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Chinese Journal of Chemical Engineering 2024年第2期66卷 263-272页

作者： Kai Ge Yiping Huang Yuanhui Ji Jiangsu Province hi-tech Key Laboratory for Biomedical research School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China

The high throughput prediction of the thermodynamic phase behavior of active pharmaceutical ingredients(APIs)with pharmaceutically relevant excipients remains a major scientific challenge in the screening of pharmaceutical *** this work,a developed machine-learning model efficiently predicts the solubility of APIs in polymers by learning the phase equilibrium principle and using a few molecular *** the few-shot learning framework,thermodynamic theory(perturbed-chain statistical associating fluid theory)was used for data augmentation,and computational chemistry was applied for molecular descriptors'*** results showed that the developed machine-learning model can predict the API-polymer phase diagram accurately,broaden the solubility data of APIs in polymers,and reproduce the relationship between API solubility and the interaction mechanisms between API and polymer successfully,which provided efficient guidance for the development of pharmaceutical formulations.

关键词： Multi-task machine learning Density functional theory Hydrogen bond interaction Miscibility Solubility

Cell signaling mechanisms and metabolic regulation of germination and dormancy in barley seeds

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The Crop Journal 2017年第6期5卷 459-477页

作者： Zhenguo Ma Natalia V.Bykova Abir U.Igamberdiev Department of Biology Memorial University of Newfoundland Pacific Forestry centre Natural Resources Canada Morden research and development centre Agriculture and Agri-Food Canada

During germination of barley(Hordeum vulgare L.) seeds, important morphological and physiological changes take place, including development of organs and tissues and activation of metabolic pathways. Germination and dormancy of seeds are regulated by abscisic acid, gibberellins, reactive oxygen species(ROS), reactive nitrogen species(RNS)and several other factors. Activities of ascorbate-glutathione cycle enzymes, responsible for scavenging ROS, strongly increase. Catalase and superoxide dismutase activities, also scavenging ROS, decrease at the onset of seed germination and then increase. With the increase in aerobic metabolism after radicle protrusion, the activities of the fermentation enzymes lactate and alcohol dehydrogenase decline rapidly. The RNS-scavenging activity of S-nitrosoglutathione reductase decreases in the course of seed germination, in concert with elevation of nitric oxide production and protein nitrosylation. This activity supports the role of RNS in regulating seed germination. Transcription of various genes at different phases of seed germination exhibits phase-specific changes. During imbibition, genes involved in cell wall metabolism are highly expressed; in the middle phase of seed germination before radicle protrusion, genes involved in amino acid synthesis, protein synthesis, and transport and nucleic acid synthesis are upregulated significantly, and after radicle protrusion, genes involved in photosynthetic metabolism are induced. In summary, signal transduction and metabolic regulation of seed germination involve diverse reactions and complex regulation at different levels of metabolic organization.

关键词： Seed germination Reactive oxygen species Reactive nitrogen species Signal transduction Gene expression

Association mapping of quantitative trait loci for yield-related agronomic traits in rice(Oryza sativa L.)

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Journal of Integrative Agriculture 2016年第10期15卷 2192-2202页

作者： XU Fei-fei JIN Liang HUANG Yan TONG Chuan CHEN Ya-ling BAO Jin-song Institute of Nuclear Agricultural Sciences Zhejiang University research & development centre of Flower Zhejiang Academy of Agricultural Sciences

high yield in rice mainly depends on large grain weight, ideal plant architecture and proper flowering time adapting to various geographic regions. To help achieve higher yield, phenotype variations of heading date（HD）, plant architecture and grain shape in a panel of 416 rice accessions were investigated in this study. A total of 143 markers including 100 simple sequence repeat（SSR） markers and 43 gene-tagged markers were employed in association mapping to detect quantitative trait loci（QTL） responsible for these variations. Among the 7 subpopulations, POP5 in japonica group showed the largest values of HD and grain width（GW）, but the smallest values of grain length（GL） and grain length to width ratio（GLW）. Among the six indica groups, POP7 had the largest values of HD, GL, GLW, and 1 000-grain weight（TGW）. A total of 27 QTLs were detected underlying these phenotypic variations in single year, while 12 of them could be detected in 2006 and 2007. GS3 marker was closely associated with GL, GW and GLW, and widely distributed in different groups. The starch synthesis related gene markers, SSI, SSIIa, SBE1, AGPL4, and ISA1, were linked to plant height（PH）, panicle length（PL）, flag leaf length（FLL）, GW, and GLW. The SSR markers, RM267, RM340 and RM346, were linked to at least two traits. Therefore, these new markers will probably be used to improve rice grain yield or plant architecture when performing marker-assisted selection of proper alleles.

关键词： yield plant architecture heading date association mapping marker-assisted selection

Effect of Si,Cu and Fe on mechanical properties of cast semi-solid 206 alloys

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Transactions of Nonferrous Metals Society of China 2010年第9期20卷 1555-1560页

作者： A.LEMIEUX J.LANGLAIS D.BOUCHARD X.GRANT CHEN Rio Tinto Alcan Arvida Research and Development Centre Rio Tinto Alcan Laterrière Works NRC-Aluminium technology centre Université du Québec à Chicoutimi

The development of a modified 206 alloy whose composition was optimized to minimize hot tearing during semi-solid forming was reported. The effect of varying silicon, copper and iron contents was investigated using a design of experiment (DOE) approach. Semi-solid slurries were prepared using the SEED process and injected into a high pressure die casting press. The hot tearing sensitivity results were reported for different alloy variants. The microstructure evolution during the semi-solid preparation was presented along with actual die cast components. The effects of silicon, copper and iron on mechanical properties in the T7 condition were also analyzed. Beyond the benefit of reducing hot tearing, it is shown that the tensile and fatigue properties remain compatible with the automotive industry requirements.

关键词： semi-solid forming 206 aluminum alloy SEED process hot tearing mechanical properties

Removal of copper from molybdenite concentrate by mesophilic and extreme thermophilic microorganisms

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International Journal of Mining Science and technology 2013年第6期23卷 827-834页

作者： Abdollahi Hadi Manafi Zahra Shafaei Sied Ziaedin Noaparast Mohammad Manafi Moorkani Navid School of Mining College of EngineeringUniversity of Tehran Sarcheshmeh Copper Complex Research and Development Centre

Mixed mesophilic and extreme thermophilic bioleaching were evaluated to remove copper from the molybdenite *** tests were carried out in shake flasks and in a 50-L *** shake flask tests were performed with different inoculum size,solids density,*** temperature in order to identify optimum *** highest amount of copper elimination,75%was obtained with extreme thermophilic microorganisms(at 12%inoculation,10%solids,65℃and a pH of 1.5).The highest copper elimination by mesophilic microorganisms was 55%(at 12%inoculation,5%solids,30℃at pH 2).The optimum conditions in shake flask tests were applied to 7 days batch tests in a50-L *** thermophilic experiment gave the best copper elimination of 60%(at 12%inoculation,10%solids,65℃and pH 1.5).Mesophilic test removed 50%of the copper(at 12%inoculation,10%solids,35℃at pH 2).

关键词： Bioleaching Molybdenite concentrate Copper removal Mesophilic and extreme thermophilic microorganisms

Proteomics analysis of Trichoplusia ni midgut epithelial cell brush border membrane vesicles

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Insect Science 2019年第3期26卷 424-440页

作者： Muhammad Afzal Javed Cathy Coutu David A. Theilmann Martin A. Erlandson Dwayne D. Hegedus Saskatoon research and development centre Agriculture and Agri-Food Canada Saskatoon Saskatchewan Canada Summerland research and development centre Agriculture and Agri-Food Canada Summerland British Columbia Canada Department of Food & Bio-Product Sciences University of Saskatchewan Saskatoon Saskatchewan Canada

The insect midgut epithelium is composed of columnar, goblet, and regenerative cells. Columnar epithelial cells are the most abundant and have membrane protrusions that form the brush border membrane (BBM) on their apical side. These increase surface area available for the transport of nutrients, but also provide opportunities for interaction with xenobiotics such as pathogens, toxins and host plant allelochemicals. Recent improvements in proteomic and bioinfbrmatics tools provided an opportunity to determine the proteome of the T. ni BBM in unprecedented detail. This study reports the identification of proteins from BBM vesicles (BBMVs) using single dimension polyacrylamide gel elec? trophoresis coupled with multi-dimensional protein identification technology. More than 3000 proteins were associated with the BBMV of which 697 were predicted to possess either a signal peptide, at least one transmembrane domain or a GPI-anchor signal. Of these, bioinfbrmatics analysis and manual curation predicted that 185 may be associated with the BBMV or epithelial cell plasma membrane. These are discussed with respect to their predicted functions, namely digestion, nutrient uptake, cell signaling, development, cell-cell interactions, and other functions. We believe this to be the most detailed proteomic analysis of the lepidopteran midgut epithelium membrane to date, which will provide information to better understand the biochemical, physiological and pathological processes taking place in the larval midgut.

关键词： brush border membrane vesicles midgut proteomic analysis Trichoplusiani

Microjet flow control in an ultra-compact serpentine inlet

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Chinese Journal of Aeronautics 2015年第5期28卷 1381-1390页

作者： Da Xingya Fan Zhaolin Fan Jianchao Zeng Liquan Rui Wei Zhou Run State Key Laboratory of Aerodynamics China Aerodynamics Research and Development Center high Speed Aerodynamics Institute China Aerodynamics Research and Development Center China Aerodynamics research and development Center

Microjets are used to control the internal flow to improve the performance of an ultra-compact serpentine inlet. A highly offset serpentine inlet with length-to-diameter ratio of 2.5 is designed and static tests are conducted to analyze the internal flow characteristics in terms of pressure recovery, distortion and flow separation. Flow separation is encountered in the second S-turn, and two strong counter-rotating vortices are formed at the aerodynamic interthce plane （AIP） face which occupy a quarter of the outlet area and result in severe pressure loss and distortion. A flow control model employing a row of microjets in the second turn is designed based on the internal flow characteristics and simplified CFD simulations. Flow control tests are conducted to verify the control effectiveness and understand the characteristics as a function of inlet throat Mach number, injection mass flow ratio, jet Mach number and momentum coefficient. At all test Mach numbers, microjet flow control （MFC） effectively improves the recovery and reduces the distortion intensity. Between inlet throat Mach number 0.2 and 0.5, the strong flow separation in the second S-turn is suppressed at an optimum jet flow ratio of less than 0.65%, resulting in a maximum improvement of 4% for pressure recovery coefficient and a maximum decrease of 75% for circumferential distortion intensity at cruise. However, in order to suppress the flow separation, the injection rate should retain in an effective range. When the injection rate is higher than this range, the flow is degraded and the distortion contour is changed from 90° circumferential distortion pattern to 180° circumferential distortion pattern. Detailed data analysis shows that this optimum flow ratio depends on inlet throat Mach number and the monlcntunl coefficient affects the control effectiveness in a dual stepping manner.

关键词： Active flow control Distortion intensity:Micro jet Pressure recovery Serpentine inlet

Studies and Properties of Ceramics with high Thermal Conductivity

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Journal of Rare Earths 2006年第Z1期24卷 189-192页

作者： Chen Guangle Fan Shigang Zhao Chunxia Wang Kun Xia Shuqin research Institute of Synthetic Crystals Research and Development Center Beijing 100018 China Research Institute of Synthetic Crystals Research and Development Center Beijing 100018 China Research Institute of Synthetic Crystals Research and Development Center Beijing 100018 China Research Institute of Synthetic Crystals Research and Development Center Beijing 100018 China Research Institute of Synthetic Crystals Research and Development Center Beijing 100018 China

The sintering technology of the AlN ceramics power were discussed. It is discussed that the compound sintering aids is consistent with the enhancement of the the thermal conductivity of AlN ceramics, and sintering technics is helped to the improvement of density. It is analyzed how to sinter machinable AlN ceramics with high thermal conductivity. And the microstructure of compound ceramics based on AlN was studied.

关键词： sintering aids hot-pressed high thermal conductivity machinable composite ceramics

Matching traditional Chinese medicine and western medicine-based research:Advanced nutraceutical development for proactive gastric cancer prevention

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3798-3819页

作者： Matteo Micucci Bian-Zhao Xiang Chen-Min Ting hiu-Yee Kwan Michele Mari Michele Retini Sabrina Burattini Riham Osman Udodinma Jude Okeke Fuad Othman Abdullah Federico Gianfanti Michela Battistelli Department of Biomolecular Sciences University of Urbino Carlo BoUrbino 61029Italy Hong Kong Chinese Medicine Clinical Study centre Chinese EQUATOR CentreSchool of Chinese MedicineChinese Clinical Trial Registry(Hong Kong)Hong Kong Baptist UniversityHong Kong 999077China centre for Chinese Herbal Medicine Drug development Hong Kong Baptist UniversityHong Kong 999077China centre for Cancer and Inflammation research School of Chinese MedicineHong Kong Baptist UniversityHong Kong 999077China Department of Chemistry College of ScienceSalahaddin University-ErbilErbil 44001Iraq Department of Pharmacognosy Faculty PharmacyTishk International UniversityErbil 44001Iraq Institute of Oncology research Bellinzona CH6500Switzerland Universitàdella Svizzera Italiana Lugano CH6900Switzerland

Gastric cancer(GC),the third leading cause of cancer-related death globally,is complex and *** review explores multidisciplinary investigations of traditional Chinese medicine(TCM)combined with Western medical practices,emphasizing the development of nutraceuticals for cancer *** advanced analytical chemistry and food chemistry techniques,this study investigated how TCM components may be optimized for nutraceutical *** on molecular interactions with GC pathways,particularly the NF-κB,PI3K/Akt,and Wnt/β-catenin pathways,we examined the effects of TCM polyherbal formulas,extracts,and isolated *** agents modulate apoptosis and cellular proliferation,underscoring their potential in preventive *** convergence of nutraceutical and medicine food homology studies highlights a significant shift towards integrating TCM-derived compounds in a preventive health *** approach aims not only to enhance efficacy and reduce side effects but also to champion a preventive paradigm using personalized medicine to advance proactive health maintenance and disease *** combination of TCM and western medical practices offers promising avenues for future research and practical applications in GC prevention.

关键词： Traditional Chinese medicine Precision medicine Molecular network Phytochemistry Food chemistry Nutraceuticals Gastric cancer

Production systems and important antimicrobial resistant-pathogenic bacteria in poultry:a review

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Journal of Animal Science and Biotechnology 2023年第2期14卷 481-500页

作者： Philip H.W.Mak Muhammad Attiq Rehman Elijah G.Kiarie Edward Topp Moussa S.Diarra Guelph research and development centre Agriculture and Agri-Food Canada(AAFC)GuelphONCanada Department of Animal Biosciences University of GuelphGuelphONCanada London research and development Center AAFCLondonONCanada.

Economic losses and market constraints caused by bacterial diseases such as colibacillosis due to avian pathogenic Escherichia coli and necrotic enteritis due to Clostridium perfringens remain major problems for poultry producers,despite substantial efforts in prevention and *** have been used not only for the treatment and prevention of such diseases,but also for growth ***,these practices have been linked to the selection and spread of antimicrobial resistant bacteria which constitute a significant global threat to humans,ani-mals,and the *** break down the antimicrobial resistance(AMR),poultry producers are restricting the antimicrobial use(AMU)while adopting the antibiotic-free(ABF)and organic production practices to satisfy consum-ers’***,it is not well understood how ABF and organic poultry production practices influence AMR profiles in the poultry gut *** Gram-negative(Salmonella enterica serovars,Campylobacter jejuni/coli,***)and Gram-positive(Enterococcus spp.,Staphylococcus *** ***)bacteria harboring multiple AMR determinants have been reported in poultry including organically-and ABF-raised *** this review,we discussed major poultry production systems(conventional,ABF and organic)and their impacts on AMR in some potential pathogenic Gram-negative and Gram-positive bacteria which could allow identifying issues and opportuni-ties to develop efficient and safe production practices in controlling pathogens.

关键词： Antibiotic-free Antimicrobial resistance Conventional feeding Organic Poultry