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Prognostic utility of gamma-glutamyl transpeptidase to platelet ratio in patients with solitary hepatitis B virus-related hepatocellular carcinoma after hepatectomy

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World Journal of gastrointestinal Oncology 2024年第12期16卷 4579-4596页

作者： Cheng-Kun Yang Zhong-Liu Wei Xiao-Qiang Shen Yu-Xuan Jia Qiong-Yuan Wu Yong-Guang Wei Hao Su Wei Qin Xi-Wen Liao Guang-Zhi Zhu Tao Peng Department of Hepatobiliary surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina guangxi key laboratory of enhanced recovery after surgery for gastrointestinal cancer Nanning 530021Guangxi Zhuang Autonomous RegionChina Department of Tuina Nanning Hospital of Traditional Chinese MedicineNanning 530022Guangxi Zhuang Autonomous RegionChina

BACKGROUND The prognostic impact of preoperative gamma-glutamyl transpeptidase to platelet ratio(GPR)levels in patients with solitary hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)following radical resection has not been *** To examine the clinical utility of GPR for prognosis prediction in solitary HBVrelated HCC *** A total of 1167 solitary HBV-related HCC patients were retrospectively *** levels were compared with 908 non-HCC *** survival(OS)and recurrence-free survival(RFS)were evaluated,and cox proportional hazard model analyses were performed to identify independent risk *** in characteristics were adjusted by propensity score matching(PSM).Subgroup and stratified survival analyses for HCC risks were performed,and a linear trend of the hazard ratio(HR)according to GPR levels was *** GPR levels of patients with solitary HBV-related HCC were higher than those with hepatic hemangiomas,chronic hepatitis B and healthy control(adjusted Pafter the PSM balance *** low GPR group had improved OS(P0.6 was associated with a worse OS and higher recurrence rate(P for trend<0.001).CONCLUSION Preoperative GPR can serve as a noninvasive indicator to predict the prognosis of patients with solitary HBVrelated HCC.

关键词： Gamma-glutamyl transpeptidase to platelet ratio Hepatitis B virus Hepatocellular carcinoma Prognosis Propensity score matching

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Nutritional therapy for gastroparesis

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Journal of Nutritional Oncology 2023年第1期8卷 25-30页

作者： Zhen Wang Qin-Zhou Song Jin-Xun Jiang Xiang-Hua Wu Jun-Qiang Chen Departmentof gastrointestinal Surgry The First Aflated Hospital of Guangxi Medical UniversityNanningGuangxiChina guangxi key laboratory of enhanced recovery after surgery of gastrointestinal cancer NanningGuangxiChina

Gastroparesis is a common postoperative complication of abdominal surgery,mainly manifested by postprandial fullness,early satiety,nausea,vomiting,and *** should be addressed with a comprehensive treatment plan that includes nutritional therapy and medications such as metoclopramide,domperidone,cisapride,and antiemetic *** treatment,such as pyloroplasty or partial gastrectomy,should be considered if the conservative therapy is *** and parenteral nutrition therapy can promote the recovery of gastrointestinal function,maintain the mucosal integrity and immunity,and reduce ***,nutrition can play an important role in the treatment of gastroparesis.

关键词： Gastroparesis Nutritional therapy surgery

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Change of tumor-infiltrating lymphocyte of associating liver partition and portal vein ligation for staged hepatectomy for hepatocellular carcinoma

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World Journal of gastrointestinal surgery 2022年第9期14卷 1008-1025页

作者： Wei Wang Zhen-Feng Deng Ji-Long Wang Ling Zhang Li Bao Bang-Hao Xu Hai Zhu Ya Guo Zhang Wen Department of Hepatobiliary surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina guangxi key laboratory of enhanced recovery after surgery for gastrointestinal cancer The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina key laboratory of cancer Prevention and Therapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300000China

BACKGROUND The role of tumor-infiltrating lymphocytes(TILs)in the growth and progression of hepatocellular carcinoma(HCC)has attracted widespread *** To evaluate the feasibility of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)for massive HCC by exploring the role of TIL in the tumor *** Fifteen massive HCC patients who underwent ALPPS treatment and 46 who underwent hemi-hepatectomy were selected for this *** score matching was utilized to match patients in ALPPS and hemi-hepatectomy groups(1:1).Quantitative analysis of TILs in tumor and adjacent tissues between the two groups was performed by immunofluorescence staining and further analyses with oncological *** the meantime,trends of TILs in peripheral blood RESULTS Continuous measurement of tumor volume and necrosis volume showed that the proportion of tumor necrosis volume on the seventh day after stage-I ALPPS was significantly higher than the pre-operative value(P=0.024).In the preoperative period of stage-I ALPPS,the proportion of tumor necrosis volume in the high CD8+T cell infiltration group was significantly higher than that in the low group(P=0.048).CONCLUSION TIL infiltration level maintained a dynamic balance during the preoperative period of *** with right hemi-hepatectomy,the ALPPS procedure does not cause severe immunosuppression with the decrease in TIL infiltration and pathological changes in immune components of peripheral *** results suggested that ALPPS is safe and feasible for treating massive HCC from the perspective of *** addition,high CD8+T cell infiltration is associated with increasing tumor necrosis in the perioperative period of ALPPS.

关键词： Associating liver partition and portal vein ligation for staged hepatectomy Tumor-infiltrating lymphocytes Multiplexed immunohistochemistry Tumor necrosis

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CD4^(+)CD25^(+) regulatory T cells decreased future liver remnant after associating liver partition and portal vein ligation for staged hepatectomy

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World Journal of gastrointestinal surgery 2023年第5期15卷 917-930页

作者： Wei Wang Chun-Hui Ye Zhen-Feng Deng Ji-Long Wang Ling Zhang Li Bao Bang-Hao Xu Hai Zhu Ya Guo Zhang Wen Department of Hepatobiliary surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina guangxi key laboratory of enhanced recovery after surgery for gastrointestinal cancer The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina key laboratory of cancer Prevention and Therapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300000China

BACKGROUND Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)is an innovative surgical approach for the treatment of massive hepatocellular carcinoma(HCC),the key to successful planned stage 2 ALPPS is future liver remnant(FLR)volume growth,but the exact mechanism has not been *** correlation between regulatory T cells(Tregs)and postoperative FLR regeneration has not been *** To investigate the effect of CD4^(+)CD25^(+)Tregs on FLR regeneration after *** Clinical data and specimens were collected from 37 patients who developed massive HCC treated with *** cytometry was performed to detect changes in the proportion of CD4^(+)CD25^(+)Tregs to CD4^(+)T cells in peripheral blood before and after *** analyze the relationship between peripheral blood CD4^(+)CD25^(+)Treg proportion and clinicopathological information and liver *** The postoperative CD4^(+)CD25^(+)Treg proportion in stage 1 ALPPS was negatively correlated with the amount of proliferation volume,proliferation rate,and kinetic growth rate(KGR)of the FLR after stage 1 *** with low Treg proportion had significantly higher KGR than those with high Treg proportion(P=0.006);patients with high Treg proportion had more severe postoperative pathological liver fibrosis than those with low Treg proportion(P=0.043).The area under the receiver operating characteristic curve between the percentage of Tregs and proliferation volume,proliferation rate,and KGR were all greater than *** CD4^(+)CD25^(+)Tregs in the peripheral blood of patients with massive HCC at stage 1 ALPPS were negatively correlated with indicators of FLR regeneration after stage 1 ALPPS and may influence the degree of fibrosis in patients’*** percentage was highly accurate in predicting the FLR regeneration after stage 1 ALPPS.

关键词： Associating liver partition and portal vein ligation for staged hepatectomy Regulatory T cells Future liver remnant

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The Role of the PNI and NLR in Nutritional Risk Screening and Assessment of Gastric cancer Patients

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Journal of Nutritional Oncology 2022年第4期7卷 192-198页

作者： Hui Chao Ruan Xiang Hua Wu Dao Lai Huang Xiao Bin Fu Chao Zhang Kun Zhou Guan Yu Zhu Dang Liu Jin Tao Cai Ming Hao Tan guangxi Medical University NanningGuangxi 530021China guangxi key laboratory of enhanced recovery after surgery for gastrointestinal cancer NanningGuangxi 530021China Department of gastrointestinal Gland surgery The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China

Background The use of nutritional risk screening and assessment is becoming increasingly common in cancer *** Nutritional Risk Screening 2002(NRS 2002)is a nutritional risk screening programe with good *** patient generated-subjective global assessment(PG-SGA)is a method used to assess the nutritional status of cancer *** prognostic nutritional index(PNI)and neutrophil to lymphocyte ratio(NLR)are considered to be predictors of the prognosis following treatment for patients with a variety of ***,the relationship between the PNI and NLR in the nutritional screening and assessment in patients with gastric cancer is *** A retrospective analysis was performed on 378 patients with gastric cancer who underwent surgery at the First Affiliated Hospital of guangxi Medical University from August 2019 to December *** 2002 and PG-SGA were performed within 24 hours of admission,and indicators such as the serum albumin level,body mass index(BMI),PNI and NLR were *** In the grouping based on the NRS2002,patients in the positive group(NRS 2002≥3)had a higher platelet value,a higher median NLR,and a lower PNI than those in the negative group(NRS 2002cancer patients are closely related to the results of the nutritional risk screening and a

关键词： Nutritional risk screening 2002 Patient-Generated Subjective Global Assessment Gastric cancer Prognostic nutritional index Neutrophil-to-lymphocyte ratio

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Overexpression of HOXB9 promotes metastasis and indicates poor prognosis in colon cancer

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Chinese Journal of cancer Research 2014年第1期26卷 72-80页

作者： Kai Huang Rongfa Yuan Kai Wang Junwen Hu Zixi Huang Chen Yan Wei Shen Jianghua Shao Department of General surgery Second Affiliated Hospital of Nanchang University Department of gastrointestinal surgery Jiangxi Provincial Cancer Hospital Jiangxi Province key laboratory of Molecular Medicine

Objective：Homeobox B9 （HOXB9） is proposed to be involved in tumor angiogenesis and *** investigated the role of HOXB9 in the progression of colon ***：HOXB9 expression was investigated by immunohistochemically and Western blotting in 128 colon cancer patients and the results were analyzed statistically associated with clinicopathological data and survival of the *** effect of HOXB9 on cell invasion and metastases abilities were analyzed in vitro and in ***：HOXB9 is overexpressed in colon cancer tissues and significandy correlated with metastasis and poor survival of patients （P＜0.05,respectively）.Additionally,high levels of expression of HOXB9 were observed in metastatic lymph *** down-regulation of HOXB9 expression can inhibit the migration and invasive ability of colon cancer cells,while exogenous expression of HOXB9 in colon cancer cells enhanced cell migration and ***,stable knockdown of HOXB9 reduced the liver and lung metastasis of colon cancer in ***：HOXB9 may play an important role in the invasion and metastasis of colon cancer cells and may be a useful biomarker for metastasis and prognostic of colon cancer.

关键词： Homeobox B9 (HOXB9) colon cancer prognostic invasion metastasis

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Function of chloride intracellular channel 1 in gastric cancer cells

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World Journal of Gastroenterology 2012年第24期18卷 3070-3080页

作者： Peng-Fei Ma Jun-Qiang Chen Zhen Wang Jin-Lu Liu Bo-Pei Li Department of gastrointestinal surgery the First Affili- ated Hospital of Guangxi Medical University Nanning 530021 Guangxi Zhuang Autonomous Region China

AIM:To investigate the effect of chloride intracellular channel 1(CLIC1) on the cell proliferation,apoptosis,migration and invasion of gastric cancer ***:CLIC1 expression was evaluated in human gastric cancer cell lines SGC-7901 and MGC-803 by real time polymerase chain reaction(RT-PCR).Four segments of small interference RNA(siRNA) targeting CLIC1 mRNA and a no-sense control segment were designed by bioinformatics ***1 siRNA was selected using Lipofectamine 2000 and transfected transiently into human gastric cancer SGC-7901 and MGC-803 *** transfected efficiency was observed under fluorescence *** transfection,mRNA expression of CLIC1 was detected with RT-PCR and Western blotting was used to detect the protein *** was examined by methyl thiazolyl tetrazolium and apoptosis was detected with flow *** membrane transwell chamber and Matrigel were used for the detection of the changes of invasion and migration of the two cell ***:In gastric cancer cell lines SGC-7901 and MGC-803,CLIC1 was obviously expressed and CLIC1 siRNA could effectively suppress the expression of CLIC1 protein and *** of cells transfected with CLIC1 siRNA3 was enhanced notably,and the highest proliferation rate was 23.3%(P = 0.002) in SGC-7901 and 35.55%(P = 0.001) in MGC-803 cells at 48 *** G2/M phase proportion increased,while G0/G1 and S phase proportions *** apoptotic rate of the CLIC1 siRNA3 group obviously decreased in both SGC-7901 cells(62.24%,P = 0.000) and MGC-803 cells(52.67%,P = 0.004).Down-regulation of CLIC1 led to the inhibition of invasion and migration by 54.31%(P = 0.000) and 33.62%(P = 0.001) in SGC-7901 and 40.74%(P = 0.000) and 29.26%(P = 0.002) in ***,there was no significant difference between the mock group cells and the negative control group cells.

关键词： Chloride intracellular channel 1 Gastric car-cinoma Small interference RNA Apoptosis Invasion Migration

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Intestinal stem cell marker LGR5 expression during gastric carcinogenesis

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World Journal of Gastroenterology 2013年第46期19卷 8714-8721页

作者： Zhi-Xue Zheng Yu Sun Zhao-De Bu Lian-Hai Zhang Zi-Yu Li Ai-Wen Wu Xiao-Jiang Wu Xiao-Hong Wang Xiao-Jing Cheng Xiao-Fang Xing Hong Du Jia-Fu Ji Department of gastrointestinal surgery Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital and Institute Department of Pathology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education)Peking University Cancer Hospital and Institute Clinical Gastric cancer Research laboratory Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital and Institute Tissue Bank Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital and Institute

AIM:To investigate the differential expression of leu-cine-rich repeat-containing G protein-coupled receptor5(LGR5)in gastric cancer tissues and its significance related to tumor growth and ***:Formalin-fixed biopsy specimens of intestinal metaplasia(n=90),dysplasia(n=53),gastric adenocarcinoma(n=180),metastases in lymph nodes and the liver(n=15),and lesion-adjacent normal gastric mucosa(controls;n=145)were obtained for analysis from the Peking University cancer Hospital’s Department of Pathology and gastrointestinal surgery tissue archives(January 2003 to December 2011).The biopsied patients’demographic and clinicopathologic data were retrieved from the hospital’s medical records *** specimen was subjected to histopathological typing to classify the tumor node metastasis(TNM)stage and to immunohistochemistry staining to detect the expression of the cancer stem cell marker *** intergroup differences in LGR5 expression were assessed by Spearman’s rank correlation analysis,and the relationship between LGR5 expression level and the patients’clinicopathological characteristics was evaluated by theχ2test or Fisher’s exact ***:Significantly more gastric cancer tissues showed LGR5+staining than normal control tissues(all Pcancer-associated enhanced expression of LGR5 was found to be signifcantly

关键词： Leucine-rich repeat-containing G protein-coupled receptor 5 cancer stem cell Gastric cancer Intestinal metaplasia Tumorigenesis

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Prognostic value of cachexia defined by the Asian Working Group for Cachexia criteria in patients with gastric cancer

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Journal of Nutritional Oncology 2024年第2期9卷 63-71,I0001页

作者： Hai-Lun Xie Li-Shuang Wei Shu-Yao Wang Chang-Hong Xu Guo-Tian Ruan He-Yang Zhang Han-Ping Shi Jun-Qiang Chen Department of gastrointestinal Gland surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Department of General surgery Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Center of cancer Nutrition and Metabolism Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China guangxi key laboratory of enhanced recovery after surgery for gastrointestinal cancer The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina guangxi Clinical Research Center for enhanced recovery after surgery The First Affiliated Hospital of GuangxiMedical UniversityNanning 530021GuangxiChina and 7guangxi Zhuang Autonomous Region Engineering Research Center for Artificial Intelligence Analysis of Multimodal Tumor Images The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina

Background:The Asian Working Group for Cachexia(AWGC)criteria are newly proposed diagnostic standards specifically designed for Asian *** research focused on validating the predictive value of the AWGC criteria for assessing the prognosis and medical burden of patients with gastric ***:Cox proportional hazards analysis was conducted to evaluate the association between cachexia and overall *** regression analysis was used to assess whether there was an independent association between cachexia and the 90-day mortality,the length of stay and the quality of ***’s concordance index was utilized to demonstrate the discriminative ability of different diagnostic criteria for ***:AWGC-defined cachexia was an independent risk factor for a reduced overall survival in patients(HR=1.397,95%CI=1.209–1.615,Pcancer,whereas cachexia defined by the Fearon criteria was *** with AWGC-defined cachexia exhibited significant reductions in physical function,role function,emotional function,cognitive function,social functioning,and overall quality-of-life ***,cachectic patients showed higher levels of fatigue,nausea and vomiting,pain,dyspnea,sleep disturbance,appetite loss,constipation,and financial difficulties.A multivariate logistic regression showed that patients with AWGC-defined cachexia had a 126.1%increased risk of impaired quality of life(OR=2.261,95%CI=1.859–2.749,P<0.001).Conclusions:The AWGC criteria are an

关键词： Cachexia AWGC criteria Survival 90-Day mortality Gastric cancer

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Research progress of minimally invasive surgery for gastric cancer

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Chinese Journal of cancer Research 2023年第4期35卷 343-353页

作者： Hao Su Zhaode Bu key laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Center of Gastrointestinal CancerPeking University Cancer Hospital&InstituteBeijing 100142China

Since the first laparoscopic radical surgery for early gastric cancer 30 years ago, there has been a gradual shift from“open” to “minimally invasive” surgery for gastric cancer. This transition is due to advancements in refined anatomy, enlarged field of view, faster recovery, and comparable oncological outcomes. Several high-quality clinical studies have demonstrated the safety and effectiveness of laparoscopy in the treatment of both early and locally advanced gastric cancer. The role of perioperative chemotherapy in managing locally advanced gastric cancer has been widely recognized, and there have been continuous breakthroughs in the exploration of targeted therapy and immunotherapy for perioperative treatment. Additionally, the application of indocyanine green near-infrared imaging technology, 3D laparoscopic technology, and robotic surgery systems has further improved the accuracy and minimally invasive nature of gastric cancer surgeries. Looking ahead, the field of minimally invasive surgery for gastric cancer is expected to become more standardized, resulting in a significant enhancement in the quality of life for gastric cancer patients.

关键词： Minimally invasive gastric cancer laparoscopic gastrectomy research progress

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