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Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin Xing Xuyun Hua Yuwen Zhang Xin Xue Jiajia wu Mouxiong Zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of traditional chinese medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

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Mining Syndrome Differentiating Principles from traditional chinese medicine Clinical Data

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Computer Systems Science & Engineering 2022年第3期40卷 979-993页

作者： Jialin Ma Zhaojun Wang Hai Guo Qian Xie Tao Wang Bolun Chen Jiangsu Internet of Things and Mobile Internet Technology Engineering Laboratory Huaiyin Institute of TechnologyHuaian223003China huaiyin wu jutong institute of traditional chinese medicine Huaian223000China The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University Huaian223000China Jiangsu Eazytec Co. Ltd.WuxiChina University of Fribourg Fribourg1700Switzerland

Syndrome differentiation-based treatment is one of the key characteristics of traditional chinese medicine(TCM).The process of syndrome differentiation is difficult and challenging due to its complexity,diversity and *** syndrome principles from historical records of TCM using data mining(DM)technology has been of high interest in recent ***,in most relevant studies,existing DM algorithms have been simply developed for TCM mining,while the combination of TCM theories or its characteristics with DM algorithms has rarely been *** paper presents a novel Symptom-Syndrome Topic Model(SSTM),which is a supervised probabilistic topic model with three-tier Bayesian *** the SSTM,syndromes are considered as observed topic labels to distinguish certain symptoms from possible symptoms according to their different *** generation of our model is in full compliance with the syndrome differentiation theory of *** results show that the SSTM is more effective than other models for syndrome differentiating.

关键词： TCM syndrome differentiation topic model LDA SSTM

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Tuina alleviates neuropathic pain through regulate the activation of microglia and the secretion of inflammatory cytokine in spinal cord

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Journal of traditional chinese medicine 2024年第4期44卷 762-769页

作者： wu Zhiwei ZHU Qingguang KONG Lingjun SONG Pengfei ZHOU Xin GUO Guangxin ZHANG Shuaipan HE Tianxiang CHENG Yanbin FANG Min Yueyang Hospital of Integrated traditional chinese and Western medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China institute of Tuina Shanghai Institute of Traditional Chinese MedicineShanghai 200437China Shuguang Hospital Shanghai University of Traditional Chinese MedicineShanghai 200021China Department of Acupuncture and Tuina Shanghai University of Traditional Chinese MedicineShanghai 201203China

OBJECTIVE:To observe the analgesic effects of Tuina on neuropathic pain(NPP)and the underlying ***:Forty-eight Sprague-Dawley(SD)rats were assigned by random into three treatment groups:sham,chronic constriction injury(CCI),and *** group contained sixteen *** model was generated by ligating the right sciatic *** changes of CCI were assessed by the paw withdrawal threshold(PWT)and paw withdrawal latency(PWL).In addition,biochemical techniques such as immunofluorescence staining,enzyme-linked immunosorbent assay(ELISA)and Western blotting were used to profile levels of microglia activation and inflammatory factors in the spinal dorsal horn(SDH)of ***(clockwise pressing and rubbing)was performed at Chengshan(BL57)to observe the analgesic effects on CCI rats and the underlying ***:Rats with CCI experienced significant reduction in the PWT and PWL of the right hind paw relative to CCI group at day *** treatment rescued this situation significantly on days 10 and ***,Iba-1,microglia M1 receptor CD68,tumor necrosis factor-α(TNF-α),and interleukin-1β(IL-1β)were higher in the right SDH for CCI group compared to the sham group on day *** expected,Tuina partially downregulated the CCI-induced overexpressed Iba-1,CD68,TNF-α,and IL-1βin the SDH of CCI ***:Tuina induces a time-dependent cumulative analgesic effect in CCI rats by inhibiting the activation of microglia and the secretion of IL-1βand TNF-αin SDH.

关键词： Tuina neuralgia microglia inflammatory cytokine spinal cord

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A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu wu Zhongjie Zhu Hongwei Zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

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Extracellular signal-regulated kinase, substance P and neurokinin-1 are involved in the analgesic mechanism of herb-partitioned moxibustion

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Neural Regeneration Research 2017年第9期12卷 1472-1478页

作者： Zhi-yuan Li Yan-ting Yang Jue Hong Dan Zhang Xiao-fei Huang Li-jie wu Huan-gan wu Zheng Shi Jie Liu Yi Zhu Xiao-peng Ma Shanghai University of traditional chinese medicine Zhejiang Provincial Hospital of traditional chinese medicine Shanghai Research institute of Acupuncture and Meridian

Herb-partitioned moxibustion can effectively mitigate visceral pain, a major symptom in inflammatory bowel disease, but the analgesic lnechanism is still unclear. Moreover, extracellular signal-regulated kinase, substance P, and neurokinin-1 are involved in formation of central hyperalgesia. Thus, we postulated that the analgesic effect of herb-partitioned moxibustion may be associated with these factors. Accordingly, in this study, we established an inflammatory bowel disease visceral pain model in rat by enema with a mixed solution of 5% trinitrobenzenesulfonic acid and 50% ethanol. Bilateral Tianshu （ST25） and Qihai （CV6） points were selected for herb-partitioned moxi- bustion. Our results showed that herb-partitioned moxibustion improved visceral pain and down-regulated extracellular signal-regulated kinase, substance P, and neurokinin-1 protein and mRNA expression in dorsal root ganglia. These results indicate that down-regulation of extracellular signal-regulated kinase, substance E and neurokinin-1 protein and mRNA may be a central mechanism for the analgesic effect of herb-partitioned moxibustion.

关键词： nerve regeneration inflammatory bowel disease visceral pain herb-partitioned moxibustion analgesic effect Tianshu (ST25) Qihai (CV6) dorsal root ganglion extracellular signal-regulated kinase substance P neurokinin-I neural regeneration

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Potential Treatment of COVID-19 with traditional chinese medicine: What Herbs Can Help Win the Battle with SARS-CoV-2?

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Engineering 2022年第12期19卷 139-152页

作者： Lin Li Yuzheng wu Jiabao Wang Huimin Yan Jia Lu Yu Wang Boli Zhang Junhua Zhang Jian Yang Xiaoying Wang Min Zhang Yue Li Lin Miao Han Zhang State Key Laboratory of Component-Based chinese medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Key Laboratory of Pharmacology of traditional chinese Medical Formulae Ministry of EducationTianjin University of Traditional Chinese MedicineTianjin 301617China institute of traditional chinese medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province–Ministry Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Integrative medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Evidence-Based medicine Center Tianjin University of Traditional Chinese MedicineTianjin 301617China College of traditional chinese medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

traditional chinese medicine(TCM)has been successfully applied worldwide in the treatment of coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).However,the pharmacological mechanisms underlying this success remain ***,the aim of this review is to combine pharmacological assays based on the theory of TCM in order to elucidate the potential signaling pathways,targets,active compounds,and formulas of herbs that are involved in the TCM treatment of COVID-19,which exhibits combatting viral infections,immune regulation,and amelioration of lung injury and *** reports on target screening are elucidated using virtual prediction via docking analysis or network pharmacology based on existing *** results of these reports indicate that an intricate regulatory mechanism is involved in the pathogenesis of ***,more pharmacological research on the natural herbs used in TCM should be conducted in order to determine the association between TCM and COVID-19 and account for the observed therapeutic effects of TCM against COVID-19.

关键词： traditional chinese medicine SARS-CoV-2 COVID-19 Antivirus Anti-inflammation Immune regulation

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Polysaccharide extracts of Astragalus membranaceus and Atractylodes macrocephala promote intestinal epithelial cell migration by activating the polyamine-mediated K^+ channel

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chinese Journal of Natural medicines 2018年第9期16卷 674-682页

作者： ZENG Dan HU Can LI Ru-Liu LIN Chuan-Quan CAI Jia-Zhong wu Ting-Ting SUI Jing-Jing LU Wen-Biao CHEN Wei-Wen Pi-wei institute Guangzhou University of Chinese Medicine College of traditional chinese medicine Guangzhou University of Chinese Medicine

Astragalus membranaceus(Radix Astragali, RA) and Atractylodes macrocephala(Rhizoma Atractylodis Macrocephalae, RAM) are often used to treat gastrointestinal diseases. In the present study, we determined the effects of polysaccharides extracts from these two herbs on IEC-6 cell migration and explored the potential underlying mechanisms. A migration model with IEC-6 cells was induced using a single-edged razor blade along the diameter of cell layers in six-well polystyrene plates. The cells were grown in control--media or media containing spermidine(5 μmol·L^(-1), SPD), alpha-difluoromethylornithine(2.5 mmol·L^(-1), DFMO), 4-Aminopyridine-(40 μ-mol·L^(-1), 4-AP), the polysaccharide extracts of RA or RAM(50, 100, or 200 mg·L^(-1)), DFMO plus SPD, or DFMO plus polysaccharide extracts of RA or RAM for 12 or 24 h. Next, cytosolic free Ca^(2+)([Ca^(2+)]cyt) was measured using laser confocal microscopy, and cellular polyamine content was quantified with HPLC. Kv1.1 mRNA expression was assessed using RT-qPCR and Kv1.1 and RhoA protein expressions were measured with Western blotting analysis. A cell migration assay was carried out using Image-Pro Plus software. In addition, GC-MS was introduced to analyze the monosaccharide composition of both polysaccharide extracts. The resutls showed that treatment with polysaccharide extracts of RA or RAM significantly increased cellular polyamine content, elevated [Ca^(2+)]cyt and accelerated migration of IEC-6 cells, compared with the controls(P < 0.01). Polysaccharide extracts not only reversed the inhibitory effects of DFMO on cellular polyamine content and [Ca^(2+)]cyt, but also restored IEC-6 cell migration to control level(P < 0.01 or < 0.05). Kv1.1 mRNA and protein expressions were increased(P < 0.05) after polysaccharide extract treatment in polyamine-deficient IEC-6 cells and RhoA protein expression was increased. Molar ratios of D-ribose, D-arabinose, L-rhamnose, D-mannose, D-glucose, and D-galactose was 1.0:14.1:0.3:19.9:181.3

关键词： Intestinal epithelial cell (IEC-6) Cell migration Polysaccharide extracts Astragalus membranaceus Atractylodes macrocephala Polyamines K^+ channel

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Effect of astragaloside IV and salvianolic acid B on antioxidant stress and vascular endothelial protection in the treatment of atherosclerosis based on metabonomics

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chinese Journal of Natural medicines 2022年第8期20卷 601-613页

作者： KONG Xiang-Lin LYU Qin ZHANG Ya-Qi KANG Dong-Fang LI Chao ZHANG Lei GAO Zi-Chen LIU Xin-Xin wu Ji-Biao LI Yun-Lun Experimental Center Shandong University of Traditional Chinese MedicineJinan 250355China Graduate School Liaoning University of Traditional Chinese MedicineShenyang 110847China College of Continuing Education Shandong University of Traditional Chinese MedicineJinan250355China Innovative institute of chinese medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China College of traditional chinese medicine Shandong University of Traditional Chinese MedicineJinan 250355China Department of Cardiology the Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250011China

Vascular endothelial cells and oxidation reduction system play an important role in the pathogenesis of atherosclerosis(AS).If these conditions are disordered,it will inevitably lead to plaque formation and even *** IV(AsIV)and salvianolic acid B(Sal B)are the main active ingredients of Astragalus membranaceus and Salvia miltiorrhiza,respectively,and found to ameliorate vascular endothelial dysfunction and protect against oxidative stress in recent ***,it is still unknown if the combination of AsIV and Sal B(AsIV+Sal B)can inhibit the development of plaque through amplifying the protective effect of vascular endothelial cells and anti-oxidative stress *** clarify the role of AsIV+Sal B in AS,we observed the efficacy of each group(Control,Model,AsIV,Sal B,and AsIV+Sal B)by biomolecular assays,such as observing the pathological morphology of the aorta by oil red O staining,evaluating the level of oxidative stress and endothelial cells in the serum by the Elisa test,and analyzing the changes of all small molecule metabolites in liver tissue by *** showed that AsIV,Sal B and AsIV+Sal B decreased the deposition of lipid in the arterial wall,so as to exert the effect of anti-oxidant stress and vascular endothelial protection,where the inhibitory effect of AsIV+Sal B was the most *** analysis showed that Sal B regulated the metabolic pathways of arginine and *** regulated glycerol metabolism and saturated fatty acid biosynthesis ***+Sal B is mainly related to the regulation of the citrate cycle(TCA cycle),alanine,aspartic acid,and glutamate metabolism,cysteine,and methionine *** acid and methionine are synergistic metabolites that exert an enhancing effect when AsIV and Sal B were used in *** conclusion,we demonstrated that AsIV acompanied with Sal B can be successfully used for anti-oxidative stress and vascular endothelial protection of AS,and succinic ac

关键词： Salvianolic acid B Astragaloside IV Metabolomics Oxidative stress Vascular endothelial damage

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Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats

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World Journal of Gastroenterology 2017年第34期23卷 6220-6230页

作者： Zhi-Yuan Li Yan Huang Yan-Ting Yang Dan Zhang Yan Zhao Jue Hong Jie Liu Li-Jie wu Cui-Hong Zhang Huan-Gan wu Ji Zhang Xiao-Peng Ma Shanghai University of traditional chinese medicine Huangpu Hospital of Integrated traditional chinese and Western medicine Shanghai Shanghai Research institute of Acupuncture and Meridian Yunnan University of traditional chinese medicine

AIM To investigate the effects of herb-partitioned moxibustion(HPM) on phosphorylation of mitogen-activated extracellular signal-regulated kinase(MEK)1, extracellular signal-regulated kinase(ERK)1/2 and c AMP response element binding protein(CREB) in spinal cord of rats with chronic inflammatory visceral pain(CIVP), and to explore the central mechanism of HPM in treating *** Male Sprague-Dawley rats were randomized into normal, model, HPM, sham-HPM, MEK-inhibitor and dimethyl sulfoxide(DMSO) groups. The CIVP model was established using an enema mixture of trinitrobenzene sulfonic acid and ethanol. HPM was applied at bilateral Tianshu(ST25) and Qihai(CV6) acupoints in the HPM group, while in the sham-HPM group, moxa cones and herb cakes were only placed on the same points but not ignited. The MEK-inhibitor and DMSO groups received L5-L6 intrathecal injection of U0126 and 30% DMSO, respectively. Abdominal withdrawal reflex(AWR), mechanical withdrawal threshold(MWT) and thermal withdrawal latency(TWL) were applied for the assessment of pain behavior. The colonic tissue was observed under an optical microscope after hematoxylin-eosin staining. Expression of phosphor(p)MEK1, p ERK1/2 and p CREB in rat spinal cord was detected using Western blotting. The levels of MEK, ERK and CREB m RNA in rat spinal cord were detected using real-time polymerase chain reaction. RESULTS Compared with the normal group, the AWR scores were increased significantly(P < 0.01) and the MWT and TWL scores were decreased significantly(P < 0.05) in the model, sham-HPM and DMSO groups. Compared with the model group, the AWR scores were decreased significantly(P < 0.01) and the MWT and TWL scores were increased significantly in the HPM and MEK-inhibitor groups(P < 0.05). Compared with the sham-HPM and DMSO groups, the AWR scores were decreased significantly(P < 0.01) and the MWT and TWL scores were increased significantly(P < 0.05) in the HPM and MEK-inhibitor groups. Compared with the norma

关键词： Herb-partitioned moxibustion Chronic inflammatory visceral pain Pain behavior Analgesia MEK Extracellular signal-regulated kinase c AMP response element binding protein Signaling pathway

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Cytotoxic 7-Methoxylated Caged Xanthones from the Twigs of Garcinia oligantha

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chinese Journal of Chemistry 2021年第10期39卷 2898-2910页

作者： Jin-Ling Yang Wen-Wei Fu Qian Xiang Rong wu Yue-Xun Tang Chang-wu Zheng Yue Lu Hua Zhou Hong-Xi Xu School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China institute of Cardiovascular Disease of Integrated traditional chinese and Western medicine Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203 China

Main observation and conclusion Nineteen unprecedented 7-methoxylated caged xanthones(1—19)were isolated from the twigs of Garcinia oligantha under the guidance of NMR *** structures and absolute configurations were demonstrated by extensive spectroscopic data,single-crystal X-ray diffraction,electronic circular dichroism(ECD)calculations,and the modified Mosher's *** 1 is a rare scalemic 7-methoxylated neo-caged xanthone,which was resolved using HPLC with CD detection on a chiral-phase AD column,and compounds 2—3 are rare 7-methoxylated caged xanthones with the hydrogenatedΔ^(8(8a))double *** compounds exhibited promising inhibitory activities against four human cancer cell lines with IC50 values ranging from 1.9 to 14.3μmol/L.A cell apoptosis analysis using flow cytometry showed that compound 11 could induce apoptosis in a dose dependent ***,PARP,caspase-9,and Bcl-2 western blotting suggested that compound 11-induced apoptosis may be involved in caspase-dependent pathway.

关键词： Garcinio oligantha Caged Xanthones Structure elucidation X-ray diffraction Tumor cell apoptosis

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