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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital center for disease control and prevention of Sheyang County Department of Cancer prevention and control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan center for disease control and prevention Office for Cancer control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou center for disease control and prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation center for prevention and control of Endemic and Ethnic Regional diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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An NIR-Ⅱ-emissive Ru(Ⅱ) metallacycle for efficient and safe immunotherapy

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Science China Chemistry 2025年第01期 5-7页

作者： Chonglu Li Jianbo Zhan Biao Dong Institute of Health Inspection and Testing Hubei Provincial Center for Disease Control and Prevention State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University

Immunotherapy, as a groundbreaking cancer treatment, has gained considerable attention for its utilization of the body’s immune system to combat tumors [1]. This therapy induces tumor cell apoptosis, triggering a sustained anti-tumor immune response and effectively preventing tumor recurrence and metastasis [2]. The fundamental principle lies in inducing tumor cell death through specific treatment modalities, leading to the release of a cascade of signaling molecules and antigens, thereby mobilizing the immune system to actively identify and attack tumor cells [3].

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Prevalence,Incidence,and Characteristics of Tuberculosis Among Known Diabetes Patients—A Prospective Cohort Study in 10 Sites,2013–2015

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China CDC weekly 2022年第3期4卷 41-46页

作者： Jun Cheng Yanling Yu Qiongjin Ma Zhijian Wang Qingrong Zhou Guolong Zhang Shuangyi Hou Lin Zhou Feiying Liu Lan Xia Lin Xu Canyou Zhang Yinyin Xia Hui Chen Hui Zhang Lixia Wang National center for Tuberculosis control and prevention China CDCBeijingChina Heilongjiang provincial center for disease control and prevention HarbinHeilongjiangChina Minhang District center for disease control and prevention ShanghaiChina center for disease control and prevention of Danyang County DanyangJiangsuChina center for disease control and prevention of Jiangshan city JiangshanZhejiangChina Henan provincial center for disease control and prevention ZhengzhouHenanChina Hubei provincial center for disease control and prevention WuhanHubeiChina center for Tuberculosis control of Guangdong Province GuangzhouGuangdongChina guangxi center for disease prevention and control NanningGuangxi Zhuang Autonomous RegionChina Sichuan provincial center for disease control and prevention ChengduSichuanChina Yunnan provincial center for disease control and prevention KunmingYunnanChina

Summary What is already known about this topic?The association of diabetes mellitus(DM)with both increased risk of tuberculosis(TB)and unfavorable treatment outcomes has been identified by many studies(1).However,epidemic data for TB cases in DM patients is absent in *** is added by this report?This current population-based prospective cohort study,conducted in ten counties located in eastern,central,and western China during 2013–2015,revealed a high prevalence and incidence of TB in known DM *** TB cases were captured by active case-finding and a much higher presence of being asymptomatic among TB/DM patients was *** are the implications for public health practice?Active case-finding should be carried out in DM patients and populations at high risk for developing TB.A TB symptom screening-based case-finding strategy is not enough;chest radiography check should be done once a year for these patients.

关键词： finding Diabetes Patients

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Vaccine-Associated Paralytic Poliomyelitis--8 PLADs,China,October 2012–March 2014

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China CDC weekly 2020年第50期2卷 955-961页

作者： Ning Wen Fang Fang Wenbo Xu Huaqing Wang Yong Zhang Qiru Su Yao Liu Haibo Wang Shuangli Zhu Xiaoxiao Zhang Wenzhou Yu Dongmei Yan Zhenguo Zhang Qiu Tan Fubao Ma Aihu Dong Yu Liu Keli Li Li Zheng Lixin Hao Dongyan Wang Chunxiang Fan Wendi Wu Huiming Luo Aiqiang Xu Weizhong Yang Chinese center for disease control and prevention BeijingChina Department of Neurology Beijing Children’s HospitalCapital Medical UniversityBeijingChina National Institute for Viral disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina Shenzhen Children’s Hospital ShenzhenGuangdongChina Shandong provincial Key Laboratory of Infectious disease control and prevention Shandong Provincial Center for Disease Control and Prevention/Academy of Preventive MedicineShandong UniversityJinanShangdongChina Clinical Research Institute Peking UniversityBeijingChina Henan provincial center for disease control and prevention JinanHenanChina Hebei provincial center for disease control and prevention ShijiazhuangHebeiChina Guangdong provincial center for disease control and prevention GuangzhouGuangdongChina Jiangsu provincial center for disease control and prevention NanjingJiangsuChina guangxi provincial center for disease prevention and control NanningGuangxiChina Sichuan provincial center for disease prevention and control ChengduSichuanChina Hubei provincial center for disease prevention and control WuhanHubeiChina

Introduction:Poliomyelitis is a highly contagious,seasonal viral disease caused by any of three poliovirus(PV)serotypes(types 1,2,or 3).Oral poliovirus vaccine(OPV)on rare occasions causes vaccineassociated paralytic poliomyelitis(VAPP)in recipients of OPV and close contacts of recently vaccinated *** study describes the epidemiology of VAPP when an all OPV schedule was used in the Expanded Program on Immunization(EPI).Methods:VAPP cases were identified using standardized diagnostic criteria from data reported by 8 provincial-level administrative divisions(PLADs)to the National Acute Flaccid Paralysis(AFP)Surveillance System in an 18-month period between October 2012 and March ***:During this period,28 VAPP cases were *** the number of births as a denominator,the estimated incidence of VAPP was 2.47 cases per million *** the number of OPV doses administered through routine immunization,the VAPP incidence was 0.55 cases per million *** vaccine-recipient VAPP cases,22(85%)were associated with the first dose of OPV;3 were associated with the second OPV *** relative risk of VAPP following the first dose compared with the second dose was *** and Implications for Public Health Practice:The per-dose and per-child incidences of VAPP were consistent with incidence estimates by the World Health Organization(WHO).The vast majority(85%)of VAPP in China was associated with the first dose of OPV in an all-OPV *** inactivated polio vaccine(IPV)is known to prevent VAPP from subsequent doses of OPV in immunocompetent children,this association provided strong evidence for using an IPV-first,sequential IPVOPV polio vaccination schedule in China during the globally-synchronized cessation of type 2 OPV and introduction of IPV in 2016.

关键词： doses epidemiology routine

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Epidemiological Features of Foodborne disease Outbreaks in Catering Service Facilities—China,2010–2020

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China CDC weekly 2023年第22期5卷 479-484页

作者： Donglei Lu Jikai Liu Hong Liu Yunchang Guo Yue Dai Junhua Liang Lili Chen Lizi Xu Ping Fu Ning Li Shanghai Municipal center for disease control and prevention ShanghaiChina China National center for Food Safety Risk Assessment BeijingChina Jiangsu provincial center for disease control and prevention Nanjing CityJiangsu ProvinceChina Guangdong provincial center for disease control and prevention Guangzhou CityGuangdong ProvinceChina Zhejiang provincial center for disease control and prevention Hangzhou CityZhejiang ProvinceChina Anhui provincial center for disease control and prevention Hefei CityAnhui ProvinceChina

Introduction:In terms of food preparation settings,catering service facilities have been identified as locations with the highest incidence of foodborne disease outbreaks in *** 2010,the China National center for Food Safety Risk Assessment has established the Foodborne disease Outbreak Surveillance System(FDOSS)to monitor foodborne disease ***,data from the FDOSS has provided a more accurate depiction of the epidemic characteristics of outbreaks within these ***:From 2010 to 2020,the FDOSS gathered data related to the prevalence of outbreaks,cases,hospitalizations,and deaths linked to foodborne disease outbreaks in catering service *** study examined the temporal and geographical distribution,pathogenic factors,and contributing variables of these outbreaks over the course of the ***:From 2010 to 2020,China’s catering service facilities reported 18,331 outbreaks,which resulted in 206,718 illnesses,68,561 hospitalizations,and 201 *** second and third quarters of the year accounted for 76.12%of the outbreaks and 72.93%of the *** primary pathogenic factors were pathogenic organisms,which caused 4,883(26.64%)outbreaks,94,047(45.50%)cases,32,170(46.92%)hospitalizations,and 21(10.45%)*** were 5,607(30.59%)outbreaks in restaurants,2,876(15.69%)outbreaks from street vendors,and 2,560(13.97%)outbreaks in employee canteens in ***:The implementation of relevant control methods,including health education and promotion,is critical for addressing foodborne diseases in catering service *** food safety training sessions for restaurant personnel and managers are essential to ensuring the effective management of these health risks.

关键词： Service restaurant facilities

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Emergency Response for a Laboratory Biosafety Incident

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Biomedical and Environmental Sciences 2019年第3期32卷 231-233页

作者： ZHANG En Min WANG Jia Qi GAO Li Dong ZHAN Zhi Fei ZHANG Heng HU Yan Hong WEI Jian Chun LIANG Xu Dong WAN Kang Lin WEI Qiang National Institute for Communicable disease control and prevention Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control Chinese center for disease control and prevention Hunan provincial center for disease control and prevention Changsha center for disease control and prevention Yuelu District center for disease control and prevention

On December 14, 2017, a faculty member of a university in Hunan Province reported that an anthrax vaccine strain might have recovered virulence during an undergraduate experiment and potential exposure could not be ruled out for the students involved. Upon receiving the case report, the CDC, health bureaus, and local governments at the county, prefectural, and provincial levels promptly organized experts in different fields (including epidemiologists, biosafety experts, and laboratory testing experts) for case investigation, evaluation, and response. As the investigation results showed, no virulence recovery was identified in the involved anthrax vaccine strain;and no contamination of Bacillus anthracis was detected at the involved areas. Thus, the university returned to normal functioning.

关键词： Emergency Response Laboratory Biosafety Incident

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On-Site Assessment of a Cryogenic Disinfectant for the Alpine Environment and Outer Packaging of Frozen Items

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Biomedical and Environmental Sciences 2023年第2期36卷 174-184页

作者： SHEN Jin YANG Bin XIAO Jia Qing LI Lu Yao SUN Hui Hui DUAN Hong Yang ZHANG Wei LIANG Chen CHEN Lu LI Li CHEN Yan Yan LYU Yuan TANG Song WANG Jiao ZHANG Liu Bo WANG Lin National Institute of Environment Health Chinese Center for Disease Control and PreventionBeijing 100021China Shandong provincial center for disease control and prevention Jinan 250013ShandongChina Heilongjiang provincial center for disease control and prevention Harbin 150030HeilongjiangChina

Objective To study the effectiveness and feasibility of cryogenic disinfectants in different cold scenarios and analyze the key points of on-site cryogenic *** Qingdao and Suifenhe were selected as application sites for the manual or mechanical spraying of cryogenic *** same amount of disinfectant(3,000 mg/L)was applied on cold chain food packaging,cold chain containers,transport vehicles,alpine environments,and article *** killing log value of the cryogenic disinfectant against the indicator microorganisms(Staphylococcus aureus and Escherichia coli)was used to evaluate the on-site disinfection *** When using 3,000 mg/L with an action time of 10 min on the ground in alpine regions,the surface of frozen items,cold-chain containers,and cold chain food packaging in supermarkets,all external surfaces were successfully disinfected,with a pass rate of 100%.The disinfection pass rates for cold chain food packaging and cold chain transport vehicles of centralized supervised warehouses and food processing enterprises were 12.5%(15/120),81.67%(49/60),and 93.33%(14/15),respectively;yet,the surfaces were not fully *** Cryogenic disinfectants are effective in disinfecting alpine environments and the outer packaging of frozen *** application of cryogenic disinfectants should be regulated to ensure that they cover all surfaces of the disinfected object,thus ensuring effective cryogenic disinfection.

关键词： Cryogenic disinfectant COVID-19 An alpine environment Disinfection Outer packaging of frozen items

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Impact of HIV/HCV Co-Infection on Mortality and Attrition in Antiretroviral Therapy Among People with HIV — guangxi Zhuang Autonomous Region, China, 2003–2022

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China CDC weekly 2023年第44期5卷 973-977,I0001页

作者： He Jiang Qiuying Zhu Jinghua Huang Xiuling Wu Bo Li Xuanhua Liu Qin Meng Shuai Tang Guanghua Lan guangxi Key Laboratory of AIDS prevention and control and Achievement Transformation Guangxi Center for Disease Prevention and ControlNanning CityGuangxi Zhuang Autonomous RegionChina guangxi Key Laboratory for Major Infectious diseases prevention and control and Biosafety Emergency Response Guangxi Center for Disease Prevention and ControlNanning CityGuangxi Zhuang Autonomous RegionChina

Summary What is already known about this topic?The effects of concurrent human immunodeficiency virus(HIV)/hepatitis C virus(HCV)infection on mortality and patient attrition in those undergoing antiretroviral therapy ... 详细信息

关键词： mortality Therapy Impact

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Characteristics of Settings and Etiologic Agents of Foodborne disease Outbreaks—China,2020

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China CDC weekly 2021年第42期3卷 889-893页

作者： Hongqiu Li Weiwei Li Yue Dai Yuyan Jiang Junhua Liang Santao Wang Maoqiang Zhuang Zheng Huang Lizi Xu Bo Xue Jikai Liu Haihong Han Sara M.Pires Ping Fu Yunchang Guo National Health Commission Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijingChina Jiangsu provincial center for disease control and prevention NanjingJiangsuChina guangxi center for disease prevention and control NanningGuangxi Zhuang Autonomous RegionChina Guangdong provincial center for disease control and prevention GuangzhouGuangdongChina Shanxi provincial center for disease control and prevention TaiyuanShanxiChina Shandong center for disease control and prevention JinanShandongChina Fujian provincial center for disease control and prevention FuzhouFujianChina Anhui provincial center for disease control and prevention HefeiAnhuiChina Shaanxi provincial Centre for disease control and prevention Xi'anShaanxiChina National Food Institute Technical University of DenmarkLyngbyDenmark.

Introduction:Foodborne diseases are a growing public health problem and have caused a large burden of disease in *** study analyzed epidemiological characteristics of foodborne diseases in China in 2020 to provide a scientific basis for prevention and control ***:Data were collected from 30 of 31 provincial-level administrative divisions(PLADs)in the mainland of China,excluding Xizang(Tibet)Autonomous Region,via the National Foodborne disease Outbreaks Surveillance System・The number and proportion of outbreaks,illnesses,hospitalizations,deaths by setting,pathogen-food category pairs and etiology were ***:In 2020,7,073 foodborne disease outbreaks were reported,resulting in 37,454 illnesses and 143 *** the identified pathogens,microbial pathogens were the most common confirmed etiology,accounting for 41.7%of *** mushrooms caused the largest proportion of outbreaks(58.0%)and deaths(57.6%).For venues where foodborne disease outbreaks occur,household had the highest number of outbreaks(4,140)and deaths(128),and catering service locations caused the largest proportion of illnesses(59.9%).Outbreaks occurring between June and September accounted for 62.8%of total ***:Foodborne disease outbreaks mainly occurred in households・Microbial pathogens remained the top cause of outbreak-associated *** mushrooms were ranked the top cause of deaths in private homes in *** supervision and management of food safety and health education should be strengthened to reduce the burden of foodborne diseases・Publicity should be increased to reduce the incidence of mushroom poisonings in families,and supervision and management of food should be strengthened to reduce microbial contamination.

关键词： strengthened mainland prevention

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