Association between serum albumin levels and disease severity in adult patients with dengue: A 7-year retrospective cohort study in China's Mainland

作     者：Changtai Wang Huiqin Yang Jielan Xu Jian Wang Lingzhai Zhao Wenxin Hong Fuchun Zhang 

作者机构：Department of Infectious DiseaseGuangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina Department of Clinical LaboratoryGuangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina Department of Infectious DiseaseGuangzhou Red Cross HospitalJinan UniversityGuangzhouChina 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2023年第16卷第5期

页      面：204-212,I0001页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by Special Program of Science and Technology of Guangdong Province(Grant No.:2013A020229001) the Major Program of Guangzhou Healthcare Collaborative Innovation(Grant No.:201803040006) Basic and applied basic research project jointly funded by the University of Guangzhou(Grant No.:2023A03J0810) 

主　　题：Dengue Severe dengue Serum albumin Hypoalbuminemia Prediction 

摘      要：Objective:To identify the association between serum albumin levels and disease severity among adult patients with dengue in China s ***:This retrospective cohort study analyzed the data of adult patients(aged≥18 years)hospitalized with laboratory-confirmed dengue in a tertiary center for infectious diseases from 2013 to 2019 in China s *** albumin levels were estimated and compared between patients with severe dengue and non-severe ***,the association between serum albumin levels and severe dengue was evaluated using a generalized linear model[relative risks(RR)].Multivariate logistic regression analysis was performed to identify the potential predictors of severe ***:Overall,1568 patients were included in this *** these patients,34(2.17%)developed severe *** median serum albumin levels were significantly lower in patients with severe dengue than that in those with non-severe dengue(33 g/L vs.37 g/L,P0.001).After adjustment for age,sex,and comorbidities,hypoalbuminemia(RR 4.877,95%CI 2.193-11.461,P0.001)was found to be a predictor of severe *** albumin levels(OR 1.303,95%CI 1.161-1.462,P0.001)and age(OR 1.038,95%CI 1.017-1.061,P0.001)were significant risk factors for severe *** area under the curve for serum albumin levels to distinguish severe dengue was ***:Lower serum albumin levels were significantly associated with disease severity in adult patients with *** on admission resulted in at least a four-fold increased risk of severe dengue.