检索结果-南通市图书馆

Exploring the Mechanism of Tripterygium wilfordii Against Cancer Using Network Pharmacology and Molecular Docking

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2022年第3期8卷 417-425页

作者： Shui-Xiu Xiao Shao-Jin Li Wan-Xian Fang Jv Chen Hai-Jian Li Yong-Li Situ Obstetrics and Gynecology Shenzhen Longhua District Central HospitalShenzhen 518110GuangdongChina Medical Laboratory Shenzhen Longhua District Central HospitalShenzhen 518110GuangdongChina Research Department Guangzhou Darui Biotechnology Co.Ltd.Guangzhou 510670GuangdongChina Department of Pharmacy Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524023GuangdongChina Department of Clinical Laboratory Medicine Guangdong Second Provincial Central HospitalGuangzhou 510317GuangdongChina College of Pharmacy Jinan UniversityGuangzhou 510632GuangdongChina

Background: The root of Tripterygium wilfordii(Tripterygii radix), a natural powerful traditional Chinese medicine(TCM) for various diseases treatment, has been used for centuries in the Asian countries as anti-rheumatoid arthritis(RA) agent, antioxidant agent, and anti-inflammatory agent. Its combination with other herbs in treating RA has been explored. The anti-RA effect of T. wilfordii for cancer treatment has been supported by some evidence. Aims and Objectives: To investigate the anticancer mechanism of T. wilfordii, bioinformatics databases were used to identify its active ingredients. Materials and Methods: Target proteins associated with cancer were determined using a network pharmacology analysis platform, and 25 key active compounds and 55 key targets of T. wilfordii were identified in our study. A common potential mechanism of T. wilfordii involvement in cancer was disclosed by in-depth network analysis of diseases, functions, and ***, the analysis results of the TCM-disease target protein interaction network revealed 5 potential targets;subsequently, a total of 30targets(these 5 targets, as well as 25 previously identified compounds) were subjected to molecular docking. Results: Our results showed that the therapeutic effect of T. wilfordii in cancer is characterized by multiple components, targets, and pathways. The regulation of signaling pathways such as Kaposi sarcoma-associated herpes virus infection, colorectal cancer, small-cell lung cancer, and prostate cancer may be the important pharmacodynamic basis of anticancer therapy. Conclusion: Triptonoditerpenic acid inhibited proliferation and induced apoptosis in SW480 cells. The mechanism may be related to the downregulation of Bcl-2 expression, upregulation of Bax mRNA expression, and expression inhibition of PTGS2.

关键词： Tripterygium wilfordii cancer network pharmacology molecular docking

A novel cascaded energy conversion system inducing efficient and precise cancer therapy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第2期20卷 663-676页

作者： Yong Kang Na Kong Meitong Ou Ying Wang Qicai Xiao Lin Mei Bing Liu Liqun Chen Xiaobin Zeng Xiaoyuan Ji center Lab of Longhua Branch and Department of Infectious Disease Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen518020GuangdongChina Academy of Medical Engineering and Translational Medicine Medical CollegeTianjin UniversityTianjin300072China School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityGuangzhou510275China Department of Disease Control and Prevention Rocket Force Characteristic Medical Center16 Xinjiekouwai StreetXicheng DistrictBeijing10088China

Cancer therapies based on energy conversion,such as photothermal therapy(PTT,light-to-thermal energy conversion)and photodynamic therapy(PDT,light-to-chemical energy conversion)have attracted extensive attention in preclinical ***,the PTT-related hyperthermia damage to surrounding tissues and shallow penetration of PDT-applied light prevent further advanced clinical ***,we developed a thermoelectric therapy(TET)based on thermoelectric materials constructed p-n heterojunction(SrTiO_(3)/Cu_(2)Se nanoplates)on the principle of light-thermal-electricity-chemical energy *** irradiation and natural cooling-induced the temperature gradient(35-45℃),a self-build-in electric field was constructed and thereby facilitated charges separation in bulk SrTiO_(3)and Cu_(2)***,the contact between SrTiO_(3)(n type)and Cu_(2)Se(p type)constructed another interfacial electric field,further guiding the separated charges to re-locate onto the surfaces of SrTiO_(3)and Cu_(2)*** formation of two electric fields minimized probability of charges *** note,high-performance superoxide radicals and hydroxyl radicals’generation from O_(2)and H_(2)O under catalyzation by separated electrons and holes,led to intracellular ROS burst and cancer cells apoptosis without apparent damage to surrounding *** of bulk and interfacial electric fields in heterojunction for improving charges separation and transfer is also expected to provide a robust strategy for diverse applications.

关键词： Thermoelectric therapy Photothermal therapy Reactive oxygen species p-n heterojunction Energy conversion

IGF2BP3-induced activation of EIF5B contributes to progression of hepatocellular carcinoma cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2022年第2期30卷 77-87页

作者： XIAOYIN LI QIAN WANG HONGFENG LIANG SHISHENG CHEN HAIWEN CHEN YAOYONG LU CHANGFU YANG Department of Oncology(Section 3) Gaozhou People’s HospitalGaozhouChina South China Research center for Acupuncture and Moxibustion Medical College of Acu-Moxi and RehabilitationGuangzhou University of Chinese MedicineGuangzhouChina The Second Affiliated Hospital of guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine) GuangzhouChina Affiliated Nanfang Hospital(Branch Tai He Hospital)of Southern Medical University GuangzhouChina

In this study,we investigated the functional role of eukaryotic initiation factor 5B(EIF5B)in hepatocellular carcinoma(HCC)and the underlying *** analysis demonstrated that the EIF5B transcript and protein levels as well as the EIF5Bcopy number were signiﬁcantly higher in the HCC tissues compared with the non-cancerous liver ***-regulation of EIF5B signiﬁcantly decreased proliferation and invasiveness of the HCC ***,EIF5B knockdown suppressed epithelial-mesenchymal transition(EMT)and the cancer stem cell(CSC)***-regulation of EIF5B also increased the sensitivity of HCC cells to 5-ﬂuorouracil(5-FU).In the HCC cells,activation of the NF-kappa B signaling pathway and IkB phosphorylation was signiﬁcantly reduced by EIF5B ***2BP3 increased the stability of the EIF5B mRNA in an m6A-dependent *** data suggested that EIF5B is a promising prognostic biomarker and therapeutic target in HCC.

关键词： EIF5B NF-jB Epithelial-mesenchymal transition Cancer stem cells N6-methyladenosine Hepatocellular carcinoma

Association between maternal gestational diabetes and allergic diseases in offspring:a birth cohort study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2023年第10期19卷 972-982页

作者： Yu-Jing Chen Li-Zi Lin Zhao-Yan Liu Xin Wang Shamshad Karatela Yu-Xuan Wang Shan-Shan Peng Bi-Bo Jiang Xiao-Xu Li Nan Liu Jin Jing Li Cai Department of Maternal and Child Health School of Public HealthSun Yat-Sen UniversityNo.74 Zhongshan Road 2Yuexiu DistrictGuangzhou 510080Guangdong ProvincePeople’s Republic of China Guangdong Provincial Engineering technology Research center of Environmental Pollution and Health Risk Assessment Department of Occupational and Environmental HealthSchool of Public HealthSun Yat-Sen UniversityGuangzhouPeople’s Republic of China Department of Nutrition School of Public HealthSun Yat-Sen UniversityGuangzhouPeople’s Republic of China Guangdong Provincial Key Laboratory of Food Nutrition and HealthSchool of Public HealthSun Yat-Sen UniversityGuangzhouPeople’s Republic of China Key Laboratory of Brain Cognition and Education SciencesMinistry of EducationGuangzhouChina Faculty of Health and Behavioural Sciences Pharmacy Australia Centre of ExcellenceUniversity of QueenslandWoolloongabbaQLDAustralia Global Health Research center Duke Kunshan UniversityKunshanPeople’s Republic of China Department of Medical Statistics School of Public HealthSun Yat-Sen UniversityGuangzhouPeople’s Republic of China Institute for Brain Research and Rehabilitation South China Normal UniversityGuangzhouPeople’s Republic of China Institute of Tropical Health and Medicine(AITHM) James Cook UniversityTownsvilleQLDAustralia

Background Previous studies have linked gestational diabetes(GDM)with allergies in ***,the effect of specific glucose metabolism metrics was not well characterized,and the role of polyunsaturated fatty acids(PUFAs),a modifier of metabolism and the immune system,was *** aimed to investigate the association between maternal GDM and allergic diseases in children and the interaction between glucose metabolism and PUFAs on allergic *** This prospective cohort study included 706 mother–child dyads from guangzhou,*** GDM was diagnosed via a 75-g oral glucose tolerance test(OGTT),and dietary PUFAs were assessed using a validated food frequency *** disease diagnoses and the age of onset were obtained from medical records of children within three years *** Approximately 19.4%of women had GDM,and 51.3%of children had any allergic *** was positively associated with any allergic diseases(hazard ratio[HR]1.40;95%confidence interval(CI)1.05–1.88)and eczema(HR 1.44;95%CI 1.02–1.97).A unit increase in OGTT after two hours(OGTT-2 h)glucose was associated with an 11%(95%CI 2%–21%)higher risk of any allergic diseases and a 17%(95%CI 1–36%)higher risk of food *** positive associations between OGTT-2 h glucose and any allergic diseases were strengthened with decreased dietary a-linolenic acid(ALA)and increased n-6 PUFAs,linoleic acid(LA),LA/ALA ratio,and n-6/n-3 PUFA *** Maternal GDM was adversely associated with early-life allergic diseases,especially *** were the first to identify OGTT-2 h glucose to be more sensitive in inducing allergy risk and that dietary PUFAs might modify the associations.

关键词： Allergic disease Cohort study Eczema Gestational diabetes Polyunsaturated fatty acid

A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2023年第1期14卷 64-68页

作者： Fei Feng Yunkai Zhu Yanlong Ma Yuyan Wang Yin Yu Xinran Sun Yuanlin Song Zhugui Shao Xinxin Huang Ying Liao Jingyun Ma Yuping He Mingyuan Wang Longhai Tang Yaowei Huang Jincun Zhao Qiang Ding Youhua Xie Qiliang Cai Hui Xiao Chun Li Zhenghong Yuan Rong Zhang Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Medical CollegeShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China Department of Pulmonary Medicine Zhongshan HospitalShanghai Key Laboratory of Lung Inflammation and InjuryFudan UniversityShanghai 200032China The center for Microbes Development and HealthCAS Key Laboratory of Molecular Virology&ImmunologyInstitute Pasteur of ShanghaiCAS Center for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Technical center for Animal Plant and Food Inspection and Quarantine of Shanghai CustomsShanghai 200032China Shanghai Veterinary Research Institute CAASShanghai 200241China College of Animal Science South China Agricultural UniversityGuangzhou 510642China Shanghai International Travel Healthcare center Shanghai 200335China Suzhou Blood center Suzhou 215006China Key Laboratory of Animal Virology of Ministry of Agriculture College of Animal SciencesZhejiang UniversityHangzhou 310058China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510182China center for Infectious Disease Research School of MedicineTsinghua UniversityBeijing 100086China

Dear Editor,Identifying the host factors that are utilized for virus infection and mapping their cell-type expression profile can help to understand the viral tissue/organ tropism and *** effort has been devoted to th... 详细信息

关键词： infection al. activation

Isolation of mesophyll protoplasts from tea(Camellia sinensis)and localization analysis of enzymes involved in the biosynthesis of specialized metabolites

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Beverage Plant Research 2021年第1期1卷 3-11页

作者： Ying Zhou Rufang Deng Xinlan Xu Ziyin Yang Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement&Guangdong Provincial Key Laboratory of Applied Botany South China Botanical GardenChinese Academy of Sciences723 Xingke RoadTianhe DistrictGuangzhou 510650China center of Economic Botany Core Botanical GardensChinese Academy of Sciences723 Xingke RoadTianhe DistrictGuangzhou 510650China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing 100049China

Specialized metabolites in tea(Camellia sinensis)are fundamental quality *** is important to characterize gene function in vivo to identify key enzymes and reactions involved in the biosynthesis of such *** we report a transient expression method to analyze gene function in isolated tea mesophyll *** method is an alternative approach to traditional genetic transformation for studies on gene function in *** screened several tea cultivars and different digestion conditions to optimize protoplast *** of newly emerged leaves of ***‘Zhongbai 4’with 3%cellulase R-10 and 0.3%macerozyme R-10 for about 12 h yielded approximately 107 mesophyll *** encoding enzymes involved in secondary metabolite synthesis were transiently expressed in the protoplasts,and their subcellular locations were *** further improvements in the transfection efficiency,this transient expression system will contribute greatly to the analyses of in vivo gene function in tea.

关键词： transient Camellia analysis

Validation of the chinese version of the EORTC QLQ-CR29 in patients with colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第10期23卷 1891-1898页

作者： Jin-bo Lin Lei Zhang Dong-Wen Wu Zhou-Huan xi xue-Jun Wang Yun-Shou Lin Wakana Fujiwara Jing-Ru Tian Min Wang Peng Peng Ai Guo Zhen Yang Le Luo Ling-Ya Jiang Qia-Qia Li xue-Ying Zhang Yun-Feng Zhang Hou-Wei xu bing Yang xun-Lin Li Yi-xiong Lei School of Public Health Guangzhou Medical University Longgang Central Hospital of Shenzhen Department of Thoracic Surgery Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin Lung Cancer Center Xiangya School of Medicine Central South University Department of Gastrointestinal Surgery Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin Lung Cancer Center Tianjin Medical University School of Medicine Georgetown University Department of Radiation Oncology Tumor HospitalXiangya School of Medicine of Central South University Longgang district Peoples Hospital of Shenzhen1 Cancer center of guangzhou Medical University

AIM To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29 (EORTC QLQ-CR29) in Chinese patients with colorectal cancer (CRC). METHODS From March 2014 to January 2015, 356 patients with CRC from four different hospitals in China were enrolled in the study, and all patients self-administered the EORTC QLQ-CR29 and the quality of life core questionnaire (EORTC QLQ-C30). Evaluation of the scores was based on the Karnofsky Performance Scale (KPS). The reliability and validity of the questionnaires were assessed by Cronbach's proportional to coefficient, the Spearman correlation test and Wilcoxon rank sum test. RESULTS The EORTC QLQ-CR29 showed satisfactory reliability (proportional to > 0.7), although the urinary frequency and blood and mucus in stool dimensions had only moderate reliability (proportional to = 0.608). The multitrait scaling analyses showed good convergent (r > 0.4) and discriminant validity. Significant differences were obtained for each item in the different KPS subgroups (KPS 80). Body image and most single- item dimensions showed statistically significant differences in patients with a stoma compared with the rest of the patients. CONCLUSION The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients.

关键词： Colorectal cancer Health-related quality of life EORTC QLQ-CR29 China's Mainland

The prognostic and therapeutic implications of circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers in the first-line chemotherapy of HER2-negative metastatic breast cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2019年第1期39卷 1-10页

作者： Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17Panjiayuan NanliChaoyang DistrictBeijing 100021P.R.China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China SurExam Bio-Tech Guangzhou Technology Innovation BaseScience CityGuangzhou 510000GuangdongP.R.China Department of Cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Medical Oncology Huanxing Cancer HospitalBeijing 100021P.R.China

Background:Epithelial-mesenchymal transition(EMT)is implicated in the metastatic process and presents a chal-lenge to epithelial cell adhesion molecule-based detection of circulating tumor cells(CTCs),which have been demon-strated to be a prognostic indicator in metastatic breast *** evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression,no standard recommendations have been established for clinical *** study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer ***:We enrolled 108 human epidermal growth factor receptor 2-negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes(including epithelial CTCs,biphenotypic epithelial/mesenchymal CTCs,and mesenchymal CTCs)in peripheral blood *** operating characteristic curve analyses of total CTC count and the proportion of mesenchymal CTCs for predicting the 1-year progression-free survival(PFS)rate were conducted to determine the optimal cut-off values,and Kaplan-Meier analysis and Cox proportional hazards regression analysis were performed to investigate the prognostic value of the cut-off values of both total CTC count and the proportion of mesenchymal CTCs in ***:For predicting the 1-year PFS rate,the optimal cut-off value of total CTC count was 9.5(Area under the curve[AUC]=0.538,95%confidence interval[CI]=0.418-0.657),and that of the proportion of mesenchymal CTCs was 10.7%(AUC=0.581,95%CI=0.463-0.699).We used the two cut-off values in combination to forecast PFS in which the total CTC count was equaled to or exceeded 10/5 mL with the proportion of mesenchymal CTCs surpassed 10.7%.Patients who met the combined criteria had significantly shorter median PFS than did those who did not meet the criteria(6.2 vs.9.9 months,P=0.010).A nomog

关键词： Breast cancer Circulating tumor cells Epithelial-mesenchymal transition Prognosis Therapeutic implication

Suppressed concentration quenching and tunable photoluminescence in Eu^(2+)-activated Rb_(3)Y(PO_(4))_(2)phosphors for full-spectrum lighting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第11期13卷 2688-2698页

作者： Ming Zhao Yeping Ge Yurong Li Xiaoyan Song Zhiguo Xia Xinping Zhang Institute of Information Photonics technology School of Physics and Optoelectronic EngineeringBeijing University of TechnologyBeijing 10083China College of Materials Science and Engineering Key Laboratory of Advanced Functional MaterialsEducation Ministry of ChinaBeijing University of TechnologyBeijing 10083China State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied TechniquesGuangdong Engineering Technology Research and Development Center of Special Optical Fiber Materials and DevicesSchool of Physics and OptoelectronicsSouth China University of TechnologyGuangzhou 510641China

Highly efficient inorganic phosphors are desirable for lighting-emitting diode light sources,and increasing the doping concentration of activators is a common approach for enhancing the photoluminescence quantum yield(PLQY).However,the constraint of concentration quenching poses a great challenge for improving the ***,we propose a fundamental design principle by separating activators and prolonging their distance in Eu^(2+)-activated Rb_(3)Y(PO_(4))_(2)phosphors to inhibit concentration quenching,in which different quenching rates are controlled by the Eu distribution at various crystallographic *** blue-violet-emitting Rb_(3)Y(PO_(4))2:xEu(x=0.1%–15%)phosphors,with the occupation of Rb1,Rb2 and Y sites by Eu^(2+),exhibit rapid luminescence quenching with optimum external PLQY of 10%due to multi-channel energy ***,as the Eu concentration increases above 20%,Eu^(2+)prefer to occupy the Rb1 and Y sites with separated polyhedra and large interionic distances,resulting in green emission with suppressed concentration quenching,achieving an improved external PLQY of 41%.Our study provides a unique design perspective for elevating the efficiency of Eu^(2+)-activated phosphors toward high-performance inorganic luminescent materials for full-spectrum lighting.

关键词： quenching lighting concentration