检索结果-南通市图书馆

Ankylosing spondylitis coexisting with Clonorchis sinensis infection: A case report

World Journal of Clinical Cases 2024年第5期12卷 1018-1024页

作者： Tian-Xin Yi Wei Liu Wen-Fei Leng Xiao-Chuan Wang Liang Luo Department of Rheumatology Traditional Chinese Medicine Hospital Dianjiang ChongqingChongqing 408300China Department of Orthopaedic Traditional Chinese Medicine Hospital Dianjiang ChongqingChongqing 408300China Department of chinese medicine The People's Hospital of Yubei District of Chongqing CityChongqing 401120China

BACKGROUND Ankylosing spondylitis(AS)is a chronic immune-mediated inflammatory *** prevailing theory links AS onset to infections in susceptible ***,infections may impair the immune *** studies have investigated links between AS and various infections-bacterial,viral,fungal,and other microorganism ***,limited attention has been given to the association between AS and Clonorchis sinensis(***)*** SUMMARY A 27-year-old male with a 10-yr history of AS presented to our hospital with inflammatory lower back pain as the primary *** years ago,the patient had achieved a stable condition after treatment with biological ***,he experienced a recurrence of lumbosacral pain with an unexplained cause 10 d before hospital admission.A lumbosacral magnetic resonance imaging(MRI)scan revealed bone marrow edema in the left sacroiliac joint,and laboratory indicators were ***,the presence of *** eggs was detected in the *** patient was prescribed praziquantel,resulting in the disap-pearance of *** eggs in subsequent routine stool tests and relief from lumbosacral pain.A follow-up MRI scan performed after 4 months revealed a reduction in bone marrow edema around the left sacroiliac *** *** infections could potentially trigger the exacerbation of *** should pay attention to investigating the presence of *** Ankylosing spondylitis(AS)is a chronic inflammatory and rheumatic disease resulting from an imbalance between innate and acquired immune responses[1].While it can affect any part of the spine,its primary symptoms are persistent back pain and stiffness in the lower back and *** prevalence of AS per 10000 individuals is 23.8 in Europe,31.9 in North America,16.7 in Asia,10.2 in Latin America,and 7.4 in Africa[2].Infections commonly occur in the first 3 months and may act as potential triggers for the

关键词： Ankylosing spondylitis Clonorchis sinensis Parasites Infection Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unraveling the mechanism of malancao in treating ulcerative colitis:A multi-omics approach

引用

World Journal of Clinical Cases 2024年第17期12卷 3105-3122页

作者： Xing-Long Huang Lu-Na Wu Qin Huang Yue Zhou Lei Qing Feng Xiong Hui-Ping Dong Tai-Min Zhou Kai-Li Wang Jue Liu hospital of traditional chinese medicine in qijiang district Chongqing 401420China qijiang Health Center for Maternal and Child Care Chongqing 401420China College of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025Guizhou ProvinceChina

BACKGROUND Malancao(MLC)is a traditional chinese medicine with a long history of utilization in treating ulcerative colitis(UC).Nevertheless,the precise molecular mechanisms underlying its efficacy remain *** study leveraged ultrahigh-performance liquid chromatography coupled with exactive mass spectrometry(UHPLC-QE-MS),network pharmacology,molecular docking(MD),and gene microarray analysis to discern the bioactive constituents and the potential mechanism of action of MLC in UC *** To determine the ingredients related to MLC for treatment of UC using multiple databases to obtain potential targets for *** This research employs UHPLC-QE-MS for the identification of bioactive compounds present in MLC plant ***,the study integrates the identified MLC compound-related targets with publicly available databases to elucidate common drug disease ***,the R programming language is utilized to predict the central targets and molecular pathways that MLC may impact in the treatment of ***,MD are conducted using AutoDock Vina software to assess the affinity of bioactive components to the main targets and confirm their therapeutic *** Firstly,through a comprehensive analysis of UHPLC-QE-MS data and public database resources,we identified 146 drug-disease cross targets related to 11 bioactive *** Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis highlighted that common disease drug targets are primarily involved in oxidative stress management,lipid metabolism,atherosclerosis,and other *** also affect AGE-RAGE and apoptosis signaling ***,by analyzing the differences in diseases,we identified key research *** core targets are related to 11 active substances,including active ingredients such as quercetin and ***,MD analysis revealed the stability of compound-protein binding,particularly between JUNLuteolin,JUN-Quercetin,HSP90A

关键词： Malancao Ulcerative colitis Mass spectrum Network pharmacology Molecular docking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeting oxidative stress with natural products: A novel strategy for esophageal cancer therapy

引用

World Journal of Gastrointestinal Oncology 2024年第2期16卷 287-299页

作者： Fang Cao Han-Ling Zhang Cui Guo Xue-Liang Xu Qiang Yuan Department of Rehabilitation III Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Rehabilitation Chongqing Fuling District Maternal and Child Health HospitalChongqing 408000China Department of Rehabilitation Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

Esophageal cancer(ESC)is a malignant tumor that originates from the mucosal epithelium of the esophagus and is part of the digestive *** the exact pathogenesis of ESC has not been fully elucidated,excessive oxidative stress is an important characteristic that leads to the development of many *** expression of several proteins and transcription factors contributes to oxidative stress in ESCs,which alters the growth and proliferation of ESCs and promotes their *** compounds,including alkaloids,terpenes,polyphenols,and xanthine compounds,can inhibit reactive oxygen species production in *** compounds reduce oxidative stress levels and subsequently inhibit the oc-currence and progression of ESC through the regulation of targets and pathways such as the cytokine interleukins 6 and 10,superoxide dismutase,the NF-+ACY-kappa+ADs-B/MAPK pathway,and the mammalian Nrf2/ARE target ***,targeting tumor oxidative stress has become a key focus in anti-ESC *** review discusses the potential of Natural products(NPs)for treating ESCs and summarizes the application prospects of oxidative stress as a new target for ESC *** findings of this review provide a reference for drug development targeting ***,further high-quality studies will be necessary to determine the clinical efficacy of these various NPs.

关键词： Oxidative stress Natural products Esophageal cancer Reactive oxygen species

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of marker genes associated with N6-methyladenosine and autophagy in ulcerative colitis

引用

World Journal of Clinical Cases 2024年第10期12卷 1750-1765页

作者： Xiao-Yan Liu Dan Qiao Ya-Li Zhang Zi-Xuan Liu You-Lan Chen Ren-Ye Que Hong-Yan Cao Yan-Cheng Dai Department of Gastroenterology Shanghai Traditional Chinese Medicine-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Institute of Digestive Diseases Long Hua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Gastroenterology Shu Guang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Both N6-methyladenosine(m6A)methylation and autophagy are considered relevant to the pathogenesis of ulcerative colitis(UC).However,a systematic exploration of the role of the com-bination of m6A methylation and autophagy in UC remains to be *** To elucidate the autophagy-related genes of m6A with a diagnostic value for *** The correlation between m6A-related genes and autophagy-related genes(ARGs)was ***,gene set enrichment analysis(GSEA)was performed on the characteristic ***,the expression levels of four characteristic genes were verified in dextran sulfate sodium(DSS)-induced colitis in *** GSEA indicated that BAG3,P4HB and TP53INP2 were involved in the inflammatory response and TNF-αsignalling via nuclear factor ***,polymerase chain reaction results showed significantly higher mRNA levels of BAG3 and P4HB and lower mRNA levels of FMR1 and TP53INP2 in the DSS group compared to the control *** This study identified four m6A-ARGs that predict the occurrence of UC,thus providing a scientific reference for further studies on the pathogenesis of UC.

关键词： Ulcerative colitis m6A Autophagy Characteristic genes Immune infiltration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1

引用

chinese Journal of Integrative medicine 2024年第6期30卷 534-542页

作者： LI Jie CHEN Ya-feng GAO Lei LI Yi-jie FENG Dian-xu Department of General Surgery Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China

Objective To investigate the effect of honokiol(HON)and the role of high-mobility group protein B1(HMGB1)on the pathogenesis of severe acute pancreatitis(SAP).Methods Thirty mice were numbered according to weight,and randomly divided into 5 groups using a random number table,including control,SAP,SAP and normal saline(SAP+NS),SAP and ethyl pyruvate(SAP+EP),or SAP+HON groups,6 mice in each *** of pancreas,intestine,and blood were collected 12 h after SAP model induction for examination of pathologic changes,immune function alterations by enzyme linked immunosorbent assay(ELISA),and Western *** vitro experiments,macrophages were divided into 5 groups,the control,lipopolysaccharide(LPS),LPS+DMSO(DMSO),LPS+anti-HMGB1 monoclonal antibody(mAb),and LPS+HON *** tight connection level was determined by transmission electron microscopy and fluorescein *** location and acetylation of HMGB1 were measured by Western ***,pyridone 6 and silencing signal transducer and activator of the transcription 1(siSTAT1)combined with honokiol were added to determine whether the Janus kinase(JAK)/STAT1 participated in the regulation of honokiol on *** protein expression levels of HMGB1,JAK,and STAT1 were detected using Western *** Mice with SAP had inflammatory injury in the pancreas,bleeding of intestinal tissues,and cells with disrupted *** in the SAP+HON group had significantly fewer pathological *** with SAP also had significant increases in the serum levels of amylase,lipase,HMGB1,tumor necrosis factor-α,interleukin-6,diamine oxidase,endotoxin-1,and *** in the SAP+HON group did not show these abnormalities(P<0.01).Studies of Caco-2 cells indicated that LPS increased the levels of occludin and claudin-1 as well as tight junction permeability,decreased the levels of junctional adhesion molecule C,and elevated intercellular permeability(P<0.01).HON treatment blocked these *** of

关键词： severe acute pancreatitis intestinal barrier dysfunction honokiol high-mobility group protein B1 Januskinase signal transducerand activatorof transcription1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analyzing the potential mechanism of Buyang Huanwu decoction for the treatment of salt-sensitive hypertension based on network pharmacology and in vivo experiments

引用

traditional medicine Research 2024年第7期9卷 49-61页

作者： Jian-Bo Wang Yi Qu Ren-Jun Yu Guo-Rui Xu Ya-Nan Xue Jia-Hao Zhang Yong-Gang Ma Li-De Zhang traditional chinese medicine Innovation Engineering Technology Center Liaoning University of Traditional Chinese MedicineShenyang 110847China. Key Laboratory of Visceral Image Theory and Application of traditional chinese medicine Ministry of EducationShenyang 110847China. Center for Research and Evaluation of Higher traditional chinese medicine Education Liaoning University of Traditional Chinese MedicineShenyang 110847China. Emergency Department Nanjing Lishui District Hospital of Traditional Chinese MedicineJiangsu 211200China. College of Acupuncture and Moxibustion Liaoning University of Traditional Chinese MedicineShenyang 110847China. Department of Rehabilitation the Second Affiliated Hospital of Liaoning University of Chinese MedicineShenyang 110034China. College of Integrated chinese and Western medicine Liaoning University of Traditional Chinese MedicineShenyang 110847China.

Background:Buyang Huanwu decoction(BHD)is a traditional chinese medicine herbal formula used for treating hypertension,particularly in the later stages of hypertension when it is associated with intracerebral *** study aims to investigate the treatment mechanism of BHD to provide a basis for its clinical application in hypertension ***:Network pharmacology analysis and cell culture experiments were performed to explore the potential proteins and mechanisms of action of BHD against *** compounds related to BHD were screened,and relevant targets associated with hypertension and BHD were *** docking technology was used to identify the effective signaling pathway based on the Kyoto Encyclopedia of Genes and Genomes and protein-protein interaction network ***,the effects and mechanisms of BHD on salt-sensitive hypertensive endothelial cells were ***:Ninety-three potential therapeutic targets for BHD and salt-sensitive hypertension were found to be closely associated with the PI3K/Akt/eNOS signaling pathway and oxidative *** experiments further indicated the pivotal role of endothelial cells in hypertension,and validation analysis showed that BHD significantly preserved cell morphology,suppressed oxidative stress reactions,activated the PI3K/Akt/eNOS signaling pathways,preserved normal endothelial cell function,and reduced cell ***:BHD effectively activates the PI3K/Akt/VEGF signaling pathway,attenuates oxidative stress-induced injury in endothelial cells exposed to high salt levels,and mitigates apoptosis,supporting the use of traditional chinese medicine BHD in the treatment of salt-sensitive hypertension.

关键词： BHD salt-sensitive hypertension network pharmacology oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification and characterization of chemical constituents in Mahuang Guizhi Decoction and their metabolites in rat plasma and brain by UPLC-Q-TOF/MS

引用

chinese Herbal medicines 2024年第3期16卷 466-480页

作者： Ping Wei Shiying Huang Juan Yang Mo Zhao Qiugu Chen Xiaoyu Deng Jianping Chen Yisheng Li Pingshan district Maternal & Child Healthcare hospital of Shenzhen Pingshan General Hospital of Southern Medical University Shenzhen Key Laboratory of hospital chinese medicine Preparation Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine Shenzhen Longgang Otorhinolaryngology hospital

Objective:Mahuang Guizhi Decoction(MGD),an essential herbal pair in traditional chinese medicine,is able to release cold,fever and asthma,mainly containing alkaloids,flavonoids,phenylpropanoids and amino ***,the absorption and distribution of these four category compounds in vivo still remained ***:In our research,we utilized UPLC-Q-TOF-MS technique to identify the constituents within MGD,as well as the prototypes of MGD and their metabolites absorbed in plasma and *** further profiled the drug-time curve of prototypes and metabolites of MGD both in plasma and ***:Our results showed that 105 constituents were characterized in *** of them could be absorbed into blood,and ten of them could be distributed into *** also discovered eight new bio-transformed metabolites in blood,and a half of which could pass through the blood-brain *** addition,all components detected in vivo could be absorbed and distributed ***:These findings provide an approachable method to analyze the potential bio-active compounds in MGD and their in vivo behaviors,which could promote the efficacious material basis study of MGD and the security of clinical utilization.

关键词： chemical constituents Mahuag Guizhi Decoction metabolites rat plasma and brain UPLC-Q-TOF-MS

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Monotropein Induced Apoptosis and Suppressed Cell Cycle Progression in Colorectal Cancer Cells

引用

chinese Journal of Integrative medicine 2024年第1期30卷 25-33页

作者： GAO Quan LI Lin ZHANG Qi-man SHENG Qin-song ZHANG Ji-liang JIN Li-jun SHANG Rui-yan School of Pharmacy and Department of Medical Oncology the Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-Cancer chinese medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Department of Colorectal Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Beijing Tong Ren Tang chinese medicine Co. Ltd.Beijing(100000)China Department of traditional chinese medicine Hangzhou Shangcheng District People's HospitalHangzhou(310006)China Department of Gynecology Hangzhou Women's HospitalHangzhou(310008)China

Objective: To determine whether monotropein has an anticancer effect and explore its potential mechanisms against colorectal cancer(CRC) through network pharmacology and molecular docking combined with experimental verification. Methods: Network pharmacology and molecular docking were used to predict potential targets of monotropein against CRC. Cell counting kit assay, plate monoclonal assay and microscopic observation were used to investigate the antiproliferative effects of monotropein on CRC cells HCT116, HT29 and LoVo. Flow cytometry and scratch assay were used to analyze apoptosis and cell cycle, as well as cell migration, respectively in HCT116, HT29, and LoVo cells. Western blotting was used to detect the expression of proteins related to apoptosis, cell cycle, and cell migration, and the expression of proteins key to the Akt pathway. Results: The Gene Ontology and Reactome enrichment analyses indicated that the anticancer potential of monotropein against CRC might be involved in multiple cancer-related signaling pathways. Among these pathways, RAC-beta serine/threonine-protein kinase(Akt1, Akt2), cyclin-dependent kinase 6(CDK6), matrix metalloproteinase-9(MMP9), epidermal growth factor receptor(EGFR), cell division control protein 42 homolog(CDC42) were shown as the potential anticancer targets of monotropein against CRC. Molecular docking suggested that monotropein may interact with the 6 targets(Akt1, Akt2, CDK6, MMP9, EGFR, CDC42). Subsequently, cell activity of HCT116, HT29 and LoVo cell lines were significantly suppressed by monotropein(P<0.05). Furthermore, our research revealed that monotropein induced cell apoptosis by inhibiting Bcl-2 and increasing Bax, induced G_1–S cycle arrest in colorectal cancer by decreasing the expressions of CyclinD1, CDK4 and CDK6, inhibited cell migration by suppressing the expressions of CDC42 and MMP9(P<0.05), and might play an anticancer role through Akt signaling pathway. Conclusions: Monotropein exerts its antitumor

关键词： monotropein chinese medicine anticancer activity colorectal cancer cells network pharmacology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mannitol inhibits the proliferation of neural stem cell by a p38 mitogen-activated protein kinase-dependent signaling pathway

引用

chinese Journal of Traumatology 2024年第1期27卷 42-52页

作者： Hai-Zhen Duan Xin Zhou Quan Hu Meng-Long Liu Shu-Hong Wang Ji Zhang Xu-Heng Jiang Tian-Xi Zhang An-Yong Yu Department of Emergency Affiliated Hospital of Zunyi Medical UniversityZunyi563000Guizhou provinceChina Dazhou Vocational College of chinese medicine Dazhou635000Sichuan provinceChina Dachuan district traditional chinese medicine hospital Dazhou635000Sichuan provinceChina

Purpose:Mannitol is one of the first-line drugs for reducing cerebral edema through increasing the extracellular osmotic ***,long-term administration of mannitol in the treatment of cerebral edema triggers damage to neurons and *** that neural stem cell(NSC)is a subpopulation of main regenerative cells in the central nervous system after injury,the effect of mannitol on NSC is still *** present study aims to elucidate the role of mannitol in NSC ***:C57 mice were derived from the animal house of Zunyi Medical University.A total of 15 pregnant mice were employed for the purpose of isolating NSCs in this ***,mouse primary NSCs were isolated from the embryonic cortex of mice and subsequently identified through immunofluorescence *** order to investigate the impact of mannitol on NSC proliferation,both cell counting kit-8 assays and neurospheres formation assays were *** vitro effects of mannitol were examined at various doses and time *** order to elucidate the role of Aquaporin 4(AQP4)in the suppressive effect of mannitol on NSC proliferation,various assays including reverse transcription polymerase chain reaction,western blotting,and immunocytochemistry were conducted on control and mannitol-treated ***,the phosphorylated p38(p-p38)was examined to explore the potential mechanism underlying the inhibitory effect of mannitol on NSC ***,to further confirm the involvement of the p38 mitogen-activated protein kinase-dependent(MAPK)signaling pathway in the observed inhibition of NSC proliferation by mannitol,SB203580 was *** data were analyzed using SPSS 20.0 software(SPSS,Inc.,Chicago,IL).The statistical analysis among multiple comparisons was performed using one-way analysis of variance(ANOVA),followed by Turkey’’s post hoc test in case of the data following a normal distribution using a Shapiro-Wilk normality *** betwe

关键词： Mannitol Cerebral edema Neural stem cell Proliferation AQP4 p38 MAPK signaling pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chang’an decoction(肠安方) alleviates endoplasmic reticulum stress by regulating mitofusin 2 to improve colitis

引用

Journal of traditional chinese medicine 2024年第3期44卷 427-436页

作者： CHEN Youlan DING Mingming HUANG Chaoyuan ZHENG Yiyuan LIU Fengbin Institute of Integrated traditional chinese and Western medicine Digestive Diseases Shuguang HospitalShanghai University of Traditional Chinese Medicine Department of Oncology Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine of Shanghai the First Clinical Medical School Guangzhou University of Chinese Medicine Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese Medicine Baiyun hospital of the First Affiliated hospital of Guangzhou University of chinese medicine

OBJECTIVE: To evaluate the protective effects of Chang'an decoction(肠安方, CAD) on colitis, and investigate the potential mechanisms underlying these effects from the perspectives of endoplasmic reticulum(ER) stress induced by mitofusin 2(MFN2). METHODS: The composition of CAD was identified by liquid chromatography-mass spectrometry technology. A mice model of dextran sulfate sodium(DSS) induced colitis was established and therapeutic effects of CAD were determined by detecting body weight, disease activity index, colon length and histopathological changes. Then, the expression levels of MFN2, ER stress markers and Nucleotide-binding domain and leucine-rich repeat protein3(NLRP3) relevant proteins were detected by polymerase chain reaction(PCR), Western blot, immunohistochemistry and immunofluorescence staining. Subsequently, knockdown and overexpression cell model were constructed to further investigate the underlying mechanism of MFN2 mediating ER stress and energy metabolism by PCR, Western blot, electron microscopy and reactive oxygen species(ROS) staining. Finally, inflammatory indicator and tight junction proteins were measured by PCR and immunofluorescence staining to evaluate the protective effects of CAD. RESULTS: Results showed that the indispensable regulatory role of MFN2 in mediating ER stress and mitochondrial damage was involved in the protective effects of CAD on colitis in mice fed with DSS. Network pharmacology analysis also revealed CAD may play a protective effect on colitis by affecting mitochondrial function. In addition, our data also suggested a causative role for MFN2 in the development of inflammatory responses and energy metabolic alterations by constructing a knockdown and overexpression cell model whereby alter proper ER-mitochondria interaction in Caco-2 cells. Furthermore, relative expression analyses of ER stress markers and NLRP3 inflammasome showed the onset of ER stress and activation of NLRP3 inflammasome, which is consistent with

关键词： Chang'an decoction colitis endoplasmic reticulum stress mitochondrial damage mitofusin 2

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：