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Chinese Journal of Chemical Engineering 2004年第6期12卷 869-876页

作者：潘吉铮章莉娟钱宇 school of Chemical Engineering South China University of Technology Guangzhou 510640 China

An oil-in-water (O/W) solvent evaporation method was used to prepare biodegradable microspheresbased on poly(D,L-lactic acid) (PLA). Nifedipine, a hydrophobic drug, was chosen as a model molecule in the studyof drug entrapment and release. Effect of preparation conditions on the size, morphology, drug loading, and releaseprofiles of micropheres was investigated. Based on in vitro release experimental findings, a diffusion/dissolutionmodel was presented for quantitative description of the resulting release behaviors and drug release kinetics fromPLA microspheres analyzed. The mathematical models were used to predict the effect of microstructure on theresulting drug release. It provided an approach to determine the suitable structure parameters for microspheres toachieve desired drug release behaviors.

关键词： microspheres drug delivery nifedipine controlled release solventevaporation structure-property relationships model

Sparsity Modulation for 6G Communications

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中国通信:英文版 2023年第10期20卷 I0002-I0005页

作者： Jun Li Shuping Dang Jia Hou Marco Di Renzo Mohamed-Slim Alouini the school of Electronics and Communication Engineering at guangzhou University GuangzhouChina school of Electrical Electronic and Mechanical EngineeringUniversity of Bristol Soochow University SuzhouChina the Intelligent Physical Communications group in the Laboratory of Signals and Systems(L2S)at Paris-Saclay University-CNRS and Centrale Supelec ParisFrance IEEE

Sparsity modulation is a promising technology for the sixth generation(6G)of communication networks,which satisfies the high requirements in terms of spectral efficiency(SE)and energy efficiency(EE).Currently,many representative sparsity modulation schemes,such as spatial modulation,index modulation,media-based modulation,reconfigurable intelligent surface(RIS)-based/reflecting modulation,and subcarrier number modulation,have attracted the attention of the wireless research *** from conventional amplitude-phase modulation schemes,sparsity modulation employs one or more modulation dimension(s)in addition to the conventional amplitude-phase constellation,so as to form higher-dimensional modulation schemes,which considerably enhance the SE at a reduced implementation complexity under proper system *** is worth noting that the modulation dimensions in current sparsity modulation schemes are not fully explored due to limited resources.

关键词： dimensions networks dimension

Surface Bioactive Modification of Alumina Ceramic by Mineralization in Modified SBF

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Journal of Bionic Engineering 2022年第6期19卷 1637-1644页

作者： Wenmin Zhang Caixia Liang Qixuan He Xiaoyan Cao Fangli Yuan Jiandong Ye school of Material Science and Engineering South China University of TechnologyGuangzhou510640China National Engineering Research Center for Tissue Restoration and Reconstruction Guangzhou510006China Guangdong Fapon Biotech Co.Ltd Dongguan523808China Inspection and Quarantine Comprehensive Technology Centre of Foshan Entry‐exit Inspection and Quarantine Bureau Foshan528042China Key Laboratory of Biomedical Materials of Ministry of Education South China University of TechnologyGuangzhou510641China

In the present study,it is found that the prepared alumina ceramics has better mineralization ability in a newly revised simulated body *** the extension of mineralization time,the amount of hydroxyapatite(HA)crystals deposited on the surface of alumina ceramics also increased *** results of cell biological experiments of alumina ceramics with hydroxyapatite surface layer demonstrate that the mineralized materials have better biological activity and osteogenesis properties in *** the meanwhile,the ALP activity and expression of osteogenesis-related genes(OPN,ALP,Col-I,and OCN)of mouse bone marrow stromal stem cells on the samples were significantly promoted by increasing the formation of HA on the surface of alumina *** research concluded that alumina ceramics with HA phase on surface had great potential to be developed as a sort of bioactive material in the bone repair field.

关键词： Alumina Biomaterials Mineralization Hydroxyapatite Osteoblasts

Synthesis, characterization and size control of zerovalent iron nanoparticles anchored on montmorillonite

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Chinese Science Bulletin 2010年第11期55卷 1092-1099页

作者： FAN MingDe YUAN Peng CHEN TianHu HE HongPing YUAN AiHua CHEN KangMin ZHU JianXi LIU Dong guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China College of Environment and Resources Inner Mongolia University Hohhot 010021 China school of Resources and Environmental Engineering Hefei University of Technology Hefei 230009 China school of Materials Science and Engineering Jiangsu University of Science and Technology Zhenjiang 212003 China school of Materials Science an Engineering Jiangsu University Zhenjian 212003 China Graduate school of the Chinese Academy of Sciences Beijing 100039 China

Zerovalent iron nanoparticles have been successfully synthesized using sodium borohydride solution reduction of ferric trichloride hexahydrate in the presence of montmorillonite as an effective protective reagent and support as well. A combination of characterizations reveals that with high monodispersity these obtained iron nanoparticles are well dispersed on clay surface, virginal from boron related impurity, and oxidation resistant well with iron core-iron oxide shell structure. The shell thickness of 3 nm remains almost invariable under ambient conditions. The size control of these iron nanoparticles has been achieved by tailoring the amount of the ferric iron, which mainly depends on the protective action of montmorillonite.

关键词：纳米颗粒钠蒙脱石零价铁规模控制合成铁纳米粒子表征氯化铁溶液

A Scheme for Preparation of W-Type Entangled Coherent State of Three-Cavity Fields

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Chinese Physics Letters 2006年第7期23卷 1695-1697页

作者：袁春华欧永成张智明 Department of Physics Shanghai Jiao Tong University Shanghai 200240 Laboratory of Photonic Information Technology School of Information and Photoelectronic Science and Engineering South China Normal University Guangzhou 510631

We present an experimental scheme to prepare the three-cavity W-type entangled coherent state in the context of dispersive cavity quantum electrodynamics. The discussion of our scheme indicates that it can be realized... 详细信息

关键词： QUANTUM COMPUTATION CHANNELS CAVITY

Manganese-doped mesoporous polydopamine nanoagent for T1-T2 magnetic resonance imaging and tumor therapy

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Nano Research 2023年第2期16卷 2991-3003页

作者： Xiuqi Hou Xi Yang Yanwen Xu Jiayin Lin Fang Zhang Xiaohui Duan Sitong Liu Jie Liu Jun Shen Xintao Shuai Zhong Cao school of Biomedical Engineering Sun Yat-sen UniversityGuangzhou 510006China Department of Radiology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Translational Medicine Institute Shenzhen Second People’s Hospitalthe First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen 518035China Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Theranostic nanodrugs combining magnetic resonance imaging(MRI)and cancer therapy have attracted extensive interest in cancer diagnosis and ***,a manganese(Mn)-doped mesoporous polydopamine(Mn-MPDA)nanodrug incorporating the nitric oxide(NO)prodrug BNN6 and immune agonist R848 was *** nanodrug responded to the H^(+)and glutathione being enriched in tumor microenvironment to release R848 and Mn^(2+).The abundant Mn^(2+)produced through a Fenton-like reaction enabled a highly sensitive T1-T2 dual-mode MRI for monitoring the tumor accumulation process of the nanodrug,based on which an MRI-guided laser irradiation was achieved to trigger the NO gas ***,R848 induced the re-polarization of tumor-promoting M2-like macrophage to a tumoricidal M1 ***,a potent synergistic antitumor effect was realized in mice bearing subcutaneous 4T1 breast cancer,which manifested the great promise of this multifunctional nanoplatform in cancer treatment.

关键词： mesoporous polydopamine magnetic resonance imaging T1-T2 dual-mode NO gas therapy immunotherapy

Integrated UHPLC-MS and network pharmacology to explore the active constituents and pharmacological mechanisms of Shenzao dripping pills against coronary heart disease

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Traditional Medicine Research 2022年第3期7卷 68-80页

作者： Tao Hu Ke-Ning Zheng Jia-Yin Liang Dan Tang Lu-Yong Zhang Ming-Hua Xian Shu-Mei Wang Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province Guangzhou 510006China school of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems Guangdong Pharmaceutical UniversityGuangzhou 510006China school of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China

Background:Shenzao dripping pills(SZDP)is an empirical prescription of traditional Chinese medicine that is mainly used to treat coronary heart ***,the chemical composition and pharmacological mechanisms of SZDP are ***:In this study,ultra-high performance liquid chromatography-quadruple-Exactive Orbitrap mass spectrometry was used to identify the chemical components in extracts and medicated plasma of ***,we performed network pharmacology methods,including target prediction by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine,protein-protein interaction network via STRING database;further,the key targets and compounds were screened using ***,the key targets and compounds were validated by molecular ***:72 chemical constituents were identified from SZDP by high performance liquid chromatography and mass spectrometry *** the components absorbed into plasma by SZDP,24 prototype components and 9 metabolized components were *** network pharmacology analysis of the prototype components showed that there are 13 key compounds(including ginsenoside Rc,Rb1,Rb2,ferulic acid,etc.),90 proteins(including proto-oncogene tyrosine-protein kinase Src,nuclear receptor subfamily 3 group C member 1,caspase-3,etc.),and 10 pathways(including estrogen,IL-17 and VEGF signaling pathway,etc.)that play an essential role in the treatment of coronary heart disease with *** addition,the results of molecular docking revealed that ginsenosides Rc,Rb2 and Rb1 have strong binding activities to the caspase-3,as well as ginsenoside Rb2 to the nuclear receptor subfamily 3 group C member ***:This study showed that SZDP might act through multiple chemical constituents and targets against coronary heart disease.

关键词： Shenzao dripping pills coronary heart disease chemical constituents network pharmacology molecular docking

Extraction of Cr(Ⅵ) from chromite ore processing residue via hydrothermal-assisted phase transformation

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Chinese Chemical Letters 2020年第7期31卷 1956-1960页

作者： Xiaofeng Mo Jin Zhou Le Lin Zuqi Zhong Shaohua Yang Xueming Liu Zhenqing Shi Dongye Zhao Zhang Lin The Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters(Ministry of Education) School of Environment and EnergySouth China University of TechnologyGuangzhou 510006China Sino-Singapore International Joint Research Institute Sino-Singapore Guangzhou Knowledge CityGuangzhou 510006China Environmental Engineering Program Department of Civil EngineeringAuburn UniversityAuburn AL 36849United States

The effective extracting Cr(Ⅵ) from chromite ore processing residue(COPR) is the key to achieve COPR detoxification and *** developed an effective method to extract Cr(Ⅵ) from COPR via controlling the phase transformation of Cr(Ⅵ)-containing *** analysis showed that Cr(Ⅵ) was mainly incorporated in the hydrocalumite(NaCa4Al2O6(SO4/CrO4)1.5-15H2O) in COPR,which was a layered-double hydroxide(LDH) with multilayer *** the hydrothermal treatment experiments,the Na2CO3 solution showed significant extraction effect of Cr(Ⅵ) and detoxification effect of *** treatment,95% of Cr(Ⅵ) was removed and the Cr(Ⅵ) concentration in the leachate was decreased to 1.6 mg/L by the toxicity characteristic leaching procedure(TCLP),within the regulatory limit disposal standard(HJ/T 301-2007,3 mg/L).Further study revealed that,during the treatment,hydrocalumite transformed into calcite(CaCO3) under the effect of mineralizer,therefore,the layered structure collapsed and the incorporated Cr(Ⅵ) was released to the ***,the Cr(Ⅵ)desorbed from calcite with the calcite particles grew into large size with smooth ***-flow experiment revealed that the amount of chromium released from CORP to the environment was significantly reduced after treatment,and it is safer for landfill *** work will provide an instructive guidance for the detoxification and recovery of COPR.

关键词： Chromite ore processing residue Hexavalent chromium extraction Hydrothermal mineralization Phase transformation

Characteristic response of striatal astrocytes to dopamine depletion

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Neural Regeneration Research 2020年第4期15卷 724-730页

作者： Yao-Feng Zhu Wei-Ping Wang Xue-Feng Zheng Zhi Chen Tao Chen Zi-Yun Huang Lin-Ju Jia Wan-Long Lei Department of Anatomy Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Institute of Medicine College of MedicineJishou UniversityJishouHunan ProvinceChina Periodical Center the Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Astrocytes and astrocyte-related proteins play important roles in maintaining normal brain function,and also regulate pathological processes in brain diseases and ***,the role of astrocytes in the dopamine-depleted striatum remains unclear.A rat model of Parkinson’s disease was therefore established by injecting 10μL 6-hydroxydopamine(2.5μg/μL)into the right medial forebrain *** staining was used to detect the immunoreactivity of glial fibrillary acidic protein(GFAP),calcium-binding protein B(S100B),and signal transducer and activator of transcription 3(STAT3)in the striatum,and to investigate the co-expression of GFAP with S100B and *** blot assay was used to measure the protein expression of GFAP,S100B,and STAT3 in the *** demonstrated that striatal GFAP-immunoreactive cells had an astrocytic appearance under normal conditions,but that dopamine depletion induced a reactive phenotype with obvious morphological *** normal striatum also contained S100B and STAT3 expression.S100B-immunoreactive cells were uniform in the striatum,with round bodies and sparse,thin ***3-immunoreactive cells presented round cell bodies with sparse processes,or were darkly stained with a large cell *** deprivation induced by 6-hydroxydopamine significantly enhanced the immunohistochemical positive reaction of S100B and *** striatal astrocytes expressed both S100B and *** dopamine deprivation increased the number of GFAP/S100B and GFAP/STAT3 double-labeled cells,and increased the protein levels of GFAP,S100B,and *** present results suggest that morphological changes in astrocytes and changes in expression levels of astrocyte-related proteins are involved in the pathological process of striatal dopamine *** study was approved by Animal Care and Use Committee of Sun Yat-sen University,China(Zhongshan Medical Ethics 2014 No.23)on September 22,2014.

关键词： 6-hydroxydopamine astrocyte dopamine depletion dopaminergic neurons Parkinson’s disease SIOOB STAT3 striatum

Sequence Analysis and Structural Prediction of the Severe Acute Respiratory Syndrome Coronavirus nsp5

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Acta Biochimica et Biophysica Sinica 2005年第7期37卷 473-479页

作者： Jia-Hai LU Ding-Mei ZHANG Guo-Ling WANG Zhong-Min GUO Juan LI Bing-Yan TAN Li-Ping OU-YANG Wen-Hua LING Xin-Bing YU Nan-Shan ZHONG~1 The Public Health school of Sun Yat-Sen University,guangzhou 510080,China 1 guangzhou Institute of Respiratory Diseases,guangzhou Medical College,guangzhou 510120,China The Public Health school of Sun Yat-Sen University Guangzhou 510080 China

The non-structural proteins (nsp or replicase proteins) of coronaviruses are relativelyconserved and can be effective targets for *** studies have been conducted into the function of thesevere acute respiratory syndrome coronavirus (SARS-CoV) *** this study,bioinformatics methodswere employed to predict the secondary structure and construct 3-D models of the SARS-CoV GD *** and sequential comparison was performed to analyze the mutation trend of the polymerasensp5 gene during the epidemic process using a nucleotide-nucleotide basic local alignment search tool(BLASTN) and a protein-protein basic local alignment search tool (BLASTP).The results indicated that thensp5 gene was steady during the epidemic process and the protein was homologous with other coronavirusnsp5 *** protein encoded by the nsp5 gene was expressed in COS-7 cells and analyzed by sodiumdodecylsulfate-polyacrylamide gel electrophoresis (SDS-PAGE).This study provided the foundation forfurther exploration of the protein's biological function,and contributed to the search for anti-SARS-CoVdrugs.

关键词： severe acute respiratory syndrome (SARS) severe acute respiratory syndrome coronavirus (SARS-CoV) non-structural protein (nsp) replicase secondary structure 3-D structure