检索结果-南通市图书馆

Predator stress-induced depression is associated with inhibition of hippocampal neurogenesis in adult male mice

Neural Regeneration research 2019年第2期14卷 298-305页

作者： Yan-Ping Wu Hua-Ying Gao Shu-Hua Ouyang Hiroshi Kurihara Rong-Rong He Yi-Fang Li guangdong Province key laboratory of pharmacodynamic constituents of tcm and new drugs research College of Pharmacy Jinan University Anti-Stress and Health research Center College of Pharmacy Jinan University

Stress has been suggested to disturb the 5-hydroxytryptamine system and decrease neurogenesis, which contribute to the development of depression. Few studies have investigated the effect of predator stress, a type of psychological stress, on depression and hippocampal neurogenesis in adult mice; we therefore investigated this in the present study. A total of 35 adult male Kunming mice were allocated to a cat stress group, cat odor stress group, cat stress + fluoxetine group, cat odor stress + fluoxetine group, or a control group(no stress/treatment). After 12 days of cat stress or cat odor stress, behavioral correlates of depression were measured using the open field test, elevated plus maze test, and dark-avoidance test. The concentrations of hippocampal 5-hydroxytryptamine and 5-hydroxyindoleacetic acid were measured using high-performance liquid chromatography-electrochemical detection. Neurogenesis was also analyzed using a bromodeoxyuridine and doublecortin double-immunostaining method. Cat stress and cat odor stress induced depression-like behaviors; this effect was stronger in the cat stress model. Furthermore, compared with the control group, cat stress mice exhibited lower 5-hydroxytryptamine concentrations, higher 5-hydroxyindoleacetic acid concentrations, and significantly fewer bromodeoxyuridine+/doublecortin+-labeled cells in the dentate gyrus, which was indicative of less neurogenesis. The changes observed in the cat stress group were not seen in the cat stress + fluoxetine group, which suggests that the effects of predator stress on depression and neurogenesis were reversed by fluoxetine. Taken together, our results indicate that depression-like behaviors induced by predator stress are associated with the inhibition of hippocampal neurogenesis.

关键词： nerve regeneration depressive disorder cat stress cat odor stress behavioral evaluation open field test elevated plus maze test dark-avoidance test 5-hydroxytryptamine 5-hydroxyindoleacetic acid hippocampal neurogenesis neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structural Modification Based on Natural Products Leads to More Drug-like Candidates

引用

Chinese Journal of Structural Chemistry 2017年第12期36卷 1947-1960页

作者：陈河如张潮蒋真磊刘杰 Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy Jinan University guangdong Province key laboratory of pharmacodynamic constituents of tcm and new drugs research Jinan University

Natural products are characterized with diverse structures and biological activities. They show a certain degree of adaptability to human beings. However, they need to be modified to increase their druggability. Several strategies including pharmacophore similarity, physicochemical property optimization, and bioactivity focus may help to make them more drug-like candidates.

关键词： natural product druggability pharmacophore similarity bioactivity focus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Targeted isolation of antiviral cinnamoylphloroglucinol-terpene adducts from Cleistocalyx operculatus by building blocks-based molecular networking approach

引用

Acta Pharmaceutica Sinica B 2024年第10期14卷 4443-4460页

作者： Jianguo Song Ruili Huang Jialiao Cai Zhenlong Wu Lijun Hu Wanyang Sun Xiaojun Huang Rongrong He Wei Tang Wencai Ye Ying Wang State key laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China guangdong Province key laboratory of pharmacodynamic constituents of tcm&new drugs research Jinan UniversityGuangzhou 510632China guangdong-Hong Kong-Macao Joint laboratory for pharmacodynamic constituents of tcm and new drugs research Jinan UniversityGuangzhou 510632China Center for Bioactive Natural Molecules and Innovative drugs research College of PharmacyJinan UniversityGuangzhou 510632China

The building blocks-based molecular network(BBMN)strategy was applied to the phytochemical investigation of Cleistocalyx operculatus,leading to the targeted isolation of eighteen novel cinnamoylphloroglucinol-terpene adducts(CPTAs)with diverse skeleton types(cleistoperones A-R,1-18).Their structures including absolute configurations were determined by extensive spectroscopic methods,quantum chemical calculations,and single-crystal X-ray crystallographic *** A(1),consisting of a cinnamoylphloroglucinol motif and two linear monoterpene moieties,represents an unprecedented macrocyclic CPTA,whose densely functionalized tricyclo[15.***.1.0^(3,8)]heneicosane bridge ring skeleton contains an enolizableβ,β′-triketone system and two different kinds of stereogenic elements(including five point and three planar chiralities).Cleistoperones B and C(2 and 3)are two new skeletal CPTAs with an unusual coupling pattern between the(nor)monoterpene moiety and the cinnamoyl chain of the cinnamoylphloroglucinol *** D(4)possesses an unprecedented cage-like 6/6/6/4/6-fused heteropentacyclic *** plausible biosynthetic pathways for 1-18 were also ***,compounds 1,4,7,8,and 18 exhibited significant antiviral activity against respiratory syncytial virus(RSV).The most potent one,cleistoperone A(1)with IC_(50) value of 1.71±0.61μmol/L,could effectively inhibit virus replication via affecting the Akt/mTOR/p70S6K signaling pathway.

关键词： Cleistocalyx operculatus Cinnamoylphloroglucinolterpene adduct Targeted isolation Molecular networking Structure elucidation Cleistoperone A Respiratory syncytial virus Antiviral activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity

引用

Acta Pharmaceutica Sinica B 2019年第2期9卷 433-442页

作者： Zhiqin Cao Shaoyang Li Jianming Lv Hao Gao Guodong Chen Takayoshi Awakawa Ikuro Abe Xinsheng Yao Dan Hu Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University Graduate School of Pharmaceutical Sciences The University of Tokyo

Fusidic acid is the only fusidane-type antibiotic that has been clinically used. However,biosynthesis of this important molecule in fungi is poorly understood. We have recently elucidated the biosynthesis of fusidane-type antibiotic helvolic acid, which provides us with clues to identify a possible gene cluster for fusidic acid(fus cluster). This gene cluster consists of eight genes, among which six are conserved in the helvolic acid gene cluster except fusC1 and fusB1. Introduction of the two genes into the Aspergillus oryzae NSAR1 expressing the conserved six genes led to the production of fusidic acid. A stepwise introduction of fusC1 and fusB1 revealed that the two genes worked independently without a strict reaction order. Notably, we identified two short-chain dehydrogenase/reductase genes fusC1 and fusC2 in the fus cluster, which showed converse stereoselectivity in 3-ketoreduction. This is the first report on the biosynthesis and heterologous expression of fusidic acid.

关键词： Biosynthesis Fungi Fusidic acid Fusidane-type antibiotics SDR

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and Crystal Structure of (9S)-2′-O-Benzoyl-9,11-[carbonylbis(oxy)]-9-deoxo-5-O-(β-D-desosaminyl)-12,21-anhydro-9-hydroxy-erythronolide A

引用

Chinese Journal of Structural Chemistry 2009年第2期28卷 191-194页

作者：王永涛陈卫民胡艾希江仁望曹高苏文魁关东 College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410082 China guangdong provincial key laboratory of pharmacodynamic constituents of tcm and new drugs research College of Pharmacy Jinan UniversityGuangzhou 510632 China

The title compound （9S）-2＇-O-benzoyl-9,11-[carbonylbis（oxy）]-9-deoxo-5-O-（-D- desosaminyl）-12,21-anhydro-9-hydroxyerythronolide A 1 was synthesized. The crystal structure of the acetone solvate of 1, C_37H_55NO11·C_3H_6O, was determined by single-crystal X-ray diffraction analysis. It belongs to monoclinic system, space group P21 with a = 14.4691（10）, b = 8.2626（6）, c = 17.5990（11） А, β= 94.167（1）°, V = 2098.4（2） А^3, Mr= 748, Z = 2, Dc= 1.184 g/cm^3,μ= 0.087 mm^-1, F（000） = 808, S = 1.026, R = 0.0542 and wR = 0.1322 for 3331 observed reflections （I〉 2σ（I））. In the solid state, molecules of 1 are linked into spirals along the b axis by O（25）-H（25）…O（29） intermolecular hydrogen bond.

关键词： crystal structure synthesis erythromycin derivatives

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pyromeconic acid derivatives from Conyza canadnsis(L.) Cronq

引用

Chinese Chemical Letters 2011年第6期22卷 694-696页

作者： Bai Lian Liu Institute of Traditional Chinese Medicine & Natural Products Jinan University Guangzhou 510632 China guangdong Province key laboratory of pharmacodynamic constituents of tcm and new drugs research Jinan University Guangzhou 510632 China

A new pyromeconic acid derivative,pyromeconic acid-3-O-β-D-glucopyranoside-3′-（O-β-D-glucopyranoside）-6′-（O-4″-hydroxybenzoate）（1）,along with two known ones,were isolated from the whole plants of Conyza *** structures were elucidated based on the analysis of their spectroscopic *** in vitro antibacterial testing results showed that all of these three compounds were inactive towards two bacterial strains,Escherichia coli and Staphyloccocus aureus.

关键词： Conyza canadensis Chemical constituents Pyromeconic acid derivatives

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chemical composition-based characterization of the anti-allergic effect of Guominkang Formula on IgE-mediated mast cells activation and passive cutaneous anaphylaxis

引用

Chinese Journal of Natural Medicines 2022年第12期20卷 925-936页

作者： TANG Ding WANG Chen GAN Qianying WANG Zhixin JIANG Renwang guangdong Province key laboratory of pharmacodynamic constituents of tcm and new drugs research and International Cooperative laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education College of PharmacyJinan UniversityGuangzhou 510000China

Guominkang(GMK),a Chinese medicine formula,has been used to treat allergic diseases in clinical settings for many *** evaluate the antiallergic effect and molecular mechanism of action of GMK extract,RBL-2H3 cell models and passive cutaneous anaphylaxis(PCA)mouse models were *** performance liquid chromatography(HPLC)and ultra-high performance liquid chromatography-mass spectrometry(UHPLC-MS)analyses were performed to characterize the chemical composition of GMK.A total of 94 compounds were identified or tentatively identified from *** of them,emodin,ursolic acid,and hamaudol,were identified for the first time as potential active compounds in GMK,since they inhibited the degranulation of mast *** anti-allergic effect of hamaudol was the first to be *** could markedly mitigate the shade of Evans Blue extravasation and ear incrassation in PCA mouse ***,GMK significantly inhibited the degranulation of mast cells,suppressed mast cell degranulation by reducing Ca2+influx and the levels of TNF-α,IL-4,and histamine,and markedly inhibited the phosphorylation of Lyn,Syk,PLCγ1,IκBα,and NF-κB *** docking results indicated that hamaudol and emodin had strong interaction with FcεRI and NF-κB related proteins,while ursolic acid only interacted with NF-κB associated *** results suggest GMK suppresses the activation of MCs both in vivo and in *** underlying mechanism of its anti-allergic activity is associated with the inhibition of FcεRI and NF-κB activation.

关键词： Guominkang(GMK) Allergic diseases Mast cells FcεRI NF-κB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel Cinobufagin Oxime Ether Derivatives as Potential Na＋/K＋-ATPase Inhibitors： Synthesis, Biological Screening and Molecular Docking

引用

Chemical research in Chinese Universities 2017年第3期33卷 378-383页

作者： LIANG Guangping CHUNG Tseyu GUO Jinhua ZHANG Rongrong XU Wei TZEN Jason T.C JIANG Renwang College of Pharmacy guangdong Province key laboratory of pharmacodynamic constituents of tcm and new drugs research Jinan University Guangzhou 510632 P. R. China Graduate Institute of Biotechnology 'National Chung-Hsing University ' Taichung 40227 China

Some cinobufagin oxime ether derivatives as potential Na＋/K＋-ATPase inkibitors were synthesized by following the side chain of istaroxime. These compounds inhibit Na＋/K＋-ATPase in a dose-dependent manner. Compound 3c with an oxyethylamine side chain that is the same as that of istaroxime showed the most potent inhibi- tion, which was stronger than compound 3a with only hydroxyoxime moiety at C3 and compound 3b with a methy-lated hydroxyoxime moiety. Molecular docking was used to explore the binding modes of the target compounds with Na＋/K＋-ATPase, which suggested that the longer ethyl amine group at C3 oxime moiety of compound 3c could make stronger interaction with Na＋/K＋-ATPase via intermolecular charge-charge and H-bond interaction as compared with other derivatives.

关键词： Cinobufagin Istaroxime Na+/K+-ATPase Molecular docking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Total Syntheses of Favolasins A,E,G and K,Polyketides Isolated from Cultures of the Basidiomycetes Fungi Favolaschia *** 18686 and Favolaschia calocera BCC 36684

引用

Chinese Journal of Chemistry 2023年第12期41卷 1450-1464页

作者： Bingbing Sheng Ping Lan Jolynn Kiong Zeinab G. Khalil Robert J. Capon Martin G.Banwell Institute for Advanced and Applied Chemical Synthesis College of Pharmacy Jinan University Guangzhou Guangdong 510632 China guangdong Province key laboratory of pharmacodynamic constituents of tcm & new drugs research Jinan University Guangzhou Guangdong 510632 China Institute for Molecular Bioscience The University of Queensland St Lucia QLD 4072 Australia guangdong key laboratory for research and the Development of Natural drugs The Marine Biomedical Research Institute Guangdong Medical University Zhanjiang Guangdong 524023 China

The structures assigned to all four members,1-4,of the recently reported favolasin class of natural product have been prepared for the first time by chemical ***-Miyaura cross-coupling chemistry was used to establish the associated biaryl *** key step used in preparing the 1,5-benzodioxepin ring system associated with compounds 3 and 4 was the acid-catalyzed 7-exo-tet cyclization of an appropriately substituted 2-(oxiran-2-ylmethoxy)phenol while a base-promoted 6-exo-tet cyclization of the same substrate was used to construct the 2,3-dihydrobenzo[b][1,4]dioxine core of target *** spectral data derived from the four synthetically-produced favolasins matched those reported for the corresponding natural *** biological screening of compounds 1-3 as well as a suite of fourteen precursors reveal that they display no notable anti-bacterial,anti-fungal or anti-tumor activities but congener K(4)is active,in the mM range,against Plasmodium falciparum.

关键词： Total syntheses Favolasins Suzuki-Miyaura cross-coupling Acetalization Anti-malarial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Discovery of unusual phloroglucinol-triterpenoid adducts from Leptospermum scoparium and Xanthostemon chrysanthus by building blocks-based molecular networking

引用

Chinese Chemical Letters 2024年第6期35卷 353-357页

作者： Jinyan Zhang Fen Liu Qian Jin Xueyi Li Qiong Zhan Mu Chen Sisi Wang Zhenlong Wu Wencai Ye Lei Wang State key laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Center for Bioactive Natural Molecules and Innovative drugs and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchJinan UniversityGuangzhou 510632China College of Pharmacy Jinan UniversityGuangzhou 510632China

The first phloroglucinol-triterpenoid hybrids,myrtphlotritins A-E(1-5),were rapidly recognized and isolated from two species of Myrtaceae by employing the building blocks-based molecular network(BBMN)*** 1-5 featured new carbon skeletons in which phloroglucinol derivatives were coupled with lupane-and dammarane-type triterpenoids through different linkage *** structures and absolute configurations were elucidated by comprehensive analysis of spectroscopic data and quantum chemical *** pathways for compounds 1-5 were proposed on the basis of the coexisting *** by the biogenetic pathways,the biomimetic synthesis of compound 1 was also ***,compounds 2,3,and 5 exhibited potent antiviral activities against herpes simplex virus type-1(HSV-1)infection,and compounds 2 and 5 displayed significant anti-inflammatory activities on RAW264.7 cells.

关键词： Phloroglucinol-triterpenoid adduct Myrtaceae Building blocks-based molecular network Biomimetic synthesis Antiviral activity Anti-inflammatory activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：