Isolation and characterization of xanthine oxidase inhibitory constituents of Pyrenacantha staudtii

作     者：Abiodun FALODUN Muhammad Irfan QADIR Muhammad Iqbal CHOULDARY 

作者机构：Department of Pharmaceutical Chemistry Faculty of Pharmacy University of Benin Benin City Nigeria H.E.J. Research Institute of Chemistry International Center for Chemical Sciences University of Karachi Karachi 75270 Pakistan 

出 版 物：《药学学报》 (Acta Pharmaceutica Sinica)

年 卷 期：2009年第44卷第4期

页      面：390-394页

核心收录：

学科分类：0710[理学-生物学] 1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 100703[医学-生药学] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100602[医学-中西医结合临床] 10[医学] 

主　　题：化合物 药用植物 氧化酶 化学分析 

摘      要：Six compounds have been isolated from the leaves of Pyrenacantha staudtii, two of which are new compounds. The new compounds have been characterized as kaempherol 3-O-β-rhamnopyranosyl (1→6)-β-D-glucopyranoside (1) and 4-β-glucopyranosyl-(2-furyl)-5-methy-l,2-glucopyranoside phenylmethanone (2). The known compounds are 3-pyridinecarboxylic acid (3), β-sitosterol (4), sitosterol 3-O-β-glucopyranoside (5) and taraxerol (6). Their structures were determined by spectroscopic and chemical evidences. The two new compounds together with 3-pyridinecarboxylic acid showed significant in vitro xanthine oxidase inhibitory activity. To the best of our knowledge, this is the first report of these compounds from this plant.