasion,and *** present study aimed to use proteomic methods to probe into the role of the EGF-EGFR-angiogenesis axis in the tumorigenesis of glioma and access the therapeutic efficacy of selumetinib on ***:Proteomic profiling was used to characterize 200 paired EGFRpositive and EGFR-negative glioma tissues of all pathological *** quantitative mass spectrometry data were used for systematic analysis of the proteomic profiles of 10 EGFR-positive and 10 EGFR-negative glioma *** analysis was used to screen target *** analysis,cell growth assay,and intracranial xenograft experiments were used to verify and test the therapeutic effect of selumetinib on ***:Advanced proteomic screening demonstrated that the expression of EGF-like domain multiple 7(EGFL7)was higher in EGFR-positive tumor tissues than in EGFR-negative tumor *** addition,EGFL7 could act as an activatorin vitro and in vivo to promote glioma cell ***7 was associated strongly with EGFR and ***7 knockdown effectively suppressed glioma cell *** treatment showed tumor reduction effect in EGFR-positive glioblastoma xenograft mouse ***:EGFL7 is a potential diagnostic biomarker and therapeutic target of *** could target the EGFR pathway and possibly improve the prognosis of EGFR-positive glioma.

关键词： Glioma Proteomics Epidermal growth factor receptor EGF-like domain multiple 7 Targeted therapy Selumetinib

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PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype

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Genes & Diseases 2024年第5期11卷 390-406页

作者： Fengsheng Dai Yixiao Yuan Jiaqi Hao Xing Cheng Xiangyi Zhou Li Zhou Rui Tian Yi Zhao Tingxiu Xiang Department of Oncology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Chongqing Key Laboratory of Translational research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China Department of Neurosurgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China hunan international scientific and technological cooperation base of brain tumor research Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Neuro-Oncology Chongqing University Cancer HospitalChongqing 400030China

Programmed cell death 2(PDCD2)is related to cancer progression and chemotherapy *** role of PDCD2 in solid cancers(excluding hematopoietic malignancies)and their diagnosis and prognosis remains *** TCGA,CGGA,GEPIA,cBioPortal,and GTEx databases were analyzed for expression,prognostic value,and genetic modifications of PDCD2 in cancer *** enrichment analysis,CCK8,colony formation assay,transwell assay,and xenograft tumor model were undertaken to study the PDCD2’s biological function in glioma(GBMLGG).The PDCD2 gene was associated with solid cancer *** the functional enrichment analysis results,PDCD2 was shown to participate in several important GBMLGG biological *** cells may be inhibited in their proliferation,migration,invasion,and xenograft tumor growth by knocking down *** research can provide new insights into solid cancer prognostic biomarkers of PDCD2.

关键词： Biomarker Glioma Programmed cell death 2 Progression Solid cancer

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GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1144-1158页

作者： Yao Long Jiaxing Guo Jielin Chen Jingyue Sun Haiyan Wang Xin Peng Zuli Wang WeiWei Lai Na Liu Long Shu Ling Chen Ying Shi Desheng Xiao Shuang Liu Yongguang Tao Department of Pathology Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Xiangya HospitalCentral South UniversityChangshaHunan 410078China NHC Key Laboratory of Carcinogenesis of Ministry of Health(Central South University) Cancer Research InstituteSchool of Basic MedicineCentral South UniversityChangshaHunan 410078China Department of Pathology Xiangya HospitalCentral South UniversityChangshaHunan 410008China hunan Key Laboratory of tumor Models and Individualized Medicine Department of Thoracic SurgerySecond Xiangya HospitalCentral South UniversityChangshaChina hunan international scientific and technological cooperation base of brain tumor research Xiangya HospitalCentral South UniversityChangshaHunan 410008China

In the treatment of most malignancies,radiotherapy plays a significant ***,the resistance of cancer cells to ionizing radiation(IR)is the main reason for the failure of radiotherapy,which causes tumor recurrence and *** this study,we confirmed that GPR162,an orphan receptor in the G-protein-coupled receptor family,acted as a novel radiotherapy sensitizer by interacting with the stimulator of interferon genes(STING),which targeted DNA damage responses,activated IRF3,accelerated the activation of type I interferon system,promoted the expression of chemokines including CXCL10 and CXCL4,and inhibited the occurrence and development of ***,the activation of STING by overexpression of GPR162 was independent of the classical pathway of *** inhibitors could resist the antitumor effect of overexpression of GPR162 in IR-induced mouse *** addition,most solid tumors showed low expression of *** the higher expression of GPR162 indicated a better prognosis in patients with lung adenocarcinoma,liver cancer,breast cancer,*** summary,these results suggested that GPR162 may serve as a potential sensitizer of radiotherapy by promoting radiotherapy-induced STING-IFN production and increasing the expression of chemokines including CXCL10 and CXCL4 in DNA damage response,providing an alternative strategy for improving cancer radiotherapy.

关键词： damage interferon radiotherapy

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Rational design of hydroxytricyanopyrrole-based probes with high affinity and rapid visualization for amyloid-β aggregates in vitro and in vivo

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Chinese Chemical Letters 2024年第5期35卷 290-295页

作者： Jiajia Lv Jie Gao Hongyu Li Zeli Yuan Nan Dong School of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China School of Pharmacy Zunyi Medical UniversityZunyi 563003China Guizhou international scientific and technological cooperation base for Medical Photo-Theranostics Technology and Innovative Drug Development Zunyi 563003China

As key biomarkers,amyloid-β(Aβ)plaques are frequently used to diagnose Alzheimer’s disease(AD).Although fluorescence imaging has proven to be effective in detecting these plaques,the gold standard probe thioflavin T(ThT),used for Aβaggregates,cannot be applied in vivo owing to its invasive ***,the development of novel fluorescent probes capable of identifying Aβplaques in situ is *** on the ThT structure,twoπ-conjugated heterocyclic D-π-A probes were designed bearing the hydroxytricyanopyrrole acceptor and N,N-dimethylaminophenyl *** probes exhibited red to near-infrared fluorescence emission(λ_(max)=732 nm),large Stokes shifts(>100 nm),exceptional signal-to-noise ratio,rapid response(research demonstrated that NT-HTCP could cross the blood-brain barrier and continue imaging the Aβplaques with a good signal-to-noise ***,the outcomes of the docking computations helped guide the development of the Aβ*** study expands the family of N,N-dimethylaminophenyl-based Aβ-sensitive fluorophores,with NTHTCP emerging as a highly promising imaging agent.

关键词： Amyloid-β Fluorescent probe Hydroxytricyanopyrrole Fluorescence imaging Alzheimer’s disease

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Near-infrared small molecular fluorescent dyes for photothermal therapy

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Chinese Chemical Letters 2019年第7期30卷 1353-1360页

作者： Yisha Chen Li Li Weijie Chen Haiyan Chen Jun Yin Department of Biomedical Engineering School of Engineering State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing 210009 China Key Laboratory of Pesticide and Chemical Biology Ministry of Education Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis International Joint Research Center for Intelligent Biosensing Technology and Health College of Chemistry Central China Normal University Wuhan 430079 China

Near-infrared(NIR)fluorescent dyes based on small organic molecules are characterized with low cytotoxicity,good biocompatibility and minimum interference from auto-fluorescence background,which are widely used in tumor *** research on molecular properties and photothermal properties of fluorescent dyes have been explored for non-invasive photothermal treatment of *** this review,we focus on the development of imaging-induced photothermal therapy of small molecules and classification according to the structures of organic molecules including cyanines,phthalocyanines,rhodamine analogues and BODIPYs.

关键词： Near-infrared fluorescent dyes Photothermal therapy Cyanine BODIPY Phthalocyanine

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Parkinson’s disease and gut microbiota:from clinical to mechanistic and therapeutic studies

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Translational Neurodegeneration 2023年第1期12卷 1-30页

作者： Xuxiang Zhang Beisha Tang Jifeng Guo Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory of hunan Province in Neurodegenerative Disorders Central South UniversityChangsha 410008China hunan international scientific and technological cooperation base of Neurodegenerative and Neurogenetic Diseases Changsha 410008China Center for Medical Genetics and hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha 410008China Engineering research Center of hunan Province in Cognitive Impairment Disorders Central South UniversityChangsha 410008China National Clinical research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China

Parkinson’s disease(PD)is one of the most prevalent neurodegenerative *** typical symptomatology of PD includes motor symptoms;however,a range of nonmotor symptoms,such as intestinal issues,usually occur before the motor *** microorganisms inhabiting the gastrointestinal tract can profoundly influence the physiopathology of the central nervous system through neurological,endocrine,and immune system pathways involved in the microbiota-gut-brain *** addition,extensive evidence suggests that the gut microbiota is strongly associated with *** review summarizes the latest findings on microbial changes in PD and their clinical relevance,describes the underlying mechanisms through which intestinal bacteria may mediate PD,and discusses the correlations between gut microbes and anti-PD *** addition,this review outlines the status of research on microbial therapies for PD and the future directions of PD-gut microbiota research.

关键词： Gut microbiota Microbiota-gut-brain axis Mechanisms Alpha-synuclein Microbial therapy

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Nanofiber-induced hierarchically-porous magnesium phosphate bone cements accelerate bone regeneration by inhibiting Notch signaling

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Bioactive Materials 2024年第7期37卷 459-476页

作者： Jingteng Chen Ling Yu Tian Gao Xiangyang Dong Shiyu Li Yinchu Liu Jian Yang Kezhou Xia Yaru Yu Yingshuo Li Sen Wang ZhengFu Fan Hongbing Deng Weichun Guo Department of Spine Surgery Renmin Hospital of Wuhan UniversityWuhan430060China Key Laboratory of Carcinogenesis and Translational research(Ministry of Education/Beijing) Department of Bone and Soft Tissue TumorPeking University Cancer Hospital and InstituteBeijing100142China Hubei Key Laboratory of Biomass Resource Chemistry and Environmental Biotechnology Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and EnergySchool of Resource and Environmental ScienceWuhan UniversityWuhan430079China

Magnesium phosphate bone cements(MPC)have been recognized as a viable alternative for bone defect repair due to their high mechanical strength and ***,their poor porosity and permeability limit osteogenic cell ingrowth and vascularization,which is critical for bone *** the current study,we constructed a novel hierarchically-porous magnesium phosphate bone cement by incorporating extracellular matrix(ECM)-mimicking electrospun silk fibroin(SF)*** SF-embedded MPC(SM)exhibited a heterogeneous and hierarchical structure,which effectively facilitated the rapid infiltration of oxygen and nutrients as well as cell ***,the SF fibers improved the mechanical properties of MPC and neutralized the highly alkaline environment caused by excess magnesium *** marrow stem cells(BMSCs)adhered excellently on SM,as illustrated by formation of more ***8 assay showed that SM promoted early proliferation of *** study also verified that SM increased the expression of OPN,RUNX2 and BMP2,suggesting enhanced osteogenic differentiation of *** screened for osteogenesis-related pathways,including FAK signaing,Wnt signaling and Notch signaling,and found that SM aided in the process of bone regeneration by suppressing the Notch signaling pathway,proved by the downregulation of NICD1,Hes1 and *** addition,using a bone defect model of rat calvaria,the study revealed that SM exhibited enhanced osteogenesis,bone ingrowth and vascularization compared with MPC *** adverse effect was found after implantation of SM in ***,our novel SM exhibited promising prospects for the treatment of critical-sized bone defects.

关键词： Critical-sized bone defects Magnesium phosphate bone cement Silk fibroin nanofibers Bone regeneration Notch signaling pathway

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Author Correction:GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3547-3548页

作者： Yao Long Jiaxing Guo Jielin Chen Jingyue Sun Haiyan Wang Xin Peng Zuli Wang WeiWei Lai Na Liu Long Shu Ling Chen Ying Shi Desheng Xiao Shuang Liu Yongguang Tao Department of Pathology Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education) Xiangya Hospital Central South University Changsha Hunan 410078 China NHC Key Laboratory of Carcinogenesis of Ministry of Health (Central South University) Cancer Research Institute School of Basic Medicine Central South University Changsha Hunan 410078 China Department of Pathology Xiangya Hospital Central South University Changsha Hunan 410008 China hunan Key Laboratory of tumor Models and Individualized Medicine Department of Thoracic Surgery Second Xiangya Hospital Central South University Changsha China hunan international scientific and technological cooperation base of brain tumor research Xiangya Hospital Central South University Changsha Hunan 410008 China

Since the publication of this article,we noticed a minor mistake in the article that needs to be *** have checked the original data;the correct data are provided in this Corrigendum as *** key findings of the article ... 详细信息

关键词： damage suppressor checked

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Intracranial pressure monitoring in neurosurgery:the present situation and prospects

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Chinese Neurosurgical Journal 2023年第3期9卷 212-223页

作者： Chenqi He Chubei Teng Zujian Xiong Xuelei Lin Hongbo Li Xuejun Li Department of Neurosurgery Xiangya HospitalCentral South UniversityChangshaHunan 410008People’s Republic of China hunan international scientific and technological cooperation base of brain tumor research Xiangya HospitalCentral South UniversityChangshaHunan 410008People’s Republic of China Department of Neurosurgery the First Affiliated HospitalUniversity of South ChinaHengyangHunan 421001People’s Republic of China

Intracranial pressure(ICP)is one of the most important indexes in *** is essential for doctors to determine the numeric value and changes of ICP,whether before or after an *** external ventricular drainage(EVD)is the gold standard for monitoring ICP,more and more novel monitoring methods are being applied *** wired ICP monitoring is still the most commonly used in ***,with the rise and development of various novel technologies,non-invasive types and invasive wireless types are gradually being used clinically or in the testing phase,as a complimentary approach of ICP *** choosing appropriate monitoring methods,clinical neurosurgeons are able to obtain ICP values safely and effectively under particular *** article introduces diverse monitoring methods and compares the advantages and disadvantages of different monitoring ***,this review may enable clinical neurosurgeons to have a broader view of ICP monitoring.

关键词： ICP Cerebrospinal fluid Zero drift Wireless telemetering Absorbable Non-invasive

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Rational Design and Application of an Indolium-Derived Heptamethine Cyanine with Record-Long Second Near-Infrared Emission

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CCS Chemistry 2022年第6期4卷 1961-1976页

作者： Xiaoxie Ma Yurou Huang Syed Ali Abbas Abedi Heejeong Kim Tan Teck Boon Davin Xiaogang Liu Wen-Chao Yang Yao Sun Sheng Hua Liu Jun Yin Juyoung Yoon Guang-Fu Yang Key Laboratory of Pesticide and Chemical Biology(Ministry of Education) Hubei International Scientific and Technological Cooperation Base of Pesticide and Green SynthesisInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079 Fluorescence research Group Singapore University of Technology and DesignSingapore 487372 Department of Chemistry and Nano Science Ewha Womans UniversitySeoul 120-750

Heptamethine cyanine dyes,typified by indocyanine green,have been extensively employed as bioimaging indicators and theranostic *** efforts have been made to develop functional heptamethine cyanine dyes with outstanding bioimaging and theranostic *** this work,we rationally designed and successfully developed a novel indolium-like heptamethine cyanine dye by installing indolium-derived polycyclic aromatic hydrocarbons on the terminal ends of a conjugated polyene *** dye showed excellent photostability and showed bright fluorescent emission in the second near-infrared(NIR-Ⅱ)window with a peak at approximately 1120 *** long wavelength emission prompted a superior bioimaging resolution in *** particular,this NIR-Ⅱ dye had the remarkable capability of marking the blood vessels of the hindlimbs,abdomens,and brains of *** significantly,this dye involved a typical indolium-like heptamethine skeleton and exhibited two strong absorption bands in the 700–1300 nm NIR range,which endowed it with an intrinsic tumor-targeting capability and a high photothermal conversion efficiency(up to 68.2%),serving for the photothermal therapy of tumors under the guidance of NIR-Ⅱ fluorescence *** work provides an efficient design strategy for achieving indolium-like heptamethine cyanine dyes with further NIR-Ⅱ emission.

关键词： fluorescent probe heptamethine cyanine second near-infrared emission molecular design biological application

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