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A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease

Neural Regeneration Research 2024年第8期19卷 1828-1834页

作者： Yongjiang Zhang Shiyi Yin Run Song Xiaoyi Lai Mengmeng Shen Jiannan Wu Junqiang Yan Key Laboratory of Neuromolecular Biology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Endoplasmic reticulum stress and mitochondrial dysfunction play important roles in Parkinson s disease,but the regulato ry mechanism remains ***-2(PHB2)is a newly discove red autophagy receptor in the mitochondrial inner membrane,and its role in Parkinson’s disease remains *** kinase R(PKR)-like endoplasmic reticulum kinase(PERK)is a factor that regulates cell fate during endoplasmic reticulum *** is regulated by PERK and is a target of the unfolded protein *** is unclear whether PERK regulates PHB2-mediated mitophagy thro ugh *** this study,we established a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mouse model of Parkinson’s *** used adeno-associated virus to knockdown PHB2 *** res ults showed that loss of dopaminergic neurons and motor deficits were aggravated in the MPTP-induced mouse model of Parkinson’s *** rexpression of PHB2 inhibited these *** also established a 1-methyl-4-phenylpyridine(MPP+)-induced SH-SY5Y cell model of Parkinson’s *** found that ove rexpression of Parkin increased co-localization of PHB2 and microtubule-associated protein 1 light chain 3,and promoted *** addition,MPP+regulated Parkin involvement in PHB2-mediated mitophagy through phosphorylation of *** findings suggest that PHB2 participates in the development of Parkinson’s disease by intera cting with endoplasmic reticulum stress and Parkin.

关键词： endoplasmic reticulum dopaminergic neuron microtubule-associated protein 1 light chain 3 mitophagy oxidative stress Parkin Parkinson’s disease PKR-like endoplasmic reticulum kinase reactive oxygen species prohibitin-2

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Comparison of white-light endoscopy,optical-enhanced and aceticacid magnifying endoscopy for detecting gastric intestinal metaplasia:A randomized trial

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World Journal of Clinical Cases 2021年第16期9卷 3895-3907页

作者： Ying-Hao Song Li-Dong Xu Meng-Xuan Xing Kun-Kun Li Xing-Guo Xiao Yong Zhang Lu Li Yan-Jing Xiao Yu-Lei Qu Hui-Li Wu Xinxiang Medical University Xinxiang 453000Henan ProvinceChina Department of Gastroenterology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina Department of Pathology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina Department of Gastroenterology People's Hospital of Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina

BACKGROUND Gastric intestinal metaplasia(GIM)is a precancerous lesion of the stomach,which severely affects human life and ***,a variety of endoscopic techniques are used to screen/evaluate *** white-light endoscopy(WLE)and acetic-acid chromoendoscopy combined with magnifying endoscopy(MEAAC)are the interventions of choice due to their diagnostic efficacy for ***-enhanced magnifying endoscopy(ME-OE)is a new virtual chromoendoscopy technique to identify GIM,which combines bandwidth-limited light and image enhancement processing technology to enhance the detection of mucosal and vascular *** hypothesized that ME-OE is superior to WLE and MEAAC in the evaluation of *** To directly compare the diagnostic value of WLE,ME-AAC,and ME-OE for detection of *** A total of 156 patients were subjected to consecutive upper gastrointestinal endoscopy examinations using WLE,ME-AAC,and *** findings were utilized as the reference ***,sensitivity,specificity,and positive and negative predictive values of the three endoscopy methods in the diagnosis of GIM were ***,the time to diagnosis with MEAAC and ME-OE was *** experts and two non-experts evaluated the GIM images diagnosed using ME-OE,and diagnostic accuracy and intra-and inter-observer agreement were *** GIM was detected in 68 of 156 patients(43.6%).The accuracy of ME-OE was highest(91.7%),followed by ME-AAC(86.5%),while that of WLE(51.9%)was ***-site analysis showed that the overall diagnostic accuracy of ME-OE was higher than that of ME-AAC(P=0.011)and WLE(P<0.001).The average diagnosis time was lower in ME-OE than in ME-AAC(64±7 s vs 151±30 s,P<0.001).Finally,the inter-observer agreement was strong for both experts(k=0.862)and non-experts(k=0.800).The internal consistency was strong for experts(k=0.713,k=0.724)and moderate for non-experts(k=0.667,k=0.598).CONCLUSION For endoscopists,especially experi

关键词： Magnifying endoscopy Optical-enhanced Acetic-acid Gastric intestinal metaplasia

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Potential regulatory effects of stem cell exosomes on inflammatory response in ischemic stroke treatment

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World Journal of Stem Cells 2023年第6期15卷 561-573页

作者： Na Chen Yan-Lin Wang Hui-Fang Sun Zhuo-Ya Wang Qi Zhang Fei-Yan Fan Yu-Cheng Ma Fei-Xiang Liu Yun-Ke Zhang First School of Clinical Medicine Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Neurology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina School of Rehabilitation Medicine Henan University of Chinese MedicineZhengzhou 450008Henan ProvinceChina

The high incidence and disability rates of stroke pose a heavy burden on *** is a significant pathological reaction that occurs after an ischemic ***,therapeutic methods,except for intravenous thrombolysis and vascular thrombectomy,have limited time *** stem cells(MSCs)can migrate,differentiate,and inhibit inflammatory immune ***(Exos),which are secretory vesicles,have the characteristics of the cells from which they are derived,making them attractive targets for research in recent ***-derived exosomes can attenuate the inflammatory response caused by cerebral stroke by modulating damage-associated molecular *** this review,research on the inflammatory response mechanisms associated with Exos therapy after an ischemic injury is discussed to provide a new approach to clinical treatment.

关键词： Mesenchymal stem cell-derived exosome MicroRNA Inflammation Ischemic stroke Adipose-derived stem cell Toll-like receptor

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Banking of perinatal mesenchymal stem/stromal cells for stem cellbased personalized medicine over lifetime:Matters arising

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World Journal of Stem Cells 2023年第4期15卷 105-119页

作者： Cheng-Hai Li Jing Zhao Hong-Yan Zhang Bin Wang Stem Cell Program of Clinical Research Center People’s Hospital of Zhengzhou University and Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Clinical Laboratory People’s Hospital of Zhengzhou University and Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Pharmacy Fuwai Central China Cardiovascular HospitalZhengzhou 450000Henan ProvinceChina Department of Neurosurgery People’s Hospital of Zhengzhou University and Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina

Mesenchymal stromal/stem cells(MSCs)are currently applied in regenerative medicine and tissue *** clinical studies have indicated that MSCs from different tissue sources can provide therapeutic benefits for *** derived from either human adult or perinatal tissues have their own unique advantages in their medical ***,clinical studies are conducted by using of cultured MSCs after thawing or short-term cryopreserved-then-thawed MSCs prior to administration for the treatment of a wide range of diseases and medical ***,cryogenically banking perinatal MSCs for potential personalized medicine for later use in lifetime has raised growing interest in China as well as in many other ***,this has led to questions regarding the availability,stability,consistency,multipotency,and therapeutic efficiency of the potential perinatal MSC-derived therapeutic products after longterm *** opinion review does not minimize any therapeutic benefit of perinatal MSCs in many diseases after short-term *** article mainly describes what is known about banking perinatal MSCs in China and,importantly,it is to recognize the limitation and uncertainty of the perinatal MSCs stored in cryobanks for stem cell medical treatments in whole *** article also provides several recommendations for banking of perinatal MSCs for potentially future personalized medicine,albeit it is impossible to anticipate whether the donor will benefit from banked MSCs during her/his lifetime.

关键词： Mesenchymal stromal/stem cells Adult mesenchymal stromal/stem cells Perinatal mesenchymal stromal/stem cells Perinatal tissue Stem cell bank Personalized medicine

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Repressing iron overload ameliorates central poststroke pain via the Hdac2-Kv1.2 axis in a rat model of hemorrhagic stroke

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Neural Regeneration Research 2024年第12期19卷 2708-2722页

作者： He Fang Mengjie Li Jingchen Yang Shunping Ma Li Zhang Hongqi Yang Qiongyan Tang Jing Cao Weimin Yang Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Nutrition The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurology Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Human Anatomy School of Basic Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Neuroscience Research Institute Zhengzhou University Academy of Medical SciencesZhengzhouHenan ProvinceChina

Thalamic hemorrhage can lead to the development of central post-stroke *** in histone acetylation levels,which are regulated by histone deacetylases,affect the excitability of neurons surrounding the hemorrhagic ***,the regulato ry mechanism of histone deacetylases in central post-stroke pain remains unclea ***,we show that iron overload leads to an increase in histone deacetylase 2expression in damaged ventral posterolateral nucleus *** this increase restored histone H3 acetylation in the Kcna2 promoter region of the voltage-dependent potassium(Kv)channel subunit gene in a rat model of central post-stroke pain,thereby increasing Kcna2expression and relieving central ***,in the absence of nerve injury,increasing histone deacetylase 2 expression decreased Kcna2expression,decreased Kv current,increased the excitability of neurons in the ventral posterolateral nucleus area,and led to neuropathic pain ***,treatment with the iron chelator deferiprone effectively reduced iron overload in the ventral posterolateral nucleus after intracerebral hemorrhage,reversed histone deacetylase 2 upregulation and Kv1.2 downregulation,and alleviated mechanical hypersensitivity in central post-stroke pain *** results suggest that histone deacetylase 2 upregulation and Kv1.2 downregulation,mediated by iron overload,are important factors in central post-stroke pain pathogenesis and co uld se rve as new to rgets for central poststroke pain treatment.

关键词： central post-stroke pain hemorrhagic stroke histone deacetylase iron overload voltage-gated potassium ion channel 1.2

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Electroacupuncture improves learning and memory functions in a rat cerebral ischemia/reperfusion injury model through PI3K/Akt signaling pathway activation

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Neural Regeneration Research 2021年第6期16卷 1011-1016页

作者： Hui-Ling Wang Fei-Lai Liu Rui-Qing Li Ming-Yue Wan Jie-Ying Li Jing Shi Ming-Li Wu Jun-Hua Chen Wei-Juan Sun Hong-Xia Feng Wei Zhao Jin Huang Ren-Chao Liu Wen-Xue Hao Xiao-Dong Feng Rehabilitation Center the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhouHenan ProvinceChina Department of Rehabilitation Medicine Fujian University of Chinese MedicineFuzhouFujian ProvinceChina Department of Rehabilitation Medicine Henan University of Chinese MedicineZhengzhouHenan ProvinceChina

Electroacupuncture has been widely used to treat cognitive impairment after cerebral ischemia,but the underlying mechanism has not yet been fully *** have shown that autophagy plays an important role in the formation and development of cognitive impairment,and the phosphoinositide 3-kinase(PI3K)/Akt signaling pathway plays an important role in autophagy *** investigate the role played by the PI3K/Akt signaling pathway in the electroacupuncture treatment of cerebral ischemia/reperfusion rat models,we first established a rat model of cerebral ischemia/reperfusion through the occlusion of the middle cerebral artery using the suture *** at 2 hours after modeling,electroacupuncture was delivered at the Shenting(GV24)and Baihui(GV20)acupoints,with a dilatational wave(1-20 Hz frequency,2 mA intensity,6 V peak voltage),for 30 minutes/day over 8 consecutive *** results showed that electroacupuncture reduced the infarct volume in a rat model of cerebral ischemia/reperfusion injury,increased the mRNA expression levels of the PI3K/Akt signaling pathwayrelated factors Beclin-1,mammalian target of rapamycin(mTOR),and PI3K,increased the protein expression levels of phosphorylated Akt,Beclin-1,PI3K,and mTOR in the ischemic cerebral cortex,and simultaneously reduced p53 mRNA and protein expression *** the Morris water maze test,the latency to find the hidden platform was significantly shortened among rats subjected to electroacupuncture stimulation compared with rats without electroacupuncture *** the spatial probe test,the number of times that a rat crossed the target quadrant was increased in rats subjected to electroacupuncture stimulation compared with rats without electroacupuncture *** stimulation applied to the Shenting(GV24)and Baihui(GV20)acupoints activated the PI3K/Akt signaling pathway and improved rat learning and memory *** study was approved by the Animal Ethics Committee

关键词： acupuncture brain central nervous system factor neurological function pathways protein stroke

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Acupuncture Treatment of Superficial Pain by Subcutaneous Needling

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Journal of Traditional Chinese Medicine 2002年第2期22卷 117-118页

作者：邬水兰朱剑文公维军毛树章 tcm hospital of Xingan County Jiangxi Province 331300 People's hospital of Daqing City Heiiongiiang Province 163317

　　Subcutaneous needling is an old art of the 'twelve needling methods' in tcm for treating arthralgia due to cold or disorders in the superficial tissues. Some cases are effectively treated as introduced below.……

关键词： Acupuncture Therapy Adult Humans Male Middle Aged Soft Tissue Injuries Tennis Elbow Tenosynovitis

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Acupuncture at Back-Shu point improves insomnia by reducing inflammation and inhibiting the ERK/NF-κB signaling pathway

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World Journal of Psychiatry 2023年第6期13卷 340-350页

作者： Ming-Ming Zhang Jing-Wei Zhao Zhi-Qiang Li Jing Shao Xi-Yan Gao Department of Pain Treatment Luoyang Orthopedic Traumatological Hospital of Henan ProvinceZhengzhou 471002Henan ProvinceChina Department of Geriatric Medicine The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina Department of Acupuncture and Moxibustion The Third Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina

BACKGROUND Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall *** medicine mainly uses sedatives and hypnotic drugs to treat insomnia,and long-term use is prone to drug resistance and other adverse *** has a good curative effect and unique advantages in the treatment of *** To explore the molecular mechanism of acupuncture at Back-Shu point for the treatment of *** We first prepared a rat model of insomnia,and then carried out acupuncture for 7 consecutive *** treatment,the sleep time and general behavior of the rats were *** Morris water maze test was used to assess the learning ability and spatial memory ability of the *** expression levels of inflammatory cytokines in serum and the hippocampus were detected by *** was used to detect the mRNA expression changes in the ERK/NF-κB signaling *** blot and immunohistochemistry were carried out to evaluate the protein expression levels of RAF-1,MEK-2,ERK1/2 and NF-κ*** Acupuncture can prolong sleep duration,and improve mental state,activity,diet volume,learning ability and spatial *** addition,acupuncture increased the release of 1L-1β,1L-6 and TNF-αin serum and the hippocampus and inhibited the mRNA and protein expression of the ERK/NF-κB signaling *** These findings suggest that acupuncture at Back-Shu point can inhibit the ERK/NF-κB signaling pathway and treat insomnia by increasing the release of inflammatory cytokines in the hippocampus.

关键词： ERK/NF-κB signaling pathway Acupuncture Insomnia Inflammation Acupuncture at Back-Shu point Traditional Chinese medicine

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Gut microbiota alteration and modulation in hepatitis B virus-related fibrosis and complications:Molecular mechanisms and therapeutic inventions

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World Journal of Gastroenterology 2022年第28期28卷 3555-3572页

作者： Yao-Guang Li Zu-Jiang Yu Ang Li Zhi-Gang Ren Department of Infectious Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Gene hospital of henan province Precision Medicine CenterThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Jinan Microecological Biomedicine Shandong Laboratory Jinan 250000Shandong ProvinceChina

Hepatitis B virus(HBV)has posed a threat to public health,mainly resulting in liver *** long-term accumulation of extracellular matrix,patients with chronic hepatitis B are at high risk of developing into liver fibrosis and cirrhosis and even life-threatening hepatic *** occurrence of complications such as spontaneous bacterial peritonitis and hepatic encephalopathy greatly increases disability and *** deeper understanding of the bidirectional interaction between the liver and the gut(gut-liver axis),there is a growing consensus that the human health closely relates to the gut *** by animal and human studies,the gut microbiota alters as the HBV-related liver fibrosis initials and progresses,characterized as the decrease of the ratio between“good”and“potentially pathogenic”*** the primary disease is controlled via antiviral treatment,the gut microbiota dysfunction tends to be ***,the recovery of gut microbiota can promote the regression of liver *** strategies targeted on gut microbiota(rifaximin,probiotics,engineered probiotics and fecal microbiota transplantation)have been applied to animal models and patients,obtaining satisfactory results.

关键词： Hepatitis B virus Gut microbiota Liver fibrosis Liver cirrhosis Hepatic encephalopathy Fecal microbiota transplantation

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Circulating copeptin level and the clinical prognosis of patients with chronic liver disease

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World Journal of Gastroenterology 2023年第31期29卷 4797-4808页

作者： Hao-Qian Tan Ming Zhao Zan Huang Yang Liu Han Li Long-Hui Ma Jun-Ying Liu Department of Gastroenterology Zhoukou Central Hospital Affiliated to Xinxiang Medical UniversityZhoukou 466000Henan ProvinceChina Department of Gastroenterology Zhoukou Central HospitalZhoukou 466000Henan ProvinceChina Department of Teaching and Research Zhoukou Central HospitalZhoukou 466000Henan ProvinceChina

BACKGROUND The relationship between copeptin and the severity of circulatory dysfunction and systemic stress response in patients with chronic liver disease(CLD)has been ***,the potential of serum copeptin levels to predict the prognosis of CLD patients remains *** To conduct a systematic review and meta-analysis to investigate the correlation between serum copeptin and transplant-free survival(TFS)in this *** To achieve the objective of the meta-analysis,PubMed,Embase,the Cochrane Library,and the Web of Science were searched to identify observational studies with longitudinal *** Cochrane Q test was utilized to assess betweenstudy heterogeneity,and the I2 statistic was ***-effects models were employed to combine the outcomes,taking into account the potential influence of *** Ten datasets including 3133 patients were *** follow-up durations were 1 to 48 mo(mean:12.5 mo).Overall,it was shown that a high level of serum copeptin was associated with a poor TFS[risk ratio(RR):1.82,95%confidence interval:1.52-2.19,P0.05).CONCLUSION Patients with CLD who have high serum copeptin concentrations may be associated with a poor clinical prognosis.

关键词： Chronic liver disease Liver cirrhosis Copeptin Prognosis Mortality Meta-analysis

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