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Oncology Research 2024年第2期32卷 421-432页

作者： SEUNG-HEE GWAK JUHYUN LEE EUNJI OH DOHYUN LEE WONSHIK HAN JONGMIN KIM KYONG-TAI KIM Department of Life Sciences Pohang University of Science and TechnologyPohang37673Korea R&D Center NovMetaPharma Co.Ltd.Pohang37668Korea Department of Surgery and Cancer Research Institute Seoul National University College of MedicineSeoul03080Korea Generative Genomics Research Center Global Green Research&Development CenterHandong Global UniversityPohang37554Korea

Genetic information is transcribed from genomic DNA to mRNA,which is then translated into threedimensional *** can undergo various post-transcriptional modifications,including RNA editing that alters mRNA sequences,ultimately affecting protein *** this study,RNA editing was identified at the 499th base(c.499)of human vaccinia-related kinase 2(VRK2).This RNA editing changes the amino acid in the catalytic domain of VRK2 from isoleucine(with adenine base)to valine(with guanine base).Isoleucine-containing VRK2 has higher kinase activity than the valine-containing VRK2,which leads to an increase in tumor cell *** we reported that VRK2 directly interacts with dystrobrevin-binding protein(dysbindin)and results in reducing its ***,we demonstrate that isoleucine-containing VRK2 decreases the level of dysbindin than valinecontaining *** interacts with cyclin D and thereby regulates its expression and *** reduction in the level of dysbindin by isoleucine-containing VRK2 further enhances the cyclin D expression,resulting in increased tumor growth and reduction in survival *** has also been observed that in patient samples,VRK2 level was elevated in breast cancer tissue compared to normal breast ***,the isoleucine form of VRK2 exhibited a greater increase in breast cancer ***,it is concluded that VRK2,especially dependent on the 167th variant amino acid,can be one of the indexes of tumor progression and proliferation.

关键词： VRK2 Kinase activity Breast cancer Tumor RNA editing Cell proliferation Cell growth

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Heterogeneous integration of 2D materials on Si charge-coupled devices as optical memory

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Science China(Information Sciences) 2024年第6期67卷 190-197页

作者： Zheng BIAN Feng TIAN Zongwen LI Xiangwei SU Tianjiao ZHANG Jialei MIAO Bin YU Yang XU Yuda ZHAO College of Integrated Circuits Hangzhou Global Scientific and Technological Innovation CentreZhejiang University

Optical memory integrates the function of optical sensing in memory devices, remarkably promoting the interconnection between sensory and memory terminals. Silicon charge-coupled photodetectors and floating gate memory have been widely used in imaging and storage technologies, respectively. However,the heterogeneous integration of the two devices requires technological innovation and complex electrical connections. In this work, we adopt a three-dimensional layer stacking method to design a novel optical memory device. On the top of Si charge-coupled photodetectors, we successively deposit two-dimensional graphene,hexagonal boron nitride, and molybdenum disulfide as a floating gate layer, a tunneling layer, and a readout layer, respectively. By applying a gate bias on lightly doped Si, a deep depletion layer is formed with a high voltage potential drop. Under dark conditions, the depletion layer cannot be filled, and the electric field across the h-BN tunnel barrier is relatively small. Under light irradiation, the deep depletion layer is gradually filled, and the h-BN tunneling layer withstands the increasing electric field, resulting in charge storage in the floating gate layer. Based on this mechanism, the device exhibits a gate voltage-dependent operation mode, including an integrated optical sensing-memory mode and an electrically driven storage mode. Under moderate gate voltage, the device can effectively detect the optical information with varied intensity and store the optical information in the floating gate, displaying optically controlled memory characteristics. Our work demonstrates a compact device structure for optical memory and displays excellent optically controlled memory performance, which can be applied in artificial vision systems.

关键词： heterogeneous integration charge-coupled device floating gate optical memory molybdenum disulfide lightly doped silicon

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Time to treat the climate and nature crisis as one indivisible global health emergency

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Stroke & Vascular Neurology 2024年第4期9卷 325-327页

作者： Chris Zielinski on behalf of the authorship group listed below Centre for global Health University of WinchesterWinchesterUK 不详

Over 200 health journals call on the United Nations(UN),political leaders and health professionals to recognise that climate change and biodiversity loss are one indivisible crisis and must be tackled together to pres... 详细信息

关键词： preserve global divisible

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The potential impact of increased whole grain consumption among Chinese adults on reducing healthcare costs and carbon footprint

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Journal of Integrative Agriculture 2024年第8期23卷 2842-2852页

作者： Xin Zhang Jingjing Wang Fuli Tan Haixiu Gao Shenggen Fan Academy of global Food Economics and Policy China Agricultural UniversityBeijing 100083China

Excessive consumption of refined grains harms human health and ecosystem *** grains,as a healthy and sustainable alternative to refined grains,can benefit individual health by providing dietary fiber,B vitamins,and bioactive ***,they aid in improving the environment due to their higher extraction rate and lower carbon emission during the processing ***,few studies have attempted to evaluate the economic and social benefits of increasing the amount of whole grain in grain *** paper estimates the potential savings in healthcare costs and reduced food carbon footprints(CFs)that could result from a shift toward whole grain consumption following the Chinese Dietary Guidelines(CDG).We investigate hypothetical scenarios where a certain proportion(5–100%)of Chinese adults could increase their whole grain intakes as proposed by CDG to meet the average shortfall of 30.2 *** that case,the healthcare costs for associated diseases(e.g.,type2 diabetes mellitus(T2DM),cardiovascular disease(CVD),and colorectal cancer(CRC))are expected to reduce by a substantial amount,from USD 2.82 to 56.37 billion;the carbon emission levels are also projected to decrease by0.24–5.72 million *** study provides compelling evidence that advocating for the transition towards greater consumption of whole grain products could benefit individual health,the environment,and society,by reducing both healthcare costs and carbon emissions.

关键词： whole grains cost analysis public health life cycle assessment(LCA) carbon footprint

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Interworking between Modbus and internet of things platform for industrial services

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Digital Communications and Networks 2024年第2期10卷 461-471页

作者： Sherzod Elamanov Hyeonseo Son Bob Flynn Seong Ki Yoo Naqqash Dilshad JaeSeung Song Department of Convergence Engineering for Intelligent Drone Sejong UniversitySouth Korea SyncTechno Inc South Korea Exacta global Smart Solutions USA Coventry university UK

In the era of rapid development of Internet of Things(IoT),numerous machine-to-machine technologies have been applied to the industrial *** to the divergence of IoT solutions,the industry is faced with a need to apply various technologies for automation and *** fact leads to a demand for an establishing interworking mechanism which would allow smooth interoperability between heterogeneous *** of the major protocols widely used today in industrial electronic devices is ***,data generated by Modbus devices cannot be understood by IoT applications using different protocols,so it should be applied in a couple with an IoT service layer ***2M,a global IoT standard,can play the role of interconnecting various protocols,as it provides flexible tools suitable for building an interworking framework for industrial ***,in this paper,we propose an interworking architecture between devices working on the Modbus protocol and an IoT platform implemented based on oneM2M *** the proposed architecture,we introduce the way to model Modbus data as oneM2M resources,rules to map them to each other,procedures required to establish interoperable communication,and optimization methods for this *** analyze our solution and provide an evaluation by implementing it based on a solar power management use *** results demonstrate that our model is feasible and can be applied to real case scenarios.

关键词： Internet of things Interoperability Interworking Modbus oneM2M

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Repositioning fertilizer manufacturing subsidies for improving food security and reducing greenhouse gas emissions in China

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Journal of Integrative Agriculture 2024年第2期23卷 430-443页

作者： Zongyi Wu Xiaolong Feng Yumei Zhang Shenggen Fan Academy of global Food Economics and Policy China Agricultural UniversityBeijing 100083China College of Economics and Management China Agricultural UniversityBeijing 100083China

China removed fertilizer manufacturing subsidies from 2015 to 2018 to bolster market-oriented reforms and foster environmentally sustainable ***,the impact of this policy reform on food security and the environment remains inadequately ***,although green and low-carbon technologies offer environmental advantages,their widespread adoption is hindered by prohibitively high *** study analyzes the impact of removing fertilizer manufacturing subsidies and explores the potential feasibility of redirecting fertilizer manufacturing subsidies to invest in the diffusion of these *** the China Agricultural university Agri-food Systems model,we analyzed the potential for achieving mutually beneficial outcomes regarding food security and environmental *** findings indicate that removing fertilizer manufacturing subsidies has reduced greenhouse gas(GHG)emissions from agricultural activities by 3.88 million metric tons,with minimal impact on food *** fertilizer manufacturing subsidies to invest in green and low-carbon technologies,including slow and controlled-release fertilizer,organic-inorganic compound fertilizers,and machine deep placement of fertilizer,emerges as a strategy to concurrently curtail GHG emissions,ensure food security,and secure robust economic ***,we propose a comprehensive set of government interventions,including subsidies,field guidance,and improved extension systems,to promote the widespread adoption of these technologies.

关键词： food security fertilizer manufacturing subsidies agri-food systems greenhouse gas emissions

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The multiple roles of crop structural change in productivity,nutrition and environment in China:A decomposition analysis

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Journal of Integrative Agriculture 2024年第5期23卷 1763-1773页

作者： Xiangyang Zhang Yumei Zhang Shenggen Fan College of Economics and Management China Agricultural UniversityBejing 100083China Academy of global Food Economics and Policy China Agricultural UniversityBejing 100083China

China's crop structure has undergone significant changes in the last two decades since 2000,with an increase in the share of cereals,vegetables,and fruit,squeezing out other *** a result,land productivity,nutrient supply,and carbon emissions have *** to reallocate limited farmland among crops to achieve the multiple goals of agrifood systems becomes an important *** study explores the sources of land productivity and nutrition supply growth and carbon emissions reduction,and identifies the multiple roles of crop structural change from 2003 to 2020 based on a decomposition *** results reveal that the growth within crops is still the primary driver in land productivity and nutrition supply and the reduction in carbon ***,structural change also plays various roles at different *** 2003 to 2010,crop structural change increased the total calorie supply but lowered land productivity and contributed at least 70%of the total growth of carbon *** crop structure was relatively stable,and their effects were modest from 2010 to *** 2015 to 2020,the crop structural change began to play a greater role and generate synergistic effects in improving land productivity,micronutrient supply,and reducing carbon emissions,contributing to approximately a quarter of the growth of land productivity and 30%of total carbon emissions *** results suggest that strategies for crop structural change should comprehensively consider its multiple impacts,aiming to achieve co-benefits while minimizing trade-offs.

关键词： crop structural change land productivity nutrition carbon emissions

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Transforming agri-food systems for multiple wins in nutrition,inclusion and environment

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Journal of Integrative Agriculture 2024年第2期23卷 355-358页

作者： Shenggen Fan Qiran Zhao Jingjing Wang Academy of global Food Economics and Policy/College of Economics and Management China Agricultural UniversityBeijing 100083China

The call for agri-food system transformation is urgent in many global development agendas(UN 2023).Food systems have contributed to economic prosperity and feeding the world,but they are also associated with numerous challenges,including climate change,continued hunger,poor diets and malnutrition,and increasing disparities(Webb et al.2020;Fanzo et al.2021).

关键词： continued nutrition urgent

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Market-based solution in China to finance the clean from the dirty

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Fundamental Research 2024年第2期4卷 324-333页

作者： Haoqi Qian Rong Ma Libo Wu Institute for global Public Policy Fudan UniversityShanghai 200433China LSE-Fudan Research Centre for global Public Policy Fudan UniversityShanghai 200433China School of Economics Fudan UniversityShanghai 200433China Shanghai Institute for Energy and Carbon Neutrality Strategy Fudan UniversityShanghai 200433China

Financial incentives play a key role in promoting renewable energy investments that can help China achieve the‘dual carbon’*** national emissions trading scheme(ETS)and the renewable energy portfolio standard(RPS)are two existing market-based policy instruments that can generate stable expected returns for low-carbon *** paper studies the interactive distribution effects of these two market-based *** use the micro-level thermal power plant data to investigate the abatement effects of the national ETS,in which the details show that the existing rate-based ETS will result in higher negative impacts on power units,whose installed capacities are smaller than 400 *** interactive distribution effects between the two markets will occur when the permit allocation standards of the national ETS become stricter than the existing *** in Eastern China and Northern China will face high pressure on costs in both ETS and RPS *** the levels of the permit allocation standards are set as 70%of the existing ones and the carbon price is assumed to be 200 yuan/ton in 2030,the annual market size of the national ETS will be nearly 100 billion yuan,and the annual market size is predicted to be 250 billion *** the existing rate-based national ETS,the China Certified Emission Reduction(CCER)mechanism will have an offsetting effect,which should be taken into serious consideration during the policy-making processes in the future.

关键词： Emission trading scheme Renewable energy portfolio standard Green finance Policy interactions China certified emission reduction Distribution effect

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Simultaneous detection of the shuttling motion of liquid metal droplets in channels under alternating pressure and capacitive sensor signals

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Microsystems & Nanoengineering 2024年第2期10卷 83-90页

作者： Shinji Bono Ryotaro Nakai Satoshi Konishi Research Organization of Science and Technology Ritsumeikan UniversityShigaJapan Ritsumeikan Advanced Research Academy KyotoJapan Ritsumeikan global Innovation Research Organization Ritsumeikan UniversityShigaJapan Graduate School of Science and Engineering Ritsumeikan UniversityShigaJapan

Implementing a signal-switching mechanism for the selective use of integrated sensors and actuators plays a crucial role in streamlining the functionality of miniaturized ***,a liquid metal droplet(LMD)-based signal-switching mechanism is introduced to achieve such *** modulation with a 100-μm spatial resolution enabled precise control of the position of the LMDs within a *** integrating the channel with asymmetrically structured electrodes,the effect of the shuttle-like movement of LMD on the temporal changes in the overall capacitance was ***,analysis of the capacitive peaks revealed the directional movement of the LMDs,enabling estimation of the position of the LMDs without direct *** addition,we achieved successful signal extraction from the capacitive sensor that was linked to the activated electrodes,thereby enabling selective data *** proposed signal-switching mechanism method achieved a detection accuracy of~0.1 *** sensor’s ability to simultaneously detect the LMD position and generate a signal underscores its significant potential for multiplexing in multisensing systems,particularly in concealed environments,such as in vivo settings.

关键词： liquid thereby integrating

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