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Design,fabrication,and characterization of hierarchical mechanical metamaterials

Frontiers of Mechanical Engineering 2024年第1期19卷 73-83页

作者： Jian SONG Junfei YAN Bengang YI Automotive Engineering research institute BYD Auto Industry Co.Ltd.Shenzhen 518000China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518060China

Natural mechanical materials,such as bamboo and bone,often exhibit superior specific mechanical properties due to their hierarchical porous *** the principle of hierarchy as inspiration can facilitate the development of hierarchical mechanical metamaterials(HMMs)across multiple length scales via 3D *** this work,we propose self-similar HMMs that combine octet-truss(OCT)architecture as the first and second orders,with cubic architecture as the third or more *** HMMs were fabricated using stereolithography 3D printing,with the length sizes ranging from approximately 200µm to the centimeter *** compressive stress–strain behaviors of HMMs exhibit a zigzag characteristic,and the toughness and energy absorption can be significantly enhanced by the hierarchical *** compressive moduli are comparable to that of natural materials,and the strengths are superior to that of most polymer/metal foams,alumina hollow/carbon lattices,and other natural ***,the flexural stress–strain curves exhibit a nonlinear behavior,which can be attributed to the hierarchical architecture and local damage *** relatively high mechanical properties can be attributed to the synergistic effect of the stretch-dominated OCT architecture and the bending-dominated cube ***,an ultralight HMM-integrated unmanned aerial vehicle(HMM-UAV)was successfully designed and *** HMM-UAV is~85%lighter than its bulk counterpart,remarkably extending the flight duration time(~53%).This work not only provides an effective design strategy for HMMs but also further expands the application benchmark of HMMs.

关键词： 3D printing mechanical metamaterials hierarchical architecture mechanical behavior unmanned aerial vehicle(UAV)

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Rapid and sensitive detection of Epstein-Barr virus antibodies in nasopharyngeal carcinoma by chemiluminescence strips based on iron-porphyrin single atom nanozyme

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Nano research 2024年第3期17卷 1827-1836页

作者： Daji Wang Jie Wang Dan Liu Jiuyang He Meiying Wang Haibing Huang Guohui Nie Hui Ding Xiyun Yan Nanozyme Synthesis Center Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Center for Drug Evaluation National Medical Products AdministrationBeijing 100022China shenzhen Key Laboratory of nanozymes and Translational Cancer research Department of Otolaryngologyand Shenzhen Institute of Translational MedicineShenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen 518035China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Department of Rheumatology and Immunology Shenzhen Second People’s HospitalThe First Affiliated Hospital of Shenzhen UniversityShenzhen 518055China

The correlation between Epstein-Barr virus(EBV)infection and nasopharyngeal carcinoma(NPC)risk has been extensively *** continual monitoring of EBV-IgAs provides a promising approach of NPC screening in its early *** this study,we successfully synthesized a single-atom nanozyme(SANzyme)through the application of iron-porphyrin based metal organic framework(MOF-FeP).The MOF-FeP possesses precisely-defined electronic and geometric structures that accurately mimic highly-evolved catalytic site of natural *** peroxidase-like activity of MOF-FeP enables it to catalyze the chemiluminescence of luminol *** integrating MOF-FeP into a traditional strip,we created a rapid and highly-sensitive evaluation tool for detecting ***,the MOF-FeP strip enables the simultaneous detection of three EBV-IgAs,greatly improving the accuracy of EBV-associated NPC *** sensitivities of the MOF-FeP strip(75.56%–93.30%)surpass those of current enzyme-linked immunosorbent assay(ELISA)methods(64.44%–82.22%).This test takes only 16 min to perform as opposed to the customary 1–2 h required for standard ***,the MOF-FeP strip is suitable for whole blood samples,thereby significantly simplifying the sample preparation and detection *** conclusion,the MOF-FeP strip combines the simplicity of traditional strip with the high catalytic activity of *** innovative MOF-FeP strip offers a new point-of-care strategy for EBV-IgAs detection,which is expected to markedly facilitate early screening for EBV-associated diseases.

关键词： iron-porphyrin single-atom nanozyme(SANzyme) chemiluminescence strips Epstein-Barr virus(EBV) nasopharyngeal carcinoma(NPC) antibody detection

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Relative peripheral refraction in school children with different refractive errors using a novel multispectral refraction topographer

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1477-1482页

作者： Hui-Ling Hu Serena Zhe-Chuang Li Ai-Ying Feng Hao-Xi Zhong Jing-Feng Mu Mei-Zhou Liu shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina NIMO Ophthalmology research institute Beijing 100176China

AIM:To compare relative peripheral refraction(RPR)in Chinese school children with different refractive errors using multispectral refraction topography(MRT).METHODS:A total of 713 eyes of primary school children[172 emmetropia(E),429 low myopia(LM),80 moderate myopia(MM),and 32 low hypermetropia(LH)]aged 10 to 13y were *** were measured using MRT without *** results showed RPR at 0-15°(RPR 0-15),15°-30°(RPR 15-30),and 30°-45°(RPR 30-45)annular in the inferior(RPR-I),superior(RPR-S),nasal(RPR-N),and temporal(RPR-T)*** equivalent(SE)was detected and calculated using an ***:There were significant differences of RPR 15-30 between groups MM[0.02(-0.12;0.18)]and LH[-0.13(-0.36;0.12)](P<0.05),MM and E[-0.06(-0.20;0.10)](P<0.05),and LM[-0.02(-0.15;0.15)]and E(P<0.05).There were also significant differences of RPR 30-45 between groups MM[0.45(0.18;0.74)]and E[0.29(-0.09;0.67)](P<0.05),and LM[0.44(0.14;0.76)]and E(P<0.001).RPR values increased from the hyperopic to medium myopic group in each *** were significant differences of RPR-S between groups MM[-0.02(-0.60;0.30)]and E[-0.44(-0.89;-0.04)](P<0.001),and LM[-0.28(-0.71;0.12)]and E(P<0.05).There were also significant differences of RPR-T between groups MM[0.37(0.21;0.78)]and LH[0.14(-0.52;0.50)](P<0.05),LM[0.41(0.06;0.84)]and LH(P<0.05),and LM and E[0.29(-0.10;0.68),P<0.05].A Spearman’s correlation analysis showed a negative correlation between RPR and SE in the 15°-30°(P=0.005),30°-45°(P<0.05)annular(P=0.002),superior(P<0.001),and temporal(P=0.001)***:Without pupil dilation,values for RPR 15-30,30-45,RPR-S,and T shows significant differences between myopic eyes and emmetropia,and the differences are negatively correlated with SE.

关键词： relative peripheral refraction myopia school children multispectral refraction topography

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Multiple-dimensioned defect engineering for graphite felt electrode of vanadium redox flow battery

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Carbon Energy 2024年第2期6卷 143-153页

作者： Yingqiao Jiang Yinhui Wang Gang Cheng Yuehua Li Lei Dai Jing Zhu Wei Meng Jingyu Xi Ling Wang Zhangxing He School of Chemical Engineering North China University of Science and TechnologyTangshanChina Tsinghua shenzhen International Graduate School Institute of Materials ResearchTsinghua UniversityShenzhenChina

The scarcity of wettability,insufficient active sites,and low surface area of graphite felt(GF)have long been suppressing the performance of vanadium redox flow batteries(VRFBs).Herein,an ultra-homogeneous multipledimensioned defect,including nano-scale etching and atomic-scale N,O codoping,was used to modify GF by the molten salt ***_(4)Cl and KClO_(3) were added simultaneously to the system to obtain porous N/O co-doped electrode(GF/ON),where KClO_(3) was used to ultra-homogeneously etch,and O-functionalize electrode,and NH4Cl was used as N dopant,***/ON presents better electrochemical catalysis for VO_(2)+/VO_(2)+ and V3+/V2+ reactions than only O-functionalized electrodes(GF/O)and *** enhanced electrochemical properties are attributed to an increase in active sites,surface area,and wettability,as well as the synergistic effect of N and O,which is also supported by the density functional theory ***,the cell using GF/ON shows higher discharge capacity,energy efficiency,and stability for cycling performance than the pristine cell at 140 mA cm^(−2) for 200 ***,the energy efficiency of the modified cell is increased by 9.7% from 55.2% for the pristine cell at 260 mA cm^(−2).Such an ultra-homogeneous etching with N and O co-doping through“boiling”molten salt medium provides an effective and practical application potential way to prepare superior electrodes for VRFB.

关键词： graphite felt molten salt N O co-doping ultra-homogeneous etching vanadium redox flow battery

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Theoretical optimization of micropillar arrays for structurally stable bioinspired dry adhesives

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 124-129页

作者： Ke Ni Zhengzhi Wang Department of Engineering Mechanics School of Civil EngineeringWuhan UniversityWuhan 430072China Wuhan University shenzhen research institute Shenzhen 518108China

Inspired by the excellent adhesion performances of setae structure from organisms,micro/nano-pillar array has become one of the paradigms for adhesive *** micropillar arrays are composed of the resin pillars for adhesion and the substrate with different elastic modulus for *** stress singularity at the bi-material corner between the pillars and the substrate can induce the failure of the micropillar-substrate corner and further hinder the fabrication and application of micropillar arrays,yet the design for the stability of the micropillar array lacks systematical and quantitative *** this work,we develop a semi-analytical method to provide the full expressions for the stress distribution within the bi-material corner combining analytical derivations and numerical *** predictions for the stress within the singularity field can be obtained based on the full expressions of the *** good agreement between the predictions and the FEM results demonstrates the high reliability of our *** adopting the strain energy density factor approach,the stability of the pillar-substrate corner is assessed by predicting the failure at the *** the elastic mismatch between the pillar and substrate given in this paper,the stability can be improved by increasing the ratio of the shear modulus of the substrate to that of the *** study provides accurate predictions for the stress distribution at the bi-material corner and can guide the optimization of material combinations of the pillars and the substrate for more stable bioinspired dry adhesives.

关键词： Micropillar array Stability Bi-material corner Dry adhesive

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A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys

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Neuroscience Bulletin 2024年第1期40卷 90-102页

作者： Yefei Chen Jingyi Wang Jing Liu Jianbang Lin Yunping Lin Jinyao Nie Qi Yue Chunshan Deng Xiaofei Qi Yuantao Li Ji Dai Zhonghua Lu Department of Anesthesiology Shenzhen Maternity and Child Healthcare HospitalThe First School of Clinical MedicineSouthern Medical UniversityShenzhen 518027China shenzhen Technological research Center for Primate Translational Medicine Shenzhen Key Laboratory for Molecular Biology of Neural DevelopmentShenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Biomedical research institute Hubei University of MedicineShiyan 442000China Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Retrograde adeno-associated viruses(AAVs)are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical and functional characterization of neural ***,few retro-grade AAV capsids have been shown to offer access to cor-tical projection neurons across different species and enable the manipulation of neural function in non-human primates(NHPs).Here,we report the development of a novel retro-grade AAV capsid,AAV-DJ8R,which efficiently labeled cortical projection neurons after local administration into the striatum of mice and *** addition,intrastriatally injected AAV-DJ8R mediated opsin expression in the mouse motor cortex and induced robust behavioral ***,AAV-DJ8R markedly increased motor cortical neuron firing upon optogenetic light stimulation after viral delivery into the macaque *** data demonstrate the usefulness of AAV-DJ8R as an efficient retrograde tracer for cortical projection neurons in rodents and NHPs and indicate its suitability for use in conducting functional interrogations.

关键词： Retrograde AAV Capsid variant Cortical projection neuron Optogenetics Monkey

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Resonance mechanism of flapping wing based on fluid structure interaction simulation

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Chinese Journal of Aeronautics 2024年第5期37卷 243-262页

作者： Yueyang GUO Wenqing YANG Yuanbo DONG Dong XUE National Key Laboratory of Science and Technology on Aerodynamic Design and research School of AeronauticsNorthwestern Polytechnical UniversityXi'an 710072China research&Development institute of Northwestern Polytechnical University in shenzhen Shenzhen 518063China Yangtze River Delta research institute of Northwestern Polytechnical University Taicang 215400China

Certain insect species have been observed to exploit the resonance mechanism of their *** order to achieve resonance and optimize aerodynamic performance,the conventional approach is to set the flapping frequency of flexible wings based on the Traditional Structural Modal(TSM)***,there exists controversy among researchers regarding the relationship between frequency and aerodynamic *** that the structural response of wings can be influenced by the surrounding air vibrations,an analysis known as Acoustic Structure Interaction Modal(ASIM)is introduced to calculate the resonant *** this study,Fluid Structure Interaction(FSI)simulations are employed to investigate the aerodynamic performance of flapping wings at modal frequencies derived from both TSM and ASIM *** performance is evaluated for various mass ratios and frequency ratios,and the findings indicate that the deformation and changes in vortex structure exhibit similarities at mass ratios that yield the highest aerodynamic ***,the flapping frequency associated with the maximum time-averaged vertical force coefficient at each mass ratio closely aligns with the ASIM frequency,as does the frequency corresponding to maximum ***,the ASIM analysis can provide an effective means for predicting the optimal flapping frequency for flexible ***,it enables the prediction that flexible wings with varying mass ratios will exhibit similar deformation and vortex structure *** paper offers a fresh perspective on the ongoing debate concerning the resonance mechanism of Flexible Flapping Wings(FFWs)and proposes an effective methodology for predicting their aerodynamic performance.

关键词： Flexible Flapping Wing(FFW) Acoustic Structure Interaction Modal(ASIM) Fluid Structure Interaction(FSI) Resonance mechanism Aerodynamic performance

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Total Synthesis of Laurane and Guaiane Sesquiterpenoids via Oxidative Nazarov Reaction

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Chinese Journal of Chemistry 2024年第11期42卷 1267-1274页

作者： Yuye Chen Wenqing Chen Zhiting Zhang Jing Xu shenzhen Grubbs institute and Department of Chemistry and Guangming Advanced research institute and Guangdong Provincial Key Laboratory of Catalysis and shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis Southern University of Science and TechnologyShenzhenGuangdong518055 China

As one of the most common structural motifs in natural products,cyclopentenones usually can be fabricated by Nazarov cyclization using divinyl ketones or functionalized tertiary divinyl carbinols(TDCs)as ***,straightforward method for transforming unfunctionalized TDCs to their corresponding cyclopentenones is currently ***,we wish to report the total syntheses of four structurally distinct terpenoids,namely laurane-type marine sesquiterpenoids isolaurene,debromoaplysin and aplysin,and guaiane sesquiterpenoid guaiadienone A,all using a novel synthetic method,named oxidative Nazarov cyclization,as the key *** work demonstrated our robust method is suitable for synthesizing various highly substituted cyclopentenones.

关键词： Total synthesis Synthetic methods Sesquiterpenoids Oxidative Nazarov reaction Electrocyclization Oxoammonium salt Pericyclic reaction Annulation

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Model-driven CT reconstruction algorithm for nano-resolution x-ray phase contrast imaging

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Chinese Physics B 2024年第7期33卷 646-650页

作者：谭雨航蔡学宝杨杰成苏婷郑海荣梁栋朱佩平葛永帅 research Center for Medical Artificial Intelligence Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China institute of Electronic Paper Displays South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China Paul C Lauterbur research Center for Biomedical Imaging Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

The low-density imaging performance of a zone plate-based nano-resolution hard x-ray computed tomography(CT)system can be significantly improved by incorporating a grating-based Lau interferometer. Due to the diffraction, however,the acquired nano-resolution phase signal may suffer splitting problem, which impedes the direct reconstruction of phase contrast CT(nPCT) images. To overcome, a new model-driven nPCT image reconstruction algorithm is developed in this study. In it, the diffraction procedure is mathematically modeled into a matrix B, from which the projections without signal splitting can be generated invertedly. Furthermore, a penalized weighted least-square model with total variation(PWLSTV) is employed to denoise these projections, from which nPCT images with high accuracy are directly *** experiments demonstrate that this new algorithm is able to work with phase projections having any splitting distances. Moreover, results also reveal that nPCT images of higher signal-to-noise-ratio(SNR) could be reconstructed from projections having larger splitting distances. In summary, a novel model-driven nPCT image reconstruction algorithm with high accuracy and robustness is verified for the Lau interferometer-based hard x-ray nano-resolution phase contrast imaging.

关键词： splitting phase image reconstruction algorithm grating interferometer

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Secure Tracking Control via Fixed-Time Convergent Reinforcement Learning for a UAV CPS

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1699-1701页

作者： Zhenyu Gong Feisheng Yang the School of Automation Northwestern Polytechnical UniversityXi’an 710129 the research&Development institute of Northwestern Polytechnical University in shenzhen Shenzhen 518063China

Dear Editor,This letter is concerned with the secure tracking control problem in the unmanned aerial vehicle(UAV) system by fixed-time convergent reinforcement learning(RL). By virtue of the zero-sum game,the false da... 详细信息

关键词： Secure Fixed false

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