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Neural Regeneration research 2025年第11期20卷 3217-3218页

作者： Laura Huggon Emma L.Clayton uk Dementia research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and ALS affecting upper and lower motor neurons),these two diseases are complexly *** and ALS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

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Neural Regeneration research 2025年第4期20卷 1081-1082页

作者： John Mitrofanis Jonathan Stone Michael R.Hamblin Pierre Magistretti Alim-Louis Benabid Glen Jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

A national longitudinal cohort study of factors contributing to uk medical students’mental ill-health symptoms

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General Psychiatry 2023年第2期36卷 92-105页

作者： Asta Medisauskaite Milou E W M Silkens Antonia Rich Medical School UCLLondonUK Department of health Services research and Management City University of LondonLondonUK

Background The mental health of current medical students is predictive of their mental health as future *** prevalence of anxiety,depression and burnout is high among medical students,but less is known about the occurrence of other mental ill-health symptoms,such as eating or personality disorders,and factors contributing to mental ***(1)To explore the prevalence of various mental ill-health symptoms in medical students and(2)to investigate what medical school factors and students’attitudes contribute to these mental ill-health *** Between November 2020 and May 2021,medical students from nine geographically spread medical schools in the uk participated by completing online questionnaires at two points in time,approximately 3 months *** Of the 792 participants who filled in the questionnaire at baseline,over half experienced medium to high somatic symptoms(50.8%;402)and drank alcohol at hazardous levels(62.4%;494).Adjusted longitudinal data analysis of 407 students who completed the follow-up questionnaire demonstrated that less supportive educational climates that were more competitive and less centralised around the students,lower feelings of belongingness,greater stigma towards mental ill-health and lower intentions to seek help for mental ill-health,all contributed to students’mental ill-health *** Medical students experience a high prevalence of various mental ill-health *** study suggests that medical school factors and students’attitudes towards mental ill-health are significantly associated with students’mental health.

关键词： filled doctor competitive

Investigating the impact of poverty on colonization and infection with drugresistant organisms in humans:a systematic review

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Infectious Diseases of Poverty 2018年第1期7卷 750-760页

作者： Vivian Alividza Victor Mariano Raheelah Ahmad Esmita Charani Timothy MRawson Alison HHolmes Enrique Castro-anchez NIHR health Protection research Unit in healthcare Associated Infection and Antimicrobial Resistance Imperial College LondonLondonUK health Group Management DepartmentImperial College Business SchoolExhibition RoadLondonUK

Background:Poverty increases the risk of contracting infectious diseases and therefore exposure to *** there is lacking evidence on the relationship between income and non-income dimensions of poverty and antimicrobial *** such relationship would strengthen antimicrobial stewardship ***:A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)***,Ovid,MEDLINE,EMBASE,Scopus,CINAHL,PsychINFO,EBSCO,HMIC,and Web of Science databases were searched in October *** and retrospective studies reporting on income or non-income dimensions of poverty and their influence on colonisation or infection with antimicrobial-resistant organisms were *** quality was assessed with the Integrated quality criteria for review of multiple study designs(ICROMS)***:Nineteen articles were *** and homelessness were associated with antimicrobial resistance in community and hospital *** high-income countries,low income was associated with Streptococcus pneumoniae and Acinetobacter baumannii resistance and a seven-fold higher infection *** low-income countries the findings on this relation were *** of education was linked to resistant *** and Escherichia *** papers explored the relation between water and sanitation and antimicrobial resistance in low-income ***:Despite methodological limitations,the results suggest that addressing social determinants of poverty worldwide remains a crucial yet neglected step towards preventing antimicrobial resistance.

关键词： Poverty Antimicrobial stewardship Drug resistance

COP27 climate change conference:urgent action needed for Africa and the world

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Stroke & Vascular Neurology 2023年第3期8卷 178-180页

作者： Chris Zielinski uk health Alliance on Climate Change LondonUK

Wealthy nations must step up support for Africa and vulnerable countries in addressing past,present and future impacts of climate change The 2022 report of the Intergovernmental Panel on Climate Change paints a dark picture of the future of life on earth,charac-terised by ecosystem collapse,species extinc-tion and climate hazards such as heatwaves and floods.

关键词： climate floods action

Characterising populations living close to intensive farming and composting facilities in England

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Frontiers of Environmental Science & Engineering 2021年第3期15卷 97-109页

作者： Philippa Douglas Daniela Fecht Deborah Jarvis National Heart and Lung Institute MRC Centre for Environment and HealthImperial College LondonLondonSW36LZUK Centre for Radiation Chemical and Environmental HazardsPublic Health EnglandHarwell CampusDidcotOxfordshireOX 11 ORQUK uk Small Area health Statistics Unit MRC Centre for Environment and HealthSchool of Public HealthImperial College LondonLondonW2 IPGUK

Bioaerosol exposure has been linked to adverse respiratory *** farming and composting facilities are important anthropogenic sources of *** aimed to characterise populations living close to intensive farming and composting *** also infer whether the public are becoming more concerned about anthropogenic bioaerosol emissions,using reports of air pollution related incidents attributed to *** mapped the location of 1,257 intensive farming and 310 composting facilities in England in relation to the resident population and its characteristics(sex and age),area characteristics(deprivation proxy and rural/urban classification)and school locations stratified by pre-defined distance bands from these bioaerosol *** also calculated the average number of air pollution related incidents per year per *** found that more than 16%of the population and 15%of schools are located within 4,828 m of an intensive farming facility or 4,000 m of a composting facility;few people(0.01%)live very close to these sites and tend to be older *** to composting facilities,populations are more likely to be urban and more *** number of incidents were attributed to a small proportion of facilities;population characteristics around these facilities were *** indicate that populations living near composting facilities(particularly>250 to≤4,000 m)are mostly located in ur6an areas(80188%of the population),which supports the need for more community health studies to be *** could also be used to inform risk management strategies at facilities with higher numbers of incidents.

关键词： Composting Intensive farming Bioaerosol Population characteristics Public health

Locally Enhanced Flow and Electric Fields Through a Tip Effect for Efficient Flow‑Electrode Capacitive Deionization

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Nano-Micro Letters 2025年第2期17卷 1-17页

作者： Ziquan Wang Xiangfeng Chen Yuan Zhang Jie Ma Zhiqun Lin Amor Abdelkader Maria‑Magdalena Titirici Libo Deng College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China research Center for Environmental Functional Materials College of Environmental Science and EngineeringTongji University1239 Siping RoadShanghai 200092People’s Republic of China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore Department of Engineering Faculty of Science and TechnologyBournemouth UniversityTalbot CampusFern BarrowPooleEngland BH125BBUK Institut de Chimie de Nice UniversitéCôte d’AzurUMR CNRS 727228 Av.Valrose06108 NiceFrance Department of Chemical Engineering Imperial College LondonSouth Kensington CampusExhibition RdLondon SW72AZUK

Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of ***,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current ***,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport *** effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal *** the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current ***,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current ***,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.

关键词： Flow-electrode Capacitive deionization Current collector Tip effect Desalination

Pazopanib in advanced soft tissue sarcomas

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Signal Transduction and Targeted Therapy 2019年第1期4卷 538-547页

作者： Alex T.J.Lee Robin L.Jones Paul H.Huang Division of Molecular Pathology The Institute of Cancer ResearchLondonUK Sarcoma Unit The Royal Marsden NHS Foundation TrustLondonUK Division of Clinical Studies Institute of Cancer ResearchLondonUK

Pazopanib is the first and only tyrosine kinase inhibitor currently approved for the treatment of multiple histological subtypes of soft tissue sarcoma(STS).Initially developed as a small molecule inhibitor of vascular endothelial growth factor receptors,preclinical work indicates that pazopanib exerts an anticancer effect through the inhibition of both angiogenic and oncogenic signaling *** the establishment of optimal dosing and safety profiles in early phase studies and approval for the treatment of advanced renal cell carcinoma,pazopanib was investigated in STS.A landmark phase III randomized study demonstrated improved progression-free survival with pazopanib compared to that with placebo in pretreated patients with STS of various *** efficacy of pazopanib in specific STS subtypes has been further described in real-world-based case series in both mixed and subtype-specific STS *** present,there are no clinically validated predictive biomarkers for use in selecting patients with advanced STS for pazopanib therapy,limiting the clinical effectiveness and cost-effectiveness of the *** this review,we summarize the preclinical and clinical data for pazopanib,outline the evidence base for its effect in STS and explore reported studies that have investigated putative biomarkers.

关键词： sarcoma clinical approval

Why is malaria associated with poverty? Findings from a cohort study in rural Uganda

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Infectious Diseases of Poverty 2016年第1期5卷 715-725页

作者： Lucy S.Tusting John Rek Emmanuel Arinaitwe Sarah G.Staedke Moses R.Kamya Jorge Cano Christian Bottomley Deborah Johnston Grant Dorsey Steve W.Lindsay Jo Lines Department of Disease Control London School of Hygiene&Tropical MedicineLondonUK Big data Institute Nuffield Department of MedicineUniversity of OxfordOxfordUK Infectious Diseases research Collaboration KampalaUganda Department of Clinical research London School of Hygiene and Tropical MedicineLondonUK School of Medicine Makerere University College of Health SciencesKampalaUganda MRC Tropical Epidemiology Group London School of Hygiene and Tropical MedicineLondonUK Department of Economics SOASUniversity of LondonLondonUK Department of Medicine University of CaliforniaSan FranciscoUSA School of Biological and Biomedical Sciences Durham UniversityDurhamUK

Background:Malaria control and sustainable development are linked,but implementation of‘multisectoral’intervention is restricted by a limited understanding of the causal pathways between poverty and *** investigated the relationships between socioeconomic position(SEP),potential determinants of SEP,and malaria in Nagongera,rural ***:Socioeconomic information was collected for 318 children aged six months to 10 years living in 100 households,who were followed for up to 36 *** density was recorded using monthly light trap *** prevalence was measured routinely every three months and malaria incidence determined by passive case ***,we evaluated the association between success in smallholder agriculture(the primary livelihood source)and ***,we explored socioeconomic risk factors for human biting rate(HBR),parasite prevalence and incidence of clinical malaria,and spatial clustering of socioeconomic ***,we investigated the role of selected factors in mediating the association between SEP and ***:Relative agricultural success was associated with higher *** turn,high SEP was associated with lower HBR(highest versus lowest wealth index tertile:Incidence Rate Ratio 0.71,95%confidence intervals(CI)0.54–0.93,P=0.01)and lower odds of malaria infection in children(highest versus lowest wealth index tertile:adjusted Odds Ratio 0.52,95%CI 0.35–0.78,P=0.001),but SEP was not associated with clinical malaria *** analysis suggested that part of the total effect of SEP on malaria infection risk was explained by house type(24.9%,95%CI 15.8–58.6%)and food security(18.6%,95%CI 11.6–48.3%);however,the assumptions of the mediation analysis may not have been fully ***:Housing improvements and agricultural development interventions to reduce poverty merit further investigation as multisectoral interventions against *** interdisplinary research is needed to understa

关键词： Malaria Socioeconomic Poverty Development Housing Wealth index Uganda