Prognostic value of cachexia defined by the Asian Working Group for Cachexia criteria in patients with gastric cancer

作     者：Hai-Lun Xie Li-Shuang Wei Shu-Yao Wang Chang-Hong Xu Guo-Tian Ruan He-Yang Zhang Han-Ping Shi Jun-Qiang Chen Hai-Lun Xie;Li-Shuang Wei;Shu-Yao Wang;Chang-Hong Xu;Guo-Tian Ruan;He-Yang Zhang;Han-Ping Shi;Jun-Qiang Chen

作者机构：Department of Gastrointestinal Gland SurgeryThe First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Department of General SurgeryBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of GastroenterologyBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China Center of Cancer Nutrition and MetabolismBeijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Guangxi Key Laboratory of Enhanced Recovery after Surgery for Gastrointestinal CancerThe First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Clinical Research Center for Enhanced Recovery after SurgeryThe First Affiliated Hospital of GuangxiMedical UniversityNanning 530021GuangxiChina and 7Guangxi Zhuang Autonomous Region Engineering Research Center for Artificial Intelligence Analysis of Multimodal Tumor ImagesThe First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina 

出 版 物：《Journal of Nutritional Oncology》 (肿瘤营养学杂志（英文）)

年 卷 期：2024年第9卷第2期

页      面：63-71,I0001页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Young Elite Scientists Sponsorship Program by CAST(No.2022QNRC001) 

主　　题：Cachexia AWGC criteria Survival 90-Day mortality Gastric cancer 

摘      要：Background:The Asian Working Group for Cachexia(AWGC)criteria are newly proposed diagnostic standards specifically designed for Asian *** research focused on validating the predictive value of the AWGC criteria for assessing the prognosis and medical burden of patients with gastric ***:Cox proportional hazards analysis was conducted to evaluate the association between cachexia and overall *** regression analysis was used to assess whether there was an independent association between cachexia and the 90-day mortality,the length of stay and the quality of ***’s concordance index was utilized to demonstrate the discriminative ability of different diagnostic criteria for ***:AWGC-defined cachexia was an independent risk factor for a reduced overall survival in patients(HR=1.397,95%CI=1.209–1.615,P0.001).The predictive accuracy of the AWGC criteria was markedly superior to that of the Fearon criteria(χ2=39.025 vs 13.877).Compared with Fearon standards,the AWGC criteria offered a 2.9%enhancement in clinical benefit(0.029,95%CI=0.048–0.008,P=0.005).Logistic regression analysis showed that only AWGC-defined cachexia was an independent risk factor for 90-day mortality(OR=2.142,95%CI=1.397–3.282,P0.001)and prolonged hospitalization(OR=1.958,95%CI=1.587–2.416,P0.001)in patients with gastric cancer,whereas cachexia defined by the Fearon criteria was *** with AWGC-defined cachexia exhibited significant reductions in physical function,role function,emotional function,cognitive function,social functioning,and overall quality-of-life ***,cachectic patients showed higher levels of fatigue,nausea and vomiting,pain,dyspnea,sleep disturbance,appetite loss,constipation,and financial difficulties.A multivariate logistic regression showed that patients with AWGC-defined cachexia had a 126.1%increased risk of impaired quality of life(OR=2.261,95%CI=1.859–2.749,P0.001).Conclusions:The AWGC criteria are an