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Effect of matrix-nanoparticle interactions on recognition of aryldiazonium nanoparticle-imprinted matrices

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Nano Research 2019年第2期12卷 265-271页

作者： Netta Bruchiel-Spanier Linoy Dery Noam Tal Shahar Dery Elad Gross Daniel Mandler Institute of Chemistry The Hebrew University of Jerusalem Jerusalem 9190401 Israel

The selective recognition of nanoparticles (NPs) can be achieved by nanoparticle-imprinted matrices (NAIMs),where NPs are imprinted in a matrix followed by their removal to form voids that can reuptake the original *** recognition depends on supramolecular interactions between the matrix and the shell of the NPs,as well as on the geometrical suitability of the imprinted voids to accommodate the ***,gold NPs stabilized with citrate (AuNPs-cit) were preadsorbed onto a conductive surface followed by electrografting of p-aryldiazonium salts (ADS) with different functional *** thickness of the matrix was carefully controlled by altering the scan *** AuNPs-cit were removed by electrochemical *** recognition of the NAIMs was determined by the reuptake of the original AuNPs-cit by the imprinted *** found that the recognition efficiency is a function of the thickness of the NAIM layer and is sensitive to the chemical structure of the ***,a subtle change of the functional group of the p-aryldiazonium building block,which was varied from an ether to an ester,significantly affected the recognition of the NPs.

关键词： diazonium salt nanoparticles imprinting electrochemistry focused ion beam

The actuality of Lamarck: towards the bicentenary of his Philosophie Zoologique

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Integrative Zoology 2006年第1期1卷 48-52页

作者： Francis Dov POR hebrew university of jerusalem JerusalemIsrael

Lamarck,a son of the age of natural philosophy and revolutionary ideas,turned to zoology,the field in which he made his major impact,in his old *** then,the world had already shifted towards a different intellectual atmosphere and,due to this anachronism,he was snubbed and even ridiculed by the mainstream *** his basic ideas about the active role of organisms in and the progressive unraveling of evolution stubbornly survived along the academic fringes and,more importantly,among the humanistic *** developments in genetic inheritance,embryology,immunology and behavioral studies vindicate,at least in part,the 200-year-old vision of Lamarck.

关键词： Lamarck new genetics progressive evolution role of behavior

Global epigenetic changes during somatic cell reprogramming to iPS cells

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Journal of Molecular Cell Biology 2011年第6期3卷 341-350页

作者： Anna Mattout Alva Biran Eran Meshorer Department of Genetics Institute of Life SciencesThe Hebrew University of JerusalemJerusalem 91904Israel

Embryonic stem cells(ESCs)exhibit unique chromatin features,including a permissive transcriptional program and an open,decondensed chromatin *** pluripotent stem cells(iPSCs),which are very similar to ESCs,hold great promise for therapy and basic ***,the mechanisms by which reprogramming occurs and the chromatin organization that underlies the reprogramming process are largely *** we characterize and compare the epigenetic landscapes of partially and fully reprogrammed iPSCs to mouse embryonic fibroblasts(MEFs)and ESCs,which serves as a standard for *** immuno-fluorescence and biochemical fractionations,we analyzed the levels and distribution of a battery of histone modifications(H3ac,H4ac,H4K5ac,H3K9ac,H3K27ac,H3K4me3,H3K36me2,H3K9me3,H3K27me3,and gH2AX),as well as HP1a and lamin *** find that fully reprogrammed iPSCs are epigenetically identical to ESCs,and that partially reprogrammed iPSCs are closer to ***,combining both time-course reprogramming experiments and data from the partially reprogrammed iPSCs,we find that heterochromatin reorganization precedes Nanog expression and active histone ***,these data delineate the global epigenetic state of iPSCs in conjunction with their pluripotent state,and demonstrate that heterochromatin precedes euchromatin in reorganization during reprogramming.

关键词： chromatin pluripotency reprogramming iPSCs ESCs histone modifications epigenetics

Demonstration of an integrated nanophotonic chip-scale alkali vapor magnetometer using inverse design

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Light(Science & Applications) 2021年第4期10卷 562-569页

作者： Yoel Sebbag Eliran Talker Alex Naiman Yefim Barash Uriel Levy Department of Applied Physics The Center for Nanoscience and NanotechnologyThe Hebrew University of JerusalemJerusalem 91904Israel

Recently,there has been growing interest in the miniaturization and integration of atomic-based quantum *** addition to the obvious advantages brought by such integration in facilitating mass production,reducing the footprint,and reducing the cost,the flexibility offered by on-chip integration enables the development of new concepts and *** particular,recent advanced techniques based on computer-assisted optimization algorithms enable the development of newly engineered photonic structures with unconventional *** this concept further,we hereby demonstrate the design,fabrication,and experimental characterization of an integrated nanophotonic-atomic chip magnetometer based on alkali vapor with a micrometer-scale spatial resolution and a magnetic sensitivity of 700 pT/*** presented platform paves the way for future applications using integrated photonic-atomic chips,including high-spatial-resolution magnetometry,near-field vectorial imaging,magnetically induced switching,and optical isolation.

关键词： magnetometer alkali enable

Challenges and opportunities in IR nanospectroscopy measurements of energy materials

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Nano Research 2019年第9期12卷 2200-2210页

作者： Elad Gross Institute of Chemistry and Center far Nanoscience and Nanotechnology The Hebrew University of JerusalemJerusalem 91904Israel

The performance of functional materials and specifically energy-related functional materials,such as fuel cells,solar cells,batteries and catalysts depends on the their local,nanoscale ***,heterogeneities in the phase,structure and composition of these functional materials makes it difficult to directly monitor and identify the influence of local physicochemical parameters on their global *** this review we will discuss recent developments in the field of IR nanospectroscopy that enables the extraction of detailed chemical information at the nanoscale and the identification of nanoscale properties that influence the global performances of functional ***,we will discuss the ways by which infrared (IR) nanospectroscopy techniques,namely photo thermal induced resonance (PTIR) and scattering scanning near-field optical microscopy (s-SNOM),are utilized in order to identify nanoscale properties and their influence on the functionality of halide-perovskite solar cells and catalytic *** the last part of this review we will address the technical challenges and opportunities in expanding the scope of IR nanospectroscopy measurements into the field of electrochemistry-based functional materials.

关键词： infrared(IR)nanospectroscopy photo thermal in duced resonance(PTIR) scattering sea nning n ear-field optical microscopy(s-SNOM) heterogeneous catalysis perovskite solar cells

MoSe_(2)/WS_(2) heterojunction photodiode integrated with a silicon nitride waveguide for near infrared light detection with high responsivity

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Light(Science & Applications) 2023年第3期12卷 456-464页

作者： Rivka Gherabli S.R.K.C.Indukuri Roy Zektzer Christian Frydendahl Uriel Levy Department of Applied Physics The Faculty of ScienceThe Center for Nanoscience and NanotechnologyThe Hebrew University of JerusalemJerusalem91904Israel

We demonstrate experimentally the realization and the characterization of a chip-scale integrated photodetector for the near-infrared spectral regime based on the integration of a MoSe_(2)/WS_(2) heterojunction on top of a silicon nitride *** configuration achieves high responsivity of~1 A W−1 at the wavelength of 780 nm(indicating an internal gain mechanism)while suppressing the dark current to the level of~50 pA,much lower as compared to a reference sample of just MoSe_(2) without WS_(2).We have measured the power spectral density of the dark current to be as low as~1×10^(−12) A Hz−0.5,from which we extract the noise equivalent power(NEP)to be~1×10^(−12) W Hz^(−0.5).To demonstrate the usefulness of the device,we use it for the characterization of the transfer function of a microring resonator that is integrated on the same chip as the *** ability to integrate local photodetectors on a chip and to operate such devices with high performance at the near-infrared regime is expected to play a critical role in future integrated devices in the field of optical communications,quantum photonics,biochemical sensing,and more.

关键词： heterojunction waveguide resonator

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时间分辨光电离质谱

化学通报 1996年第7期 24-30页

作者：凌云 hebrew university 以色列

介绍了时间分辨光电离质谱（ＴＰＩＭＳ）以及在离子单分子解离反应动力学及能量学研究中的应用。与传统光电离质谱不同，时间分辨光电离质谱可以得出时间分辨的光电离效率曲线（ＰＩＥ），它能够克服传统动力学位移。用ＲＲＫＭ／ＱＥ... 详细信息

介绍了时间分辨光电离质谱（ＴＰＩＭＳ）以及在离子单分子解离反应动力学及能量学研究中的应用。与传统光电离质谱不同，时间分辨光电离质谱可以得出时间分辨的光电离效率曲线（ＰＩＥ），它能够克服传统动力学位移。用ＲＲＫＭ／ＱＥＴ统计理论计算模拟时间分辨的ＰＩＥ曲线，可得出分子离子分解反应的动力学参数：活化能Ｅｏ活化熵△ｓ￣（≠），以及各离子的生成热数据和分子离子的键能数据。

关键词：光电离质谱动力学位移动力学能量学 TPIMS

Longitudinal changes in cardiac function in the very elderly: the jerusalem longitudinal cohort study

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Journal of Geriatric Cardiology 2019年第11期16卷 800-805页

作者： David Leibowitz Irit Stessman-Lande Hend Sliman Jeremy M Jacobs Jochanan Stessman Dan Gilon jerusalem Institute of Aging Research Hadassah-Hebrew University Medical CenterMount-ScopusJerusalemIsrael Coronary Care Unit Hadassah–Hebrew University Medical CenterMount-ScopusJerusalemIsrael Department of Geriatrics and Rehabilitation Hadassah-Hebrew University Medical CenterMount-ScopusJerusalemIsrael

Background People over the age of 85 are a rapidly growing age group with a high incidence of congestive heart failure(CHF),in particular heart failure with preserved ejection fraction(HFp EF).The diagnosis of CHF is challenging and longitudinal data assessing cardiac structure and function are necessary to distinguish physiologic from pathologic cardiac *** objective of the study was to determine longitudinal changes in cardiac struture and function from ages 85 to 94 years using home *** Subjects were recruited from the jerusalem Longitudinal Cohort *** three members of the initial cohort(32 F,31 M)who underwent home echocardiography at age 85 were the subjects of the current study and underwent repeat home 2-D and Doppler echocardiographic assessment at age *** There were no significant longitudinal changes in left ventricular mass index(LVMI),however LV end-diastolic volume significantly decreased from 113.4±30 to 103.6±35.5 m L(P<0.02).Ejection fraction(EF)remained stable,however longitudinal systolic function significantly decreased with age from 7.9±1.8 to 6.6±1.4 cm/s2(P<0.0001).Diastolic function as assessed by increased E:e’(11.2±3.4 to 16±7.5,P<0.0001)and increased left atrial volume index(34.1±11.3 to 42.4±13.7 m L/m^2,P<0.0001)was reduced with *** This study demonstrated preserved EF with decreased longitudinal systolic function and diastolic function without significant change in LV *** in LV function in the very elderly may be independent of changes in LV geometry.

关键词： Echocardiography The elderly Ventricular function

The impact of aging on cardiac remodeling in chronic mitral regurgitation

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Journal of Geriatric Cardiology 2023年第10期20卷 748-755页

作者： David Leibowitz Donna Zwas Ronen Beeri Ronny Alcalai Israel Gotsman Heart Institute Hadassah Medical Center and Faculty of MedicineHebrew University of JerusalemJerusalemIsrael

BACKGROUND Chronic mitral regurgitation(MR)is a volume overload state that causes dilatation of the left sided cardiac *** presence of significant dilatation is considered an indication for mitral valve intervention,however,aging may affect left ventricular(LV)remodeling independently of valvular *** objective of this study was to examine age-related changes in cardiac remodeling in a broad population of patients with chronic *** Consecutive subjects that underwent echocardiography examinations recorded in the echocardiography database of a university-affiliated laboratory were *** were categorized into none/mild,moderate or severe *** purposes of analysis of differences with aging,the population was divided into groups above and below 70 years of age and standard echocardiographic measurements were compared between the *** A total of 3492 subjects with at least moderate MR(mean age:76 years,52%female)were included in the study and compared to 18,250 subjects with none or mild *** patients had significantly smaller LV end-diastolic diameters and volumes and significantly larger left atrial(LA)volumes when compared to the younger *** volume index increased in both age groups as MR severity increased,while LV end-diastolic volume increased with increasing MR only in the younger *** Cardiac remodeling in chronic MR is significantly influenced by *** based recommendations of timing of mitral valve interventions in asymptomatic MR patients,based on assessment of LA and LV remodeling,may need to take age into account.

关键词： remodeling mitral cardiac