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Caprylic Acid Improves Lipid Metabolism, Suppresses the Inflammatory Response and Activates the ABCA1/p-JAK2/pSTAT3 Signaling Pathway in C57BL/6J Mice and RAW264.7 Cells

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Biomedical and Environmental Sciences 2022年第2期35卷 95-106页

作者： ZHANG Xin Sheng ZHANG Peng LIU Ying Hua XU Qing ZHANG Yong LI Hui Zi LIU Lu LIU Yu Meng YANG Xue Yan XUE Chang Yong Department of Nutrition the First Medical Center of PLA General HospitalBeijing 100853China guizhou crops of chinese armed police force Guiyang 550001GuizhouChina Department of Nutrition PLA Rocket Force Characteristic Medical CenterBeijing 100088China

Objective This study aimed to investigate the effects of caprylic acid(C8:0)on lipid metabolism and inflammation,and examine the mechanisms underlying these effects in mice and *** Fifty-six 6-week-old male C57BL/6J mice were randomly allocated to four groups fed a highfat diet(HFD)without or with 2%C8:0,palmitic acid(C16:0)or eicosapentaenoic acid(EPA).RAW246.7 cells were randomly divided into five groups:normal,lipopolysaccharide(LPS),LPS+C8:0,LPS+EPA and LPS+*** serum lipid profiles,inflammatory biomolecules,and ABCA1 and JAK2/STAT3 mRNA and protein expression were *** C8:0 decreased TC and LDL-C,and increased the HDL-C/LDL-C ratio after injection of *** LPS,it decreased TC in mice(P<0.05).Moreover,C8:0 decreased the inflammatory response after LPS treatment in both mice and cells(P<0.05).Mechanistic investigations in C57BL/6J mouse aortas after injection of LPS indicated that C8:0 resulted in higher ABCA1 and JAK2/STAT3 expression than that with HFD,C16:0 and EPA,and resulted in lower TNF-α,NF-κB mRNA expression than that with HFD(P<0.05).In RAW 264.7 cells,C8:0 resulted in lower expression of pNF-κBP65 than that in the LPS group,and higher protein expression of ABCA1,p-JAK2 and p-STAT3 than that in the LPS and LPS+cAMP groups(P<0.05).Conclusion Our studies demonstrated that C8:0 may play an important role in lipid metabolism and the inflammatory response,and the mechanism may be associated with ABCA1 and the p-JAK2/p-STAT3 signaling pathway.

关键词： Caprylic acid Inflammatory cytokine ATP binding cassette transporter A1 Janus kinase 2 Signal transducer and activator of transcription 3

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Analysis on clinical distribution and drug resistance of pathogenic bacteria in the of 1368 cases mid-stream urine

Analysis on clinical distribution and drug resistance of pat...

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2014浙江省医学会男科学泌尿外科学学术年会

作者： Xiang HONG Qing kang XU Yue DUAN Wei hua SHEN Tain qing YU Xian jun SUN Department of Urology Zhejiang Provincal Crops Hospital of Chinese People’s Armed Police Force

Objective to analyze the pathogens and antibiltic resistance of urine cultu-re in patients with ureteral stones for the guidance of clinical medicine treatment and prevention and rational use of *** 1368 patients of ureteral stones treated clean urine culture and sensitivity from January of 2011-June of 2013 in our *** 238 pathogens were isolated from 1368 urine *** positive cocci accounted for 30.25%(72 cases),The majority was Enterococcus fasium and Staphylococcus aureus;In which Gram negative bacilli accounted for 66.81%(159 cases),the majority was the Escherichia coli(***)and Pseudomonas aeruginosa;Fungi accounted for 2.94%(7cases).There are a large difference in resistance to different bacterials,the performance is the different degrees of *** This study showed that with positive rate of 17.4%of the *** majority was Enterococcus fasium and the Escherichia coli(***).It is necessary for patients with ureteral calculi gived urine culture before *** are lagare significance to reduce the generation of broad-spectrum antibiotics and a reasonable choice of antibiotics.

关键词： Ureteral stones urine culture pathogens drug resistance

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Low-temperature 3D-printed collagen/chitosan scaffolds loaded with exosomes derived from neural stem cells pretreated with insulin growth factor-1 enhance neural regeneration after traumatic brain injury

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Neural Regeneration Research 2023年第9期18卷 1990-1998页

作者： Xiao-Yin Liu Yin-He Feng Qing-Bo Feng Jian-Yong Zhang Lin Zhong Peng Liu Shan Wang Yan-Ruo Huang Xu-Yi Chen Liang-Xue Zhou Department of Neurosurgery West China HospitalWest China Medical SchoolSichuan UniversityChengduSichuan ProvinceChina Tianjin Key Laboratory of Neurotrauma Repair Pingjin Hospital Brain CenterCharacteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Department of Respiratory and Critical Care Medicine People’s Hospital of Deyang CityAffiliated Hospital of Chengdu College of MedicineDeyangSichuan ProvinceChina Department of Liver Surgery&Liver Transplantation State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduProvinceChina Department of General Surgery the Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina The First Affiliated Hospital of Chengdu Medical College ChengduSichuan ProvinceChina Department of Anesthesiology Huashan HospitalFudan UniversityShanghaiChina Institute of Medical Security for Maritime Rights Protection of Characteristic Medical Center of chinese People’s armed police force TianjinChina

There are various clinical treatments for traumatic brain injury,including surgery,drug therapy,and rehabilitation therapy;howeve r,the therapeutic effects are *** combined with exosomes represent a promising but challenging method for improving the repair of traumatic brain *** this study,we determined the ability of a novel 3D-printed collagen/chitosan scaffold loaded with exosomes derived from neural stem cells pretreated with insulin-like growth factor-1(3D-CC-INEXOS) to improve traumatic brain injury repair and functional recove ry after traumatic brain injury in *** scaffolds comprising collagen,chitosan,and exosomes derived from neural stem cells pretreated with insulin-like growth fa ctor-1(INEXOS) continuously released exosomes for *** of 3D-CC-INExos scaffolds significantly improved motor and cognitive functions in a rat traumatic brain injury model,as assessed by the Morris water maze test and modified neurological seve rity *** addition,immunofluorescence staining and transmission electron microscopy showed that3D-CC-INExos implantation significantly improved the recove ry of damaged nerve tissue in the injured *** conclusion,this study suggests that transplanted3D-CC-INExos scaffolds might provide a potential strategy for the treatment of traumatic brain injury and lay a solid foundation for clinical translation.

关键词： 3D printing angiogenesis chitosan collagen exosomes functional recovery insulin-like growth factor-1 neural regeneration neural stem cells traumatic brain injury

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HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3755-3766页

作者： Chenxing Da Jun Pu Zhe Liu Jing Wei Yiping Qu Yongxing Wu Bingyin Shi Jian Yang Nongyue He Peng Hou Key Laboratory for Tumor Precision Medicine of Shaanxi Province and Department of Endocrinology The First Affiliated Hospital of Xi’an Jiaotong University710061 Xi’anPeople’s Republic of China Department of Diagnostic Radiology The First Affiliated Hospital of Xi’an Jiaotong University710061 Xi’anPeople’s Republic of China Department of Neurosurgery The First Affiliated Hospital of Xi’an Jiaotong University710061 Xi’anPeople’s Republic of China State Key Laboratory of Bioelectronics Southeast University210096 NanjingPeople’s Republic of China Shanxi Provincial crops Hospital of chinese People’s armed police force 710054 Xi’anPeople’s Republic of China

HACE1,an E3 ubiquitin-protein ligase,is frequently inactivated and has been evidenced as a putative tumor suppressor in different types of ***,its role in glioma remains ***,we observed increased expression of HACE1 in gliomas related to control subjects,and found a strong correlation of high HACE1 expression with poor prognosis in patients with WHO grade III and IV as well as low-grade glioma(LGG)patients receiving ***1 knockdown obviously suppressed malignant behaviors of glioma cells,while ectopic expression of HACE1 enhanced cell growth in vitro and in *** studies revealed that HACE1 enhanced protein stability of nuclear factor erythroid 2-related factor 2(NRF2)by competitively binding to NRF2 with another E3 ligase ***,HACE1 also promoted internal ribosome entry site(IRES)-mediated mRNA translation of *** effects did not depend on its E3 ligase ***,we demonstrated that HACE1 dramatically reduced cellular ROS levels by activating NRF2,thereby decreasing the response of glioma cells to ***,our data demonstrate that HACE1 causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells by activating NRF2,and indicate that it may act as the role of prognostic factor and potential therapeutic target in glioma.

关键词： glioma HACE malignant

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Three-dimensional-printed collagen/chitosan/secretome derived from HUCMSCs scaffolds for efficient neural network reconstruction in canines with traumatic brain injury

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Regenerative Biomaterials 2022年第1期9卷 572-584页

作者： Xiaoyin Liu Guijun Zhang Pan Wei Lin Zhong Yaxing Chen Jianyong Zhang Xuyi Chen Liangxue Zhou Department of Neurosurgery West China HospitalWest China Medical SchoolSichuan UniversityChengdu 610041SichuanChina Department of Neurosurgery The First People’s Hospital Of Long Quan yi DistrictChengdu 610000SichuanChina Tianjin Key Laboratory of Neurotrauma Repair Pingjin Hospital Brain CenterCharacteristic Medical Center of People’s Armed Police ForcesTianjin 300162China The First Affiliated Hospital of Chengdu Medical College Chengdu 610500SichuanChina Department of General Surgery the Affiliated Hospital of Guizhou Medical UniversityGuiyang CN 540000P.R.GuizhouChina Institute of Medical Security for Maritime Rights Protection of Characteristic Medical Center of chinese People’s armed police force(PAP) Tianjin300162China

The secretome secreted by stem cells and bioactive material has emerged as a promising therapeutic choice for traumatic brain injury(TBI).We aimed to determine the effect of 3D-printed collagen/chitosan/secretome derived from human umbilical cord blood mesenchymal stem cells scaffolds(3D-CC-ST)on the injured tissue regeneration process.3D-CC-ST was performed using 3D printing technology at a low temperature(20C),and the physical properties and degeneration rate were *** utilization of low temperature contributed to a higher cytocompatibility of fabricating porous 3D architectures that provide a homogeneous distribution of *** after the establishment of the canine TBI model,3D-CC-ST and 3D-CC(3D-printed collagen/chitosan scaffolds)were implanted into the cavity of *** implantation of scaffolds,neurological examination and motor evoked potential detection were performed to analyze locomotor function *** and immunofluorescence staining were performed to evaluate *** group treated with 3D-CC-ST had good performance of behavior *** 3D-CC-ST significantly reduced the cavity area,facilitated the regeneration of nerve fibers and vessel reconstruction,and promoted endogenous neuronal differentiation and synapse formation after *** implantation of 3D-CC-ST also markedly reduced cell apoptosis and regulated the level of systemic inflammatory factors after TBI.

关键词： traumatic brain injury canines secretome low temperature extrusion 3D printing collagen chitosan

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Single-balloon and spiral enteroscopy may have similar diagnostic and therapeutic yields to double-balloon enteroscopy:Results from a meta-analysis of randomized controlled trials and prospective studies

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World Journal of Meta-Analysis 2020年第2期8卷 153-162页

作者： Yong Gu Xin Shi Yan Yang Xiao-Fei Ye Qiong Wu Zhi-Ping Yang Shui-Xiang He Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Digestive System Diseases Shaanxi Provincial Crops Hospital of Chinese People's Armed Police ForceXi'an 710054Shaanxi ProvinceChina State Key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi'an 710032Shaanxi ProvinceChina Department of Health Statistics Second Military Medical UniversityShanghai 200433China

BACKGROUND Double-balloon,single-balloon,and spiral enteroscopy(DBE,SBE,and SE)have revolutionized the management of intestinal ***,evidence about efficacies of these methods is *** aimed to conduct a meta-analysis comparing the clinical outcomes among DBE,SBE,and *** We searched randomized controlled trials and prospective studies in MEDLINE,PubMed,EMBASE,Cochrane Library,and chinese CQVIP *** referencing the comparison of at least two of these three methods were *** outcome was diagnostic *** outcomes were therapeutic yield,total enteroscopy,examination time,time to maximum insertion,and depth of maximal insertion(DMI).RESULTS Eleven studies including 727 patients were identified:DBE vs SE(n=6),DBE vs SBE(n=4),and SBE vs SE(n=1).The diagnostic and therapeutic yields did not differ significantly when comparing DBE with SE[odds ratio(OR)=1.19,95%confidence interval(CI):0.68-2.08;OR=1.17,95%CI:0.61-2.23]and DBE with SBE(OR=0.85,95%CI:0.55-1.33;OR=1.71,95%CI:0.64-4.60).Total enteroscopy,examination time,time to maximum insertion,and DMI were similar between SBE and *** was superior to SE with regard to DMI[mean difference(MD)=36.76,95%CI:5.09-68.43],with longer time to maximum insertion(MD=15.14,95%CI:12-18.27)and examination time(MD=12.98,95%CI:9.57-16.38).CONCLUSION DBE and SBE have similar clinical *** with DBE,SE seems to have similar diagnostic and therapeutic yields,but shorter procedural time in cost of less depth of *** needs further evaluation vs *** is recommended for complete enteroscopy.

关键词： Double-balloon enteroscopy Single-balloon enteroscopy Spiral enteroscopy Meta-analysis Randomized controlled trials

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Baseline Characteristics and Treatment Patterns of the Patients Recruited to the China Registry of Hepatitis B

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Journal of Clinical and Translational Hepatology 2019年第4期7卷 322-328页

作者： Shan Shan Hong You Junqi Niu Jia Shang Wen Xie Yuexin Zhang Xun Li Hong Ren Hong Tang Huiguo Ding Xihong Wang Yuemin Nan Xiaoguang Dou Tao Han Lingyi Zhang Xiaoqing Liu Cunliang Deng Jilin Cheng Xiaozhong Wang Qing Xie Shumei Lin Yan Huang Youqing Xu Yong Xiong Wu Li Xuebing Yan Hongxin Piao Wenxiang Huang Qinghua Lu Weijin Gong Shiping Li Xiaoxuan Hu Xiaolan Zhang Shourong Liu Yufang Li Dongliang Yang Hai Li Caixia Yang Mingliang Cheng Liaoyun Zhang Huanwei Zheng Xinhua Luo Feng Lin Lei Wang Guanghua Xu Xiaoyuan Xu Lai Wei Jinlin Hou Zhongping Duan Hui Zhuang Xizhong Yang Yuanyuan Kong Jidong Jia the CR-HepB study group,Beijing,China Liver Research Center Beijing Friendship HospitalCapital Medical UniversityBeijing Key Laboratory of Translational Medicine on Liver CirrhosisNational Clinical Research Center for Digestive DiseasesBeijingChina Department of Hepatology First Hospital of Jilin UniversityChangchunJilinChina Department of Infectious Diseases Henan Provincial People's HospitalZhengzhouHenanChina Center of Liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijingChina Department of Infectious Diseases First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of General Surgery The First Hospital of Lanzhou UniversityLanzhouGansuChina Department of Infectious Diseases The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Center of Infectious Diseases West China Hospital of Sichuan UniversityChengduSichuanChina Department of Gastroenterology and Hepatology Beijing Youan HospitalCapital Medical UniversityBeijingChina Center of Infectious Diseases The Third People's Hospital of TaiyuanTaiyuanShanxiChina Department of Traditional and Western Medical Hepatology The Third Hospital of Hebei Medical UniversityShijiazhuangHebeiChina Department of Infectious Diseases Shengjing Hospital of China Medical UniversityShenyangLiaoningChina Department of Hepatology Tianjin Third Central HospitalTianjin Medical UniversityTianjinChina Department of Hepatology Lanzhou University Second HospitalLanzhouGansuChina Department of Infectious Diseases Peking Union Medical College HospitalBeijingChina Department of Infectious Diseases The Affiliated Hospital of Southwest Medical UniversityLuzhouGansuChina Department of Gastroenterology Shanghai Public Health Clinical CenterShanghaiChina Department of Hepatology Xinjiang Uygur Autonomous Region Traditional Chinese Medicine HospitalUrumqiXinjiangChina Department of Infectious Diseases Shanghai Ruijin HospitalJiao Tong University School of MedicineShanghaiChina Department of Infectious Diseases Th

Background and Aims: Chronic hepatitis B virus(HBV)in-fection remains a major public health problem ***,we describe the baseline characteristics and treatment pro-files of HBV-infected patients recruited to the China Registry of Hepatitis ***: Inclusion criteria were patients with different stages of chronic HBV infection and complete key *** criteria were patients with hepatocellular *** baseline clinical,laboratory and treatment pro-files were ***: Finally,40,431 patients were *** median age was 43 years,with 65.2%being men and 51.3%being positive for hepatitis B e antigen(HBeAg).The most common initial diagnosis was chronic hep-atitis B(81.0%),followed by cirrhosis(9.3%),inactive carrier of hepatitis B surface antigen(HBsAg)(6.7%),and immune tolerant phase of hepatitis B infection(3.0%).Among the 21,228 patients who were on treatment,88.0%,10.0%and 2.0%received nucleos(t)ide analogues(NAs),interferon or combination of NAs and interferon,*** propor-tion of patients who received preferred NAs(entecavir or te-nofovir disoproxil fumarate)had increased from 13.5%in 2003 to 79.7%in ***: We concluded that middle-aged men accounted for most of the patients with chronic hepatitis B in this cross-sectional *** half of the patients were *** were the most com-monly used therapy,and use of the preferred NAs had steadily increased in the past decade.

关键词： Hepatitis B Treatment Registry

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Fungal diversity notes 929-1035:taxonomic and phylogenetic contributions on genera and species of fungi

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Fungal Diversity 2019年第2期95卷 1-273页

作者： Rungtiwa Phookamsak Kevin D.Hyde Rajesh Jeewon D.Jayarama Bhat E.B.Gareth Jones Sajeewa S.N.Maharachchikumbura Olivier Raspe Samantha C.Karunarathna Dhanushka N.Wanasinghe Sinang Hongsanan Mingkwan Doilom Danushka S.Tennakoon Alexandre R.Machado Andre L.Firmino Aniket Ghosh Anuruddha Karunarathna Armin Mesic Arun Kumar Dutta Benjarong Thongbai Bandarupalli Devadatha Chada Norphanphoun Chanokned Senwanna Deping Wei Dhandevi Pem Frank Kwekucher Ackah Gen-Nuo Wang Hong-Bo Jiang Hugo Madrid Hyang Burm Lee Ishani D.Goonasekara Ishara S.Manawasinghe Ivana Kusan Josep Cano Josepa Gene Junfu Li Kanad Das Krishnendu Acharya K.N.Anil Raj K.P.Deepna Latha K.W.Thilini Chethana Mao-Qiang He Margarita Duenas Margita Jadan Maria P.Martin Milan C.Samarakoon Monika C.Dayarathne Mubashar Raza Myung Soo Park M.Teresa Telleria Napalai Chaiwan Neven Matocec Nimali Ide Silva Olinto L.Pereira Paras Nath Singh Patinjareveettil Manimohan Priyanka Uniyal Qiu-Ju Shang Rajendra P.Bhatt Rekhani H.Perera Renato Lucio Mendes Alvarenga Sandra Nogal-Prata Sanjay K.Singh Santhiti Vadthanarat Seung-Yoon Oh Shi-Ke Huang Shiwali Rana Sirinapa Konta Soumitra Paloi Subashini C.Jayasiri Sun Jeong Jeon Tahir Mehmood Tatiana Baptista Gibertoni Thuong T.T.Nguyen Upendra Singh Vinodhini Thiyagaraja V.Venkateswara Sarma Wei Dong Xian-Dong Yu Yong-Zhong Lu Young Woon Lim Yun Chen Zdenko Tkalcec Zhi-Feng Zhang Zong-Long Luo Dinushani A.Daranagama Kasun M.Thambugala Saowaluck Tibpromma Erio Camporesi Timur S.Bulgakov Asha J.Dissanayake Indunil C.Senanayake Dong Qin Dai Li-Zhou Tang Sehroon Khan Huang Zhang Itthayakorn Promputtha Lei Cai Putarak Chomnunti Rui-Lin Zhao Saisamorn Lumyong Saranyaphat Boonmee Ting-Chi Wen Peter E.Mortimer Jianchu Xu Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Institute of Animal Science State Key Laboratory of AnimalNutritionChinese Academy of Agricultural SciencesBeijing 100193People’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Rai 50150Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius No.128/1-J Co-Op Azad Housing SocietyCurcaGoa VelhaIndia Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Botanic Garden Meise Nieuwelaan 381860 MeiseBelgium Federation Wallonie-Bruxelles Service general de l’Enseignement universitaire et de la Recherche scientifiqueRue A.Lavallee 11080 BrusselsBelgium Shenzhen Key Laboratory of Microbial Genetic Engineering College of Life Science and OceanographyShenzhen University3688Nanhai AvenueNanshanShenzhen 518060People’s Republic of China Department of Plant Medicine National Chiayi University300 Syuefu RoadChiayi City 60004Taiwan Departamento de Micologia Universidade Federal de PernambucoRecifePernambucoBrazil Instituto de Ciencias Agrarias Universidade Federal de UberlandiaMonte CarmeloMinas GeraisBrazil Department of Botany&Microbiology H.N.B.Garhwal UniversitySrinagarGarhwal 246174UttarakhandIndia Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Ruder Boskovic Institute Bijenicka cesta 5410000 ZagrebCroatia Molecular and Applied Mycology and Plant Pathology Laboratory Department of BotanyUniversity of CalcuttaKolkataWest Bengal

This article is the ninth in the series of Fungal Diversity Notes,where 107 taxa distributed in three phyla,nine classes,31 orders and 57 families are described and *** described in the present study include 12 new genera,74 new species,three new combinations,two reference specimens,a re-circumscription of the epitype,and 15 records of sexualasexual morph connections,new hosts and new geographical *** new genera comprise Brunneofusispora,Brunneomurispora,Liua,Lonicericola,Neoeutypella,Paratrimmatostroma,Parazalerion,Proliferophorum,Pseudoastrosphaeriellopsis,Septomelanconiella,Velebitea and ***-four new species are Agaricus memnonius,***,Aleurodiscus patagonicus,Amanita flavoalba,***,Amphisphaeria mangrovei,Baorangia major,Bartalinia kunmingensis,Brunneofusispora sinensis,Brunneomurispora lonicerae,Capronia camelliaeyunnanensis,Clavulina thindii,Coniochaeta simbalensis,Conlarium thailandense,Coprinus trigonosporus,Liua muriformis,Cyphellophora filicis,Cytospora ulmicola,Dacrymyces invisibilis,Dictyocheirospora metroxylonis,Distoseptispora thysanolaenae,Emericellopsis koreana,Galiicola baoshanensis,Hygrocybe lucida,Hypoxylon teeravasati,Hyweljonesia indica,Keissleriella caraganae,Lactarius olivaceopallidus,Lactifluus midnapurensis,Lembosia brigadeirensis,Leptosphaeria urticae,Lonicericola hyaloseptispora,Lophiotrema mucilaginosis,Marasmiellus bicoloripes,Marasmius indojasminodorus,Micropeltis phetchaburiensis,Mucor orantomantidis,Murilentithecium lonicerae,Neobambusicola brunnea,Neoeutypella baoshanensis,Neoroussoella heveae,Neosetophoma lonicerae,Ophiobolus malleolus,Parabambusicola thysanolaenae,Paratrimmatostroma kunmingensis,Parazalerion indica,Penicillium dokdoense,Peroneutypa mangrovei,Phaeosphaeria cycadis,Phanerochaete australosanguinea,Plectosphaerella kunmingensis,Plenodomus artemisiae,***,Proliferophorum thailandicum,Pseudoastrosphaeriellopsis kaveriana,Pseudohelicomyces menglunicu

关键词： 86 new taxa Agaricomycetes Ascomycota Basidiomycota Dacrymycetes Dothideomycetes Eurotiomycetes Lecanoromycetes Leotiomycetes Mucoromycetes Mucoromycota Pezizomycetes Sordariomycetes Taxonomy

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Twin peaks of in-hospital mortality among patients with STEMI across five phases of COVID-19 outbreak in China:a nation-wide study

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Science China(Life Sciences) 2022年第9期65卷 1855-1865页

作者： Jianping Li Nan Zhang Ziyi Zhou Xiao Huang Weiyi Fang Hongbing Yan Jiyan Chen Weimin Wang Dingcheng Xiang Xi Su Bo Yu Yan Wang Yawei Xu Lefeng Wang Chunjie Li Kai Huang Xiaobin Wang Yong Huo Junbo Ge Department of Cardiology Peking University First HospitalBeijing 100044China Key Laboratory of Precision Nutrition and Food Quality Ministry of EducationDepartment of Nutrition and HealthCollege of Food Sciences and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Institute of Biomedicine Anhui Medical UniversityHefei 230032China Department of Cardiovascular Medicine Second Affiliated Hospital of Nanchang UniversityNanchang 330008China Department of Cardiology Huadong Hospital Affiliated to Fudan UniversityShanghai 200050China Department of Cardiology Fuwai Hospital Chinese Academy of Medical SciencesShenzhen 518057China Department of Cardiology Guangdong Provincial People’s HospitalGuangzhou 510080China Department of Cardiology Peking University People’s HospitalBeijing 100044China Department of Cardiology General Hospital of Southern Theatre CommandGuangzhou 510010China Department of Cardiology Wuhan ASIA Heart HospitalWuhan 430010China Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Cardiology Xiamen Cardiovascular Hospital Xiamen UniversityXiamen 361004China Department of Cardiology Shanghai Tenth People’s HospitalShanghai 200072China Department of Cardiology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100069China Department of Emergency Tianjin Chest HospitalTianjin 300074China Department of Cardiology Union Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Population Family and Reproductive HealthJohns Hopkins University Bloomberg School of Public HealthBaltimore 21218USA Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China

Lockdown and re-opening may become cyclical due to the recurrent waves of the COVID-19 *** studies have examined temporal trends and determinants of in-hospital mortality among patients with ST-segment elevation myocardial infarction(STEMI),a life-threatening condition that requires emergency medical *** nation-wide data before,during and after the Wuhan lockdown,we aimed to depict temporal patterns and major determinants of STEMI in-hospital mortality in China across five time periods of the COVID-19 *** analyzed the data of 283,661 STEMI patients who were admitted to 4,487 chest-pain-centers across China,from January 1,2019 to May 31,*** with the period before the lockdown,STEMI in-hospital mortality increased by 25%(OR 1.25,95%CI 1.16–1.34)during Early Lockdown,by 12%(OR 1.12,95%CI 1.03–1.22)during Later Lockdown,by 35%(OR 1.35,95%CI 1.21–1.50)during Early Lift,and returned to pre-COVID risk(OR 1.04,95%CI 0.95–1.14)during Later *** each time-period,we observed a clear mortality gradient by timing and types of revascularization *** conclusion,the COVID-19 epidemic had a significant adverse impact on STEMI in-hospital mortality,with bimodal peaks during early lockdown and early lift periods and clear mortality gradients by timing and types of revascularization procedure,independent of the time periods.

关键词： COVID-19 STEMI mortality lockdown re-opening

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