Surface Bioactive Modification of Alumina Ceramic by Mineralization in Modified SBF
作者机构：School of Material Science and EngineeringSouth China University of TechnologyGuangzhou510640China National Engineering Research Center for Tissue Restoration and ReconstructionGuangzhou510006China Guangdong Fapon Biotech Co.LtdDongguan523808China Inspection and Quarantine Comprehensive Technology Centre of Foshan Entry‐exit Inspection and Quarantine BureauFoshan528042China Key Laboratory of Biomedical Materials of Ministry of EducationSouth China University of TechnologyGuangzhou510641China
出 版 物：《Journal of Bionic Engineering》 (仿生工程学报（英文版）)
年 卷 期：2022年第19卷第6期
页 面：1637-1644页
核心收录：
学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学]
基 金：National Natural Science Foundation of China(Grant no.52172280) National Key R&D Program of China(Grant no.2016YFB0700803)
主 题：Alumina Biomaterials Mineralization Hydroxyapatite Osteoblasts
摘 要：In the present study,it is found that the prepared alumina ceramics has better mineralization ability in a newly revised simulated body *** the extension of mineralization time,the amount of hydroxyapatite(HA)crystals deposited on the surface of alumina ceramics also increased *** results of cell biological experiments of alumina ceramics with hydroxyapatite surface layer demonstrate that the mineralized materials have better biological activity and osteogenesis properties in *** the meanwhile,the ALP activity and expression of osteogenesis-related genes(OPN,ALP,Col-I,and OCN)of mouse bone marrow stromal stem cells on the samples were significantly promoted by increasing the formation of HA on the surface of alumina *** research concluded that alumina ceramics with HA phase on surface had great potential to be developed as a sort of bioactive material in the bone repair field.
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