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Triose phosphate export from chloroplasts and cellular sugar content regulate anthocyanin biosynthesis during high light acclimation

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Plant Communications 2023年第1期4卷 42-61页

作者： Max-Emanuel Zirngibl Galileo Estopare Araguirang Anastasia Kitashova Kathrin Jahnke Tobias Rolka Christine Kühn Thomas Nägele Andreas S.Richter university of Rostock Institute for BiosciencesPhysiology of Plant MetabolismAlbert-Einstein-Strasse 318059 RostockGermany humboldt-universit€at zu berlin Institute of BiologyPhysiology of Plant Cell OrganellesPhilippstrasse 1310115 BerlinGermany Ludwig-Maximilians-universit€at M€unchen Faculty of BiologyPlant Evolutionary Cell Biology82152 Planegg-MartinsriedGermany

Plants have evolvedmultiple strategies to cope with rapid changes in the *** high light(HL)acclimation,the biosynthesis of photoprotective flavonoids,such as anthocyanins,is ***,the exact nature of the signal and downstreamfactors forHL induction of flavonoid biosynthesis(FB)is still under ***,we show that carbon fixation in chloroplasts,subsequent export of photosynthates by triose phosphate/phosphate translocator(TPT),and rapid increase in cellular sugar content permit the transcriptional and metabolic activation of anthocyanin biosynthesis during HL *** combination with genetic and physiological analysis,targeted and whole-transcriptome gene expression studies suggest that reactive oxygen species and phytohormones play only a minor role in rapid HL induction of the anthocyanin branch of *** addition to transcripts of FB,sugar-responsive genes showed delayed repression or induction in tpt-2 during HL treatment,and a significant overlapwith transcripts regulated by SNF1-related protein kinase 1(SnRK1)was observed,including a central transcription factor of *** of mutants with increased and repressed SnRK1 activity suggests that sugar-induced inactivation of SnRK1 is required for HL-mediated activation of anthocyanin *** study emphasizes the central role of chloroplasts as sensors for environmental changes as well as the vital function of sugar signaling in plant acclimation.

关键词： flavonoid biosynthesis acclimation sugar signaling high light anthocyanin SnRK1

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印尼新几内亚巴布亚省豕蛙属4新种(两栖纲:姬蛙科)(英文)

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动物学报 2008年第4期54卷 653-674页

作者： Rainer GNTHER Museum fr Naturkunde Humboldt-Universitt zu Berlin

姬蛙科豕蛙属(Choerophryne)已知5种,几乎都分布于新几内亚岛东部地区,已有物种的描述多基于较少数量的标本,由于标本贫乏,迄今无后续研究。本文针对采集于1998-2003年的50号标本,对该属进行了再研究,并描述了分布于新几内亚岛的巴布亚... 详细信息

姬蛙科豕蛙属(Choerophryne)已知5种,几乎都分布于新几内亚岛东部地区,已有物种的描述多基于较少数量的标本,由于标本贫乏,迄今无后续研究。本文针对采集于1998-2003年的50号标本,对该属进行了再研究,并描述了分布于新几内亚岛的巴布亚西北地区鲜为人知的4新种。与同属已知物种比较,新种的有效性得到来自形态、声谱以及分子数据的综合分析结果的支持。在新几内亚岛西部地区豕蛙属4新种中,至少有3种的种群密度很高,从而极大增加了对该属的了解。

关键词：两栖类无尾目姬蛙科豕蛙属新种形态生态声谱 mtDNA 新几内亚巴布亚

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Modulation by buffers of Ca2+ release from single and clustered IP3 receptors

Modulation by buffers of Ca2+ release from single and cluste...

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第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： Sten Reudiger Institut fur Physik Humboldt-Universit at zu Berlin

＜正＞We study numerically Ca2+ release through single or clustered Inositol 1,4,5-Trisphosphate（IP3）receptor channels[1] on the ER membrane under the presence of buffer ***

关键词： intracellular calcium dynamics buffer proteins IP3R cell signalling stochastic dynamics

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A Review of Unified A Posteriori Finite Element Error Control

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Numerical Mathematics(Theory,Methods and Applications) 2012年第4期5卷 509-558页

作者： C.Carstensen M.Eigel R.H.W.Hoppe C.Löbhard Department of Mathematics Humboldt Universität zu BerlinD-10099 BerlinGermany Department of Computational Science and Engineering Yonsei UniversitySeoul 120-749Korea Department of Mathematics University of HoustonHouston TX 77204-3008USA. Institute of Mathematics University of AugsburgD-86159 AugsburgGermany

This paper aims at a general guideline to obtain a posteriori error estimates for the finite element error control in computational partial differential *** the abstract setting of mixed formulations,a generalised formulation of the corresponding residuals is proposed which then allows for the unified estimation of the respective dual ***,this can be done with an approach which is applicable in the same way to conforming,nonconforming and mixed ***,the unified approach is applied to various model *** particular,we consider the Laplace,Stokes,Navier-Lamé,and the semi-discrete eddy current equations.

关键词： A posteriori error analysis finite element method nonconforming finite element method mixed finite element method adaptive algorithm Poisson equation Laméequations Stokes equations Maxwell equations unified a posteriori error analysis discontinuous Galerkin residual estimator

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Molecular phylogenetic evidence that the Chinese viviparid genus Margarya(Gastropoda:Viviparidae) is polyphyletic

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Chinese Science Bulletin 2013年第17期58卷 2154-2162页

作者： DU LiNa YANG JunXing RINTELEN Thomas von CHEN XiaoYong ALDRIDGE David State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences Museum für Naturkunde Leibniz-Institut für Evolutionsund Biodiversit tsforschung an der Humboldt-Universit t zu BerlinBerlin 10115Germany Aquatic Ecology Group Department of ZoologyCambridge University

We investigated the phylogeny of the viviparid genus Margarya,endemic to Yunnan,China,using two mitochondrial gene fragments(COI and 16S rRNA).The molecular phylogeny based on the combined dataset indicates that Margarya is polyphyletic,as two of the three well-supported clades containing species of Margarya also comprise species from other viviparid *** one clade,sequences of four species of Margarya even cluster indiscriminately with those of two species of Cipangopaludina,indicating that the current state of Asian viviparid taxonomy needs to be ***,these data suggest that shell evolution in viviparids is complex,as even the large and strongly sculptured shells of Margarya,which are outstanding among Asian viviparids,can apparently be easily converted to simple smooth *** molecular data also indicate that the species status of the six extant species of Margarya should be re-assessed.

关键词：分子进化田螺中国腹足纲分子系统发育证据基因片段 rRNA

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Multiband emission from single β-NaYF_(4)(Yb,Er) nanoparticles at high excitation power densities and comparison to ensemble studies

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Nano Research 2021年第11期14卷 4107-4115页

作者： Florian Frenzel Christian Würth Oleksii Dukhno Frédéric Przybilla Lisa MWiesholler Verena Muhr Thomas Hirsch Yves Mély Ute Resch-Genger Federal Institute for Materials Research and Testing(BAM) Division 1.2 BiophotonicsRichard-Willstaetter-Str.1112489BerlinGermany Laboratory of Biomaging and Pathologies UMR 7021 CNRSUniversity of Strasbourg67000StrasbourgFrance Institute of Analytical Chemistry Chemo-and BiosensorsUniversity of Regensburg93040RegensburgGermany Institut für Physik and IRIS Adlershof Humboldt-Universität zu BerlinNewtonstraße 1512489BerlinGermany

Ensemble and single particle studies of the excitation power density (P)-dependent upconversion luminescence (UCL) of core and core-shell β-NaYF_(4):Yb,Er upconversion nanoparticles (UCNPs) doped with 20% Yb^(3+) and 1% or 3% Er^(^(3+)) performed over a P regime of 6 orders of magnitude reveal an increasing contribution of the emission from high energy Er^(3+) levels at P > 1 kW/cm^(2). This changes the overall emission color from initially green over yellow to white. While initially the green and with increasing P the red emission dominate in ensemble measurements at P < 1 kW/cm^(2), the increasing population of higher Er^(^(3+)) energy levels by multiphotonic processes at higher P in single particle studies results in a multitude of emission bands in the ultraviolet/visible/near infrared (UV/vis/NIR) accompanied by a decreased contribution of the red luminescence. Based upon a thorough analysis of the P-dependence of UCL, the emission bands activated at high P were grouped and assigned to 2–3, 3–4, and 4 photonic processes involving energy transfer (ET), excited-state absorption (ESA), cross-relaxation (CR), back energy transfer (BET), and non-radiative relaxation processes (nRP). This underlines the P-tunability of UCNP brightness and color and highlights the potential of P-dependent measurements for mechanistic studies required to manifest the population pathways of the different Er^(3+) levels.

关键词： upconversion luminescence single nanoparticle study high power excitation emission color luminescence decay kinetics

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静脉和动脉内注射对比剂对可疑冠心病病人肾损伤影响的比较:一项随机试验

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国际医学放射学杂志 2019年第6期 729-730页

作者： E.Sch?nenberger P.Martus M.Bosserdt E.Zimmermann R.Tauber M.Laule 许棚棚 Department of Radiology Charité-Universit?smedizin Berlin Humboldt-Universit?t and Freie Universit? zu Berlin

摘要目的比较静脉和动脉内注入对比剂与急性肾损伤(AKI)的关系,分析AKI与慢性肾病之间的关系[定义为预估肾小球滤过率(eGFR至少轻度降低)]。材料与方法该前

关键词：可疑冠心病对比剂肾损伤动脉内注射随机试验

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SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 129-146页

作者： Jes-Niels Boeckel Maximilian Mobius-Winkler Marion Muller Sabine Rebs Nicole Eger Laura Schoppe Rewati Tappu Karoline E.Kokot Jasmin M.Kneuer Susanne Gaul Diana M.Bordalo Alan Lai Jan Haas Mahsa Ghanbari Philipp Drewe-Boss Martin Liss Hugo A.Katus Uwe Ohler Michael Gotthardt Ulrich Laufs Katrin Streckfuss-Bomeke Benjamin Meder Department of Cardiology Angiology and PneumologyUniversity Hospital HeidelbergD-69120 HeidelbergGermany Klinik und Poliklinik fur Kardiologie Universitatskrankenhaus LeipzigD-04103 LeipzigGermany German Center for Cardiovascular Research(DZHK) Partner site HeidelbergD-69120 HeidelbergGermany Clinic for General and Interventional Cardiology/Angiology Herz-und Diabeteszentrum NRWRuhr-Universitat BochumD-32545 Bad OeynhausenGermany Department of Cardiology and Pneumology University HospitalGeorg-August University GoettingenD-37075 GoettingenGermany German Center for Cardiovascular Research(DZHK) Partner site GoettingenD-37075 GoettingenGermany berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine in the Helmholtz AssociationD-10115 BerlinGermany Institute of Biology Humboldt Universitat zu BerlinD-10099 BerlinGermany Neuromuscular and Cardiovascular Cell Biology Max Delbruck Center for Molecular Medicine in the Helmholtz AssociationD-13092 BerlinGermany German Center for Cardiovascular Research(DZHK) Partner site BerlinD-10117 BerlinGermany Stanford Genome Technology Center Department of GeneticsStanford Medical SchoolPalo AltoCA 94304USA

Alternative mRNA splicing is a fundamental process to increase the versatility of the *** humans,cardiac mRNA splicing is involved in the pathophysiology of heart *** in the splicing factor RNA binding motif protein 20(RBM20) cause severe forms of *** identify novel cardiomyopathy-associated splicing factors,RNA-seq and tissue-enrichment analyses were performed,which identified up-regulated expression of Sam68-Like mammalian protein 2(SLM2) in the left ventricle of dilated cardiomyopathy(DCM) *** the human heart,SLM2 binds to important transcripts of sarcomere constituents,such as those encoding myosin light chain2(MYL2),troponin 13(TNNI3),troponin T2(TNNT2),tropomyosin 1/2(TPM1/2),and titin(TTN).Mechanistically,SLM2 mediates intron retention,prevents exon exclusion,and thereby mediates alternative splicing of the mRNA regions encoding the variable proline-,glutamate-,valine-,and lysine-rich(PEVK) domain and another part of the I-band region of *** summary,SLM2 is a novel cardiac splicing regulator with essential functions for maintaining cardiomyocyte integrity by binding to and processing the mRNAs of essential cardiac constituents such as titin.

关键词： Splicing Titin Dilated cardiomyopathy KHDRBS3 SLM2

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Genes & Diseases 2022年第6期9卷 1506-1520页

作者： Jon Christiansen Anne-Katrin Guttsches Ulrike Schara-Schmidt Matthias Vorgerd Christoph Heute Corinna Preusse Werner Stenzel Andreas Roos Department of Pediatric Neurology Centre for Neuromuscular DisordersCentre for Translational Neuro-and Behavioral SciencesUniversity Hospital EssenUniversity Duisburg-Essen45147 EssenGermany Department of Neurology Heimer Institute for Muscle ResearchUniversity Hospital BergmannsheilRuhr University Bochum44789 BochumGermany Department of Adult and Pediatric Diagnostic Interventional RadiologyNuclear MedicineBG University Hospital Bergmannsheil Bochum44789 BochumGermany Charite´e universitatsmedizin berlin Freie Universitat Berlin10117 BerlinGermany humboldt-universitat zu berlin Department of Neuropathology10117 BerlinGermany Department of Neurology with Institute for Translational Neurology University Hospital MunsterAlbert-Schweitzer-Campus 148149 MunsterGermany Children’s Hospital of Eastern Ontario Research Institute University of OttawaOttawaON K1H 8L1Canada

Anoctamin-5(ANO5)is a multi-pass membrane protein localized to the sarcolemma and the sarcoplasmic *** were linked to rare autosomal recessive muscle ***,we summarize the clinical spectrum,imaging data and molecular research findings as well as results of animal modeling,which significantly moved forward the understanding of mechanisms underlying ANO5-related muscle *** that precise histological information on inflammatory processes taking place in patient-derived muscle are still lacking,an(immuno)histological study on biopsies derived from six ANO5-patients was performed showing focal accumulation of necrotic fibers,mild fiber-size variances and *** addition,MRI data of four ANO5-patients(including a 10-year follow-up in one patient)are presented and discussed in the context of previously published ***,data presented in this article combining a review of the literature with own myopathological findings address scientific trends and open questions on ANO5-related muscle diseases,which would be of significant interest for a wide neuromuscular diseases *** conclude,a clear genotypeephenotype correlation does not exist,and ANO5-related muscle disorders might represent the next entity of a clinical continuum with varying degree of muscle cell *** addition,results of pre-clinical studies allowed the definition of suitable cell and animal models characterized by certain histological and functional pathologies resembling the human *** models might serve as suitable systems for testing of interventional concepts in future.

关键词： Anoctamin-5 LGMDR12 MMD3 Muscle inflammation Muscle MRI

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Bisimulation-based stabilization of probabilistic Boolean control networks with state feedback control

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Frontiers of Information Technology & Electronic Engineering 2020年第2期21卷 268-280页

作者： Nan JIANG Chi HUANG Yao CHEN Jürgen KURTHS School of Economic Information Engineering Southwestern University of Finance and EconomicsChengdu 611130China School of Mathematics Southeast UniversityNanjing 210096China Potsdam Inslxtute for Climate Impact Research Potsdam 14412Germany Department of Phystcs Humboldt-Universitcit zu BerlinBerlin 12489Germany Samtov State university Saratov 410012Russia

This study is concerned with probabilistic Boolean control networks(PBCNs)with state feedback control.A novel definition of bisimilar PBCNs is proposed to lower computational *** understand more on bisimulation relations between PBCNs,we resort to a powerful matrix manipulation called semi-tensor product(STP).Because stabilization of networks is of critical importance,the propagation of stabilization with probability one between bisimilar PBCNs is then considered and proved to be ***,the transient periods(the maximum number of steps to implement stabilization)of two PBCNs are certified to be identical if these two networks are paired with a bisimulation *** results are then extended to the probabilistic Boolean networks.

关键词： Probabilistic Boolean control network Bisimulation Stabilization with probability one State feedback control

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