检索结果-南通市图书馆

Differences in oxidative stress dependence between gastric adenocarcinoma subtypes

World Journal of Gastroenterology 2006年第7期12卷 1005-1012页

作者： Brigitte Bancel JacauesEstève Jean-Christophe Souquet Shinya Toyokuni Hiroshi Ohshima Brigitte Pignatelli hospital de la croix-rousse Department of PathologyLyonFrance Centre hospital de la croix-rousse Department of GastroenterologyLyonFrance department of Pathology and Biology of Diseases Graduate School of MedicineKyoto UniversityKyotoJapan Brigitte Pignatelli International Agency for Research on Cancer.Endogenous Risk Factors GroupLyon.France Clinical Epidemiology Unit Department of Medical InformationHospices Civils de LyonFrance

AIM： To investigate the extent of oxidative stress in preneoplastic and neoplastic gastric mucosa in relation to their pathological criteria and histological subtypes. METHODS： A total of 104 gastric adenocarcinomas from 98 patients （88 infiltrative and 16 intraepithelial tumors） were assessed immunohistochemically for expression of iNOS and occurrence of nitrotyrosine （NTYR）-containing proteins and 8-hydroxy-2＇-deoxyguanosine （8-OH- dG）-containing DNA, as markers of NO production and damages to protein and DNA. RESULTS： Tumor cells staining for iNOS, NTYR and 8-OH-dG were detected in 41%, 62% and 50% of infiltrative carcinoma, respectively. The three markers were shown for the first time in intraepithelial carcinoma. The expression of iNOS was significantly more frequent in tubular carcinoma （TC） compared to diffuse carcinoma （DC）（54% vs 18%; P=0.008） or in polymorphous carcinoma （PolyC）（54% vs 21% ; P=0.04）. NTYR staining was obviously more often found in TC than that in PolyC （72% vs 30% ; P=0.03）. There was a tendency towards a higher rate of iNOS staining when distant metastasis （pM） was present. In infiltrative TC, the presence of oxidative stress markers was not significantly correlated with histological grade, density of inflammation, the depth of infiltration （pT）, lymph nodes dissemination （pN） and pathological stages （pTNM）.CONCLUSION： The iNOS-oxidative pathway may play an important role in TC, but moderately in PolyC and DC. DNA oxidation and protein nitration occur in the three subtypes. Based on the significant differences of NTYR levels, TC and PolyC appear as two distinct subtypes.

关键词： Gastric neoplasms Nitric oxide synthase Hpylori Nitrotyrosine 8-hydroxydeoxyguanosine Oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polymorphic multiple hepatocellular adenoma including a non-steatotic HNF1α-inactivated variant

引用

Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 552-555页

作者： Kayvan Mohkam Benjamin Darnis Jean-Baptiste Cazauran Agnès Rode Anne-Frédérique Manichon Christian Ducerf Brigitte Bancel Jean-Yves Mabrut department of General Surgery and Liver Transplantation Hospices Civils de Lyon Croix-Rousse University HospitalLyon France department of Radiology Hospices Civils de Lyon Croix-Rousse University HospitalLyon France department of Surgical Pathology Hospices Civils de Lyon Croix-Rousse University HospitalLyon France Equipe Mixte de Recherche 3738 Ecole Doctorale EDISS 205 Université Lyon 1 France

To the Editor:Hepatocellular adenomas(HCAs)consist of benign liver tumors favored by the use of oral contraceptives,which preferentially occur in women.[1,2]They expose to the risk of hemorrhage(20%of cases)and more rarely,to the risk of malignant transformation(4%-10%of cases).[3,4]Multiple HCAs,which are defined by the presence of 10 or more

关键词： HNF Polymorphic multiple hepatocellular adenoma including a non-steatotic HNF1 HCA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lenvatinib applicability in the therapeutic strategy of patients with hepatocellular carcinoma

引用

Hepatobiliary Surgery and Nutrition 2023年第2期12卷 248-251页

作者： Philippe Merle Hepatology Unit University Croix-Rousse HospitalHospices Civils de LyonLyonFrance

The Expert Consensus on the management of lenvatinib tolerance in patients with hepatocellular carcinoma(HCC)was published(1).There,the authors discussed how possibly lenvatinib-related adverse events could be managed in aim to ensure continued lenvatinib therapy at the highest possible dose,and as a result to gain optimal benefit on survival of *** this editorial,the place of lenvatinib in HCC therapeutic strategies as well as its tolerance are reviewed and discussed.

关键词： Hepatocellular carcinoma(HCC) treatment lenvatinib

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interdepartmental miscommunication regarding radiology:Addressing chronic challenges and exploring solutions

引用

World Journal of Radiology 2024年第5期16卷 109-114页

作者： Nikolaos-Achilleas Arkoudis Emmanouil Karofylakis Ornella Moschovaki-Zeiger Spyridon Prountzos Evgenia Efthymiou George Samonis Christos Koutserimpas Research Unit of Radiology and Medical Imaging National and Kapodistrian University of AthensAthens 11528Greece The Second department of Radiology General University Hospital“Attikon”National and Kapodistrian University of AthensChaidari 12462Greece Addenbrooke’s hospital Cambridge University Hospitals NHS Foundation TrustCambridge CB20QQUnited Kingdom department of Medicine University of CreteHeraklionCrete 71500Greece The First department of Oncology Metropolitan HospitalNeon FalironAthens 18547Greece Orthopaedics Surgery and Sports Medicine department FIFA Medical Centre of ExcellenceCroix-Rousse HospitalLyon University HospitalLyon 69004France department of Anatomy National and Kapodistrian University of AthensAthens 11527Greece

Effective communication and collaboration among healthcare professionals are crucial for delivering high-quality patient *** miscommunication poses a significant challenge to healthcare systems,potentially undermining the quality of healthcare services *** the same manner,communication barriers between referring physicians and radiologists can specifically affect radiology services and patient *** article attempts to put the spotlight on the ever-present chronic challenges of this issue and prompt readers to recognize the relevant potential pitfalls in their daily clinical *** solutions are explored and proposed,which should be tailored to the specific needs and issues that each individual institution may face.

关键词： Radiology Miscommunication Collaboration Barriers Solutions Patient care Healthcare services Referring physician Challenges Medical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Double cholecystectomy in case of accessory gallbladder:Not as easy as two cholecystectomies

引用

Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 93-95页

作者： Benjamin Darnis Kayvan Mohkam Fran?ois Cauchy Jean-Yves Mabrut department of General Surgery and Liver Transplantation Hospices Civils de Lyon Croix-Rousse University Hospital Ecole Doctorale EDISS 205 Université Lyon 1 HPB Surgery and Liver Transplantation Unit Beaujon Hospital

To the Editor:Accessory gallbladders(AG)are rare and their management are usually *** variations are related with an abnormal division of the bile ducts precursors between the 5th and the 12th week of *** et al.[1]proposed an anatomical classification of these variations based on the embryologic abnormalities *** type 1 both gallbladders are connected to the common bile duct at the same *** type 2 the AG can reach either the common bile duct(ductular type)or an intrahepatic biliary duct(trabecular type).In type 3,three gallbladders are present.

关键词： gallbladders Harlaftis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Refractory intraocular hypertension after dexamethasone-implant intravitreal injection treated with Preserflo MicroShunt implantation

引用

International Journal of Ophthalmology(English edition) 2023年第4期16卷 656-658页

作者： Lucas Sejournet Amina Rezkallah Olivier Loria laurent Kodjikian Thibaud Mathis Philippe denis department of Ophthalmology Hôpital de la Croix-RousseHospices Civils de LyonLyon 69361France laboratoire UMR-CNR 5510 Matéis UniversitéLyon 1Villeurbane 69100France

dear Editor,Herein,we report a case of a patient who presented with refractory ocular hypertension(OHT)after a dexamethasone implant(deX-I)*** pressure(IOP)was finally managed after Preserflo Micro Shunt implantation,... 详细信息

关键词： injection hypertension after

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multiple evanescent white dot syndrome relapse following BNT162b2 mRNA COVID-19 vaccination

引用

国际眼科杂志:英文版 2023年第10期16卷 1724-1726页

作者： Lucas Sejournet laurent Kodjikian Amina Rezkallah Philippe denis Thibaud Mathis Olivier Loria department of Ophthalmology Hôpital de la Croix-RousseHospices Civils de LyonLyon F-69004France 2Laboratoire UMR-CNR 5510 MatéisUniversitéLyon 1Villeurbane 69100France

dear Editor,We report a case of multiple evanescent white dot syndrome(MEWDS)relapse following mRNA corona virus disease 2019(COVID-19)*** is a choroidal inflammatory disease belonging to the group of“white dot syndromes”group,with an excellent prognosis[1].MEWDS is usually idiopathic,but there have been reports of MEWDS following viral infection or vaccination[1-2].

关键词： vaccination relapse white

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combination therapy for advanced hepatocellular carcinoma:do we see the light at the end of the tunnel?

引用

Hepatobiliary Surgery and Nutrition 2021年第2期10卷 180-192页

作者： Ti Zhang Philippe Merle Huaqi Wang Haitao Zhao Masatoshi Kudo department of Hepatic Surgery Fudan University Shanghai Cancer CenterShanghai Medical CollegeFudan UniversityShanghaiChina department of Hepatology Hôpital de la Croix-RousseHospices Civils de LyonUniversitéLyon 1103 Grande rue de la Croix RousseLyonFrance department of Hepatobiliary Surgery Tianjin Medical University Cancer Institute and HospitalTianjinChina department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical College(CAMS&PUMC)BeijingChina department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka-SayamaJapan

Importance:Combination therapies of anti-PD-1 and anti-angiogenesis regimens are emerging rapidly and exhibit more promising anti-tumor efficacy for advanced hepatocellular carcinoma(HCC),and consistently it is the hotspot in clinical ***:To elaborate several issues which are warranted further consideration as more regimens are being investigated in combination *** Review:We searched PubMed,MEDLINE,Cochrane Library and Google Scholar by 2021 February for publications on combination therapies for ***:Several clinical issues are worth reconsidering,such as the evaluation on appropriate primary endpoints in phase III clinical trials as for different practical problems,the translation of surrogate endpoint objective response rate(ORR)benefits into overall survival(OS)benefits,and whether conversion surgery contributes to initial expectations of long-term survival or *** concepts in novel immunotherapy and targeted therapy in combination with loco-regional therapies may improve overall survival for *** and Relevance for Reviews:Comprehensive understanding of the mechanism of immunotherapy and targeted therapy contributes to better prognosis of advanced HCC and more explorative combination therapies are needed.

关键词： Hepatocellular carcinoma(HCC) angiogenesis immunotherapy combination therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

XEN gel stent: a total delayed-onset postoperative hyphema

引用

International Journal of Ophthalmology(English edition) 2019年第7期12卷 1224-1226页

作者： Amina Rezkallah Thibaud Mathis Philippe denis laurent Kodjikian department of Ophthalmology Croix-Rousse University Hospital University of Lyon Lyon 69004 France UMR-CNRS 5510 Mateis University of Medicine Lyon1 Lyon 69008France

dear Editor,Minimally invasive glaucoma surgery (MIGS) is a lessinvasive surgical alternative to filtering surgery for reducing intraocular pressure (IOP). This technique has been shown to offer long-term outcomes equivalent to filtering surgery[1]. The XEN gel implant (Allergan Inc., CA, USA) is one of MIGS procedures. This implant consists of a 6-mm tube of collagen-derived gelatin cross-linked with glutaraldehyde, preloaded in an injector.

关键词： Minimally invasive glaucoma surgery(MIGS) lessinvasive surgical alternative reducing intraocular pressure(IOP)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recurrent hyphema after trabeculectomy: an atypical case of Swan syndrome

引用

International Journal of Ophthalmology(English edition) 2021年第10期14卷 1633-1635页

作者： Pierre Leroux Amina Rezkallah laurent Kodjikian Olivier Loria Thibaud Mathis Philippe denis department of Ophthalmology Croix-Rousse University HospitalHospices Civils de LyonUniversity of LyonLyon 69004France University of Lyon 1 UMR-CNRS 5510 MatéisVilleurbanne 69100France Stem Cell and Brain Research Institute INSERM U1208Bron 69500France

dear Editor,Trabeculectomy is the gold standard surgery for treatment of glaucoma. Early complications include wound leaks, responsible for ocular hypotony and serous choroidal detachment, and bleb fibrosis. Postoperative hyphema is also a well-known complication, most frequently induced by iris bleeding from the peripheral iridotomy. In most cases, bleeding occurs in the first months after surgery.

关键词： bleeding surgery wound

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：