检索结果-南通市图书馆

Early identification of stroke through deep learning with multi-modal human speech and movement data

Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li school of Computer science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital stroke scale(CPss)and the Face Arm speech Test(FAsT)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAsT,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,slowFast,X3D,TPN,Timesformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAsT could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAsT screening stroke

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

smart Gas sensors:Recent Developments and Future Prospective

引用

Nano-Micro Letters 2025年第3期17卷 55-86页

作者： Boyang Zong shufang Wu Yuehong Yang Qiuju Li Tian Tao shun Mao College of Environmental science and Engineering Biomedical Multidisciplinary Innovation Research InstituteShanghai East HospitalState Key Laboratory of Pollution Control and Resource ReuseTongji University1239 Siping RoadShanghai 200092People’s Republic of China shanghai Institute of Pollution Control and Ecological security Shanghai 200092People’s Republic of China Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510280People’s Republic of China

Gas sensor is an indispensable part of modern society withwide applications in environmental monitoring,healthcare,food industry,public safety,*** the development of sensor technology,wireless communication,smart monitoring terminal,cloud storage/computing technology,and artificial intelligence,smart gas sensors represent the future of gassensing due to their merits of real-time multifunctional monitoring,earlywarning function,and intelligent and automated *** electronicand optoelectronic gas sensors have been developed for high-performancesmart gas *** the development of smart terminals and the maturityof integrated technology,flexible and wearable gas sensors play an increasingrole in gas *** review highlights recent advances of smart gassensors in diverse *** structural components and fundamentalprinciples of electronic and optoelectronic gas sensors are described,andflexible and wearable gas sensor devices are ***,sensorarray with artificial intelligence algorithms and smart gas sensors in“Internet of Things”paradigm are ***,the challengesand perspectives of smart gas sensors are discussed regarding the future need of gas sensors for smart city and healthy living.

关键词： smart gas sensor Electronic sensor Optoelectronic sensor Flexible and wearable sensor Artificial intelligence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

引用

Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanhong Peng Meng Chen Lin Zhong Luji Huang F U Cheng Xindan sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The second school of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELIsA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' UTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ubiquitin-specific protease 1 facilitates tumor immune escape from natural killer cells and predicts the prognosis in small cell lung cancer

引用

Oncology research 2025年第1期33卷 213-224页

作者： shiqin Jiang Yichun Tang Feng Ma Yuchun Niu Lei sun Department of Clinical Pharmacy Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine Shenzhen 518104 China. Department of Pathology Zhujiang Hospital Southern Medical University Guangzhou 510280 China. Department of Radiation Oncology The First People's Hospital of Foshan Foshan 528000 China. Department of Oncology The First Affiliated Hospital of Jinan University Jinan University Guangzhou 510630 China. Department of Oncology The First Dongguan Affiliated Hospital Guangdong Medical University Dongguan 523721 China.

Objective:small cell lung cancer (sCLC) is commonly recognized as the most fatal lung cancer type. Despite substantial advances in immune checkpoint blockade therapies for treating solid cancers, their benefits are limited to a minority of patients with sCLC. In the present study, novel indicators for predicting the outcomes and molecular targets for sCLC treatment were elucidated.Methods:We conducted bioinformatics analysis to identify the key genes associated with tumor-infiltrating lymphocytes in sCLC. The functional role of the key gene identified in sCLC was determined both and .Results:A significant correlation was observed between patient survival and CD56dim natural killer (NK) cell proportion. Furthermore, we noted that the hub gene ubiquitin-specific protease 1 (UsP1) is closely correlated with both CD56dim NK cells and overall survival in sCLC. Bioinformatics analysis revealed that UsP1 is upregulated in sCLC. In addition, gene set enrichment analysis revealed that UsP1 overexpression hinders NK cell-mediated immune responses. By co-cultivating NK-92 cells with sCLC cells, we demonstrated that NK cell cytotoxicity against sCLC could be improved either via UsP1 knock-down or pharmacological inhibition. Furthermore, using a nude-mice xenograft tumor model, we noted that UsP1 inhibition effectively suppressed tumor proliferation and increased the expression of NK cell-associated markers.Conclusions:Our study findings highlight the importance of NK cells in regulating sCLC. UsP1 overexpression can inhibit NK cell-mediated immunity; therefore, UsP1 may serve not only as a prognostic biomarker but also as a potential molecular target of sCLC therapy.

关键词： Immune escape Natural killer (NK) cell Prognosis small cell lung cancer (sCLC) Ubiquitin-specific protease 1 (UsP1)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

引用

World Journal of Clinical Cases 2025年第4期13卷 18-27页

作者： Cheng-Cheng Wei Yu-Qing Huang Cheng-Hong Yu Department of Cardiology Tongxiang First People's HospitalTongxiang 314500Zhejiang ProvinceChina Department of Cardiology Guangdong Cardiovascular InstituteGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained *** To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive *** Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of *** changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal *** examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%*** The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the *** the course of a mean follow-up of 4.8 years,143 ischemic strokes *** normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et *** changed and ischemic stroke WJCC https://*** 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;Ps 0.233),*** In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.

关键词： Longitudinal change Hypertension Dyslipidemia Lipid profile Ischemic stroke

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Limitation of Rapid Tests for DENV2 Infection in Host with Unique Immune status:Low Ns1 Antigenemia and Deficient Antibody Responses

引用

Virologica sinica 2020年第4期35卷 478-480页

作者： Lei Yu Yingfen Wen Mengrong Xiang Wenxin Hong Lingzhai Zhao Fuchun Zhang guangzhou eighth people’s hospital Guangzhou Medical UniversityGuangzhou 510060China

Dear Editor,Dengue infections are caused by all four serotypes of dengue virus(DENV1–4).In recent years it has been confirmed that DENV-1 and DENV-2 are co-circulated in guangzhou,Guangdong,China(Lai et al.2015;Luo et al.2017).DENV-2 strains were imported from Thailand and Indonesia(Luo et al.2017;Zhao et al.2014,2016),and had become the second local circulated serotype in guangzhou.

关键词： al. Antigen Antibody

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Epidemiological and clinical features of children with the Omicron BA.5.2 subvariant in guangzhou

引用

signal Transduction and Targeted Therapy 2023年第5期8卷 2075-2077页

作者： Feng Li Yinghua He Xianglong Lan Lu Li Fei Gu Zhao Ye Lv Wang Zhenghui Cen Weichun Zhu Haisheng Yu guangzhou eighth people’s hospital Guangzhou Medical UniversityGuangzhou510440China

Dear Editor,Coronavirus disease 2019(COVID-19)is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2(sARs-CoV-2).Compared with previous variants,Omicron strains are more easily transmissible,have a greater ability to evade the human immune response,and are characterized as naturally virulence attenuated.1 During the early stages of the COVID-19 pandemic,it became apparent that children were less easily infected than adults.

关键词： acute respiratory clinical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association between serum albumin levels and disease severity in adult patients with dengue: A 7-year retrospective cohort study in China's Mainland

引用

Asian Pacific Journal of Tropical Medicine 2023年第5期16卷 204-212,I0001页

作者： Changtai Wang Huiqin Yang Jielan Xu Jian Wang Lingzhai Zhao Wenxin Hong Fuchun Zhang Department of Infectious Disease Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina Department of Clinical Laboratory Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina Department of Infectious Disease Guangzhou Red Cross HospitalJinan UniversityGuangzhouChina

Objective:To identify the association between serum albumin levels and disease severity among adult patients with dengue in China's ***:This retrospective cohort study analyzed the data of adult patients(aged≥18 years)hospitalized with laboratory-confirmed dengue in a tertiary center for infectious diseases from 2013 to 2019 in China's *** albumin levels were estimated and compared between patients with severe dengue and non-severe ***,the association between serum albumin levels and severe dengue was evaluated using a generalized linear model[relative risks(RR)].Multivariate logistic regression analysis was performed to identify the potential predictors of severe ***:Overall,1568 patients were included in this *** these patients,34(2.17%)developed severe *** median serum albumin levels were significantly lower in patients with severe dengue than that in those with non-severe dengue(33 g/L vs.37 g/L,Pstment for age,sex,and comorbidities,hypoalbuminemia(RR 4.877,95%CI 2.193-11.461,Ps found to be a predictor of severe *** albumin levels(OR 1.303,95%CI 1.161-1.462,Psignificant risk factors for severe *** area under the curve for serum albumin levels to distinguish severe dengue was ***:Lower serum albumin levels were significantly associated with disease severity in adult patients with *** on admission resulted in at least a four-fold increased risk of severe dengue.

关键词： Dengue severe dengue serum albumin Hypoalbuminemia Prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characteristics of sARs-CoV-2 Delta variant-infected individuals with intermittently positive retest viral RNA after discharge

引用

National science Review 2022年第10期9卷 63-66页

作者： Lu Li Jingyan Tang Zhiwei Xie Qingxin Gan Guofang Tang Zhongwei Hu Huimin Zeng Jingrong shi Jiaojiao Li Yan Li Changwen Ke Min Kang Dan Liang Huan Lu Yuwei Tong Xilong Deng Jinxin Liu Hongzhou Lu Fuxiang Wang Fengyu Hu Feng Li Nanshan Zhong Xiaoping Tang guangzhou eighth people's hospital Guangzhou Medical University Guangdong Provincial Center for Disease Control and Prevention The Third people's hospital of shenzhen guangzhou Laboratory National Clinical Research Center for Respiratory Diseases of First Affiliated hospital guangzhou Medical University

sARs-CoV-2-infected patients will be discharged when viral ribonucleic acid(RNA) is consecutively negative at least twice over a 24-h ***,we have demonstrated that positive retest viral RNA,a particular clinical phenomenon initially observed in discharged sARs-CoV-2-infected patients in early 2020 [1,2],is the occasional reoccurrence of Polymerase Chain Reaction (PCR)-detectable viral RNA but not reinfection [3].Unfortunately,workable strategies to effectively discriminate against individuals likely to have positive retest viral RNA are still ***,for safety concerns,a mandatory minimum of 14-day quarantine in hospitals or hotels had been strictly applied for discharged *** that the Delta Variant of Concern (VOC),the dominant sARs-CoV-2 strain in 2021,

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The compartmentalized upper respiratory mucosa needs time to rally a sufficient immune force for sARs-CoV-2 clearance

引用

Cellular & Molecular Immunology 2022年第12期19卷 1425-1428页

作者： Xiaowen Zheng Xiaoping Tang Feng Li guangzhou eighth people’s hospital Guangzhou Medical UniversityGuangzhou510440China guangzhou Laboratory Bio-IslandGuangzhou510320China

sARs-CoV-2 viral reoccurrence,which is defined as reliable detection of mature virus or viral products in discharged or recovered individuals with at least two consecutive negative detections of viral genomic ribonucleic acid(RNA)by standard reverse transcription polymerase chain reaction(RT‒PCR),raises public concerns about transmission risk and warrants exploration of the underlying mechanism.

关键词： mechanism. mucosa respiratory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：