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Chinese Journal of Natural Medicines 2024年第5期22卷 455-465页

作者： YANG Yao TONG Jing XIE Xianshun CAO Hong FU Yong LUO Yong LIU Shan CHEN Wen YANG Ning hengyang medical school University of South ChinaHengyang 421200China Emergency Department Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China hengyang medical school The Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Hemato-oncology Department Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Department of Breast and Thyroid Surgery Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China

In this study,we reported the discovery and structure-activity relationship analysis of chrysin derivatives as a new class of inhibitors targeting poly(ADP-ribose)polymerase 1(PARP1).Among these derivatives,compound 5d emerged as the most effective chrysin-based inhibitor of PARP1,with an IC50 value of 108 nmol·L^(-1).This compound significantly inhibited the proliferation and migration of breast cancer cell lines HCC-1937 and MDA-MB-436 by inducing DNA ***,5d induced apoptosis and caused an extended G1/S-phase in these cell *** docking studies revealed that 5d possesses a strong binding affinity toward *** vivo,in a xenograft model,5d effectively reduced tumor growth by downregulating PARP1 ***,compound 5d shows promise as a potential therapeutic agent for the treatment of BRCA wild-type breast cancer.

关键词： Chrysin derivatives PARP1 Antitumor DNA damage Small molecules

Amide naphthotubes:Biomimetic macrocycles for selective molecular recognition

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Chinese Chemical Letters 2024年第4期35卷 124-131页

作者： Cheng-Da Zhao Huan Yao Shi-Yao Li Fangfang Du Li-Li Wang Liu-Pan Yang school of Pharmaceutical Science Postdoctoral Research Station of Basic MedicineHengyang Medical SchoolUniversity of South ChinaHengyang 421001China

Selective molecular recognition in water is routine for bioreceptors,but remains challenging for synthetic *** is principally because noncovalent interactions are usually less efficient in aqueous *** mimicking the cavity feature of bioreceptors,*** Jiang proposed and clarified the concept of“endo-functionalized cavity”.Through situating polar binding sites into a deep hydrophobic cavity,we designed and synthesized several macrocyclic hosts,among which amide naphthotubes are the most *** hosts can selectively recognize various polar molecules including organic micropollutants,drug molecules,and chiral molecules in water by employing the hydrophobic effect and shielded hydrogen *** addition,these biomimetic hosts have been applied in spectroscopic analysis,adsorptive separation and *** this review,we provide an overview of recent advances on amide naphthotubes with special emphasis on the efforts of Jiang's *** are convinced that these biomimetic macrocycles will make further contributions to supramolecular chemistry and beyond.

关键词： Molecular recognition Supramolecular chemistry Amide naphthotube Endo-functionalized cavity Biomimetic macrocycle

Photochemical synthesis and group transfer reactions of azoxy compounds

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Chinese Chemical Letters 2024年第8期35卷 1-2页

作者： Mei Peng Wei-Min He school of Pharmaceutical Science Hengyang Medical SchoolUniversity of South ChinaHengyang 421001China

Azoxy compounds are extensively utilized in various fields,including dyes,polymerization *** high nitrogen and oxygen content make them ideal for use as energy storage materials[1-4].Additionally,azoxy functional groups are found in various natural *** 1949,chemists successfully isolated natural congener of azoxy compounds from cycads,marking a significant ***,azoxy compounds were also discovered in mushrooms,sponges,and soil-dwelling bacteria,showing promising pharmaceutical activity,including antimicrobial,antifungal or antibacterial agents(Scheme 1)[5].

关键词： compounds synthesis sponge

Cytokine Storm:The Novel Mechanism for Sleep Deprivation-induced Multiple Organ Dysfunction Syndrome

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Neuroscience Bulletin 2024年第7期40卷 1031-1033页

作者： Liwen Wang Huimei Liu Li Qin Lanfang Li Institute of Pharmacy and Pharmacology University of South ChinaHengyang 421001China hengyang medical school University of South ChinaHengyang 421001China

It is well known that sleep is one of the inevitable activities of daily living and it is one of the most important factors contributing to human *** in mammals is a cyclic occurrence of two distinct states,rapid eye ... 详细信息

关键词： NREM Sleep movement

High glucose promotes macrophage M1 polarization through miR-32/Mef2d/cAMP signaling pathway

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Genes & Diseases 2024年第2期11卷 539-541页

作者： Cong Chen Jingsong Cao Yan Gao Xiaoping Xie Zhibo Zhao Qing Yuan Yuqi He Xuyu Zu Jianghua Liu The First Affiliated Hospital Institute of Endocrinology and MetabolismCenter for Clinical Research in DiabetesHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China The First Affiliated Hospital Department of Laboratory MedicineHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China The First Affiliated Hospital Institute of OncologyHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China

Chronic inflammation is a crucial inducerof diabetesvascular *** is that high glucose easily induces macrophage activation.1 Macrophages are the principal participants in innate immunity and exist in all human *** pathological vascular,infiltrated macrophages secrete inflammatory factors leading to an increase in plaque stability.?In macrophage polarization,autophagy plays an important *** of macrophage autophagy could induce macrophage polarization from the M1 phenotype to M2 phenotype and inhibit inflammatory reactions.3 Our previous research found that high glucose condition promotes miR-32 expression and macrophage M1 polarization,4 but the mechanism of miR-32 promoting macrophage M1 polarization is *** this study,we found that,under a high-glucose condition,miR-32/Mef2d/cAMP signaling promoted M1 macrophage polarization via inhibited *** results provide a theoretical and experimental basis for the prevention and treatment of T2D vascular inflammation.

关键词： macrophage miR prevention

M^(6)A modification in cardiovascular disease:With a focus on programmed cell death

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Genes & Diseases 2024年第5期11卷 272-284页

作者： Wen Li Yao Liu Ruiyan Xu Yuan Zong Lu He Jun Hu Guohua Li Institute of Cardiovascular Disease Key Laboratory for Arteriosclerology of Hunan ProvinceHunan International Scientific and Technological Cooperation Base of Arteriosclerotic DiseaseDepartment of PathophysiologyMOE Key Lab of Rare Pediatric DiseasesHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular Medicine The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Obstetrics and Gynecology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular Surgery The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China

N^(6)-methyladenosine(m^(6)A)methylation is one of the most predominant internal RNA modifications in eukaryotes and has become a hot spot in the field of epigenetics in recent *** diseases(CVDs)are a leading cause of death *** evidence demonstrates that RNA modifications,such as the m^(6)A modification,are associated with the development and progression of many diseases,including *** increasing body of studies has indicated that programmed cell death(PCD)plays a vital role in ***,the molecular mechanisms underlying m^(6)A modification and PCD in CVDs remain poorly ***,elaborating on the highly complex connections between the m^(6)A mechanisms and different PCD signaling pathways and clarifying the exact molecular mechanism of m^(6)A modification mediating PCD have significant meaning in developing new strategies for the prevention and therapy of *** is great potential for clinical application.

关键词： Apoptosis Autophagy Cardiovascular diseases Ferroptosis N^(6)-methyladenosine Programmed cell death Pyroptosis

Assessing the current situation and the influencing factors affecting perceived stigma among older patients after leukemia diagnosis

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World Journal of Psychiatry 2024年第6期14卷 812-821页

作者： Xuan Tang Shuang-Qin Chen Jiang-Hua Huang Cai-Feng Deng Jie-Qiong Zou Juan Zuo Department of Neurology Hengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina Department of Hematology Hengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Psychological problems are becoming increasingly prominent among older patients with leukemia,with patients potentially facing stigmatization after ***,there is limited research on the stigma experienced by these patients and the factors that may contribute to *** To investigate the stigma faced by older patients after being diagnosed with leukemia and to analyze the potential influencing *** A retrospective analysis was conducted using clinical data obtained from questionnaire surveys,interviews,and the medical records of older patients with leukemia admitted to the hengyang medical school from June 2020 to June *** data obtained included participants’basic demographic information,medical history,leukemia type,family history of leukemia,average monthly family income,pension,and tendency to conceal *** Chinese versions of the Social Impact Scale(SIS),Perceived Social Support Scale(PSSS),Self-Rating Anxiety Scale(SAS),and Self-Rating Depression Scale(SDS)were used to assess indicators related to stigma,social support,and mental health *** used Pearson’s correlation coefficient to analyze the strength and direction of the relationship between the scores of each scale,and regression analysis to explore the factors related to the stigma of older patients with leukemia after *** Data from 120 patients with leukemia aged 65-80 years were *** total score on the SIS and PSSS was 43.60±4.07 and 37.06±2.87,*** SAS score was 58.35±8.32 and the SDS score was 60.58±*** stigma experienced by older leukemia patients was negatively correlated with social support(r=-0.691,P<0.05)and positively correlated with anxiety and depression(r=0.506,0.382,P<0.05).Age,education level,smoking status,average monthly family income,pension,and tendency to conceal illness were significantly associated with the participants’level of stigma(P<0.05).Age,smoking status,social support,anxiety,and depressi

关键词： Senile leukemia Stigma Social support Anxiety Depression Influencing factors

3-Methyladenine potentiates paclitaxel-induced apoptosis and phosphorylation of cyclin-dependent kinase 1 at thr161 in nasopharyngeal carcinoma cell

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BIOCELL 2024年第5期48卷 861-872页

作者： XIAOQI WU YECHUAN HE YEQIN YUAN XIAN TAN LIN ZHU DANLING WANG BINYUAN JIANG hengyang medical school University of South ChinaHengyang421001China Institute for Future Sciences University of South ChinaChangsha410008China medical Research Center The Affiliated Changsha Central HospitalHengyang Medical SchoolUniversity of South ChinaChangsha410004China Department of Clinical Laboratory The Affiliated Changsha Central HospitalHengyang Medical SchoolUniversity of South ChinaChangsha410004China

Background:Nasopharyngeal carcinoma(NPC)exhibits a significant prevalence in the southern regions of China,and paclitaxel(PTX)is frequently employed as a medication for managing advanced ***,drug resistance is typically accompanied by a poor *** the synergistic potential of combining multiple chemotherapeutic agents may represent a promising avenue for optimizing treatment ***:This study investigated whether 3-Methyladenine(3-MA)could potentiated the effect of PTX and its potential molecular *** were divided into the following categories:Negative control(NC)with the solvent dimethyl sulfoxide(DMSO,0.5%v/v),PTX(400 nM),3-MA(4 mM),and PTX(400 nM)+3-MA(4 mM).The viability of NPC cells was assessed using both the cell counting kit-8(CCK-8)assay and the colony formation *** observation was performed to identify morphological cell *** cytometry was used to assess cell cycle status,mitochondrial membrane potential(MMP),and apoptotic *** blotting was conducted to quantify the protein ***:3-MA enhanced PTX-specific inhibition of NPC cell ***,either alone or in combination with 3-MA,caused cell cycle halt at the G2/M phase in the majority of NPC cells,and the combination treatment of PTX with 3-MA induced a higher rate of NPC cell death compared to PTX *** blotting results revealed the combination of PTX with 3-MA heightened activation of cyclin-dependent kinase 1(CDK1),a key molecule in shifting cells from mitotic arrest to apoptosis,led to a reduction in Myeloid Cell Leukemia 1(MCL-1)expression and an increase in Poly(ADP-ribose)polymerase(PARP)***:The concurrent administration of PTX with 3-MA effectively enhances PTX’s inhibitory impact on NPC and activates the apoptosis signal regulated by CDK1.

关键词： Nasopharyngeal carcinoma Paclitaxel 3-Methyladenine Cell cycle Apoptosis

Ultra-highly selective recognition of nucleosides over nucleotides by rational modification of tetralactam macrocycle and its application in enzyme assay

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Chinese Chemical Letters 2024年第6期35卷 274-278页

作者： Huan Yao Jian Qin Yan-Fang Wang Song-Meng Wang Liu-Huan Yi Shi-Yao Li Fangfang Du Liu-Pan Yang Li-Li Wang school of Pharmaceutical Science Postdoctoral Research Station of Basic MedicineHengyang Medical SchoolUniversity of South ChinaHengyang 421001China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

Artificial macrocycle with high binding selectivity in water is often challenging but urgently needed in various research and application ***,we report a new water-soluble biomimetic tetralactam macrocycle and realize the ultra-high selectivity to nucleosides over corresponding monophosphate nucleotides by rational *** introduction of charged groups at the periphery of endofunctionalized cavity makes the selectivity(guanosine to guanosine 5-monophosphate)increase remarkably from 100 to *** on the ultra-high selectivity of biomimetic tetralactam macrocycle,the sensitive CD73 enzyme activity assay was then achieved through product-selective fluorescence indicator displacement ***,the capability of the proposed method for inhibitor screening was successfully displayed.

关键词： Rational modification Biomimetic macrocycle Ultra-high selectivity Enzyme assay

Moving doubly heavy baryon in a strongly coupled plasma via holography

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Chinese Physics C 2024年第8期48卷 42-55页

作者： Xuan Liu Jia-Jie Jiang Xun Chen Mitsutoshi Fujita Akira Watanabe school of Nuclear Science and Technology University of South ChinaHengyang 421001China school of Mathematics and Physics University of South ChinaHengyang 421001China

Gauge/gravity duality is used to study the properties of the doubly heavy baryon(QQq)at finite rapidity and temperature in heavy-ion *** investigate the impact of rapidity on string breaking and screening of QQq and compare these effects with the results for QQ¯in *** reveal that the string-breaking distances of QQq and QQ¯are close in the confined state,and the effects of rapidity and temperature on the string breaking are not *** interesting result shows that QQq cannot be determined at sufficiently high temperatures and ***,QQ¯can exist under any conditions as long as the separation distance is sufficiently ***,the screening distances of QQq and QQ¯are compared at finite rapidity and *** on the above analysis,we infer that QQ¯is more stable than QQq at finite rapidity and temperature.

关键词： holographic QCD QGP heavy quark