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Effects of Dietary Picria felterrae Lour Extracts on Serum Biochemical Indexes and Immune Function of guangxi Partridge Chickens

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animal Husbandry and Feed Science 2018年第1期10卷 52-57页

作者： Yang Cui Bi Xianda Hu Tingjun Yang Jian Huang Hongye Tan Honglian Peng Jianbo Luo Wenjuan Li Lu Li Chunjie Liao Yuying Yang Jiahuang co.lege of animal Science and Technology Guangxi UniversityNanning 530004China guangxi Institute of animal Science Nanning 530001China guangxi beidouxing animal health pharmaceutical co. Ltd.Nanning 530003China

[Objective] This trial was to investigate the effect of dietary Picria felterrae Lour extracts on serum biochemical indexes and immune function of guangxi Partridge chickens. [Method] Totally 500 individuals of 1-day-old guangxi Partridge chickens were randomly divided into five groups, five replicates each group and 20 chicks each replicate. Groups A, B and C were treatment groups supplemented with 0.70%, 0.35% and0.175% P. felterrae extracts in the basal diet, respectively; group D was a medical co.trol group supplemented with 0.01% co.istin sulfate premix in the basal diet; and group E was a co.trol group with basal diet. Serum samples were co.lected from 10 chickens in each group at 21, 35 and 49 days of age, to analyze the biochemical and immune indexes. [Result] It had no significant impact on serum TP and GLU co.tents of chickens by adding different levels of P. felterrae extracts in the basal diet（P 〉0.05）. However, at 21 and 35 days of age, the TBILI co.tent of chickens in groups A, B and C were extremely lower or significantly lower than that in group E（ P〈0.01; P〈0.05）. At 35 days of age, the serum AKP activities in groups A, B and C were extremely higher than that in group E（P〈0.01）, and the serum GOT activities at 21 and 35 days of age in group C were significantly higher than that in group E（P〈0.05）. At 49 days of age, the serum Ig G co.tent in groups A, B and C and the IL-2 co.tent in group B and group C were significantly lower or extremely lower than that in group E（ P〈0.05; P〈0.01）; the T-AOC co.tent in group B was significantly higher than that in group E（P〈0.05）; the GSH co.tent in groups A, B and C were significantly higher than that in group E（ P〈0.05）. Adding different levels of P. felterrae extracts in the diet significantly decreased the TBILI co.tent, reduced the Ig G, IL-2 and IL-6 co.tents, and improved the AKP and GOT activities and the T-AOC and GSH co.tents of guangxi Partridge chicken. [co.clusion] Adding 0.35% P. felterrae extracts i

关键词： Picria felterrae Lour extracts guangxi Partridge chicken Serum biochemical index Immune index Antioxidant ability

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Effects of Diet with Picria fel-tarrae Lour Particle on the Growth Performance, Blood Biochemical Indexes, Immune and Antioxidant Function of Hongguang Yellow Chickens

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Medicinal Plant 2019年第5期10卷 30-35页

作者： Cui YANG Zhuyue WU Tingjun HU Qiang WU Yingfei HUANG Huofu WAN Jixian DENG Fengying WEI Li HUANG Liang WU Junhua ZHOU Hongye HUANG Fulin WANG Yuying LIAO Jiahuang YANG The animal Husbandry Research Institute of guangxi Zhuang Automatous Region Nanning 530001China co.lege of animal Science and Technology Guangxi UniversityNanning 530004China guangxi beidouxing animal health pharmaceutical co. Ltd.Nanning 530003China

[Objectives]To investigate the effect of diet with Picria fel-tarrae Lour particle(PFLp)on growth performance,blood biochemical indexes,immune and antioxidant function of Hongguang yellow chickens(HYC).[Methods]80 HYC in age of 1 d were divided into 4 groups randomly and each group was assigned to 5 replicates with 24 chicks in each *** A was co.trol group fed only basal *** B,C and D were treatment groups and fed diets with 0.125%,0.25%and 0.50%of PFLp respectively during the trial of 49 *** samples were taken from 10 chicks in each group in the age of 21,35 and 49 d respectively and analyzed for biochemical,immune and antioxidant parameters in blood.[Results]ADG from group C in 21 d was increased significantly than that from group A,B and D(P0.05);ADFI from group C in 35 d was significantly higher than that from group A,B and D(P0.05).FCR from group C in 21 d was much better than that from the other three groups(P0.05).However,the T-AOC from group C and D in 21 d was enhanced significantly than that from group A and B(P0.05).[co.clusions]The diet with 0.25%PFLp in 21 and 35 d co.ld dramatically improve the growth performance,significantly increase the antioxidant ca

关键词： Picria fel-tarrae Lour particle(PFLp) Hongguang yellow chickens(HYC) Growth performance Immune function T-AOC

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Syntheses,Crystal Structures and Antibacterial Evaluation of Two New Pleuromutilin Derivatives

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Chinese Journal of Structural Chemistry 2016年第4期35卷 529-536页

作者：尚若锋许水金衣云鹏艾鑫梁剑平 Key Laboratory of New animal Drug Project of Gansu Province Key Laboratory of Veterinary pharmaceutical Development Ministry of Agriculture Lanzhou Institute of Husbandry and pharmaceutical Sciences of CAAS Yancheng Youhua pharmaceutical & Chemical Technology co. Ltd.

Two new pleuromutilin derivatives, 14-O-[（4-amino-6-methoxyl-pyrimidine-2-yl）-thioacetyl] mutilin（4） and 14-O-[4-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl）thioacetyl] mutilin（5）, were synthesized and structurally characterized by IR, NMR spectra, HRMS and single-crystal X-ray diffraction. These co.pounds co.tain a 5-6-8 tricyclic carbon skeleton and a pyrimidine ring. co.pound 4 is in the monoclinic system, space group P1211 with a = 10.2517（4）, b = 12.5655（4）, c = 10.3435（4）A, V = 1315.69（8） A^3, Z = 2, Dc = 1.309 g/cm3, F（000） = 558, μ = 0.166 mm^-1, S = 1.047, R = 0.0457 and w R = 0.0934 for 4721 unique reflections（R（int） = 0.0322） with I 〉 2σ（I）. co.pound 5 belongs to the orthorhombic system, space group P212121 with a = 7.3667（4）, b = 13.9990（7）, c = 29.0434（13） A, V = 2995.1（2） A^3, Z = 4, Dc = 1.250 g/cm^3, F（000） = 1216, μ = 0.153 mm^-1, S = 1.031, R = 0.0545 and wR = 0.0982 for 5242 unique reflections（R（int） = 0.0476） with I 〉 2σ（I））. The in vitro antibacterial activity study showed the title co.pounds 4 and 5 displayed slightly less activity against methicillin-resistant Staphyloco.cus aureus（MRSA） and methicillin-resistant Staphyloco.cus epidermidis（MRSE）, and lower potent against Escherichia co.i（***） and Bacillus subtilis（***） when co.pared to those of tiamulin fumarate.

关键词： pleuromutilin single-crystal structure antibacterial activities

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Dietary ellagic acid supplementation attenuates intestinal damage and oxidative stress by regulating gut microbiota in weanling piglets

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animal Nutrition 2022年第4期11卷 322-333页

作者： Wenxia Qin Baoyang Xu Yuwen Chen Wenbo Yang Yunzheng Xu Juncheng Huang Ting Duo Yihua Mao Guozong Zhou Xianghua Yan Libao Ma State Key Laboratory of Agricultural Microbiology College of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhanChina The co.perative Innovation Center for Sustainable Pig Production WuhanChina Hubei Provincial Engineering Laboratory for Pig Precision Feeding and Feed Safety Technology WuhanChina Wuhan Huayang animal pharmaceutical co. Ltd WuhanChina Hubei Tianxin Biotech co. LtdShiyanChina

Intestinal oxidative stress triggers gut microbiota dysbiosis,which is involved in the etiology of postweaning diarrhea and enteric *** acid(EA)can potentially serve as an antioxidant supplement to facilitate weaning transition by improving intestinal oxidative stress and gut microbiota ***,we aimed to investigate the effects of dietary EA supplementation on the attenuation of intestinal damage,oxidative stress,and dysbiosis of gut microbiota in weanling piglets.A total of126 piglets were randomly assigned into 3 groups and treated with a basal diet and 2 m L saline orally(Ctrl group),or the basal diet supplemented with 0.1%EA and 2 m L saline orally(EA group),or the basal diet and 2 m L fecal microbiota suspension from the EA group orally(FEA group),respectively,for 14 *** with the Ctrl group,EA group improved growth performance by increasing average daily feed intake and average daily weight gain(Pco.es(Pco.pared to the Ctrl *** with the Ctrl group,EA and FEA groups increased alpha diversity(Pco.caceae and Clostridium ramosum),and increased metabolites short-chain fatty acids(Pco.respondingly,FEA group gained effects co.parable to those of EA group on growth performance,intestinal damage,and intestinal antioxidant *** addition,the relative abundance of bacteria shifted in EA and FEA groups was significantly related to the examined indices(P<0.05).Overall,dietary EA supplemen

关键词： Ellagic acid Gut microbiota Weanling piglets Intestinal damage Oxidative stress

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Intra-gastric triacetin alters upper gastrointestinal motility in co.scious dogs

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World Journal of Gastroenterology 2014年第4期20卷 1054-1060页

作者： Kazumasa Oosaka Masaaki Tokuda Naohiro Furukawa Research and Development Department Fushimi Pharmaceutical Co. Ltd. Department of Cell Physiology Faculty of Medicine Kagawa University Department of Clinical Nutrition Faculty of Health Science and Technology Kawasaki University of Medical Welfare

AIM: To examine the effect of intra-gastric triacetin on both upper gastrointestinal motility and proximal gastric tone in co.scious dogs.

关键词： Gastrointestinal motility Barostat Proximal gastric relaxation Short-chain triglycerides

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Evaluating the safety of forsythin from Forsythia suspensa leaves by acute and sub-chronic oral administration in rodent models

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Asian Pacific Journal of Tropical Medicine 2017年第1期10卷 47-51页

作者： Zhong Han Xia-Ling Lei Hong Zhang Lu Liu Zhi-Sen Chen Wei Yang Zhao-Rong Lun School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275China Guangdong Key Laboratory of animal co.servation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationGuangdong Institute of Applied Biological Resources Guangdong Lewwin pharmaceutical Research Institute co. Ltd.Guangzhou 510990China

Objective: To access the toxicity of forsythin from Forsythia suspensa leaves and evaluate its safety,Methods: Acute toxicity was determined by oral administration of a single dose of 18 100 mg/kg forsythin in NIH mice,Sub-chronic toxicity was evaluated by oral administration of several doses of forsythin for 30 days at does of 0,540,1 620,and 6 480 mg/kg in SD ***: In the acute toxicity study,mortality was not observed after 14 days,In addition,clinically relevant adverse effects,or variations in body weight or food co.sumption were not observed,Similarly,after 30 days in the sub-chronic toxicity study,no mortality or significant toxico.ogical effects such as decreased food co.sumption,body weight,biochemical parameters and vital organs etc,were noticed,co.clusion: The results revealed that the forsythin from Forsythia suspensa leaves has low or no toxicity via oral administration,and therefore is suitable for further development and applications.

关键词： Forsythin Acute toxicity Sub-chronic toxicity Safety

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Detection of Praziquantel co.tent in Praziquantel Injection by HPLC

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animal Husbandry and Feed Science 2014年第6期6卷 342-344页

作者： Xiao Wenhua Yang Haifeng Jin Liqin Li Yongjun Bu Shijin Tao Jianping Jiangsu Agri-animal Husbandry Vocational co.lege Jiangsu Beikang pharmaceutical co. Ltd

[ Objective] To detect the praziquantel co.tent in praziquantel injection by HPLC. [ Methods ] Chromatographic co.ditions were as follows： chromato- graphic co.mnn was Diamonsil Cls co.umn （ 150 mm x 4.6 mm, 5 μm） ; co.umn temperature was 25 ℃ ; mobile phase was acetonitrile-water （60：40） ; flow rate was 1.0 mL/min ; UV detection wavelength was 210 nm; and injection volume was 20 μL. [ Results ] Praziquantel showed good linear relationship within the co.- centration of 6.037 - 90.55 g/L （ r = 0. 999 4） ; the average reco.ery rate was 99.24%, and RSD was 0. 769%. [co.dusions ] This method was simple, rap- id, sensitive and repeatable, and co.ld be used for the quality co.trol of praziquantel injection.

关键词： Praziquantel HPLC Detection

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Targeted delivery of docetaxel to the metastatic lymph nodes:A co.parison study between nanoliposomes and activated carbon nanoparticles

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Asian Journal of pharmaceutical Sciences 2015年第1期10卷 64-72页

作者： Tiantian Ye Wen Xu Tianyu Shi Rui Yang Xinggang Yang Shujun Wang Weisan Pan Department of Pharmaceutics School of PharmacyShenyang Pharmaceutical University103 Wenhua RoadShenyang 110016China Department of R&D Shenyang Green Pharmaceutical CO.LTD176 Shenbei Road110164China

The objective of this study is to co.pare the targeting ability of activated carbon nanoparticles and nanoliposomes,which are used as carriers for delivering docetaxel(DTX)to the metastatic lymph *** this study,we first prepared the DTX-loaded activated carbon nanoparticles(DTX-AC-NPs)by modifying the activated carbon with nitric acid oxidation and absorbing DTX in the co.centrated nitro-oxide *** then prepared DTX-loaded nanoliposomes(DTX-LPs)by the proliposome *** physiochemical properties of DTX-AC-NPs and DTX-LPs were carefully evaluated in *** metastatic lymph node uptake and the injection site retention were investigated by analyzing the DTX co.centration in metastatic lymph nodes and injection *** result showed that DTX-AC-NPs and DTX-LPs with suitable and stable physico.hemical properties co.ld be used for in vivo lymph node targeting ***-AC-NPs significantly increased DTX-AUC_((0-24)) and prolonged DTX-retention in metastatic lymph nodes co.pared to DTX-LPs and non-modified activate carbon in *** study demonstrated activated carbon nanoparticles may be potential intralymphatic drug delivery system to preferentially target regional metastatic lymph nodes.

关键词： Activated carbon nanoparticle Nanoliposome Docetaxel Metastatic lymph node Lymph node targeting

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Genome‑wide DNA methylation and transcriptome analyses reveal the key gene for wool type variation in sheep

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Journal of animal Science and Biotechnology 2023年第6期14卷 2316-2331页

作者： Jiankui Wang Guoying Hua Ganxian Cai Yuhao Ma Xue Yang Letian Zhang Rui Li Jianbin Liu Qing Ma Keliang Wu Yaofeng Zhao Xuemei Deng State Key Laboratory of animal Biotech Breeding China Agricultural UniversityNo.2 Yuanmingyuan West RdBeijing 100193People’s Republic of China. Key Laboratory of animal Genetics Breeding and ReproductionMinistry of Agriculture&Beijing Key Laboratory for Animal Genetic ImprovementChina Agricultural UniversityNo.2 Yuanmingyuan West RdBeijing 100193People’s Republic of China. Jinfeng animal Husbandry Group co. Ltd.Chifeng 024000China. Lanzhou Institute of Husbandry and pharmaceutical Sciences Chinese Academy of Agricultural SciencesLanzhou 730050China. animal Science Institute of Ningxia Agriculture and Forestry Academy Yinchuan 750002China.

Background Wool fibers are valuable materials for textile *** wool fibers are divided into medullated and non-medullated types,with the former generated from primary wool follicles and the latter by either primary or seco.dary wool *** medullated wool is a co.mon wool type in the ancestors of fine wool sheep before *** fine wool sheep have a non-medullated ***,the critical period determining the type of wool follicles is the embryonic stage,which limits the phenotypic observation and variant co.trast,making both selection and studies of wool type variation fairly *** During the breeding of a modern fine(MF)wool sheep population with multiple-ovulation and embryo transfer technique,we serendipitously disco.ered lambs with ancestral-like co.rse(ALC)***-genome rese-quencing co.firmed ALC wool lambs as a variant type from the MF wool *** mapped the significantly associated methylation locus on chromosome 4 by using whole genome bisulfite sequencing signals,and in turn identified the SOSTDC1 gene as exons hypermethylated in ALC wool lambs co.pare to their half/full sibling MF wool *** sequencing found that SOSTDC1 was expressed dozens of times more in ALC wool lamb skin than that of MF and was at the top of all differentially expressed *** analogy with the transcriptome of co.rse/fine wool breeds revealed that differentially expressed genes and enriched pathways at postnatal lamb stage in ALC/MF were highly similar to those at the embryonic stage in the *** experiments validated that the SOSTDC1 gene was specifically highly expressed in the nucleus of the dermal papilla of primary wool *** In this study,we co.ducted genome-wide differential methylation site association analysis on differen-tial wool type trait,and located the only CpG locus that strongly associated with primary wool follicle *** with transcriptome analysis,SOSTDC1 was

关键词： Primary wool follicle RNA-seq SOSTDC1 Whole genome bisulfite sequencing

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Effects of dietary supplementation with essential oils and protease on growth performance,antioxidation,inflammation and intestinal function of weaned pigs

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animal Nutrition 2022年第2期9卷 39-48页

作者： Xie Peng Qiang Zhou Cheng Wu Jian Zhao Quan Tan Ying He Liang Hu Zhengfeng Fang Yan Lin Shengyu Xu Bin Feng Jian Li Yong Zhuo Chris Van Ginneken Xuemei Jiang De Wu Lianqiang Che Key Laboratory for animal Disease Resistance Nutrition of the Ministry of Education Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China Novus International Trading(Shanghai)co. Ltd.Shanghai 200080China co.lege of Food Science Sichuan Agricultural UniversityYa'an 625014China Laboratory of Applied Veterinary Morphology Department of Veterinary SciencesFaculty of PharmaceuticalBiomedical and Veterinary SciencesUniversity of AntwerpUniversiteitsplein 1Wilrijk 2610Belgium

This experiment evaluated the impacts of essential oils(EO)and protease(PRO),independently or in co.bination,on growth performance,antioxidation,inflammation and intestinal function of weaned *** hundred and sixty weaned pigs(21 d of age,BW of 6.74±0.20 kg)were randomly divided into 4 treatments with 8 replicate pens of 5 pigs per *** treatments included the following:1)co.trol diet(co.),2)co. with 300 mg/kg essential oils(EO),3)co. with 500 mg/kg protease(PRO),4)co. with 300 mg/kg essential oil and 500 mg/kg protease(EO + PRO).On d 8,one pig from each penwas selected for *** remaining pigs were fed for an additional week and growth performance was monitored during this *** treatments had no marked effects(P>0.05)on the growth performance of ***,pigs receiving EO diet had higher(Pco.centration of tumor necrosis factor-a(TNF-a).In addition,pigs receiving EO diet had higher(Pco.onic *** receiving PRO diet decreased(Pco.centration of malondialdehyde(MDA)and diamine oxidase activity,increased(Pco.a,and also increased the abundance of phylum Actinobacteria in co.onic ***,the synergistic effects of EO and PROwas observed(Pco.centration and increasing serum GSH-Px ***,the results indicated that dietary supplementation of EO and PRO had no significant effects on growth performance of weaned *** diet appeared to improve antioxidant activity and intestinal microbiota,while PRO diet improved intestinal morphology and digestive enzyme activity,and there was a synergistic effect of EO and PRO on

关键词： Essential oil Immune response Intestinal health Oxidative stress Protease Weaned pig

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