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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community health service center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico I.Bohnen Department of Radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall center of Excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA Institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia Department of health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research center of Excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

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Movement analysis in the diagnosis and management of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 485-486页

作者： Johannes Burtscher Nicolas Bourdillon Jules MJanssen Daalen Aurélien Patoz Julien FBally Martin Kopp Davide Malatesta Bastiaan RBloem Institute of Sport Sciences University of LausanneLausanneSwitzerland Radboud University Medical center Department of NeurologyDonders Institute for BrainCognition and BehaviorCenter of Expertise for Parkinson and Movement DisordersNijmegenThe Netherlands Radboud University Medical center Department of Medical BioSciencesNijmegenThe Netherlands Research and Development Department Volodalen Swiss Sport LabAigleSwitzerland service of Neurology Department of Clinical NeurosciencesLausanne University Hospital(CHUV)and University of Lausanne(UNIL)LausanneSwitzerland Department of Sport Science University of InnsbruckInnsbruckAustria

Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall ***,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses *** biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).

关键词： diagnosis Clinical eventually

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Discrete Numerical Study on Type II Fracture of Partially Detached Concrete Panels in Cold Region

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Structural Durability & health Monitoring 2025年第1期19卷 167-191页

作者： Huayi Zhang Maobin Song Lei Shen Nizar Faisal Alkayem Maosen Cao College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210024China Haihe River Huaihe River and Xiaoqinghe River Basin Water Conservancy Management and Service Center of Shandong ProvinceJinan250100China College of Mechanics and Engineering Science Hohai UniversityNanjing211100China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-ﬁlled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during con-struction,the inﬂuence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefﬁcient on the bending stiffness are analyzed parametrically by the numerical simula-tion technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placementﬁrst and then prestress-tensioning is proposed.

关键词： Beam-string structure(BSS) concrete-ﬁlled steel tube(CFST) bending stiffness timing of concrete placement prestress-tensioning

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Impact of community public health care on treatment effect,health cognition,and self-management in patients with type 2 diabetes

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World Journal of Clinical Cases 2025年第5期13卷 22-29页

作者： Hong Shi Chun Liu Hong-Yan Luo Department of Infrastructure Operation West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Public health Minzu Street Community Health Service CenterWuhan 430000Hubei ProvinceChina Caotang Community health service center Chengdu 610031Sichuan ProvinceChina

BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease *** To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with *** One hundred patients with T2DM were selected as the research *** patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table *** conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing *** rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two *** The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(P<0.05).Compared with the scores before care,the cognitive level score for diabetes and self-management ability score improved after care in both *** cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than

关键词： Community public health care Type 2 diabetes Blood sugar control Self-management ability Cognition level

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Positive Associations between Bilateral High-Frequency Hearing Loss and Hypertension Risk in Short-Term Occupational Noise Exposure

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Biomedical and Environmental Sciences 2021年第12期34卷 992-997页

作者： JIN Nan ZHONG Hui Yun YUAN Fang DENG Hua Xin Department of Occupational health and Radiation health Chongqing Center for Disease Control and PreventionChongqing 400042China Xiejiawan street Community health service center Chongqing 400042China

Noise is one of the most common occupational hazards worldwide[1], and millions of workers are exposed to harmful levels of noise in the workplace[2]. Noise-induced hearing loss(NIHL) is a leading cause of occupational and recreational injury and disease[3]. There is evidence that occupational noise exposure is also associated with other health effects, such as hypertension and cardiovascular diseases, digestive disorders, behavioral disorders.

关键词： occupational cardiovascular diseases

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The antitumor effect of tanshinone IIA on antiproliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line

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Acta Pharmaceutica Sinica B 2015年第6期5卷 554-563页

作者： Jun Xie Jiahui Liu Heng Liu Shihui Liang Meigui Lin Yueyu Gu Taoli Liu Dongmei Wang Hui Gee Sui-lin Mo Department of Traditional Chinese Medicine The First Affiliated HospitalSun Yat-sen University Huanghuagang street Community health service center Liwan District Shiweitang street Community health service center School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou Higher Education Mega Center health Care and Physical Examination center The First Affiliated HospitalSun Yat-sen University

The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGFNEGFR signal pathway were investigated. The exploration of the interaction between tanshinone IIA and its target proteins provides a feasible platform for studying the anticancer mechanism of active components of herbs. The CCK-8 assay was used to evaluate the proliferative activity of A549 cells treated with tanshinone IIA (2.5-80 mu mol/E) for 24, 48 and 72 h, respectively. Flow cytometry was used for the detection of cell apoptosis and cell cycle perturbation. VEGF and VEGFR2 expression were studied by Western blotting. The binding mode of tanshinone IIA within the crystal stmcture of the VEGFR2 protein was evaluated with molecular docking analysis by use of the CDOCKER algorithm in Discovery Studio 2.1. The CCK-8 results showed that tanshinone IIA can significantly inhibit A549 cell proliferation in a dose- and time-dependent manner. Flow cytometry results showed that the apoptosis rate of tested group was higher than the vehicle control, and tanshinone IIA-treated cells accumulated at the S phase, which was higher than the vehicle control. Furthermore, the expression of VEGF and VEGFR2 was decreased in Western blot Finally, molecular docking analysis revealed that tanshinone IIA could be stably docked into the kinase domain of VEGFR2 protein with its unique modes to form H-bonds with Cys917 and pi-pi stacking interactions with Va1848. In conclusion, tanshinone IIA may suppress A549 proliferation, induce apoptosis and cell cycle arrest at the S phase. This drug may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

关键词： Non-small cell lung cancer Tanshinone IIA VEG/VEGFR signal pathway Molecular docking

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Spraying Arginine at 5 Days before Harvest Delays Postharvest Broccoli Senescence via Nutrient Accumulation

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食品科学 2025年第1期46卷 131-141页

作者： SUN Yupeng CHEN Ying SHANG Qingwen GUO Yanyin ZHANG Yuxiao WANG Yunqiao XUE Qingyue College of Agricultural Engineering and Food Science Shandong University of TechnologyZibo 255049China Zichuan District Agricultural and Rural Affairs service center Zibo 255049China

To determine the effects of preharvest arginine spraying on the nutritional level of broccoli and the mechanism of action of arginine in improving the storage quality of broccoli,arginine spraying(5 mmol/L)was conducted at 0,1,3,and 5 days before *** appearance,respiration rate,mass-loss rate,electrolyte leakage,glucosinolate,ascorbic acid,total phenol,total flavonoid,total sugar and sucrose contents,and sucrose phosphate synthase(SPS),invertase(INV),sucrose synthase synthesis(SSS)and cleavage(SSC)activities of broccoli samples were observed after 0,2,4,6,8,and 10 days of *** results showed that spraying arginine at 5 days preharvest(5-ARG)helped to inhibit broccoli respiration during storage,delay electrolyte leakage,and maintain broccoli ***,during the growth stage,total sugar accumulation was higher in the 5-ARG *** addition,during the storage period,sucrose synthesis was accelerated,while sucrose cleavage was inhibited,resulting in more sucrose retention in postharvest *** conclusion,5-ARG resulted in the accumulation of more nutrients during the growth process and effectively delayed the quality decline during storage,thereby prolonging the shelf life of ***,this study provides a theoretical basis for improving postharvest storage characteristics of broccoli through preharvest treatments.

关键词： arginine broccoli preharvest spraying nutrient accumulation storage quality postharvest senescence

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Neutrophil-to-lymphocyte ratio associated with renal function in type 2 diabetic patients

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World Journal of Clinical Cases 2024年第14期12卷 2308-2315页

作者： Jin-Li Gao Jue Shen Li-Ping Yang Li Liu Kai Zhao Xiao-Rong Pan Lei Li Ji-Ji Xu Department of Prevention and health Care Community Health Service Center of Miaohang TownShanghai 200443China Department of Prevention and health Care Community Health Service Center of Songnan TownShanghai 200434China Department of General Practice Community Health Service Center of Songnan TownShanghai 200434China Department of Administrative Community Health Service Center of Songnan TownShanghai 200434China

BACKGROUND Type 2 diabetes mellitus(T2DM)is a leading risk factor for the development and progression of chronic kidney disease(CKD).However,an accurate and con-venient marker for early detection and appropriate management of CKD in in-dividuals with T2DM is *** studies have demonstrated a strong correlation between the neutrophil-to-lymphocyte ratio(NLR)and ***-theless,the predictive value of NLR for renal damage in type 2 diabetic patients remains *** study included 1040 adults aged 65 or older with T2DM from Shanghai's Community health service *** total number of neutrophils and lym-phocytes was detected,and NLR levels were *** was defined as an estimated glomerular filtration rate≤60 mL/min/1.73 m².Participants were di-vided into four groups based on NLR *** clinical data and biochemical characteristics were compared among groups.A multivariate logistic regression model was used to analyze the association between NLR levels and *** Significant differences were found in terms of sex,serum creatinine,blood urea nitrogen,total cholesterol,and low-density lipoprotein cholesterol among patients with T2DM in different NLR groups(P<0.0007).T2DM patients in the highest NLR quartile had a higher prevalence of CKD(P for trend=0.0011).Multivariate logistic regression analysis indicated that a high NLR was an independent risk factor for CKD in T2DM patients even after adjustment for important clinical and pathological parameters(P=0.0001,odds ratio=1.41,95%confidence intervals:1.18-1.68).CONCLUSION An elevated NLR in patients with T2DM is associated with higher prevalence of CKD,suggesting that it could be a marker for the detection and evaluation of diabetic kidney disease.

关键词： Type 2 diabetes mellitus Neutrophil-to-lymphocyte ratio Chronic kidney disease Logistic regression Diabetes mellitus

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Application Value of NLR,PLR,LMR,HEART score,and POCT in Early Warning and Accurate Graded Diagnosis of High-Risk Chest Pain in Emergency Medicine

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Journal of Clinical and Nursing Research 2024年第4期8卷 93-98页

作者： Shaochang Ma Chunhua Lin Yanmei Li Yan Chen Guohui Zhang Guandu District People’s Hospital Kunming 650200Yunnan ProvinceChina guanshang street health service center Guandu DistrictKunming 650200Yunnan ProvinceChina

Objective: To evaluate the application value of neutrophils/lymphocytes (NLR), platelets/lymphocytes (PLR), lymphocytes/monocytes (LMR), HEART (history, electrocardiogram, age, risk factors, and troponin) score, and point-of- care testing (POCT) in the early warning and precise diagnosis of high-risk chest pain in emergency medicine. Methods: A total of 157 patients with acute chest pain who were admitted to the emergency department and chest pain treatment unit of our hospital between August 2022 and September 2023 were selected. Rapid testing of bedside myocardial markers (ultrasensitive troponin (hs-cTnI), myoglobin (MYO), creatine kinase isoenzyme (CK-MB), D-dimer (D-Dimer), and N-terminal B-type natriuretic peptide precursor (NT-proBNP)) was performed on the patients using a POCT device (ThermoKing BioMQ60proB). A HEART score was used to classify the patients into low (n = 53), intermediate (n = 59), and high-risk (n = 45) groups, and the NLR, PLR, and LMR were calculated. The NLR, PLR, and LMR values were compared among the three groups of patients, and the optimal cutoff values as well as sensitivity and specificity were determined based on receiver operating characteristic (ROC) analysis. Results: The HEART scores of patients in the low-risk, intermediate-risk, and high-risk groups were (2.72 ± 0.24), (4.75 ± 0.56), and (5.32 ± 0.73) respectively, and the differences were statistically significant (P < 0.05). Compared with the low-risk group, the intermediate-risk group and high-risk group had a significantly higher NLR and PLR, and a significantly lower LMR;the high-risk group had higher NLR and PLR and lower values of LMR as compared to the other two groups, and the difference was statistically significant (P < 0.05). The ROC curves suggested that the area under the curve, sensitivity, and specificity of the combined diagnosis of NLR, PLR, LMR, HEART score, and POCT were greater than those of LR, PLR, and LMR with HEART score and POCT alone. Conclusion: Th

关键词： NLR PLR LMR POCT myocardial markers HEART score Emergency high-risk chest pain

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