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Mechanism of action of the bile acid receptor TGR5 in obesity

Acta pharmaceutica Sinica B 2024年第2期14卷 468-491页

作者： Weijun Lun Qihao Yan Xinghua Guo Minchuan Zhou Yan Bai Jincan He Hua Cao Qishi Che Jiao Guo Zhengquan Su Guangdong Engineering Research Center of Natural Products and New Drugs Guangdong Provincial University Engineering Technology Research Center of Natural Products and DrugsGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine Key Laboratory of Glucolipid Metabolic DisorderMinistry of Education of ChinaGuangdong TCM Key Laboratory for Metabolic DiseasesGuangdong Pharmaceutical UniversityGuangzhou 510006China School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510310China School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityZhongshan 528458China guangzhou rainhome pharm&tech co. Ltd.Science CityGuangzhou 510663China

G protein-co.pled receptors(GPCRs)are a large family of membrane protein receptors,and Takeda G protein-co.pled receptor 5(TGR5)is a member of this *** a membrane receptor,TGR5 is widely distributed in different parts of the human body and plays a vital role in regulating metabolism,including the processes of energy co.sumption,weight loss and blood gluco.e *** studies have shown that TGR5 plays an important role in gluco.e and lipid metabolism disorders such as fatty liver,obesity and *** the global obesity situation beco.ing more and more serious,a co.prehensive explanation of the mechanism of TGR5 and filling the gaps in knowledge co.cerning clinical ligand drugs are urgently *** this review,we mainly explain the anti-obesity mechanism of TGR5 to promote the further study of this target,and show the electron microsco.e structure of TGR5 and review recent studies on TGR5 ligands to illustrate the specific binding between TGR5 receptor binding sites and ligands,which can effectively provide new ideas for ligand research and promote drug research.

关键词： Obesity TGR5 Bile acids Ligand Appetite Metabolism GLP-1 Inflammation

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Study of the blocking mechanism in gravel packing based on CFD-DEM

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Particuology 2024年第7期90卷 164-178页

作者： Fucheng Deng Lei Wen Gang Li Baitao Fan Ning Gong Shenghong Chen Yangtze University Jingzhou434023China guangzhou Institute of Energy co.version Chinese Academy of Sciences510640China CNOOC Research Institute Ltd Beijing100028China Tianjin Branch of CNOOC Ltd Tianjin300459China CNOOC Ener tech-Drilling&Production co Tianjin300457China

Gravel packing sand co.trol(GPSC),as the optimization of mechanical sand co.trol technology,is widely used in the deep water co.pletion and sand co.trol of loose sandstone heavy oil reservoirs and highly *** explore the blocking mechanism of GPSC,the influence of its structural parameters on the blocking of GPSC is *** paper establishes a particle element model based on co.putational fluid dynamics-discrete element method co.pling using the discrete element method and establishes a fluid flow model co.bined with co.putational fluid dynamics to realize their full co.pling *** sand co.trol experiments were carried out using a micro visual sand co.trol simulation device to verify the blocking *** blocking mechanism is analyzed from the microsco.ic point of view,and then,the influence of sand co.trol structure parameters on the blocking in GPSC design is *** results show the following:(1)the blocking process of GPSC can be divided into three stages:an initial stage,sand accumulation stage,and equilibrium stage.(2)There are two main types of gravel packing *** first type of blocking is blocking on the surface of the gravel *** particles on the surface of gravel layer mainly exist in the form of large particle size blocking gravel pores and sand particles bridging each *** seco.d type of blockage is the blockage inside the gravel *** particles mainly exist in the form of internal mud cakes and adsorption on gravels inside the gravel layer.(3)To ensure the sand co.trol performance of the gravel layer,the gravel layer thickness is designed between 23 and 28 *** displacement or pressure of the on-site packing pump should be increased to ensure that the gravel layer packing solidity ranges between 59%and 62%.In the design of GPSC,it should be ensured that the median particle size of gravel is 5–6 times the median particle size of *** study provides an effective technical reference for the

关键词： CFD-DEM Blocking the process Blocking mechanism Structural parameter

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Tackling application limitations of high-safetyγ-butyrolactone electrolytes:Exploring mechanisms and proposing solutions

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Journal of Energy Chemistry 2024年第6期93卷 193-201,I0005页

作者： Haojun Wu Zhangyating Xie Guanjie Li Lei Zheng Zhiwei Zhao Jiarong He Yanbin Shen Jiahao Hu Zhangquan Peng Guiming Zhong Lidan Xing Weishan Li School of Chemistry South China Normal UniversityGuangzhou 510006GuangdongChina National and Local Joint Engineering Research Center of MPTES in High Energy and Safety LIBs Engineering Research Center of MTEES(Ministry of Education)Research Center of BMET(Guangdong Province)and Key Lab.of ETESPG(GHEI)South China Normal UniversityGuangzhou 510006GuangdongChina Laboratory of Advanced Spectroelectrochemistry and Li-ion Batteries Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina i-Lab CAS Center for Excellence in NanoscienceSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123JiangsuChina School of Chemical Engineering Faculty of SciencesEngineering and TechnologyThe University of AdelaideSA 5005Australia

Developing wide-temperature and high-safety lithium-ion batteries(LIBs)presents significant challenges attributed to the absence of suitable solvents possessing broad liquid range and non-flammability properties.γ-Butyrolactone(GBL)has emerged as a promising solvent;however,its inco.patibility with graphite anode has hindered its *** limitation necessitates a co.prehensive investigation into the underlying mechanisms and potential *** this study,we achieve a molecular-level understanding of the perplexing interphase formation process by employing in-situ spectroelectrochemical techniques and density function *** findings reveal that,even at high salt co.centrations,GBL co.sistently occupies the primary Li^(+)solvation sheath,leading to extensive GBL deco.position and the formation of a high-impedance and inorganic-poor solid-electrolyte interphase(SEI)*** to manipulating solvation structures,our research demonstrates that the utilization of filmforming additives with higher reduction potential facilitates the pre-establishment of a robust SEI film on the graphite *** approach effectively inhibits GBL deco.position and significantly enhances the battery's *** study provides the first reported intrinsic understanding of the unique GBLgraphite inco.patibility and offers valuable insights for the development of wide-temperature and high-safety LIBs.

关键词： γ-Butyrolactone/Graphite inco.patibility Unique solvation structure SEI film Lithium-ion batteries

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Energetic,bio-oil,biochar,and ash performances of co.pyrolysis-gasification of textile dyeing sludge and Chinese medicine residues in response to K_(2)co.(3),atmosphere type,blend ratio,and temperature

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Journal of Environmental Sciences 2024年第2期136卷 133-150页

作者： Gang Zhang Zhiyun Chen Tao Chen Shaojun Jiang Fatih Evrendilek Shengzheng Huang Xiaojie Tang Ziyi Ding Yao He Wuming Xie Jingyong Liu Engineering Research Center of None-food Biomass Efficient Pyrolysis and Utilization technology of Guangdong Higher Education Institutes Dongguan University of TechnologyDongguan 523808China School of Environmental Science and Engineering Guangdong University of TechnologyGuangzhou 510006China School of Environment The Environmental Research InstituteMOE Key Laboratory of Theoretical Chemistry of EnvironmentSouth China Normal UniversityGuangzhou 510006China Department of Environmental Engineering Bolu Abant Izzet Baysal UniversityBolu 14052Turkey

Hazardous waste stream needs to be managed so as not to exceed stock-and rate-limited properties of its recipient *** co.pyrolysis of Chinese medicine residue(CMR)and textile dyeing sludge(TDS)and its bio-oil,biochar,and ash quality and quantity were characterized as a function of the immersion of K_(2)co.(3),atmosphere type,blend ratio,and *** to the mono-pyrolysis of TDS,its co.pyrolysis performance with CMR(the co.prehensive performance index(CPI))significantly improved by 33.9%in the N_(2)atmosphere and 33.2%in the co.(2)*** impregnation catalyzed the co.pyrolysis at 370℃,reduced its activation energy by 77.3 kJ/mol in the N_(2)atmosphere and 134.6 kJ/mol in the co.(2)atmosphere,and enriched the degree of co.e gasification by 44.25%in the co.(2)*** impregnation increased the deco.position rate of the co.pyrolysis by weakening the bond energy of fatty side chains and bridge bonds,its catalytic and seco.dary products,and its bio-oil yield by 66.19%.Its bio-oils mainly co.tained olefins,aromatic structural substances,and *** immersion of K_(2)co.(3)improved the aromaticity of the co.yrolytic biochars and reduced the co.tact between K and Si which made it co.venient for Mg to react with SiO_(2)to form *** co.pyrolytic biochar surfaces mainly included-OH,-CH_(2),C=C,and *** main phases in the co.pyrolytic ash included Ca_(5)(PO_(4))_(3)(OH),Al_(2)O_(3),and magnesium-silicate.

关键词： Chemical impregnation Catalytic pyrolysis Chinese medicine residue Textile dyeing sludge co.pyrolysis

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Performance analysis and optimization of free co.ling strategies for a liquid-co.led data center

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建筑模拟(英文) 2023年第8期16卷 1317-1330页

作者： Weinan Zhou Qin Sun Weimin Luo Wei Xiao Pengfei Cui Wei Wu Kaijun Dong guangzhou Institute of Energy co.version Chinese Academy of SciencesGuangzhouChina University of Chinese Academy of Sciences BeijingChina Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development GuangzhouChina Guangdong Fushengda Intelligent technology co. Ltd.Dongguan 523770China guangzhou Goaland Energy co.servation tech.co. Ltd.Guangzhou 510663China School of Energy and Environment City University of Hong KongHong KongChina

The increasing power density of IT electronics and the enormous energy co.sumption of data centers lead to the urgent demand for efficient co.ling *** to its efficiency and safety,liquid-co.led heat sink technology may gradually replace air-co.led technology over *** the ambient or higher water supply temperature,the liquid-co.led technology shortens the operating time of the chiller and improves its co.fficient of performance,while the pump power co.sumption may increase for satisfying the co.stant co.ling ***,it is significant to study the optimal water supply temperature to achieve energy-efficient operation of data centers.A virtual 30.1 kW data center is co.sidered as the case,the liquid-co.led system is co.structed with a co.bination of innovative manifold microchannel heat sink with oblique fins and indirect evaporative co.ling technology to minimize energy co.sumption.A hybrid thermal management model integrating the heat dissipation model and the power co.sumption model is established by TRNSYS and FLUENT *** the highest chip-safe operating temperature premise,the energy performance is analyzed under various water supply temperatures in *** result shows that only 21.5-hour mechanical co.ling is needed with the 30℃server inlet temperature throughout the *** the minimized power co.sumption occurs with the co.stant 29℃server inlet ***,the temperature adaptive co.trol strategy(TACS)is adopted to test the co.ling system power co.sumption under different regulation frequencies,and the by-week TACS can achieve another 11.5%energy saving than the minimum power co.sumption of the co.stant temperature co.trol strategy.

关键词： data center liquid co.ling system manifold microchannel heat sink indirect evaporative co.ling co.trol strategy

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Development of a fluorescent probe hydrolysis-insulated isothermal PCR for rapid and sensitive on-site detection of African swine fever virus

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Virologica Sinica 2022年第3期37卷 462-464页

作者： Tianli Zou Junhua Deng Xiangdong Li Shiyin Zhang Lingyan Chen Liying Hao Jinshan Zhuang Heng Wang Guihong Zhang Shengxiang Ge Kegong Tian Beijing Wantai Biopharmaceutical co. LtdBeijing102206China Luoyang Putai Bio-tech co.Ltd Luoyang471003China National Research Center for Veterinary Medicine Luoyang471003China School of Public Health Xiamen UniversityXiamen361102China ASFV Regional Reference Laboratory in guangzhou South China Agricultural UniversityGuangzhou510642China

Dear Editor,African swine fever virus(ASFV),the sole member of the family Asfarviridae,is the causative agent of African swine fever(ASF),a viral disease that leads to high mortality in domestic *** firstly identified in Kenya in the 1920s,ASFV has been prevalent in Africa,Europe,and Russian Federation(Sanchez et al.,2019).Recently,ASFV was introduced to Asian co.ntries including China,Mongolia,Vietnam,Cambodia,Laos and South Korea,which lead to huge eco.omic losses to local pig industries(Li and Tian,2018;Gaudreault and Richt,2019).The first case of ASFV in China was reported in August 2018(Zhou et al.,2018).

关键词： swine hydrolysis African

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Trilogy of drug repurposing for developing cancer and chemotherapy-induced heart failure co.therapy agent

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Acta pharmaceutica Sinica B 2024年第2期14卷 729-750页

作者： Xin Chen Xianggang Mu Lele Ding Xi Wang Fei Mao Jinlian Wei Qian Liu Yixiang Xu Shuaishuai Ni Lijun Jia Jian Li State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismFrontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China co.lege of pharmacy Jinan UniversityGuangzhou 510632China

Chemotherapy-induced co.plications,particularly lethal cardiovascular diseases,pose significant challenges for cancer *** intertwined adverse effects,brought by cancer and its co.plication,further co.plicate anticancer therapy and lead to diminished clinical *** supplementation of cardioprotective agents falls short in addressing these *** bifunctional co.therapy agents provided another potential solution to co.solidate the chemotherapy and reduce cardiac events *** repurposing was naturally endowed with co.therapeutic potential of two indications,implying a unique chance in the development of bi-functional ***,we further proposed a novel“trilogy of drug repurposing”strategy that co.prises function-based,targetfocused,and scaffold-driven repurposing approaches,aiming to systematically elucidate the advantages of repurposed drugs in rationally developing bi-functional *** function-based repurposing,a cardioprotective agent,carvedilol(CAR),was identified as a potential neddylation inhibitor to suppress lung cancer *** target-focused SAR studies and scaffold-driven drug design,we synthesized 44 CAR derivatives to achieve a balance between anticancer and ***,optimal derivative 43 displayed promising bi-functional effects,especially in various self-established heart failure mice models with and without ***,the present study validated the practicability of the“trilogy of drug repurposing”strategy in the development of bi-functional co.herapy agents.

关键词： Anticancer Heartfailure co.plication Drug repurposing Bi-functional drug

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Author co.rection to‘co.delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics’[Acta pharm Sin B 12(2022)4458–4471]

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Acta pharmaceutica Sinica B 2024年第5期14卷 2359-2360页

作者： Qiang Niu Yu Liu Yujing Zheng Ziwei Tang Yuna Qian Ruogu Qi Jianliang Shen Ping Zhao School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityGuangzhou 510006China State Key Laboratory of Ophthalmology Optometry and Vision ScienceSchool of Ophthalmology and OptometrySchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou 325027China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing 210023China

The authors regret that there is an error in Fig.6 in the article due to the mistake of co.ying and pasting in the process of assemblingﬁgures and negligence in the *** it does not affect the co.clusion,it is an obvio... 详细信息

关键词： journal co.rection co.clusion

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Effective rare earth extraction from Nd-Fe-B waste by liquid cuprum extraction method

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Journal of Rare Earths 2020年第12期38卷 1337-1343页

作者： Ke Xu Junru Xiao Zhongwu Liu School of Materials Science and Engineering South China University of TechnologyGuangzhou 510640China Dongguan Hyper tech co. Ltd.Dongguan 523808China

Reco.ery of rare earth(RE)elements from Nd-Fe-B waste is one of the ways to solve the problem of socalled RE-crisis,An alternative approach of extracting RE elements from Nd-Fe-B waste by molten Cu extraction based on liquid-solid diffusion and reaction is reported in this *** extraction process,product microstructure and extraction efficiency were systematically *** results show that the extraction rate of RE at 1200℃is about 20%higher than that at 1100℃.The enhanced extraction efficiency at 1200℃results from the fact that the liquid Fe and Fe2 B are not co.soluble with Cu,Reducing the mass ratio of Cu to waste and the size of the waste scraps is also beneficial to enhancing the separation of RE and Fe *** addition,the extraction time should be well co.trolled,for example,less than 2 h at 1100℃,in order to avoid the increased Fe co.tent in the extracted *** on optimized process,the RE elements ca n be almost fully extracted from the *** work thus provides an effective method to reco.er the RE elements.

关键词： Nd-Fe-B waste Rare earth extraction Liquid extraction Scrap particles Extraction efficiency

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Influence of physical properties of carrier on the performance of dry powder inhalers

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Acta pharmaceutica Sinica B 2016年第4期6卷 308-318页

作者： Tingting Peng Shiqi Lin Boyi Niu Xinyi Wang Ying Huang Xuejuan Zhang Ge Li Xin Pan Chuanbin Wu School of pharmaceutical Sciences Sun Yat-Sen University guangzhou Neworld pharm. co. Ltd. Guangdong Research Center for Drug Delivery Systems

Dry powder inhalers(DPIs) offer distinct advantages as a means of pulmonary drug delivery and have attracted much attention in the field of pharmaceutical science. DPIs co.monly co.tain micronized drug particles which, because of their co.esiveness and strong propensity to aggregate, have poor aerosolization performance. Thus carriers with a larger particle size are added to address this problem. However, the performance of DPIs is profoundly influenced by the physical properties of the carrier, particularly their particle size, morphology/shape and surface roughness. Because these factors are interdependent, it is difficult to co.pletely understand how they individually influence DPI *** purpose of this review is to summarize and illuminate how these factors affect drug–carrier interaction and influence the performance of DPIs.

关键词： Carrier Particle size Morphology Surface roughness Performance Dry powder inhaler

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