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food Science and Human Wellness 2025年

作者： Meng Wang Man Yao Hao Yue Yingying Tian Zifang Zhao Changhu Xue Tiantian Zhang Yuming Wang SKL of Marine food Processing & Safety control， College of food Science and Engineering， Ocean University of China institute of food & Nutrition Science and Technology， Shandong Academy of Agricultural Sciences Hainan Huayan Collagen Technology Co. Sanya institute of Oceanography， Ocean University of China

It has been reported that sea cucumber intestine hydrolysates (SCIH) could promote glutamine metabolism in mice， while there is a close connection between glutamine metabolism and insulin sensitivity. However， the effect of SCIH on insulin resistance is still unclear. The results showed that SCIH hydrolyzed by flavor protease had significant activity using the insulin-induced HepG2 cell model. Animal experiments exhibited that SCIH supplementation significantly improved the high-fat and high-sucrose diet-induced impaired glucose tolerance， reduced fasting serum glucose and glycosylated serum protein. Besides， SCIH ameliorated islet vacuolization and decreased the pancreas TNF-α and IL-6 by 32.1% and 36.2%， respectively. Immunofluorescence staining results showed that SCIH promoted insulin secretion. Interestingly， SCIH significantly increased the liver glutamine levels and upregulated the expression of glutaminase1 (GLS1) and glutamate dehydrogenase 1 (GLUD1). Furthermore， SCIH increased liver acetyl-CoA levels to enhance histone acetylation and activate the gene transcription and translation on glucose metabolism-related IRS/PI3K/AKT signaling pathway， thereby attenuating insulin resistance. The present findings proposed the potential value for developing functional foods in SCIH utilization.

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A holistic strategy for quality and safety control of traditional Chinese medicines by the “iVarious” standard system

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Journal of Pharmaceutical Analysis 2017年第5期7卷 271-279页

作者： Anzhen Chen Lei Sun Hang Yuan Aiying Wu Jingguang Lu Shuangcheng Ma Qingdao institute for food and drug control National institutes for food and drug control Xinjiang institute for food and drug control

An effective quality control system is the key to ensuring the quality, safety and efficacy of traditional Chinese medicines(TCMs). However, the current quality standard research lacks top-level design and systematic design,mostly based on specific technologies or evaluation methods. To resolve the challenges and questions of quality control of TCMs, a brand-new quality standard system, named "iVarious", was proposed. The system comprises eight elements in a modular format. Meaning of every element was specifically illustrated via corresponding research instances. Furthermore, frankincense study was taken as an example for demonstrating standards and research process, based on the "i Various" system. This system highlighted a holistic strategy for effectiveness,security, integrity and systematization of quality and safety control standards of TCMs. The establishment of"i Various" integrates multi-disciplinary technologies and progressive methods, basis elements and key points of standard construction. The system provides a novel idea and technological demonstration for regulation establishment of TCMs quality standards.

关键词： iVarious Quality standard system Traditional Chinese medicines (TCMs) Quality and safety control Holistic strategy

Bacterial indole-3-propionic acid inhibits macrophage IL-1β production through targeting methionine metabolism

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Science China Life Sciences 2025年

作者： Ziyi Han Jian Fu Aiyan Gong Wenkai Ren State Key Laboratory of Livestock and Poultry Breeding College of Animal Science South China Agricultural University Animal Disease-resistant Nutrition Key Laboratory of Sichuan Province Sichuan Agricultural University China institute of Veterinary drug control

The gut microbiota plays key roles in host health by shaping the host immune responses through their metabolites, like indole derivatives from tryptophan. However, the direct role of these indole derivatives in macrophage fate decision and the underlying mechanism remains unknown. Here, we found that bacterial indole-3-propionic acid(IPA) downregulates interleukin-1beta(IL-1β) production in M1 macrophages through inhibition of nuclear factor-kappa B(NF-κB) signaling. Mechanistically, IPA binds specifically with methionine adenosyltransferase 2A(MAT2A) to promote S-adenosylmethionine(SAM) synthesis, which facilitates the DNA methylation of ubiquitin-specific peptidase 16(USP16, a deubiquitinase), and in turn promotes Toll-like receptor 4(TLR4) ubiquitination and NF-κB inhibition. Furthermore,IPA administration attenuates sepsis in mouse models induced by lipopolysaccharides(LPS), showcasing its potential as a microbial-derived adjunct in alleviating inflammation. Collectively, our findings reveal a newly found microbial metabolite-immune system regulatory pathway mediated by IPA.

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Approach to lattice-related/content-specific spectral ranges of near-infrared diffuse reflectance spectroscopy of cefazolin sodium and the construction of a quantitative model for the determination of cefazolin sodium content in different crystal forms

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Science China Chemistry 2013年第6期56卷 789-798页

作者： LIU YanYun FENG YanChun JIA YanHua HU ChangQin National institutes for food and drug control hubei institute for food and drug control institute of Medicinal Biotechnology Chinese Academy of Medical Science and Peking Union Medical College

Cefazolin sodium can form both α- and β-form crystals. It also can form dehydrated crystalline and amorphous products through different production processes. Because different polymorphic medicines usually have different physical and chemical properties, it is critical to emphasize the crystallization control of polymorphic medicines. Near-infrared （NIR） analysis, which incorporates a combination of NIR spectroscopic techniques and multivariate chemometric methods, is considered a powerful tool for the determination of the crystallinity of polymorphic drugs. The selection of optimal spectral ranges that correlate with the lattice specificity and content specificity is crucial to obtaining a specific NIR model. In the present work, near-infrared （NIR） spectra of cefazolin sodium with different crystal forms created through different processes were studied. The results suggest that wavelengths within the range of 9102.7-8597.5 cm-1 is related to the specificity of the cefazolin sodium crystal lattice and that the range of 6001.6-5496.4 cm i is associated with the quantitative content of cefazolin sodium. The two ab- sorptions are caused by the second overtone of the C-H stretching band （3nC-H） and the first overtone of C-H stretching band （2uC-H）, respectively. Using these results, we established a suitable method of constructing a universal quantitative model by using mixed samples in different crystal forms as a calibration set, selecting a content-specific range （6001.6-5496.4 cm-l）, and adding lattice-related spectral ranges where appropriate. This may provide a framework for the construction of prediction models for polymorphic medicines.

关键词： cefazolin sodium crystal form near-infrared spectroscopy crystal-specific model universal model

Smart Gas Sensors:Recent Developments and Future Prospective

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Nano-Micro Letters 2025年第3期17卷 55-86页

作者： Boyang Zong Shufang Wu Yuehong Yang Qiuju Li Tian Tao Shun Mao College of Environmental Science and Engineering Biomedical Multidisciplinary Innovation Research InstituteShanghai East HospitalState Key Laboratory of Pollution Control and Resource ReuseTongji University1239 Siping RoadShanghai 200092People’s Republic of China Shanghai institute of Pollution control and Ecological Security Shanghai 200092People’s Republic of China Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510280People’s Republic of China

Gas sensor is an indispensable part of modern society withwide applications in environmental monitoring,healthcare,food industry,public safety,*** the development of sensor technology,wireless communication,smart monitoring terminal,cloud storage/computing technology,and artificial intelligence,smart gas sensors represent the future of gassensing due to their merits of real-time multifunctional monitoring,earlywarning function,and intelligent and automated *** electronicand optoelectronic gas sensors have been developed for high-performancesmart gas *** the development of smart terminals and the maturityof integrated technology,flexible and wearable gas sensors play an increasingrole in gas *** review highlights recent advances of smart gassensors in diverse *** structural components and fundamentalprinciples of electronic and optoelectronic gas sensors are described,andflexible and wearable gas sensor devices are ***,sensorarray with artificial intelligence algorithms and smart gas sensors in“Internet of Things”paradigm are ***,the challengesand perspectives of smart gas sensors are discussed regarding the future need of gas sensors for smart city and healthy living.

关键词： Smart gas sensor Electronic sensor Optoelectronic sensor Flexible and wearable sensor Artificial intelligence

Comprehensive characterization and detection of nut allergens in bakery foods using Q-TOF mass spectrometry and bioinformatics

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food Quality and Safety 2024年第1期8卷 145-157页

作者： Daokun Xu Haolun Huang Zhen Liu YumeiWang Qinan Liu Xing Jiang JunYang Rui Ling Nanjing institute for food and drug control NanjingChina State Key Laboratory of food Science and Technology School of Food Science and TechnologyJiangnan UniversityWuxiChina Demonstration Collaborative Laboratory of Analysis and Detection Technology for food and drug Safety Nanjing Institute for Food and Drug Control and Agilent Technologies(China)NanjingChina Collaborative Laboratory for food Safety Nanjing Institute for Food and Drug Control and SCIEX(China)NanjingChina

food allergy is a growing health issue worldwide and the demand for sensitive,robust and high-throughput analytical methods is *** recent years,mass spectrometry-based methods have been established for multiple food allergen *** the present study,a novel method was developed for the simultaneous detection of almond,cashew,peanut,and walnut allergens in bakery foods using liquid chromatography–mass *** unique to these four ingredients were extracted,followed by trypsin digestion,quadrupole time-of-flight(Q-TOF)mass spectrometry and bioinformatics *** raw data were processed by de-novo sequencing module plus PEAKS DB(database search)module of the PEAKS software to screen peptides specific to each nut *** thermal stability and uniqueness of these candidate peptides were further verified using triple quadrupole mass spectrometry(QQQ-MS)in multiple reaction monitoring(MRM)*** nut species was represented by four peptides,all of which were validated for label-free quantification(LFQ).Calibration curves were constructed with good linearity and correlation coefficient(r 2)greater than *** limits of detection(LODs)were determined to range from 0.11 to 0.31 mg/kg,and were compared with the reference doses proposed by Voluntary Incidental Trace Allergen Labelling(VITAL).The recoveries of the developed method in incurred bakery food matrices ranged from 72.5%to 92.1%with relative standard deviations(RSD)offood samples confirmed the presence of these *** conclusion,this method provides insight into the qualitative and quantitative detection of trace levels of nut allergens in bakery foods.

关键词： Nut allergen Q-TOF mass spectrometry peptides label-free quantitation bakery foods.

In silico and in vitro genotoxicity evaluation of descarboxyl levofloxacin,an impurity in levofloxacin

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中国药理学与毒理学杂志 2013年第3期 470-471页

作者： ZHU Qing-fen WEI Xi QU Jian-song LI Jun WANG Wei-jian Shandong institute for food and drug control

OBJECTIVE To evaluate the genotoxicity of Descarboxyl Levofloxacin by In silico and In vitro *** Assessment of genotoxicity using Derek for Windows We used DEREK for Windows(DfW,Lhasa Ltd.,Leeds,UK) version 11.0 for toxicity *** structures are entered into the program in *** *** program applies structure-activity relationships 〔(Q) SARs〕and other expert knowledge rules to derive a reasoned prediction about the potential toxicity of the query *** reverse mutation assay(Ames test) The Salmonella histidine point mutation assay proposed by Maron and Ameswas *** *** histidine autotrophic strains(TA97,TA98,TA100 and TA102) used in this test were obtained from Shandong center for disease *** saline(NS) was used as a vehicle control.2-Aminofluorene(2-AF,10 μg /plate),1,8-dihydroxyanthraquinone(50 μg /plate),Sodium azide(NaN3,1.5 μg /plate),and Dexon(50 μg /plate) were used as positive *** levofloxacin was assayed at concentrations of 31.25,62.5,125,250,and 500 μg /***,0.1 ml of test substance(or control solution),0.1 ml of bacterial culture 〔(1-2) × 1012 L-1 〕and 0.5 ml of S9 mix(NS for treatment without activation) were mixed and poured onto the agar plates after addition of 1.8 ml of top agar(0.6% agar Difco,0.5% NaCl,50 μmol·L-1 L-histidine,50 μmol·L-1 biotin,45℃) at 45℃.Plates were inverted and incubated for 48h at 37℃ in the *** colonies were counted and the background lawn was inspected for signs of toxicity or compound *** assay was performed two times in triple and included negative and positive *** al aberrations in Chinese ham ster lung cells Chinese Hamster Lung(CHL) cells were obtained from Shandong center for disease *** cells were grown in DMEM medium supplemented with 10% heat-inactivated calf serum at 37℃ in an atmosphere containing 5% of *** test for Chromosomal aberrations in CHL cells was con

关键词： genotoxicity impurity descarboxyl levofloxacin SARs CHL chromosomal aberration

Analysis of volatile compounds in Herba Asari by single-drop micro-extraction gas chromatography mass spectrometry

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Chinese Chemical Letters 2013年第6期24卷 542-544页

作者： Guan-Jie Wang Mei-Ling Qi National institutes for food and drug control School of Chemistry Beijing Institute of Technology

A rapid headspace single-drop micro-extraction（mix） gas chromatography mass spectrometry（SDMEGC -MS） for the analysis of the volatile compounds in Herba Asari was developed in this study.A mixed solvent of n-tridecane and butyl acetate（1：1） was finally used for the extraction at 70 C for 15 min with sample amount of 0.750 g and 100 mesh particle *** the determined conditions,the pound samples of Herba Asari were directly applied for the ***-GC-MS,SPME-GC-MS and SD-GCMS methods were compared and the results showed that SDME-GC-MS method was a simple, inexpensive and effective way to measure the volatile compounds in Herba Asari and could be used for the analysis of volatile compounds in complex samples.

关键词： Single-drop micro-extraction Herba Asari Volatile compounds Traditional Chinese medicine

Identification and characterization of related substances in EVT-401 by hyphenated LC–MS techniques

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Journal of Pharmaceutical Analysis 2017年第4期7卷 223-230页

作者： Binan Zhu Yuting Lu Leilin Chen Binbin Yu Yuexin Liu Min Song Taijun Hang Key Laboratory of drug Quality control and Pharmacovigilance Ministry of Education Department of Pharmaceutical Analysis China PharmaceuticalUniversity Nanjing 210009 China Department of Chemical drug control Hubei Institute for Food and Drug Control Wuhan 430074 China Department of Pharmacy Taizhou First People's Hospital Taizhou 318200 China

A sensitive and selective method was developed for the separation and characterization of related substances(RSs) in EVT-401 by hyphenated LC–MS techniques. Complete separation of the RSs was achieved with an Inertsil ODS-SP column(250 mm×4.6 mm, 5 μm) by linear gradient elution using a mobile phase consisting of 0.2% formic acid solution, methanol and acetonitrile. EVT-401 was found to be susceptible to acid, alkaline and oxidative stresses, while relatively stable under photolytic and thermal dry stress conditions. Fourteen RSs including six process-related substances and eight degradation products were detected and identified in EVT-401 with positive ESI high-resolution TOF-MS analysis of their parent ions and the corresponding product mass spectra elucidation, and some of them were further verified by chemical synthesis and NMR spectroscopy. The specific LC–MS method developed for separation, identification and characterization of RSs is valuable for EVT-401 manufacturing process optimization and quality control.

关键词： EVT-401 Related substances LC–MS Degradation products

COVID-19 vaccines: progress and understanding on quality control and evaluation

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1646-1652页

作者： Qunying Mao Miao Xu Qian He Changgui Li Shufang Meng Yiping Wang Bopei Cui Zhenglun Liang Junzhi Wang National institutes for food and drug control BeijingChina

The outbreak of COVID-19 has posed a huge threat to global health and *** have revolutionized norms for working,socializing,learning,and ***,vaccines have been considered as most effective tools to combat with *** of the beginning of 2021,>200 COVID-19 vaccine candidates,covering nearly all existing technologies and platforms,are being research and development(R&D)by multiple manufacturers *** has posed a huge obstacle to the quality control and evaluation of those candidate vaccines,especially in China,where five vaccine platforms are deployed in *** accelerate the R&D progress of COVID-19 vaccines,the guidances on R&D of COVID-19 vaccine have been issued by National Regulatory Authorities or organizations *** Center for drug Evaluation and national quality control laboratory in China have played a leading role in launching the research on quality control and evaluation in collaboration with relevant laboratories involved in the vaccine R&D,which greatly supported the progression of vaccines R&D,and accelerated the approval for emergency use and conditional marketing of currently vaccine *** this paper,the progress and experience gained in quality control and evaluation of COVID-19 vaccines developed in China are summarized,which might provide references for the R&D of current and next generation of COVID-19 vaccines worldwide.

关键词： approval gained travel