Twin peaks of in-hospital mortality among patients with STEMI across five phases of COVID-19 outbreak in China:a nation-wide study

作     者：Jianping Li Nan Zhang Ziyi Zhou Xiao Huang Weiyi Fang Hongbing Yan Jiyan Chen Weimin Wang Dingcheng Xiang Xi Su Bo Yu Yan Wang Yawei Xu Lefeng Wang Chunjie Li Kai Huang Xiaobin Wang Yong Huo Junbo Ge 

作者机构：Department of CardiologyPeking University First HospitalBeijing 100044China Key Laboratory of Precision Nutrition and Food QualityMinistry of EducationDepartment of Nutrition and HealthCollege of Food Sciences and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Institute of BiomedicineAnhui Medical UniversityHefei 230032China Department of Cardiovascular MedicineSecond Affiliated Hospital of Nanchang UniversityNanchang 330008China Department of CardiologyHuadong Hospital Affiliated to Fudan UniversityShanghai 200050China Department of CardiologyFuwai Hospital Chinese Academy of Medical SciencesShenzhen 518057China Department of CardiologyGuangdong Provincial People’s HospitalGuangzhou 510080China Department of CardiologyPeking University People’s HospitalBeijing 100044China Department of CardiologyGeneral Hospital of Southern Theatre CommandGuangzhou 510010China Department of CardiologyWuhan ASIA Heart HospitalWuhan 430010China Department of CardiologyThe 2nd Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of CardiologyXiamen Cardiovascular Hospital Xiamen UniversityXiamen 361004China Department of CardiologyShanghai Tenth People’s HospitalShanghai 200072China Department of CardiologyBeijing Chaoyang HospitalCapital Medical UniversityBeijing 100069China Department of EmergencyTianjin Chest HospitalTianjin 300074China Department of CardiologyUnion Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of PopulationFamily and Reproductive HealthJohns Hopkins University Bloomberg School of Public HealthBaltimore 21218USA Department of CardiologyZhongshan HospitalFudan UniversityShanghai 200032China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2022年第65卷第9期

页      面：1855-1865页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：920th Hospital of Chinese People’s Liberation Army Joint Support Force Anhui Provincial Hospital Beijing Anzhen Hospital Bo Yu Chengxing Shen China-Japan Union Hospital of Jilin University Eighth Affiliated Hospital First Hospital of Lanzhou University Fujian Medical University Union Hospital Fuwai Central China Cardiovascular Hospital General Hospital of Southern Theatre Command Genshan Ma (Zhongda Hospital Southeast University Hainan General Hospital Henan University of CM Hospital of Guangxi Zhuang Autonomous Region Hospital of Liaoning Province Huaimin Guan Jinan Central Hospital Jingfeng Wang Logistics University of People’s Armed Police Force Luobu Gesang Qingdao Central Hospital Qinghai Province Cardiocerebrovascular Disease Specialist Hospital Qinghai Red Cross Hospital Second Affiliated Hospital Zhejiang University School of Medicine Second Hospital of Jilin University Shanghai Sixth People’s Hospital Affiliated to Shanghai JiaoTong university Shenzhen Traditional Chinese Medicine Hospital Sun Yat-sen Memorial Hospital Suzhou Kowloon Hospital Shanghai Jiaotong University School of Medicine Taiyuan Central Hospital of Shanxi Medical University Tianjin Chest Hospital Wuhan Asia Heart Hospital Xiamen Cardiovascular Hospital Xiamen University Xiang Ma Xiangqing Kong Xiaoshu Cheng Xingwei Zhang Xinjiang Uiger Municipal People’s Hospital Xinqiao Hospital Yitong Ma Yuanzhe Jin Zhongshan Hospital Fudan University Zunyi Medical University Zuyi Yuan Shandong University, SDU Harbin Medical University, HMU Peking University First Hospital, PKUFH Inner Mongolia Medical University, IMMU Sun Yat-sen University, SYSU Xi’an Jiaotong University, XJTU Capital Medical University, CCMU Fudan University Jilin University, JLU Ningxia Medical University Chongqing Medical University, CQMU Nanchang University, NCU Xinjiang Medical University, XJMU Sichuan University, SCU Nanjing Medical University, NMU China Medical University, CMU Hangzhou Normal University, HNU Peking University, PKU Shanxi Medical University Shanghai Xuhui District Central Hospital Jining Medical University, JNMU Tianjin Medical University, TMU Guizhou Medical University, GMU Fuwai Hospital, Chinese Academy of Medical Sciences Guangxi Medical University, GXMU Army Medical University Hebei Medical University, HEBMU Shandong Academy of Medical Sciences, SAMS 

主　　题：COVID-19 STEMI mortality lockdown re-opening 

摘      要：Lockdown and re-opening may become cyclical due to the recurrent waves of the COVID-19 *** studies have examined temporal trends and determinants of in-hospital mortality among patients with ST-segment elevation myocardial infarction(STEMI),a life-threatening condition that requires emergency medical *** nation-wide data before,during and after the Wuhan lockdown,we aimed to depict temporal patterns and major determinants of STEMI in-hospital mortality in China across five time periods of the COVID-19 *** analyzed the data of 283,661 STEMI patients who were admitted to 4,487 chest-pain-centers across China,from January 1,2019 to May 31,*** with the period before the lockdown,STEMI in-hospital mortality increased by 25%(OR 1.25,95%CI 1.16–1.34)during Early Lockdown,by 12%(OR 1.12,95%CI 1.03–1.22)during Later Lockdown,by 35%(OR 1.35,95%CI 1.21–1.50)during Early Lift,and returned to pre-COVID risk(OR 1.04,95%CI 0.95–1.14)during Later *** each time-period,we observed a clear mortality gradient by timing and types of revascularization *** conclusion,the COVID-19 epidemic had a significant adverse impact on STEMI in-hospital mortality,with bimodal peaks during early lockdown and early lift periods and clear mortality gradients by timing and types of revascularization procedure,independent of the time periods.