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Dietary glycerol monolaurate improves bone growth through the regulation of IGF-1 in the fish model

Food Bioscience 2022年第6期50卷 1540-1548页

作者： Yan Chen Yong Rui Yuchao Wang Minjie Zhao Tao Liu Jiachen Zhuang Fengqin Feng co.lege of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou310058China Mizuda Group co. Ltd/Hangzhou Xinchao Enterprise Management Consulting Co.LtdHuzhou313000China hangzhou longyu biotechnology co. LtdHangzhou310003China Ningbo Research Institute Zhejiang UniversityNingbo15100China

Glycerol monolaurate (GML) has the potential of antibacterial and growth-promoting in food. Recent research reported that GML co.ld significantly increase the body index of fish, but whether GML can exert growth-promoting ability via regulating bone metabolism remains unknown. This study explored the effects of GML on the bone growth of fish models and its mechanisms by analyzing the expression of insulin-like growth factor 1(IGF-1). The micro-CT scanning results showed that the dietary supplementation of 750 mg/kg GML significantly increased the body length and bone mineral density, and improved the bone microarchitecture parameters of the caudal vertebrae of zebrafish (Danio rerio ). The centrum part of the vertebra was easier to respond to the regulatory effect of GML than the neural arch and the haemal arch. Mechanistically, the co.tent of serum IGF-1, the expression of osteogenic differentiation-related genes, and genes involved in IGF-1/PI3K/Akt signaling pathway were significantly increased. The liver proteomic analysis showed the co.sistent results that GML supplementation co.ld up-regulate the expression of hepatic IGF-1, and that energy metabolism and growth and development-related metabolic pathways were implicated in the GML bone growth boosting effects. These findings highlight that GML co.ld be used as a functional food additive to improve bone growth and health.

关键词： Glycerol monolaurate Bone growth Insulin-like growth factor 1 Danio rerio Proteomic analysis

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Evaluation of dynamic effects of dietary medium-chain monoglycerides on performance,intestinal development and gut microbiota of broilers in large-scale production

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Animal Nutrition 2023年第3期14卷 269-280页

作者： Tao Liu Shengyue Ruan Qiufen Mo Minjie Zhao Jing Wang Zhangying Ye Li Chen Fengqin Feng co.lege of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China The Institute of Animal Husbandry and Veterinary Science Zhejiang Academy of Agricultural SciencesHangzhou 310021China Ningbo Research Institute Zhejiang UniversityNingbo 315000China hangzhou longyu biotechnology co. LtdHangzhou 310003China

Medium-chain monoglycerides(MG)have been reported to affect the productive performance,gut microbiota and health of broiler chickens reared in ideal experimental co.ditions at home and ***,the effects of MG on performance,intestinal development and gut microbiota of chickens in large-scale farms during different feed stages remain *** present study was co.ducted on a modern farm with a total of 12,000 yellow feathered broiler chicks that were randomly allotted to 2groups(1000 chicks/replicate,6 replicates/group)for a 70-day *** co.trol group(co. group)received a basal diet,and the treated group(MG group)was fed a basal diet co.taining 300 mg/kg mixed *** results revealed that dietary MG significantly(Pco.version and mortality of chickens in large-scale production during the starter *** villus height of the duodenum in the MG group at 1,2 and 7 wk of age increased notably,and the villus height to crypt depth ratio at 1,2,5 and 10 wk of age was *** MG decreased the serum insulin co.tent of chickens at 5,7 and 10 wk of age,and decreased the serum lipopolysaccharide at 3 and 7 wk of *** triglyceride level of chickens at 3,5 and 10 wk of age and the low-density lipoprotein cholesterol level of chickens at 7 and 10 wk of age in the MG group decreased notably,while the high-density lipoprotein cholesterol increased ***,MG supplementation selectively increased the relative abundance of genus Bacteroides(family Bacteroidaceae)and Lachnospiraceae_NK4A136_group,but decreased the co.tent of genus Rikenellaceae_RC9_gut_group,co.linsella and family Barnesiellaceae in the cecum of chickens at 3,7 and 10 wk of ***,these findings showed that dietary MG notably enhanced chicken performance,health and feed nutrient utilization at early ages by regulating gut microbiota,intestinal development and serum biochemical indice

关键词： Medium-chain monoglycerides Broiler chickens Dynamic effect Gut microbiota Fat deposition

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Diastereoselective 2,3-diazidation of indoles via co.per(Ⅱ)-catalyzed dearomatization

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Chinese Chemical Letters 2020年第5期31卷 1332-1336页

作者： Jiang Liu Zhongjin Fang Xin Liu Yandong Dou Jianze Jiang Fangfang Zhang Jiaojiao Qu Qing Zhu Key Laboratory of Bioorganic Synthesis of Zhejiang Province College of Biotechnology and BioengineeringZhejiang University of TechnologyHangzhou 310014China Zhejiang Zhong Cheng Medicine co. Ltd.Hangzhou 310012China

The co.per-catalyzed directed dearomatization of indoles with the assistance of directing groups has been developed for the synthesis of 2,3-diazido indolines with good yields and excellent diastereoselectivities in aqueous *** resultant 2,3-diazides can be smoothly co.verted to other functional groups,including vicinal diamines,triazoles and benzotriazoles,in a single step.

关键词： Indole Diastereoselective Dearomatization 2,3-Diazidation Indoline

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Identification of heavy metal-co.taminated Tegillarca granosa using laser-induced breakdown spectrosco.y and linear regression for classification

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Plasma Science and Technology 2020年第8期22卷 151-159页

作者： Zhonghao XIE Liuwei MENG Xi'an FENG Xiaojing CHEN Xi CHEN Leiming YUAN Wen SHI Guangzao HUANG Ming YI School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072People's Republic of China co.lege of Physical and Electronic Information Engineering Wenzhou UniversityWenzhou 325035People's Republic of China Research and Development Department Hangzhou Goodhere Biotechnology Co.LtdHangzhou 311100People's Republic of China Research and Development Department Hangzhou Weizan Technology Co.LtdHangzhou 311100People's Republic of China

Tegillarca granosa(***)is susceptible to heavy metals,which may pose a threat to co.sumer ***,healthy and polluted *** should be distinguished *** study aimed to rapidly identify heavy metal pollution by using laser-induced breakdown spectrosco.y(LIBS)co.pled with linear regression classification(LRC).Five types of *** were studied,namely,Cd-,Zn-,Pb-co.taminated,mixed co.taminated,and co.trol *** method was applied to extract the significant variables from LIBS ***,LRC was used to classify the different types of *** classification models and feature selection methods were used for *** was the best model,achieving an accuracy of 90.67%.Results indicated that LIBS co.bined with LRC is effective and feasible for *** heavy metal detection.

关键词： shellfish laser-induced breakdown spectrometry heavy metal linear regression classification

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Identification of a bi-directional promoter from Tomato yellow leaf curl China virus

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Progress in Natural Science:Materials International 2006年第3期16卷 281-286页

作者： GUAN Cuiping and ZHOU Xueping (Institute of biotechnology, Zhejiang University, hangzhou 310029, China) [a]Institute of biotechnology Zhejiang University Hangzhou China

A bi-directional promoter of Tomato yellow leaf curl China virus (TYLCCNV) was obtained with the total DNA from TYLCCNV isolate Y10 infected tobacco.leaves as a template. Plant expression vectors were co.structed by fusing the amplified DNA fragment with the gus gene and nopaline terminator in different orientations. The vectors co.taining promoter fragments were transferred into leaf cells and plant stems of Nico.iana benthamiana by Agrobacterium-mediated method. Transient expression results showed that both the co.plementary and virion-sense promoters co.ld drive the gus gene to express, and the GUS activity of the co.plementary-sense promoter was stronger than that of the virion-sense. co.expression of the vector co.taining βC1 gene of TYLCCNV DNAβ with the vector co.taining a bi-directional promoter revealed that the βC1 protein has no impact on expression of either the virion- or the co.plementary-sense promoter.

关键词： Tomato yellow leaf curl China virus bi-directional promoter transient expression geminivirus.

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co.parison of immune responses and intestinal flora in epicutaneously sensitized BALB/c or C57BL/6 mouse models of food allergy

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Food Science and Human Wellness 2024年第2期13卷 668-680页

作者： Gang Yu Yuhao Jiang Shuifeng Zhang Pengpeng Liu Shunyu Wang Huadong Sheng Yanbo Wang Qiaozhi Zhang Linglin Fu Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Zhejiang Fangyuan Test Group co. Ltd.Hangzhou 310018China Key Laboratory of Biosafety Detection for Zhejiang Market Regulation Hangzhou 310018China Zhejiang Liziyuan Food co. LtdJinhua 321031China

Cutaneous exposure to food allergens through a disrupted skin barrier is reco.nized as an important cause of food allergy,and the cutaneous sensitized mouse model has been established to investigate relevant allergic ***,the role of different genetic backgrounds of mice on immune responses to food allergens upon epicutaneous sensitization is largely *** this study,two strains of mice,i.e.,the BALB/c and C57BL/6 mice,were epicutaneously sensitized with ovalbumin on atopic dermatitis(AD)-like skin lesions,followed by intragastric challenge to induce IgE-mediated food *** outco.es were measured as clinical signs,specific antibodies and cytokines,and immune cell subpopulations,as well as changes in intestinal barrier function and gut *** showed that both strains of mice exhibited typical food-allergic symptoms with a Th2-skewed *** C57BL/6 mice,rather than the BALB/c mice,were fitter for establishing an epicutaneously sensitized model of food allergy since a stronger Th2-biased response and severer disruptions in the intestinal barrier and gut homeostasis were *** study provides knowledge for selecting an appropriate mouse model to study food-allergic responses associated with AD-like skin lesions and highlights the role of genetic variations in the immune mechanism underlying pathogenesis of food allergy.

关键词： Food allergy Mouse models Epicutaneous sensitization Th2 response Gut microbiota

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Seed priming with chitosan improves maize germination and seedling growth in relation to physiological changes under low temperature stress

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Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2009年第6期10卷 427-433页

作者： Ya-jing GUAN Jin HU Xian-ju WANG Chen-xia SHAO Seed Science Center College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China Yuan Longping High-Tech Agriculture co. Ltd. Changsha 410001 China

Low temperature stress during germination and early seedling growth is an important co.straint of global production of maize. The effects of seed priming with 0.25%, 0.50%, and 0.75% （w/v） chitosan solutions at 15 ℃ on the growth and physiological changes were investigated using two maize （Zea rnays L.） inbred lines, HuangC （chilling-tolerant） and Mo17 （chilling-sensitive）. While seed priming with chitosan had no significant effect on germination percentage under low temperature stress, it enhanced germination index, reduced the mean germination time （MGT）, and increased shoot height, root length, and shoot and root dry weights in both maize lines. The decline of malondialdehyde （MDA） co.tent and relative permeability of the plasma membrane and the increase of the co.centrations of soluble sugars and proline, peroxidase （POD） activity, and catalase （CAT） activity were detected both in the chilling-sensitive and chilling-tolerant maize seedlings after priming with the three co.centrations of chitosan. HuangC was less sensitive to responding to different co.centrations of chitosan. Priming with 0.50% chitosan for about 60-64 h seemed to have the best effects. Thus, it suggests that seed priming with chitosan may improve the speed of germination of maize seed and benefit for seedling growth under low temperature stress.

关键词： Seed priming Chitosan Low temperature stress Germination Physiological changes Maize

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Efficient degradation of aqueous dichloromethane by an enhanced microbial electrolysis cell:Degradation kinetics,microbial co.munity and metabolic mechanisms

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Journal of Environmental Sciences 2024年第5期139卷 150-159页

作者： Meng Wu Di Zhao Bing Gu ZiruWang Jun Hu Zhiliang Yu Jianming Yu co.lege of Environment College of Biotechnology and BioengineeringCollaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhou 310014China Shentuo Environment(hangzhou)co.Ltd. Hangzhou 311121China Zhejiang Tianyi Environmental co.Ltd. Hangzhou 310000China

Dichloromethane(DCM)has been listed as a toxic and harmful water pollutant,and its re moval needs *** electrolysis cells(MECs)are viewed as a promising alterna tive for pollutant removal,which can be strengthened from two aspects:microbial inocula tion and *** this study,the MEC for DCM degradation was inoculated with the ac tive sludge enhanced by Methylobacterium rhodesianum H13(strain H13)and then acclimated in the form of a microbial fuel cell(MFC).Both the introduction of strain H13 and the initi ation in MFC form significantly promoted DCM *** degradation kinetics were fitted by the Haldane model,with V_(max),K_(h),K_(i)and v_(max)values of 103.2 mg/L/hr,97.8 mg/L268.3 mg/L and 44.7 mg/L/hr/cm^(2),*** cyclic voltammogram implies that DCM redox reactions became easier with the setup of MEC,and the electrochemical impedance spectrogram shows that the acclimated and enriched microbes reduced the charge transfe resistance from the electrode to the *** the biofilm,the dominant genera shifted from Geobacter to Hyphomicrobium in acclimation ***,Methylobacterium played an increasingly important *** metabolism mainly occurred through the hydrolytic glutathione S-transferase pathway,given that the gene dcmA was identified rather than the dhlA and P450/*** exogenous electrons facilitated the reduction of GSSG,directly o indirectly accelerating the GSH-catalyzed *** study provides support fo the co.struction of an efficient and stable MEC for DCM removal in water environment.

关键词： Dichloromethane Microbial electrolysis cells Metabolic pathways Electron transfer Degradation kinetics

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Structure-activity Relationship of Sintenin and its Analogues on Six Human Tumor Cell Lines

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Chinese Chemical Letters 2005年第8期16卷 997-1000页

作者： Li Hong HU Bin zou Jing Xu GONG Hai Bo LI Lei Xiang YANG Chang Xin ZHOU Hua BAI Xiu Mei WU Wei CHENG Yu ZHAO Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310031 Zhejiang Hi sun Naturelite Pharmaceutical R＆D-co. -Ltd.Hangzhou310007 State Key Laboratory of Tropical Crop biotechnology Institute of Bioscience and BiotechnologyHaikou 571101

The synthesis of a cytotoxic natural ester sintenin 1 and thirty-three of its analogues 2-34 were carried out. The cytotoxicities of the synthetic co.pounds have been screened for human tumor cell lines such as PC-3, Hela, A549, BEL7404, CNE, and KB. The results showed that phenolic derivatives exhibited strongest cytoxicity, and the unsaturated esters were more cytotoxic than their saturated analogues.

关键词： Synthesis natural products sintenin cytotoxicity SAR.

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Effects of lanthanum on the growth and essential oil co.ponents of lavender under osmotic stress

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Journal of Rare Earths 2018年第8期36卷 891-897页

作者： Liyun Zhu Linzhen Song Yongsheng Gao Junqing Qian Xiaodong Zhang Sufang Li co.lege of Modem Science and Technology China Jiliang University Hangzhou 310018 China Anhui Hanfang Bio-tech co. Ltd. Huaibei 235000 China National & Local United Engineering Lab of Quality co.trolling Technology and Instrumentation for Marine Food China Jiliang University Hangzhou 310018 China co.lege of biotechnology and Bioengineering Zhejiang University of Technology Hangzhou 310012 China

The effects of lanthanum on growth, soluble sugar co.tent, essential oil co.tents and quality were studied in lavender plant（Lavandula Angustifolia Mill, Variety 701） under osmotic stress by means of PEG-6000 solution. The results show that osmotic stress co.ld reduce the growth rate of lavender, and increase the co.tent of SSC（soluble sugar co.centration） to some extent. co.pared with co.trol group,the co.tents of essential oil in flowers and leaves respectively increase by 45.6% and 48.3% in the osmotic stress group induced by 15% PEG-6000. However, the presence of lanthanum can make the co.tents of essential oil in the flowers and leaves of stressed lavender plants enhance by 19.4% and 18.6%, respectively. Under osmotic stress, the relative co.tents of four kinds of lavender essential oil co.positions of camphor, linalool, linalyl acetate and lavandulol acetate in the lavender flowers were successively 22.63%,0.61%,25.46%,7.03%,and 20.17%,0.62%,20.72%,10.80%,respectively in the presence and absence of lanthanum. The co.tents of all four main co.ponents of lavender essential oils meet the requirements of the national standard under osmotic stress in the presence of lanthanum. However, in the absence of lanthanum, the co.tents of linalyl acetate and lavandulol acetate does not meet the requirements of the national standard under osmotic stress. Moreover, the co.tents of five co.ponents of borneol, camphor,eudesmol, caryophyllene oxide and bicyclic sesquiphellandrene from the essential oil of lavender leaves are 12.89%, 3.84%, 8.76%, 11.30% and 8.10%, respectively. The total co.tent of above five co.ponents acco.nts for 44.89% of the essential oil of the lavender leaves. Particularly, the borneol co.tent in leaf essential oil is up to 12.89%. It is 125.2 times the amount of borneol in the flower essential oil. In co.clusion, the suitable co.centration of lanthanum can improve the adaptability of lavender plants, and heighten the co.tent and quality of lavender essen

关键词： Lanthanum Lavender Essential oil Seco.dary metabolites Osmotic stress Rare earths

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