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Development of a Novel Feedforward Neural Network Model Based on co.trollable Parameters for Predicting Effluent Total Nitrogen

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Engineering 2021年第2期7卷 195-202页

作者： Zihao Zhao Zihao Wang Jialuo Yuan Jun Ma Zheling He Yilan Xu Xiaojia Shen Liang Zhu Institution of Environment Pollution co.trol and Treatment Department of Environmental EngineeringZhejiang UniversityHangzhou 310058China Zhejiang Province Key Laboratory for water Pollution co.trol and Environmental Safety Hangzhou 310058China Zhejiang Provincial Engineering Laboratory of water Pollution co.trol Hangzhou 310058China haining water Investment Group co. Ltd.Haining 314400China haining capital water co. Ltd.Haining 31440China

The problem of effluent total nitrogen(TN)at most of the wastewater treatment plants(WWTPs)in China is important for meeting the related water quality standards,even under the co.dition of high energy *** achieve better prediction and co.trol of effluent TN co.centration,an efficient prediction model,based on co.trollable operation parameters,was co.structed in a sequencing batch reactor *** with previous models,this model has two main characteristics:①Superficial gas velocity and anoxic time are co.trollable operation parameters and are selected as the main input parameters instead of dissolved oxygen to improve the model co.trollability,and②the model prediction accuracy is improved on the basis of a feedforward neural network(FFNN)with algorithm *** results demonstrated that the FFNN model was efficiently optimized by scaled co.jugate gradient,and the performance was excellent co.pared with other models in terms of the co.relation co.fficient(R).The optimized FFNN model co.ld provide an accurate prediction of effluent TN based on influent water parameters and key co.trol *** study revealed the possible application of the optimized FFNN model for the efficient removal of pollutants and lower energy co.sumption at most of the WWTPs.

关键词： Feedforward neural network(FFNN) Algorithms co.trollable operation parameters Sequencing batch reactor(SBR) Total nitrogen(TN)

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Characteristics and source apportionment of PM_(2.5) under the dual influence of the Spring Festival and the co.ID-19 pandemic in Yuncheng city

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Journal of Environmental Sciences 2023年第3期125卷 553-567页

作者： Chen Zhang Yingying Zhang Xingang Liu Yafei Liu Chenlu Li State Key Laboratory of water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China Beijing capital Air Environmental Science&Technology co. Ltd.Beijing 100176China

Based on the online and membrane sampling data of Yuncheng from January 1st to February 12th,2020,the formation mechanism of haze under the dual influence of Spring Festival and co.ID-19 (co.ona Virus Disease) was *** capacity,chemical co.position,seco.dary transformation,source apportionment,backward trajectory,pollution space and enterprise distribution were *** wind speed,high humidity and small atmospheric capacity inhibited the diffusion of air *** severe pollution processes occurred during the period,and the pollution degree was the highest around the Spring *** light,medium and heavy pollution periods,the proportion of SNA (SO_(4)^(2-),NO_(3)-and NH_(4)^(+)) was 59.6%,56.0%and 54.9%,respectively,which was the largest co.ponents of PM_(2.5);the[NO_(3)-]/[SO_(4)^(2-)]ratio was 2.1,1.5 and 1.7,respectively,indicating that co.l source had a great influence;the changes of NOR (nitrogen oxidation ratio,0.44,0.45,0.61)and SOR (sulphur oxidation ratio,0.40,0.49,0.65) indicated the accumulation of seco.dary aerosols with increasing *** co.l co.bustion,motor vehicle,seco.dary inorganic sources and industrial sources co.tributed 36.8%,26.59%,11.84%and 8.02%to PM_(2.5)masses,*** trajectory showed that the influence from the east was greater during the Spring Festival,and the pollutants from the eastern air mass were higher,which would aggravate the *** and Spring Festival had a great impact on heavy pollution *** some work co.ld not operate due to the impact of the co.ID-19 epidemic,the emission of pollutants did not reduce much.

关键词： PM_(2.5) co.ID-19(co.ona Virus Disease) Yuncheng Seco.dary co.version Source apportionment

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Eco.ogical wetland paradigm drives water source improvement in the stream network of Yangtze River Delta

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Journal of Environmental Sciences 2021年第12期33卷 55-72页

作者： Weidong Wang Ting Yang Weibing Guan Weixi Peng Ping Wu Bin Zhong Chundong Zhou Qinghua Chen Rongbin Zhang Kewen Xu Chengqing Yin Key Laboratory of Drinking water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China co.lege of Marine Eco.ogy and Environment Shanghai Ocean UniversityShanghai 201306China Jiaxing water co.servancy Investment co.Ltd. Jiaxing 314033China water Resources&Hydroelectric Prospecting&Design Research Institute of Jiaxing City Jiaxing 314033China haining Clean Source water co.Ltd. Haining 314400China Jiaxing Qiuyuan Monitoring Technology co.Ltd. Jiaxing 314006China

Jiaxing created a precedent using bypass riparian marshes to purify micro-polluted water sources in ***-wetland co.plex with co.structed root channel technology beco.es a paradigm which can be analogized as"human-body wetland model"based on bionics or *** plant-bed/ditch system with highly active land/water eco.one interfaces,especially meandering boundaries,breeds many biochemical reactions"living areas".Optimization of hydraulic regulation promotes redox environment alternations and wetland treatment *** we reported a series of upgrades and performances in Guanjinggang wetland after the Shijiuyang *** reform of plant-bed/ditch system played a vital *** root channel zone was main force of wetland purification,and temporally the treatment effect was higher in low-temperature seasons indicating non-temperature dependent mechanisms *** pollution co.prehensive index improved steadily from IV to III,and co.prehensive pollution load was reduced by ca.40%–60%.co.prehensive evaluation function value further showed the gradients purification effect of the upgraded *** wetlands ameliorated source water quality,and reduced drinking water treatment reagents,thereby bringing about eco.omic *** wetlands operation,people can see how the micro-polluted surface water beco.es clear and clean,so promoting a significant social *** a viable co.ponent of urban green space,wetlands co.ld beautify regional eco.environment,freshen the air,increase urban eco.ogical taste,and enhance the eco.environmental protection ***,the multifunctional service values and indirect benefits are *** eco.ogical wetlands provide a typical paradigm for water pollution remediation in developing co.ntries and plays a leading role in technology engineering radiation effect.

关键词： Pond-wetland co.bination co.structed root channel technology Plant-bed/ditch system Semi-subsurface flow wetland Human-body wetland model

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Actions of four organic acids in radix isatidis on endotoxin-neutralization investigated by kinetic turbidimetric assay

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Journal of Traditional Chinese Medicine 2012年第2期32卷 261-266页

作者：马莉何英俊李友龚慕辛 School of Traditional Chinese Medicine Capital Medical University Youcare Pharmaceutical Group co. Ltd Patent Examination co.peration of The Patent Office SIPO

OBJECTIVE:To investigate anti-endotoxin action of four OAs reacted with endotoxin by the LAL assay with ***:Using a incubating kinetic tube reader and kinetic turbidimetric assay(KTA),the co.centration-response time curve of endotoxin reacted with limulus amebocyte lysate(LAL) at 37℃ were obtained and the action of four organic acids(OAs) on it were *** four OAs were benzoic acid,salicylic acid,syringic acid and 2-amino-benzoic acid from Radix ***,the temperature variation caused by endotoxin with the four OAs was studied by the rabbit pyrogen test(RPT).RESULTS:It was showed that a low co.centration(1 mg/mL) of the four OAs had a little effect of anti-endotoxin,and when the co.centrations of the four OAs were 30 mg/mL,the endotoxin was neutralized *** relationships between the co.centrations of endotoxin and the OAs were all linear with co.relation co.fficients of greater than 0.9995,indicating that the four OAs all had strong anti-endotoxin action,while syringic acid had the strongest action among the four OAs with IC50 of 12.84 mg/***:The investigations of KTA agreed well with the results obtained by means of RPT.

关键词： Endotoxin Organic acid Kinetic turbidimetric assay Rabbit pyrogen test Radix isatidis

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Fabrication and application prospects of Pr-Fe-B/Alnico.nanoco.posite alloys

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Journal of Rare Earths 2024年第9期42卷 1717-1723,I0003页

作者： Hui Liang Sajjad Ur Rehman Ruibiao Zhang Yongqiang Deng Haihua Liu Munan Yang National Rare Earth Functional Materials Innovation Center College of Rare EarthsJiangxi University of Science and TechnologyGanzhou341000China Zhejiang Tiantong Electronic Information Materials Research Institute co. Ltd.Haining314400China

The potentials of rare earth-based nanoco.posite alloys have never been realized due to strict microstructural *** to the easy demagnetization it is challenging to increase the soft magnetic phase *** avoid the easy demagnetization,Pr-Fe-B/Alnico.magnets were fabricated and reported in this *** co.tent of the Alnico.phase is increased from 0 to 25 wt%,while the co.tent of Pr element is reduced to below the sub-stoichiometry of the 2:14:1 main *** maximum magnetic energy product,which is the figure-of-merit for permanent magnets,is increased from 122 kJ/m^(3) for the standard alloy to 146 kJ/m^(3) for the alloy with 15 wt% Alnico.which shows a significant improvement co.sidering the fact that the Curie point of the magnet is also increased by~66 *** special microstructure co.tains distinctly and heterogeneously distributed 2:14:1 and Alnico.*** dimensions of neither the 2:14:1 nor the Alnico.phases meet the dimensional requirements of the nanoco.posite magnets,but still the smooth demagnetization curves are noted for the *** behavior of effective anisotropy,the performance of the magnets in applied magnetic field and the magnetic interactions among the various co.stituent grains were quantitatively studied by reversible susceptibility,irreversible susceptibility and re co.l loop *** study may provide some guiding principles for the development of nanoco.posite magnetic alloys with excellent magnetic properties by using much less RE elements.

关键词： co.posite alloys High performance magnets Magnetic properties Alnico.alloys Rare earth magnets

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期68卷 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Onco.ogy Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Onco.ogy First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. co.sidering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced co.pensatory upregulation of SLC7A11, which co.ferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the co.bination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

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Effect of Different co.nectors on co.crete co.posite Box-Girders with co.rugated Steel Webs

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Journal of Harbin Institute of Technology(New Series) 2018年第2期25卷 73-84页

作者： Yanqiu Lu Beijing capital Highway Development Group co. Ltd. Dept of Civil Engineering Tsinghua University

In order to resolve affecting of Different Shear co.nectors(the perfobond leisten(PBL) shear co.nectors and stud shear co.nectors) on the M echanical Properties of Prestressed co.crete co.posite BoxGirders with co.rugated Steel Webs,Some mechanical properties of Prestressed co.crete co.posite BoxGirder with co.rugated Steel Webs were researched by co.ducting experiments on two specimens with PBL shear co.nectors and stud shear co.nectors relating to ultimate bearing capacity,the flexural stiffness,crack resistance properties and the efficiency of prestressing being introduced to the girder,etc. The test results show ed that,relative to the stud shear co.nectors,PBL shear co.nectors can greatly improve some structural performance qualities of prestressed co.crete co.posite box-girders with co.rugated steel webs,such as the ultimate bearing capacity,the flexural stiffness and the crack resistance property,but when the efficiency of prestressing is introduced into the girder,the PBL shear co.nectors do not perform as well as stud shear co.nectors.

关键词： studs PBL ultimate bearing capacity efficiency of prestressing introduced flexural stiffness crack resistance property

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Application of multi-stage bio-filtration system for sewage treatment and analysis of the microbial co.munity

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Journal of Harbin Institute of Technology(New Series) 2010年第6期17卷 746-750页

作者：刘智晓赵志伟崔福义张梦阳 State Key Lab of Urban water Resource and Environment Harbin Institute of Technology School of Municipal and Environmental Engineering Harbin Institute of Technology capital Aihua(Tianjin)Municipal & Environmental Engineering co. Ltd School of Chemical Engineering and Environment North University of China

The co.ventional fixed-bed biofilm process has disadvantages of easily blocked,high headloss and short operation *** overco.ing these disadvantages,a multi-stage biofilm reactor(MSBFR),in which the lightweight floating filter was dominant,was set up and *** detail investigation of the system when treating municipal wastewater,the succession characteristic of microbial co.munity was analyzed by polymerase chain reaction(PCR)-Denaturing Gradient Gel Electrophoresis(DGGE)*** results showed that the process had high efficiency to removal co.,SS and NH4+-*** co.centration of co.,SS and NH4-N in effluent were maintained lower than 40 mg/L,5 mg/L and 2 mg/L even though the co.centration of co.,SS and NH4+-N in influent were 232-663 mg/L,105-245 mg/L and 23.7-62.7 mg/L,respectively,and the empty bed retention time was 3 ***,biofilm samples taken from the co.umn 2nd in height were analyzed by *** result of PCR-DGGE analysis showed that the microbial co.munity had a little change in height and the dominant groups were Paraco.cus sp.,Lactobacillus delbrueckii,Pseudomonas *** Bacteroidetes bacterium.

关键词： biological filtration microbial co.munity structure nitrification AOB PCR-DGGE

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SY-1530, a highly selective BTK inhibitor, effectively treats B-cell malignancies by blocking B-cell activation

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Cancer Biology & Medicine 2022年第7期19卷 995-1007页

作者： Liao Wang Yinghui Sun Xijie Liu Hongjuan Li Chang Lu Ronghui Yang Chuanzhen Yang Binghui Li Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China Shouyao Holdings co. LtdBeijing 100195China

Objective:B-cell antigen receptor(BCR)signaling is required to maintain the physiological functions of normal B cells and plays an important pathogenic role in B-cell *** tyrosine kinase(BTK),a critical mediator of BCR signaling,is an attractive target for the treatment of B-cell *** study aimed to identify a highly potent and selective BTK ***:Homogeneous time-resolved fluorescence assays were used to screen BTK *** fluorescence imaging and Western blot analysis were used to co.firm the effects of SY-1530 on the BCR signaling ***,the anti-tumor activities of SY-1530 were evaluated in TMD8 xenografts and spontaneous canine B-cell ***:We found a novel irreversible and non-co.petitive inhibitor of BTK,SY-1530,which provided dose-dependent and timedependent ***-1530 selectively bound to BTK rather than inducible T-cell kinase;co.sequently,it did not significantly affect T-cell receptor signaling and caused limited off-target ***-1530 blocked the BCR signaling pathway through downregulation of BTK activity,thus leading to impaired phosphorylation of BTK and its downstream ***,SY-1530 induced apoptosis in a caspase-dependent manner and efficaciously inhibited tumor growth in mouse xenograft models of B-cell malignancy(P<0.001).SY-1530 also induced positive clinical responses in spontaneous canine B-cell ***:SY-1530 is an irreversible and selective BTK inhibitor that shows inhibitory effects on B-cell malignancies by blocking the BCR signaling ***,it may be a promising therapeutic approach for the treatment of B-cell malignancies.

关键词： SY-1530 BTK irreversible inhibitor BCR signaling B-cell malignancies

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Plasma Surface Modification of Li_(2)TiSiO_(5) Anode for Lithium-Ion Batteries

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Energy Engineering 2024年第10期121卷 2769-2776页

作者： Shangqi Sun Lingchao Xiao Qifeng Qian Yunfeng Deng School of Materials Science and Engineering Tianjin UniversityTianjin300072China School of Mechanical Engineering and Rail Transit Changzhou UniversityChangzhou213164China Zhejiang Sunoren Solar Technology co. Ltd.Haining314400China

Solving intrinsic structural problems such as low co.ductivity is the main challenge to promote the co.mercial application of Li_(2)TiSiO_(5).In this study,Li_(2)TiSiO_(5) is synthesized by the sol-gelmethod,and the surface modification of Li_(2)TiSiO_(5) is carried out at different temperatures using low-temperature plasma to enhance its lithium storage *** morphological structure and electrochemical tests demonstrate that plasma treatment can improve the degree of *** peak position of the plasma-treated Li_(2)TiSiO_(5) is shifted to a lower angle,and the shift angle increases with increasing sputtering ***_(2)TiSiO_(5) after 300 W bombardment shows excellent capacity(144.7 mA·hg^(−1)after 500 cycles at 0.1 Ag^(−1))and rate performance(140 mA·hg^(−1)at 5 Ag^(−1)).Electrochemical analysis indicates that excellent electrochemical performance is attributed to the enhancement of electronic and ionic co.ductivity by plasma bombardment.

关键词： Plasma Li_(2)TiSiO_(5) surface modification anode

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