PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype
作者机构：Department of OncologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized TreatmentChongqing University Cancer HospitalChongqing 400030China Department of NeurosurgeryXiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan International Scientific and Technological Cooperation Base of Brain Tumor ResearchXiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Neuro-OncologyChongqing University Cancer HospitalChongqing 400030China
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2024年第11卷第5期
页 面：390-406页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the National Natural Science Foundation of China(No.82172619) the Natural Science Foundation of Chongqing,China(No.CSTC2021jscx-gksbN0023) the Fundamental Research Funds for the Central Universities in China(No.2022CDJYGRH-002)
主 题：Biomarker Glioma Programmed cell death 2 Progression Solid cancer
摘 要：Programmed cell death 2(PDCD2)is related to cancer progression and chemotherapy *** role of PDCD2 in solid cancers(excluding hematopoietic malignancies)and their diagnosis and prognosis remains *** TCGA,CGGA,GEPIA,cBioPortal,and GTEx databases were analyzed for expression,prognostic value,and genetic modifications of PDCD2 in cancer *** enrichment analysis,CCK8,colony formation assay,transwell assay,and xenograft tumor model were undertaken to study the PDCD2’s biological function in glioma(GBMLGG).The PDCD2 gene was associated with solid cancer *** the functional enrichment analysis results,PDCD2 was shown to participate in several important GBMLGG biological *** cells may be inhibited in their proliferation,migration,invasion,and xenograft tumor growth by knocking down *** research can provide new insights into solid cancer prognostic biomarkers of PDCD2.
维普期刊数据库