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Seismic stratigraphy and the sedimentation history in the Laxmi Basin of the eastern Arabian Sea:Constraints from IODP Expedition 355

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Geoscience Frontiers 2021年第3期12卷 489-502页

作者： Nisha Nair Dhananjai K.Pandey Anju Pandey R.Prerna National Centre for Polar and Ocean Research(ncpor) Ministry of Earth SciencesVasco-da-GamaGoa 403804India h-v3-ncpor campus Vasco-da-GamaGoa 403804India

Detailed interpretation of seismic stratigraphic sequences in the Laxmi Basin of the eastern Arabian Sea are presented in this study using closely spaced high resolution multi-channel seismic(MCS)*** stratigraphic interpretation is further corroborated using recent drilling results in the Laxmi Basin,derived from the long sediment cores collected during International Ocean Discovery Program(IODP)Expedition *** core-log interpretation discussed in the present study,offer important insights about the lithostratigraphic variations in this *** of multi-channel seismic reflection data reveal five depositional sequences(ranging from Paleocene to Recent)that led to the development of this marginal basin since the Cenozoic *** igneous basement is successfully imaged,which was also validated by deep sea coring during the IODP Expedition *** the present study,we primarily focus on the post-rift sedimentation in the Laxmi Basin and its possible *** detailed interpretation in the prevailing tectonic framework of the basin suggests that near-shelf oldest volcaniclastic sedimentation immediately overlying the acoustic basement is linked to the onset of India-Madagascar and India-Seychelles rifting activities during the Late Cretaceous ***,during the Early-Mid to Late Miocene,the basin received maximum sedimentation dominantly through an extensive mass transport mechanism implying possible large-scale deformation on the Indian *** sediment input to the basin appears to have been fed variably via the Indus Fan as well as coastal discharge from the Indian *** total sediment thickness in the Laxmi Basin ranges from 1.1 to 3.5 *** stratigraphic information and sediment isopach maps presented here provide vital information about syn-and post-rift sedimentation pattern in the region and their long term tectonic implications.

关键词： Seismic stratigraphy Laxmi Basin Arabian Sea Site U1456 Site U1457 IODP Expedition 355

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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António J.Salgado Nuno A.Silva Life and health Sciences Research Institute(ICvS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICvS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： David vC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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Medical Diagnosis Based on Multi-Attribute Group Decision-Making Using Extension Fuzzy Sets,Aggregation Operators and Basic Uncertainty Information Granule

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 759-811页

作者： Anastasios Dounis Ioannis Palaiothodoros and Anna Panagiotou Department of Biomedical Engineering Egaleo Park CampusUniversity of West AtticaAthens12243Greece

Accurate medical diagnosis,which involves identifying diseases based on patient symptoms,is often hindered by uncertainties in data interpretation and *** fuzzy set theories have emerged as effective tools to address these *** this paper,new mathematical approaches for handling uncertainty in medical diagnosis are introduced using q-rung orthopair fuzzy sets(q-ROFS)and interval-valued q-rung orthopair fuzzy sets(Ivq-ROFS).Three aggregation operators are proposed in our methodologies:the q-ROF weighted averaging(q-ROFWA),the q-ROF weighted geometric(q-ROFWG),and the q-ROF weighted neutrality averaging(qROFWNA),which enhance decision-making under *** operators are paired with ranking methods such as the similarity measure,score function,and inverse score function to improve the accuracy of disease ***,the impact of varying q-rung values is explored through a sensitivity analysis,extending the analysis beyond the typical maximum value of *** Basic Uncertain Information(BUI)method is employed to simulate expert opinions,and aggregation operators are used to combine these opinions in a group decisionmaking *** results provide a comprehensive comparison of methodologies,highlighting their strengths and limitations in diagnosing diseases based on uncertain patient data.

关键词： Medical diagnosis multi-attribute group decision-making(MAGDM) q-ROFS Ivq-ROFS BUI aggregation operators similarity measures inverse score function

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A new perspective on functional redundancy and phylogenetic niche conservatism in soil microbial communities

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Pedosphere 2020年第1期30卷 18-24页

作者： Yu JIA Joann K.WhALEN Department of Natural Resource Sciences Macdonald Campus of McGill UniversitySte-Anne-de-BellevueQuebec H9X 3V9(Canada)

Functional redundancy in soil microbial communities seems to contradict the notion that individual species have distinct metabolic niches in multi-species *** soil microbiota have the metabolic capacity for"basic"functions(e.g.,respiration and nitrogen and phosphorus cycling),but only a few soil microbiota participate in"rare"functions(e.g.,methanogenesis and mineralization of recalcitrant organic pollutants).The objective of this perspective paper is to use the phylogenetic niche conservatism theory as an explanation for the functional redundancy of soil *** niche conservatism is defined as the tendency for lineages to retain ancestral functional characteristics through evolutionary *** present-day soil microbiota is the result of a community assembly process that started when prokaryotes first appeared on *** billions of years,microbiota have retained a highly conserved set of core genes that control the essential redox and biogeochemical reactions for life on *** genes are passed from microbe to microbe,which contributes to functional redundancy in soil microbiota at the planetary *** assembly of microbial communities during soil formation is consistent with phylogenetic niche *** a specific soil,the heterogeneous matrix provides an infinite number of sets of diverse environmental conditions,i.e.,niches that lead to the divergence of microbial *** phylogenetic niche conservatism theory predicts that two or more microbial species diverging from the same clade will have an overlap in their niches,implying that they are functionally redundant in some of their metabolic *** endogenous genetic factors that constrain the adaptation of individuals and,thus,populations to changing environmental conditions constitute the core process of phylogenetic niche ***,the degree of functional redundancy in a particular soil is proportional to the complexity of the

关键词： basic function conceptual model core gene environmental factor genetic factor niche overlap rare function soil biodiversity

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Three-dimensional modelling of shear keys in concrete gravity dams using an advanced grillage method

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Water Science and Engineering 2020年第3期13卷 223-232页

作者： Mahdi Ben Ftima Steephane Lafrance Pierre Leeger Polytechnique Montreal Montreal University CampusMontrealH3C 3A7Canada

Contraction joint shear keys are resilient features of gravity dams that can be considered to increase the sliding safety factors or minimise seismic residual sliding displacements,allowing costly remedial actions to be *** paper presents a novel,robust,and computationally efficient three-dimensional(3D)modelling and simulation strategy of gravity dams,using a series of adjacent cantilever beam elements to represent individual *** monoliths are interconnected in the longitudinal direction by 3D no-tension link elements representing the lumped shear key stiffness contributions at a particular *** objective is to assess the shear key internal force demands,including the axial force,shear,and moment *** key demand-capacity ratios can then be assessed with related multi-axial failure *** 3D link element stiffness coefficients were derived from a series of 3D finite element(FE)solid models with a detailed representation of geometrical features of multiple shear *** results from the proposed method based on advanced grillage analysis show strong agreement with reference solutions from 3D FE solid models,demonstrating high accuracy and performance of the proposed *** application of the proposed advanced grillage method to a dam model with two monoliths clearly shows the advantage of the proposed method,in comparison to the classical approach used in practise.

关键词： Gravity dam Shear keys Seismic analysis Grillage analysis Finite element model Multi-scale approach

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Numerical and experimental study of wave shaper effects on detonation wave front

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Defence Technology（防务技术） 2018年第1期14卷 45-50页

作者： Khalid Naeem Arshad hussain SCME (NUST) Islamabad Simulation Lab.Room 113 SCME NUST H-12 Campus SCME (NUST) H-12 Campus

In the current study, streak camera was used to find concentricity of the assembly during detonation,investigate and compare shock front within the high explosive and behavior of the shock front on the surface of the liner, one containing wave shaper and the other without wave shaper. Streaks revealed that the whole assembly was concentric till the formation of the jet. Observed streaks vindicate the uniform propagation of shock front in both the cases. Results obtained for shock front velocities are in agreement with those obtained from simulations. In the presence of wave shaper higher shock front velocity was observed both in simulation and experiment. Simulation without wave-shaper showed that shock front struck the copper cone at grazing angle while in the presence of wave-shaper it struck at an angle of 125.

关键词： Shock front Streak camera Simulation Wave shaper

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis h.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Earthworm contributions to soil nitrogen supply in corn-soybean agroecosystems in Quebec, Canada

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Pedosphere 2021年第3期31卷 405-412页

作者： Zhor ABAIL Joann KWhALEN National Institute of Agricultural Research(INRA) Kenitra B.P.257Morocco Department of Natural Resource Sciences Macdonald Campus of McGill UniversitySte-Anne-de-BellevueQuebec H9X 3V9Canada

Accurately quantifying the soil nitrogen(N)supply in crop fields is essential for enabling environmentally sustainable and economically profitable crop *** requires using field-based methods to account for the contribution of soil biota,including earthworms,to N mineralization in temperate *** direct contribution of earthworms to the soil N cycle is the N they release throughout their life and after death,and it can be estimated using the secondary production *** study was conducted in 2014 and 2015 in two adjacent fields with annual corn-soybean rotation in Ste-Anne-de-Bellevue,Quebec,*** cumulative biomass of Aporrectodea *** two no-till corn-soybean agroecosystems was determined,and the direct N flux from these earthworms was estimated during the corn and soybean phases of the *** production was estimated by sampling earthworms biweekly during April-June and September-November and inferring the change in earthworm biomass between sampling dates using a size frequency *** N flux was calculated as the sum of the N released through excretion,during periods when earthworms were active,and from *** secondary production of the Aporrectodea population was estimated to be 8-43 g ash-free dry weight m^(-2) year^(-1),and the N flux was 22-105 kg N ha^(-1 )year^(-1).The N flux was higher at the early vegetative growth stage,which is a period of high N demand for *** findings suggest that refining the N fertilization recommendation by accounting for soil N supplied by earthworms could potentially reduce fertilizer costs and environmental N losses.

关键词： nitrogen excretionnitrogen fluxnitrogen releasesecondary productionsize frequency method

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how dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1405-1406页

作者： Livia La Barbera Paraskevi Krashia Annalisa Nobili Department of Medicine and Surgery UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly Department of Experimental Neurosciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly Department of Science and Technology for Sustainable Development and One health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc *** is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.

关键词： Alzheimer alterations dopamine

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