检索结果-南通市图书馆

Chinese journal of Natural Medicines 2018年第8期16卷 580-589页

作者： Maryam Mazhar Nurul Kabir Shabana U Simjee Dr. Panjwani Center for Molecular Medicine and Drug research International Centerjbr Chemical and Biological SciencesUniversity of Karachi Karachi 75270 Pakistan h.e.j. research institute. for chemistry International CenterJor Chemical and Biological Sciences University of Karachi Karachi 75270 Pakistan

Iron deficiency anemia is one of the most common micronutrient deficient conditions around the globe with various consequences,including the weakened immune *** is widely distributed bioflavonoid;it has been debated for its dual roles in iron ***-iron interaction in the body is a complex mechanism which has not been completely *** present study aimed to investigate the effect of quercetin on iron supplementation in iron deficiency anemia and on i NOS expression in splenic *** rat model of iron deficiency anemia was induced by feeding low iron diet to weanling rats for 20 *** animals were then administered with ferrous sulfate,quercetin,and their combination for 30 *** parameters,histopathological analysis,iron storage,CD68,i NOS and SLC40 expression in rat spleen were *** results showed that quercetin regulated iron absorption,despite SLC40 down-expression,indicating possible alternate route of iron transport,and that quercetin modulated i NOS production in splenic macrophages..

关键词： Iron deficiency anemia Inducible nitric oxide synthase Macrophages Spleen Quercetin

In vivo sedative and muscle relaxants activity of Diospyros lotus L

在线全文

学校读者我要写书评

暂无评论

Asian Pacific journal of Tropical Biomedicine 2015年第4期5卷 277-280页

作者： Abdur Rauf Ghias Uddin Bina Shaheen Siddiqui haroon Khan institute of Chemical Sciences University of Peshawar h.e.j. research institute of chemistry International Center for Chemical and Biological Sciences University of Karachi Department of Pharmacy Abdul Wali Khan University

Objective: To evaluate the sedative effect of Diospyros lotus L(D. lotus) extract in mice using the open field and Rota rod ***: For the sedative and muscle relaxants activities of extract/fractions of the plant, invivo open field and phenobarbitone-induced sleeping time were used, while the Roda rod test was employed in animals for the assessment of muscle relaxant ***: Results from this investigation revealed that the extracts of D. lotus have exhibited significant sedative effect in mice(45.98%) at 100 mg/kg i.p. When the extract was partitioned with different solvents, the n-hexane fraction was inactive whereas the chloroform fraction was the most active with 82.67% sedative effect at 50 and 100 mg/kg i.p. On the other hand,the ethyl acetate and n-butanol fractions displayed significant sedative effects(55.65% and40.87%, respectively) at 100 mg/kg i.p. Among the tested extract/fractions, only chloroform and ethyl acetate fractions showed significant(P e relaxant activity in the Rota rod ***: In short, our study provided scientific background to the traditional uses of *** as sedative.

关键词： Diospyros lotus ebenaceae Sedative Muscle relaxants activity

Mass transfer in the absorption of SO_2 and NO_x using aqueous euchlorine scrubbing solution

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of environmental Sciences 2009年第2期21卷 155-161页

作者： DeShWAL Bal-Raj Lee hyung-Keun Department of chemistry A.I.J.H.M. College Green-house Gas research Center Korea Institute of Energy Research

Attempts have been made to generate euchlorine gas by chlorate-chloride process and to utilize it further to clean up SO2 and NOx from the flue gas in a lab scale bubbling reactor. Preliminary experiments were carded out to determine the gas and liquid phase mass transfer coefficients and their correlation equations have been established. Simultaneous removal of SO2 and NOx from the simulated flue gas using aqueous euchlorine scrubbing solution has been investigated. euchlorine oxidized NO into NO2 completely and the later subsequently absorbed into the scrubbing solution in the form of nitrate. SO2 removal efficiency around 100% and NOx removal efficiency around 72% were achieved under optimal conditions. Mass balance has been confirmed by analyzing the sulfate, nitrate, euchlorine and chloride ion using ion chromatograph/auto-titrator and comparing it with their corresponding calculated values.

关键词： mass transfer sulfur dioxide nitric oxide bubbling reactor euchlorine

Bioassay-guided isolation of novel and selective urease inhibitors from Diospyros lotus

在线全文

学校读者我要写书评

暂无评论

Chinese journal of Natural Medicines 2017年第11期15卷 865-870页

作者： Abdur Rauf Ghias Uddin Bina S. Siddiqui Ajmal Khan Umar Farooq Farhan A. Khan Syed Majid Bukhari Sher Bahadar Khan Department of chemistry University ofSwabi Anbar-23561 Khyber Pakhtunkhwa Pakistan institute of Chemical Sciences University ofPeshawar Peshawar-25120 Pakistan h.e.j. research institute of chemistry International Center for Chemical and Biological Sciences University ofKarachL Ka- rachi- 75270 Pakistan Department of chemistry COMSAT Institute of Information Technology Abbottabad-22060 Pakistan UoN Chair of Oman 's Medicinal Plants and Marine Natural Products University ofNizwa Birkat Al-Mouz Nizwa-616 Oman Center of excellence for Advanced Materials research (CeAMR) Department of Chemistry Faculty of Science King Abdulaziz University Jeddah 21589 Saudi Arabia Kingdom

Two new dimeric naphthoquinones, 5′,8′-dihydroxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone(1; Di-naphthodiospyrol D) and 5′,8′-dihydroxy-5,8-dimethoxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone(2; Di-naphthodiospyrol e), along with known naphthoquinones diospyrin(3) and 8-hydroxy diospyrin(4) were isolated from the chloroform fraction of extract of Diospyros lotus roots. Their structures were elucidated by advanced spectroscopic analyses, including hSQC, hMBC, NOeSY, and j-resolved NMR experiments. The fractions and compounds 1-4 were evaluated for urease activity and phosphodiesterase-Ⅰ, carbonic anhydrase-Ⅱ and α-chymotrypsin enzyme inhibitory activities. Compounds 1 and 2 and their corresponding fractions showed significant and selective inhibitory effects on urease activities. The IC_(50) values of 1 and 2 were 260.4 ± 6.37 and 381.4 ± 4.80 μmol·L-1, respectively, using thiourea(IC_(50) = 21 ± 0.11 μmol·L^(-1)) as the standard inhibitor. This was the first report demonstrating that the naphthoquinones class showed urease inhibition.

关键词： Diospyros lotus Naphthoquinones Phosphodiesterase-Ⅰ Carbonic anhydrase-Ⅱ α-Chymotrypsin Urease inhibitory activities

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory hBorschel SickKids research institute Neuroscience and Mental Health ProgramTorontoONCanada institute of Biomaterials and Biomedical engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

在线全文

学校读者我要写书评

暂无评论

journal of energy chemistry 2025年第01期 760-769页

作者： Lin Peng Yu Bai hang Li Meixiu Qu Zhenhua Wang Kening Sun Advanced research institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

Lithium-sulfur （Li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （LiPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under e/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词：

Optimization Conditions of the Preparation of Activated Carbon Based egusi (<i>Cucumeropsis mannii</i>Naudin) Seed Shells for Nitrate Ions Removal from Wastewater

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

American journal of Analytical chemistry 2018年第10期9卷 439-463页

作者： René Blaise Ngouateu Lékéné julius Ndi Nsami Asma Rauf Daouda Kouotou Placide Desiré Belibi Belibi Muhammad Iqbal Bhanger joseph Ketcha Mbadcam Applied Physical and Analytical chemistry Laboratory Department of Inorganic Chemistry Faculty of Science University of Yaoundé I Yaoundé Cameroon h.e.j. research institute of chemistry University of Karachi Karachi Pakistan

egusi seed shells (eSS) were used as precursor for the preparation of two activated carbons (ACs) following h3PO4 and ZnCl2 activation. The effect of factors controlling the preparation of ACs such as chemical activating agent concentration (2 - 10 M), activation temperature (400°C - 700°C) and residence time (30 - 120 min) were optimized using the Box-Behnken Design (BBD). The optimized activated carbons based h3PO4 (ACP) and ZnCl2 (ACZ) were characterized by N2 adsorption, elemental analysis, atomic force microscopy (AFM), Boehm titration and Fourier transformed infrared (FTIR) techniques. The specific surface area was found to be 1053.91 and 1009.89 m2·g-1 for ACP and ACZ respectively. The adsorbents had similar surface functionalities and were both microporous. The effect of various parameters such as initial ph, concentration, and contact time on the adsorption of nitrate ions on ACP and ACZ in aqueous solution was studied. ACZ demonstrated better adsorption capacity (8.26 mg·g-1) compared to ACP (5.65 mg·g-1) at the same equilibrium time of 20 min. The adsorption process was governed by a “physical interactions” phenomenon for both adsorbents.

关键词： egusi Seed Shells Activated Carbon Optimization Nitrate Ions Wastewater Adsorption Process

Isolation and characterization of xanthine oxidase inhibitory constituents of Pyrenacantha staudtii

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

药学学报 2009年第4期44卷 390-394页

作者： Abiodun FALODUN Muhammad Irfan QADIR Muhammad Iqbal ChOULDARY Department of Pharmaceutical chemistry Faculty of Pharmacy University of Benin Benin City Nigeria h.e.j. research institute of chemistry International Center for Chemical Sciences University of Karachi Karachi 75270 Pakistan

Six compounds have been isolated from the leaves of Pyrenacantha staudtii, two of which are new compounds. The new compounds have been characterized as kaempherol 3-O-β-rhamnopyranosyl (1→6)-β-D-glucopyranoside (1) and 4-β-glucopyranosyl-(2-furyl)-5-methy-l,2-glucopyranoside phenylmethanone (2). The known compounds are 3-pyridinecarboxylic acid (3), β-sitosterol (4), sitosterol 3-O-β-glucopyranoside (5) and taraxerol (6). Their structures were determined by spectroscopic and chemical evidences. The two new compounds together with 3-pyridinecarboxylic acid showed significant in vitro xanthine oxidase inhibitory activity. To the best of our knowledge, this is the first report of these compounds from this plant.

关键词：化合物药用植物氧化酶化学分析

New antiglycation and enzyme inhibitors from Parmotrema cooperi

在线全文

学校读者我要写书评

暂无评论

Science China chemistry 2011年第12期54卷 1926-1931页

作者： M.Iqbal ChOUDhARY Meher ALI Atia-tul-WAhAB Ajmal KhAN Saima RASheeD Sajan Lal ShYAULA(Shrestha) Atta-ur-RAhMAN h.e.j.research institute of chemistry International Center for Chemical and Biological SciencesUniversity of Karachi Dr.Panjwani Center for Molecular Medicine and Drug research International Center for Chemical and Biological SciencesUniversity of Karachi Department of chemistry College of ScienceKing Saud University Nepal Academy of Science and Technology

Lichens are unique individuals which have been widely used in traditional medicines. This study was focused on the bioassayguided phytochemical investigation, and bioactivity evaluation on a lichens species, Parmotrema cooperi. This first bioassaydirected chemical study on P. cooperi has led to the isolation of ethyl heamatomate （1）, atraric acid （2）, ethyl orsellinate （3）, orsellinic acid （4）, lecanoric acid （5）, gyrophoric acid （6）, and licanorin （7）. The structures of 1-7 were mainly elucidated from spectroscopic methods including 1D, and 2D NMR spectroscopy, and mass spectrometry. These compounds were evaluated for their antiglycation, urease, a-chymotrypsin, and β-glucoronidase inhibitory activities. Few of the phenolic compounds showed significant, while most of them showed good inhibition of protein glycation, and urease activities.

关键词： lichen Parmotrema cooped ethyl heamatomate atraric acid urease inhibition antiglycation

Chemical functionalization of chitosan biopolymer and chitosan-magnetite nanocomposite with sulfonic acid for acid-catalyzed reactions

在线全文

学校读者我要写书评

暂无评论

Chinese journal of Chemical engineering 2021年第11期34卷 154-161页

作者： Majid Masteri-Farahani Samaneh Shahsavarifar research institute of Green chemistry Faculty of ChemistryKharazmi UniversityTehranIran

Chemical functionalization of chitosan biopolymer and chitosan-magnetite nanocomposite was performed with sulfonic acid functional groups to achieve new solid acid *** sulfonic acid functional groups were created through the ring opening nucleophilic reaction of amine groups of chitosan with 1,4-butane *** transform infrared spectroscopy(FT-IR)and X-ray photoelectron spectroscopies(XPS)verified the successful sulfonic acid functionalization of *** obtained sulfonic acid functionalized chitosan-magnetite nanocomposite showed superparamagnetic properties according to the vibrating sample magnetometry analysis and exhibited magnetic separation feature from dispersed *** adsorption-desorption analysis indicated the increase in surface area after formation of chitosan-magnetite nanocomposite and functionalization with sulfonic *** of the prepared solid acids exhibited high catalytic activities in the acid-catalyzed acetic acid esterification with n-butanol and benzaldehyde acetalization with ethylene glycol as model ***,they can be reused several times without considerable loss of their activities.

关键词： Chitosan Magnetite Nanostructure Sulfonic acid Catalysis esterification