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Enhancing rectal cancer liver metastasis prediction:Magnetic resonance imaging-based radiomics,bias mitigation,and regulatory considerations

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 318-321页

作者： Yuwei Zhang Department of Digital health Northern Medical CenterMiddletownNY 10940United States

In this article,we comment on the article by Long et al published in the recent issue of the World Journal of Gastrointestinal *** cancer patients are at risk for developing metachronous liver metastasis(MLM),yet early prediction remains challenging due to variations in tumor heterogeneity and the limitations of traditional diagnostic ***,there is an urgent need for noninvasive techniques to improve patient *** et al’s study introduces an innovative magnetic resonance imaging(MRI)-based radiomics model that integrates high-throughput imaging data with clinical variables to predict *** study employed a 7:3 split to generate training and validation *** MLM prediction model was constructed using the training set and subsequently validated on the validation set using area under the curve(AUC)and dollar-cost averaging metrics to assess performance,robustness,and *** employing advanced algorithms,the model provides a non-invasive solution to assess tumor heterogeneity for better metastasis prediction,enabling early intervention and personalized treatment ***,variations in MRI parameters,such as differences in scanning resolutions and protocols across facilities,patient heterogeneity(e.g.,age,comorbidities),and external factors like carcinoembryonic antigen levels introduce ***,confounding factors such as diagnostic staging methods and patient comorbidities require further validation and adjustment to ensure accuracy and *** evolving Food and Drug Administration regulations on machine learning models in healthcare,compliance and careful consideration of these regulatory requirements are essential to ensuring safe and effective implementation of this approach in clinical *** the future,clinicians may be able to utilize datadriven,patient-centric artificial intelligence(AI)-enhanced imaging tools integrated with clinical data,which would help improve early

关键词： Metachronous liver metastasis Radiomics Machine learning Rectal cancer Magnetic resonance imaging variability Bias mitigation Food and Drug Administration regulations Predictive modeling

Olfactory receptors in neural regeneration in the central nervous system

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Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

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Establishing and Sustaining Academic and Local health Collaborations: A Case Study of Practice-Based Teaching and Workforce Development

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health 2025年第1期17卷 23-48页

作者： Marissa Varrasso Stacey Cunnington Eva Nelson Alyson Codner Meredith Hurley Ami Mitchell Amanda Flanagan Donna McGrath Jacey Greece Department of Community health Sciences Boston University School of Public Health Boston MA USA Winthrop Department of Public health & Clinical Services Winthrop MA USA Tennessee Department of health Columbia TN USA

The pandemic highlighted significant gaps in the public health infrastructure impacted by shortages of public health workers, an undertrained workforce, and years of disinvestment. These gaps required innovative problem-solving by public health agencies (PHAs), including local health departments (LHDs), to respond to rapidly changing community conditions during and after the pandemic. Many schools and programs of public health (SPPH) worked with PHAs to mobilize public health (PH) students through practice-based teaching (PBT). Current research indicates PBT benefits all stakeholders—PHAs, students, faculty, SPPH, and ultimately the community served. However, more research is needed on the utility of PBT in addressing a community’s systemic public health issues, the extent to which the academic-community collaboration enhances a PHA’s capacity, and the impact of the pedagogy on preparing the workforce for an evolving PH landscape. This paper examines the process of a semester-long PBT course, guided by the PBT STEPS framework, which includes five steps from collaboration to implementation to evaluation of a PBT course. The collaborating PHA and its student group addressed community trauma and resilience issues during the semester. Additionally, it examines the longer-term impacts after the semester for the PHA, community, and the workforce by 1) conducting a formative evaluation to understand needs and gaps in the community;2) redesigning an intervention that merged the results of the formative evaluation with the intervention developed during the semester;and 3) securing funding and resources for intervention sustainability. Through the documentation of a post-course partnership between an LHD and faculty at a large school of public health, this case study illustrates the potential for PBT to lay the foundation for ongoing research that supports more impactful interventions for PHAs while bolstering the workforce abilities of students as future practitioners.

关键词： Academic and Community Collaborations Practice-Based Teaching Public health Training Workforce Development Curriculum Design Community Trauma COVID-19

Perceived Social Support and Symptoms of Depression and Anxiety among Chinese Adolescents:A Moderated Chain Mediation Model

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International Journal of Mental health Promotion 2025年第1期27卷 29-40页

作者： Le-Qing Jin Chen-Wei Pan Chun-Hua Zhao Dan-Lin Li Yi-Bo Wu Tian-Yang Zhang School of Public health Suzhou Medical CollegeSoochow UniversitySuzhou215123China Department of General Medicine and Big Data Center The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou215008China School of Public health Peking UniversityBeijing100191China Graduate School of Interdisciplinary Science and Engineering in health Systems Okayama UniversityOkayama700-8530Japan

Background:Although previous studies indicate that perceived social support might be associated with adolescent psychological problems,the specific mechanism has not been thoroughly *** on theoretical and empirical research on problematic Internet use(PIU)and sleep quality,this study explored whether they play a mediating role between perceived social support and symptoms of depression and anxiety among ***,we investigated whether these relationships varied by place of ***:A sample of 2115 Chinese adolescents was included,and analyzed data related to perceived social support,PIU,sleep quality,symptoms of depression and anxiety,and sociodemographic *** analysis,mediation,and moderation analysis were mainly ***:Perceived social support was negatively correlated with depressive symptoms(r=−0.22,p<0.001)and anxiety symptoms(r=−0.20,p<0.001)among *** and sleep quality played a chain mediating role in the relationship between perceived social support and symptoms of depression and anxiety in ***,the place of residence moderated the relationships between perceived social support and PIU and symptoms of depression and *** social support was a significant negative predictor of PIU and symptoms of depression and anxiety among adolescents in urban areas but not in rural ***:The findings suggest that low levels of perceived social support may lead to more PIU and poorer sleep quality,which may further increase the risk of symptoms of depression and anxiety in adolescents,especially in urban areas.

关键词： Perceived social support psychological problems problematic internet use sleep quality urban-rural difference

Potential effects of adenosine triphosphate and melatonin on oxidative and inflammatory optic nerve damage in rats caused by 5-fluorouracil

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 222-228页

作者： Ahmet Mehmet Somuncu Busra Parlak Somuncu Ahmet Duhan Ozbay Ibrahim Cicek Bahadir Suleyman Renad Mammadov Seval Bulut Tugba Bal Tastan Taha Abdulkadir Coban Halis Suleyman Aliyev Aydin Trabzon Kanuni Education and Research Hospital Health Sciences UniversityTrabzon 61250Turkiey Provincial health Directorate Ministry of Health of the Republic of TurkeyTrabzon 61040Turkiey Department of Ophthalmology Erzurum City HospitalHealth Sciences UniversityErzurum 25240Turkiey Department of Ophthalmology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkiey Department of Pharmacology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkiey Department of Histology and Embryology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkiey Department of Biochemistry Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Pharmacology Azerbaijan Medical UniversityBakuAZ1022Azerbaijan

AIM:To investigate the effects of adenosine triphosphate(ATP)and melatonin,which have antioxidant and antiinflammatory activities,on potential 5-fluorouracil(5-FU)-induced optic nerve damage in ***:Twenty-four rats were categorized into four groups of six rats:healthy(HG),5-FU(FUG),ATP+5-FU(AFU),and melatonin+5-FU(MFU).ATP(4 mg/kg)and melatonin(10 mg/kg)were administered intraperitoneally and orally,*** hour after ATP and melatonin administration,rats in the AFU,MFU,and FUG were intraperitoneally injected with 5-FU(100 mg/kg).ATP and melatonin were administered once daily for 10d.5-FU was administered at a single dose on days 1,3,and 5 of the *** 10d,the rats were euthanized and optic nerve tissues were *** nerve tissues were biochemically and histopathologically ***:ATP and melatonin treatments inhibited the increase in malondialdehyde(MDA)and interleukin-6(IL-6)levels,which were elevated in the *** treatments also prevented the decrease in total glutathione(tGSH)levels and the superoxide dismutase(SOD)and catalase(CAT)activities(P<0.001).This inhibition was higher in the ATP group than in the melatonin group(P<0.001).ATP prevented histopathological damage better than melatonin(P<0.05).CONCLUSION:ATP and melatonin have the potential to be used in alleviating 5-FU-induced optic nerve *** addition,ATP treatment shows better protective effects than melatonin.

关键词： adenosine triphosphate melatonin 5-fluorouracil optic nerve damage antioxidant antiinflammatory

Elevated CXCL1 triggers dopaminergic neuronal loss in the substantia nigra of C57BL/6J mice: Evaluation of a novel Parkinsonian mouse model

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Zoological Research 2025年第01期 225-235页

作者： Xi-Zhen Ma Guo-Rui Jia Meng-Yu Li Sheng-Han Zhang Zhao-Xin Wang Ning Song Ying-Juan Liu Jun-Xia Xie Institute of Brain Science and Disease School of Basic Medicine Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders Qingdao University College of Life Sciences and health University of Health and Rehabilitation Science

Substantial evidence points to the early onset of peripheral inflammation in the development of Parkinson's disease(PD), supporting the “body-first” hypothesis. However,there remains a notable absence of PD-specific animal models induced by inflammatory cytokines. This study introduces a novel mouse model of PD driven by the proinflammatory cytokine CXCL1, identified in our previous research. The involvement of CXCL1 in PD pathogenesis was validated using subacute and chronic MPTP-induced mouse models. Based on these findings, 2-month-old C57BL/6J mice were intravenously administered CXCL1(20 ng/kg/day) for 2 weeks(5 days per week), successfully replicating motor deficits and pathological alterations in the substantia nigra observed in the chronic MPTP *** results demonstrate the potential of CXCL1-induced inflammation as a mechanism for PD modeling. The model revealed activation of the PPAR signaling pathway in CXCL1-mediated neuronal damage by CXCL1. Linoleic acid, a PPAR-γ activator, significantly mitigated MPTPand CXCL1-induced toxicity and reduced serum CXCL1levels. In addition, the CXCL1-injected mouse model shortened the timeline for developing chronic PD mouse model to 2 weeks, offering an efficient platform for studying inflammation-driven processes in PD. The findings provide critical insights into the inflammatory mechanisms underlying PD and identify promising therapeutic targets for intervention.

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Oil Palm Particleboard: Properties and Fungi Susceptibility

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Journal of Renewable Materials 2025年第1期13卷 163-180页

作者： Nur Azreena Idris Madihah Ahmad Zairun Aisyah Humaira Alias Zawawi Ibrahim Noorshamsiana Abdul Wahab Biomass Technology unit Engineering and Processing DivisionMalaysian Palm Oil BoardNo.6Persiaran InstitusiBandar Baru BangiKajang43000Malaysia Plant Pathology&Biosecurity unit Biology Research Division Malaysian Palm Oil BoardNo.6Persiaran InstitusiBandar Baru BangiKajang43000Malaysia

The utilization of oil palm biomass in the production of high-value products has increased *** to the presence of sugars and starches in their tissues,oil palms have an exceptionally low natural resistance to fungi,making them susceptible to *** this study,the properties of particleboard made from oil palmﬁbers,namely empty fruit bunches(EFB),oil palm trunks(OPT),and oil palm fronds(OPF)ﬁbers and its poten-tial for fungal attack were *** chemical composition,spectroscopic characterization,morphological features,and elemental analysis of oil palm biomassﬁbers were identiﬁed and thoroughly *** mechan-ical properties and dimensional stability of the boards were assessed based on Japanese Industrial Standards(JIS)and American National Standards Institute(ANSI)*** density,strength,and moisture resistance of particleboard made from OPTﬁbers may vary from those made from OPF and EFB due to inherent changes in chemical composition andﬁber *** differences have an impact on the overall performance of the *** on the ANOVA and Tukey’s test results,signiﬁcant differences in elasticity properties were observed mainly between OPT and otherﬁbers,while bending strength revealed notable differences between various pairs of *** evaluation also highlighted variations in dimensional stability and water absorption ***,bending strength properties did not demonstrate any signiﬁcant *** the fungi test,fungal activity on the boards was observed over a two-week period in a controlled *** study revealed that oil palm-based particleboard exhibited susceptibility to fungal attacks,particularly from Aspergillus sp.,Trichoderma sp.,and Paecilomyces ***ﬁndings highlight the necessity for additional treatments to control or prevent fungal growth,thereby enhancing the commercial value of the particleboards.

关键词： Particleboard medium densityﬁberboard(MDF) empty fruit bunches(EFB) oil palm trunks(OPT) and oil palm fronds(OPF)

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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Removal of arsenic from water by silver nanoparticles and Fe-Ce mixed oxide supported on polymeric anion exchanger

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Journal of Environmental Sciences 2025年第5期151卷 540-549页

作者： Li Li Su-juan Yu Rong-gang Zheng Qing-cun Li Rui Liu Jing-fu Liu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Hubei Key Laboratory of Environmental and health Effects of Persistent Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China University of Chinese Academy of Sciences Beijing 100049China Department of Ecology and Resources Engineering He Tao CollegeInner Mongolia 015000China

By encapsulating nanoscale particles of goethite(α-FeO(OH)),hydrous ceric oxide(CeO_(2)·H_(2)O,HCO)and silver nanoparticles(AgNPs)in the pores of polystyrene anion exchanger D201,a novel nanocomposite FeO(OH)-HCO-Ag-D201 was prepared for the effective removal of arsenic from *** isotherm study shows that FeO(OH)-HCO-Ag-D201 has excellent adsorption performance for As(III)and As(V),with an increased adsorption capacity of As(III)to 40.12 mg/g compared to that of 22.03 mg/g by the composite adsorbent without AgNPs(FeO(OH)-HCO-D201).The adsorption kinetics data showed that the sorption rate of FeO(OH)-HCO-Ag-D201 for As(III)is less than that for As(V),and the adsorption of As(III)and As(V)were consistent with the pseudo-second-order model and the pseudofirst-order model,*** or basic conditions are favored for the adsorption of As(III/V)by FeO(OH)-*** with nitrate/chloride/bicarbonate,sulfate/silicate/phosphate showed more remarkable inhibition of arsenic removal by FeO(OH)-HCO-Ag-D201,whereas natural organic matter showed no interference to the arsenic *** As(V)adsorption involved different interactions such as electrostatic attraction and surface complexation,while the adsorption of As(III)involved the part oxidization of As(III)to As(V)and the simultaneous adsorption of As(III)and As(V).In addition to the Ce(IV)in CeO_(2)·H_(2)O acted as an oxidant,the synergistic effect ofα-FeO(OH)and AgNPs also contributed to the oxidization of As(III)to As(V).Moreover,the reusable property suggested that this FeO(OH)-HCO-Ag-D201 nanocomposite has great potential for arsenic-contaminated water purification.

关键词： FeO(OH)-HCO-Ag-D201 Arsenic removal Synergistic effect Oxidation Electrostatic attraction Surface complexation