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The existence of saturated vapors in the deep source region of 2017Pohang earthquake evidenced from seismic tomography

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Earth and Planetary Physics 2024年第5期8卷 811-821页

作者： JiaWei Qian HaiJiang Zhang Lei Guo Uzonna Okenna Anyiam Changsoo Cho Kang Hyeun Ji HaoRan Ma School of Carbon Neutrality Science and Engineering Anhui University of Science and Technology college of Oceanography Hohai University Laboratory of Seismology and Physics of Earth's Interior School of Earth and Space Sciences University of Science and Technology of China Hebei Earthquake Agency Geological and Environmental Science Hope College Earthquake Research Center Korea Institute of Geoscience and Mineral Resources

Geothermal resources are a promising approach to clean renewable energy; 90% of them are deep reservoirs of hot dry rock that require hydraulic fracturing to create a network of connections among wells to enable efficient heat exchange, known as an Enhanced Geothermal System（EGS）. The Pohang EGS project in south Korea led to a devasting Mw5.5 earthquake, triggered by the reservoir's EGS stimulation, the largest earthquake known to have been induced by EGS development. Detailed investigations have been conducted to understand the cause of the Pohang earthquake; the conclusion has been that overpressurized injected fluids migrated into an unknown fault triggering this large earthquake. Detailed velocity images for the source zone of the 2017 Pohang earthquake,which could be helpful for further understanding its inducing mechanism, are unavailable. However, we have assembled detailed aftershock data recorded by 41 local stations installed within about three months after the Mw5.5 Pohang earthquake, and have then applied the Vp/Vsmodel's consistency-constrained double-difference seismic tomography method to determine the high-resolution three-dimensional Vp（compressional wave velocity）, Vs（shear wave velocity）, and Vp/Vsmodels of the source region that we report here,as well as earthquake locations within the source region. The velocity images reveal that the deep source area of the 2017 Pohang earthquake is dominated by low Vp, high Vs, and low Vp/Vsanomalies, a pattern that can be caused by overpressurized vapors due to high temperatures at these depths. Based on aftershock locations and velocity features, our studies support the conclusion that the 2017Pohang earthquake was triggered by injected EGS fluids that migrated into a blind fault.

关键词： Pohang earthquake tomoDDMC low Vp/Vs saturated vapors EGS

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Exploration of the Evolution of Teacher Roles and Professional Development Needs Among University English Instructors

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Journal of Contemporary Educational Research 2024年第5期8卷 207-211页

作者： Yuanyuan Zhou Southwest Jiaotong University hope college Chengdu 610400Sichuan ProvinceChina

The role of university English instructors has evolved significantly over the years,encompassing various *** paper explores the evolution of the role of university English instructors and examines the current challenges and opportunities they face in today’s educational *** delves into the multifaceted nature of their responsibilities and discusses the importance of continuous professional development to meet the evolving needs of students and the demands of the profession.

关键词： Teacher roles Professional development University English instructors

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Research on Chinese-English Translation of Enterprise Publicity Materials from the Perspective of Adaptation Theory

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Journal of Contemporary Educational Research 2024年第5期8卷 177-181页

作者： Dehui Zeng Southwest Jiaotong University hope college Chengdu 610400Sichuan ProvinceChina

As the process of economic globalization continues to advance,China has undergone earth-shaking ***-quality products and promotional materials are crucial for Chinese companies to go global and build their *** English translation of external promotional materials is ***,some companies do not pay enough attention to their publicity,resulting in a low international *** paper analyzes the Chinese-English translation of enterprise external publicity materials from the perspective of adaptation theory,thereby exploring the translation strategies adopted under the guidance of adaptation theory,hoping to provide some references for related translation practices in the future.

关键词： Adaptation theory Enterprise publicity materials Translation strategy

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Substitutions of stem-loop subdomains in internal ribosome entry site of Senecavirus A:Impacts on rescue of sequence-modifying viruses

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Journal of Integrative Agriculture 2024年第7期23卷 2391-2406页

作者： Qianqian Wang Jie Wang Lei Zhang Xiaoxiao Duan Lijie Zhu Youming Zhang Yan Li Fuxiao Liu college of Veterinary Medicine Qingdao Agricultural UniversityQingdao 266109China college of Veterinary Medicine Inner Mongolia Agricultural UniversityHuhhot 010018China Shandong New hope Liuhe Group Co. Ltd.Qingdao 266100China Qingdao Center for Animal Disease Control&Prevention Qingdao 266199China State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China

Senecavirus A(SVA)has a positive-sense,single-stranded RNA *** 5´untranslated region harbors an internal ribosome entry site(IRES),comprising 10 larger or smaller stem-loop structures(including a pseudoknot)that have been demonstrated to be well ***,it is still unclear whether each stem-loop subdomain,such as a single stem or loop,is also highly *** clarify this issue in the present study,a set of 29 SVA cDNA clones were constructed by site-directed mutagenesis(SDM)on the *** SDM-modified scenarios included:(1)stem-formed complementary sequences exchanging with each other;(2)loop transversion;(3)loop transition;and(4)point *** cDNA clones were separately transfected into cells for rescuing viable viruses,whereas only four SVAs of interest could be recovered,and were genetically stable during 20 *** progeny grew significantly slower than the other three *** dual-luciferase reporter assay showed that none of the SDM-modified IRESes significantly inhibited the IRES *** previous study indicated that a single motif from any of the ten stem structures,if completely mutated,would cause the failure of virus ***,our present study revealed three stem structures,whose individual complementary sequences could exchange with each other to rescue sequence-modifying ***,one apical loop was demonstrated to have the ability to tolerate its own full-length transition,also having no impact on the recovery of sequence-modifying *** present study suggested that not every stem-loop structure was strictly conserved in its conformation,while the full-length IRES itself was well *** provides a new research direction on interaction between the IRES and many factors.

关键词： SVA HCV IRES HCV-like IRES stem-loop structure cDNA clone virus rescue mutation

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Insights into the mechanism of L-malic acid on drip loss of chicken meat under commercial conditions

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1312-1324页

作者： Haijun Sun Xue Yan Lu Wang Ruimin Zhu Meixia Chen Jingdong Yin Xin Zhang State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China New hope Liuhe Co. Ltd./Key Laboratory of Feed and Livestock and Poultry Products Quality&Safety ControlMinistry of AgricultureChengduSichuan 610023China Institute of Animal Husbandry and Veterinary Medicine Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China

Background A deterioration in the meat quality of broilers has attracted much more attention in recent years.L-malic acid(MA)is evidenced to decrease meat drip loss in broilers,but the underlying molecular mechanisms are still ***’s also not sure whether the outputs obtained under experimental conditions can be obtained in a com-mercial ***,we investigated the effects and mechanisms of dietary MA supplementation on chicken meat drip loss at large-scale *** Results showed that the growth performance and drip loss were improved by MA *** metabolome revealed that L-2-aminoadipic acid,β-aminoisobutyric acid,eicosapentaenoic acid,and nicotinamide,as well as amino acid metabolism pathways connected to the improvements of meat quality by MA *** transcriptome analysis further indicated that the effect of MA on drip loss was also related to the proper immune response,evidenced by the enhanced B cell receptor signaling pathway,NF-κB signaling pathway,TNF signaling pathway,and IL-17 signaling *** We provided evidence that MA decreased chicken meat drip loss under commercial *** and transcriptome revealed a comprehensive understanding of the underlying ***,MA could be used as a promising dietary supplement for enhancing the water-holding capacity of chicken meat.

关键词： Drip loss Immune response L-malic acid Meat quality Metabolome Transcriptome

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Internal m^(6)A and m^(7)G RNA modifications in hematopoietic system and acute myeloid leukemia

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Chinese Medical Journal 2024年第9期137卷 1033-1043页

作者： Xiaoxu Zhang Yanni Ma Jia Yu Rui Su Xiaoshuang Wang State Key Laboratory of Common Mechanism Research for Major Diseases State Key Laboratory for ComplexSevereand Rare DiseasesInstitute of Basic Medical SciencesChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijing 100005China Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA The Institute of Blood Transfusion Chinese Academy of Medical Sciences/Peking Union Medical CollegeChengduSichuan 610052China Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical SciencesBeijing 100005China Department of Biochemistry and Molecular Biology Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China

Epitranscriptomics focuses on the RNA-modification-mediated post-transcriptional regulation of gene *** past decade has witnessed tremendous progress in our understanding of the landscapes and biological functions of RNA modifications,as prompted by the emergence of potent analytical *** hematopoietic system provides a lifelong supply of blood cells,and gene expression is tightly controlled during the differentiation of hematopoietic stem cells(HSCs).The dysregulation of gene expression during hematopoiesis may lead to severe disorders,including acute myeloid leukemia(AML).Emerging evidence supports the involvement of the mRNA modification system in normal hematopoiesis and AML pathogenesis,which has led to the development of small-molecule inhibitors that target N6-methyladenosine(m^(6)A)modification machinery as ***,we summarize the latest findings and our most up-to-date information on the roles of m^(6)A and N7-methylguanine in both physiological and pathological conditions in the hematopoietic ***,we will discuss the therapeutic potential and limitations of cancer treatments targeting m^(6)A.

关键词： N6-methyladenosine N7-methylguanine Hematopoiesis Acute myeloid leukemia Therapeutic target RNA modifications

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Retinol is involved in the intestinal regeneration and strengthens the intestinal barrier during refeeding in broiler chickens

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Journal of Integrative Agriculture 2024年第11期 3843-3859页

作者： Youli Wang Huajin Zhou Jing Chen Yuqin Wu Yuming Guo Bo Wang Jianmin Yuan Key Laboratory of Qinghai Tibetan Plateau Animal Genetic Resource Reservation and Utilization Ministry of Education/Key Laboratory of Sichuan Province for Qinghai Tibetan Plateau Animal Genetic Resource Reservation and Exploitation College of Animal Science and Veterinary Medicine Southwest Minzu University State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Sichuan New hope Liuhe Technology Innovation Co.Ltd.

Fasting is typically used before feeding metabolizable energy assessment in broilers. Previous studies have shown that fasting cause atrophy of the intestinal villus. Whether fasting affects intestinal permeability during refeeding by altering barrier function and nutrient absorption is of concern. Here, 23-d-old broilers were randomly assigned to 5 treatments, fasted for 0, 12, 24, 36, and 48 h, respectively, and then refed for 2 d, to study the impact of different duration of fasting on the intestinal regeneration and barrier function during refeeding. Results showed that the intestinal morphology in fasted birds was recovered in 2 d of refeeding at most. As fasting durations increased,enterocytes per intestinal villus were linearly and quadratically increased(both P<0.05), whereas goblet cells per intestinal villus was linearly decreased(both P<0.05). Besides, the mRNA level of lysozyme was linearly decreased as fasting durations increased during refeeding(both P<0.05), while quadratically increased mucin 2 was observed only after 1 d of refeeding(P<0.05). Linear increase effects were observed for claudin 2 and zonula occludens-1with increased fasting durations after 1 d of refeeding(all P<0.05), and linear and quadratical effects were observed for claudin 2 at 2 d of refeeding(both P<0.05). Besides, we found that intestinal permeability to creatinine, 4 and 70 kD dextran were linearly and quadratically decreased with increased fasting durations at 6 h and 1 d of refeeding(all P<0.05). Furthermore, jejunum proteomic from birds refed for 6 h showed that birds fasted for 36 h showed increased antimicrobial peptides and upregulated retinol metabolism when compared to the nonfasted birds(P<0.05).Further study showed that retinyl ester catabolism was inhibited during fasting and enhanced during *** of intestinal organoid culture showed that retinol benefits the cell proliferation and enterocyte *** conclusion, the intestinal permeability t

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Dietary lycopene mitigates nonalcoholic steatohepatitis by regulating Nrf2/PPARα-dependent ferroptosis

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Food Science and Human Wellness 2024年

作者： Xunyu Song Daotong Li Jun Sun Xiaoying Zhang Li-Shu Wang Fang Chen college of Food Science and Nutritional Engineering， National Engineering Research Centre for Fruit and Vegetable Processing， Key Laboratory of Fruits and Vegetables Processing， Ministry of Agriculture Engineering Research Centre for Fruits and Vegetables Processing， Ministry of Education， China Agricultural University Department of Hematology and Hematopoietic Cell Transplantation Comprehensive Cancer Center， City of hope National Medical Center

The global burden of non-alcoholic steatohepatitis (NASH) is on the rise. Researchers recognize inhibiting ferroptosis， a form of cell death leading to iron-dependent oxidative damage， as a promising therapy for treating NASH. Lycopene， a natural antioxidant compound， exhibits various pharmacological properties. However， the anti-NASH efficacy of the dietary recommended concentration of lycopene and the role of lycopene in combating ferroptosis in NASH have remained unclear. Our study investigated lycopene’s impact on ferroptosis in various diet-induced mouse NASH models and corresponding cellular models， unveiling its anti-inflammatory and anti-fibrotic effects. Our findings demonstrated that lycopene notably reduced ferroptosis in MCD (methionine- and choline-deficient diet)-fed mice and a normal mouse hepatocyte cell line (NCTC1469) by restoring balanced ferrous iron levels， lipid reactive oxygen species， and normal mitochondrial morphology. These effects were linked to the regulation of ferroptosis markers GPX4 and PTGS2. Additionally， lycopene’s anti-ferroptosis action was validated in mice fed a high-fat， high-cholesterol diet and HepG2 cells treated with free fatty acid. Our transcriptomic analysis highlighted PPARα as a primary target of lycopene， crucial for activating the glutathione system because GW6471， a PPARα antagonist， blocked lycopene-induced GPX4 activation. Furthermore， Nrf2 played a crucial role in lycopene’s impact on iron metabolism-related proteins (FTH1 and TFR1). Notably， when inhibiting PPARα or Nrf2 in MCD-fed mice by GW6471 or ML385， lycopene’s protective effects against ferroptosis and NASH progression diminished. These findings underscore the crucial role of PPARα-mediated glutathione system activation and Nrf2-mediated iron metabolism modulation in lycopene's anti-ferroptosis effects.

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Impact of Low-temperature Storage on Volatile Flavor Compounds in Prepared Pork Products

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Agricultural Biotechnology 2024年第4期13卷 70-75,81页

作者： Xiulian WANG Jiamin ZHANG Ting BAI Wei WANG Kaihong YANG Lili JI college of Food and Bioengineering Chengdu UniversityChengdu 610106China Meat Processing Key Laboratory of Sichuan Province Chengdu UniversityChengdu 610106China Chengdu hope Food Co. Ltd.Chengdu 610000China

[Objectives]This study was conducted to explore the dynamic changes of volatile flavor compounds in prepared pork during storage at different low-temperature conditions.[Methods]Prepared pork was stored at 4,-4 and-18℃.The volatile flavor compounds of prepared pork were determined by solid-phase microextraction-gas chromatography-mass spectrometry(SPME-GC-MS)at days 0,7,14,21 and 28,and relative odor activity value(OAV),principal component analysis(PCA)and cluster analysis(CA)were combined to analyze changes in volatile flavor compounds of prepared pork during storage.[Results]The total number of volatile flavor compounds gradually decreased with the prolongation of the storage period,and OAV analysis identified 22 key flavor compounds(OAV≥1).The results of PCA and CA showed that 2-methyl-1-butanol,1-octen-3-ol,linalool,cineole,hexanal and nonanal were the main key flavor components,and the degree of flavor degradation was low under both superchilling and freezing *** 28 days of storage,the alcohol content in the chilling group was significantly higher than other two groups,and the overall content of volatile flavor compounds was also significantly higher than other two groups,indicating that the-4℃chilling storage was more favorable for maintaining the overall flavor of prepared pork.[Conclusions]This study provides a theoretical basis for finding a better storage method for prepared meat products.

关键词： Low-temperature storage Prepared pork Volatile flavor component Principal component analysis Cluster analysis

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SciCN:A Scientific Dataset for Chinese Named Entity Recognition

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Computers, Materials & Continua 2024年第3期78卷 4303-4315页

作者： Jing Yang Bin Ji Shasha Li Jun Ma Jie Yu college of Computer National University of Defense TechnologyChangsha410073China

Named entity recognition(NER)is a fundamental task of information extraction(IE),and it has attracted considerable research attention in recent *** abundant annotated English NER datasets have significantly promoted the NER research in the English *** contrast,much fewer efforts are made to the Chinese NER research,especially in the scientific domain,due to the scarcity of Chinese NER *** alleviate this problem,we present aChinese scientificNER dataset–SciCN,which contains entity annotations of titles and abstracts derived from 3,500 scientific *** manually annotate a total of 62,059 entities,and these entities are classified into six *** to English scientific NER datasets,SciCN has a larger scale and is more diverse,for it not only contains more paper abstracts but these abstracts are derived from more research *** investigate the properties of SciCN and provide baselines for future research,we adapt a number of previous state-of-theart Chinese NER models to evaluate *** results show that SciCN is more challenging than other Chinese NER *** addition,previous studies have proven the effectiveness of using lexicons to enhance Chinese NER *** by this fact,we provide a scientific domain-specific *** results demonstrate that our lexicon delivers better performance gains than lexicons of other *** hope that the SciCN dataset and the lexicon will enable us to benchmark the NER task regarding the Chinese scientific domain and make progress for future *** dataset and lexicon are available at:https://***/yangjingla/***.

关键词： Named entity recognition dataset scientific information extraction lexicon

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