Cytotoxic 7-Methoxylated Caged Xanthones from the Twigs of Garcinia oligantha

作     者：Jin-Ling Yang Wen-Wei Fu Qian Xiang Rong Wu Yue-Xun Tang Chang-Wu Zheng Yue Lu Hua Zhou Hong-Xi Xu Jin-Ling Yang;Wen-Wei Fu;Qian Xiang;Rong Wu;Yue-Xun Tang;Chang-Wu Zheng;Yue Lu;Hua Zhou;Hong-Xi Xu

作者机构：School of PharmacyShanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western MedicineShuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2021年第39卷第10期

页      面：2898-2910页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：sponsored partly by grants from the Three-year Development Plan Project for Traditional Chinese Medicine(No.ZY(2018-2020)-CCCX-2001-02) the Shanghai Sailing Program(No.17YF1419500)and NSFC(No.81803545) We are also grateful to NSFC-Joint Foundation of Yunnan Province(No.U1902213) the Key-Area Research Development Program of Guangdong Province(No.2020B1111110003)for financial support 

主　　题：Garcinio oligantha Caged Xanthones Structure elucidation X-ray diffraction Tumor cell apoptosis 

摘      要：Main observation and conclusion Nineteen unprecedented 7-methoxylated caged xanthones(1—19)were isolated from the twigs of Garcinia oligantha under the guidance of NMR *** structures and absolute configurations were demonstrated by extensive spectroscopic data,single-crystal X-ray diffraction,electronic circular dichroism(ECD)calculations,and the modified Mosher s *** 1 is a rare scalemic 7-methoxylated neo-caged xanthone,which was resolved using HPLC with CD detection on a chiral-phase AD column,and compounds 2—3 are rare 7-methoxylated caged xanthones with the hydrogenatedΔ^(8(8a))double *** compounds exhibited promising inhibitory activities against four human cancer cell lines with IC50 values ranging from 1.9 to 14.3μmol/L.A cell apoptosis analysis using flow cytometry showed that compound 11 could induce apoptosis in a dose dependent ***,PARP,caspase-9,and Bcl-2 western blotting suggested that compound 11-induced apoptosis may be involved in caspase-dependent pathway.