检索结果-南通市图书馆

China Medical Abstracts(Internal Medicine) 2022年第1期39卷 19-20页

作者： TANG Qiao guangxi aids prev&treat key lab Public Health SchGuangxi Med UnivNanning 530021

Objective To investigate the effect and influencing factors of anti-retroviral therapy(ART)in human imm nodeficiency virus(HIV)-positive female commercial sex workers(CSW)in guangxi Zhuang Autonomous *** A retrospective cohort study was used in this study.A total of 661 HIV-positive CSW receiving ART from the guangxi Zhuang Autonomous Region's municipal and county-level Centers for Disease Control and prevention(CDC)reported to guangxi Zhuang Autonomous Region CDC from January 1,2009 to December 31,2018 were included.

关键词： female workers effect

Local-contrastive-learning machine with both generalization and adversarial robustness: A statistical physics analysis

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 109-123页

作者： Mingshan Xie Yuchen Wang Haiping Huang PMI lab School of Physics Sun Yat-sen University Guangdong Provincial key laboratory of Magnetoelectric Physics and Devices Sun Yat-sen University

Distinct from human cognitive processing, deep neural networks trained by backpropagation can be easily fooled by adversarial examples. To design a semantically meaningful representation learning, we discard backpropagation, and instead, propose a local contrastive learning, where the representations for the inputs bearing the same label shrink(akin to boson) in hidden layers,while those of different labels repel(akin to fermion). This layer-wise learning is local in nature, being biologically plausible.A statistical mechanics analysis shows that the target fermion-pair-distance is a key parameter. Moreover, the application of this local contrastive learning to MNIST benchmark dataset demonstrates that the adversarial vulnerability of standard perceptron can be greatly mitigated by tuning the target distance, i.e., controlling the geometric separation of prototype manifolds.

关键词： machine learning statistical mechanics adversarial robustness neural networks

Mechanism of modified Chaihu Shugan formula in the treatment of epilepsy based on IncRNA-UCA1/miR-187/MAPK8 pathway

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

China Medical Abstracts(Internal Medicine) 2024年第1期41卷 13-14页

作者：李瑞暖 guangxi Molec Biol key lab TCM Prev&TreatGraduate SchGuangxi TCM UnivNanning 530023

Objective To observe the effects of Modified Chaihu Shugan Formula (MCSF) on the behavior of epileptic mice and their regulatory effects on long noncoding RNAUCA1(lncRNA-UCA1),microRNA-187(miR-187) and recombinant mitogen activated protein kinase 8(MAPK8).Methods Totally 80 mice were randomly divided into normal group,model group (pilocarpine hydrochloride 180 mg/kg).

关键词： epilepsy Chaihu UCA1

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu key lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

Revealing and predicting the long-term biomechanical response of orthokeratology by developing a patient-specific computational model

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 156-168页

作者： Yifeng Li Zhuoran Yang Ziming Yan Huibin Shi Zhanli Liu Kaijie Wang Department of Engineering Mechanics School of Aerospace Engineering Tsinghua University Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Lab

Orthokeratology(OK) is widely used for effective myopia correction and control. However, the incomplete understanding of its biomechanical mechanisms makes OK lens fitting rely heavily on clinician judgment, complicating accurate predictions of treatment outcomes. In this paper, we performed clinical experiments and numerical analysis to study corneal deformation modes and long-term changes in central corneal thickness. Clinical experiments were conducted on 194 Chinese myopic patients under OK treatment for 3 months. Based on the experimental data, a patient-specific computational biomechanical model for OK was established and validated. Specifically, the anisotropic mechanical properties of the cornea were incorporated into the model to describe the significant difference between its shear modulus(29.5 kPa) and tensile modulus(768.4 kPa). Additionally, a viscohyperelastic material model with a prolonged corneal relaxation time of 5.6 h was developed to capture the long-term deformation response. The results show that corneal thickness reduction in OK is primarily due to out-of-plane shear deformation,influenced by the cornea's low shear resistance. Modeling the extended corneal relaxation time is crucial for predicting long-term biomechanical responses. The computational model effectively captures long-term changes in central corneal thickness, potentially improving OK lens fitting accuracy.

关键词： orthokeratology computational biomechanical model long-term viscoelasticity myopia correction

Surface-confined persistent luminescence with amplified FRET efficiency for cell-cell communication monitoring

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Ziyun Miao Wenjing Dai Yubin Jin Bing Qi Jiayi Chen Lingling Qiu Yurong Wei Jie Wang The key lab of Health Chemistry&Molecular Diagnosis of Suzhou College of ChemistryChemical Engineering&Materials ScienceSoochow University

Microbial communication monitoring is vital for understanding the mechanisms beneath gut microbiota equilibrium, infections,and biomanufacturing. Herein, we reported monitoring bacterial communication by surface-confined persistent ***, we constructed core-shell structured Zn1.4Ga1.2Ge0.4O4@Zn1.4Ga1.2Ge0.4O4:Cr（ZGGO@ZGGO:Cr） persistent luminescence nanoparticles（PLNPs） with amplified FRET efficiency for the detection of azoreductase（AzoR） that participates in bacterial communication. ZGGO@ZGGO:Cr nanoparticles were functionalized with an azo black hole quencher（ZGGO@ZGGO:Cr-BHQ-3）. Due to the proximity of surface-confined persistent luminescence with the surface-bound BHQ-3,ZGGO@ZGGO:Cr-BHQ-3 exhibited a FRET efficiency up to 1.6 times that of traditional ZGGO:Cr-BHQ-3. Further, the specific catalytic reduction of azo bonds in BHQ-3 by bacterial extracellular AzoR recovers the persistent luminescence of ZGGO@ZGGO:Cr. ZGGO@ZGGO:Cr-BHQ-3 displayed superior sensitivity and speed in detecting extracellular AzoR over ZGGO:Cr-BHQ-3, attributed to its surface-confined persistent luminescence. We found that the peak secretion of AzoR occurs during the exponential growth period of bacteria including S. aureus and E. coli based on the persistent luminescence recovery rate of ZGGO@ZGGO:Cr-BHQ-3. Furthermore, ZGGO@ZGGO:Cr-BHQ-3 was used to probe the communication between different bacterial species. R. palustris is a kind of lycopene-production bacteria. We found that the cohabitation of R. palustris and S. putrefaciens boosted both AzoR secretion and lycopene production. Moreover, the secretion and activity of AzoR positively correlated with lycopene production, suggesting that AzoR may participate in the communication between R. palustris and S. putrefaciens to promote lycopene production. This study offers a robust method to enhance PLNP-based biosensing sensitivity and provides a promising strategy for microbial communication monitoring.

关键词：

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang Jian Wang Panpan Zhang Xiaomin Cheng Qinghua Guan Jing Dong Bixian Chen Lujie Jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-lab & CAS key laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State key laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

Designing Electronic Structures of Multiscale Helical Converters for Tailored Ultrabroad Electromagnetic Absorption

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 439-455页

作者： Zhaobo Feng Chongbo Liu Xin Li Guangsheng Luo Naixin Zhai Ruizhe Hu Jing Lin Jinbin Peng Yuhui Peng Renchao Che key laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle School of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Physics and Materials Nanchang UniversityNanchang 330031People’s Republic of China key laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063People’s Republic of China laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering and TechnologyFudan UniversityShanghai 200438People’s Republic of China

Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)***,the relationship between configuration and electromagnetic(EM)loss mechanism has remained ***,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA *** calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM *** a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 *** precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm ***,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB *** innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.

关键词： Metal-nonmetal co-doping 3d-2p orbital coupling Spin polarization Helical structure Broadband EM wave absorption

A Temporal Knowledge Graph Embedding Model Based on Variable Translation

在线全文

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2024年第5期29卷 1554-1565页

作者： Yadan Han Guangquan Lu Shichao Zhang Liang Zhang Cuifang Zou Guoqiu Wen key lab of Education Blockchain and Intelligent Technology Ministry of EducationGuangxi Normal UniversityGuilin 541004China and also with Guangxi Key Lab of Multi-Source Information Mining and SecurityGuangxi Normal UniversityGuilin 541004China

Knowledge representation learning(KRL)aims to encode entities and relationships in various knowledge graphs into low-dimensional continuous *** is popularly used in knowledge graph completion(or link prediction)***-based knowledge representation learning methods perform well in knowledge graph completion(KGC).However,the translation principles adopted by these methods are too strict and cannot model complex entities and relationships(i.e.,N-1,1-N,and N-N)***,these traditional translation principles are primarily used in static knowledge graphs and overlook the temporal properties of triplet ***,we propose a temporal knowledge graph embedding model based on variable translation(TKGE-VT).The model proposes a new variable translation principle,which enables flexible transformation between entities and relationship ***,this paper considers the temporal properties of both entities and relationships and applies the proposed principle of variable translation to temporal knowledge *** conduct link prediction and triplet classification experiments on four benchmark datasets:WN11,WN18,FB13,and *** model outperforms baseline models on multiple evaluation metrics according to the experimental results.

关键词： knowledge graph knowledge graph completion variable translation temporal properties link prediction triplet classification

Impact of HIV/HCV Co-Infection on Mortality and Attrition in Antiretroviral Therapy Among People with HIV — guangxi Zhuang Autonomous Region, China, 2003–2022

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China CDC weekly 2023年第44期5卷 973-977,I0001页

作者： He Jiang Qiuying Zhu Jinghua Huang Xiuling Wu Bo Li Xuanhua Liu Qin Meng Shuai Tang Guanghua Lan guangxi key laboratory of aids prevention and Control and Achievement Transformation Guangxi Center for Disease Prevention and ControlNanning CityGuangxi Zhuang Autonomous RegionChina guangxi key laboratory for Major Infectious Diseases prevention and Control and Biosafety Emergency Response Guangxi Center for Disease Prevention and ControlNanning CityGuangxi Zhuang Autonomous RegionChina

Summary What is already known about this topic?The effects of concurrent human immunodeficiency virus(HIV)/hepatitis C virus(HCV)infection on mortality and patient attrition in those undergoing antiretroviral therapy ... 详细信息

关键词： mortality Therapy Impact